ライフサイエンスコーパス: rod photoreceptor

1 e photoreceptors (equivalent to rhodopsin of rod photoreceptors).

2 dual subcellular compartments of the retinal rod photoreceptor.

3 otent stem cells (iPSCs) derived from murine rod photoreceptors.

4 sicles to selected membrane sites in retinal rod photoreceptors.

5 ursors in real time in single isolated mouse rod photoreceptors.

6 bodies of ultraviolet-sensitive cones or in rod photoreceptors.

7 romote facultative heterochromatin in mature rod photoreceptors.

8 in, Dendra2, and expressed in Xenopus laevis rod photoreceptors.

9 neurons operating immediately downstream of rod photoreceptors.

10 bly when photons arrive rarely at individual rod photoreceptors.

11 f the XOPS-mCFP transgenic line, which lacks rod photoreceptors.

12 control of transgene expression in zebrafish rod photoreceptors.

13 dendrites to form new synapses with healthy rod photoreceptors.

14 hat CNG-modulin is expressed in cone but not rod photoreceptors.

15 ker for functional abnormalities in maturing rod photoreceptors.

16 l of transgene expression can be achieved in rod photoreceptors.

17 photoreceptors and only minimal contact with rod photoreceptors.

18 cal relevance of Mef2c expression in retinal rod photoreceptors.

19 could support Rhodopsin promoter activity in rod photoreceptors.

20 ds interactions in transgenic Xenopus laevis rod photoreceptors.

21 quirements for the death of kinesin-2-mutant rod photoreceptors.

22 condary event resulting from degeneration of rod photoreceptors.

23 ld-type as well as Nrl(-/-) mice, which lack rod photoreceptors.

24 rs and that it regulates the regeneration of rod photoreceptors.

25 r beta (ERRbeta) as selectively expressed in rod photoreceptors.

26 e inner segment and outer plexiform layer of rod photoreceptors.

27 ld-type NRL that is able to convert cones to rod photoreceptors.

28 cell processes, where they contact cone and rod photoreceptors.

29 ing photosensitivity and OS morphogenesis of rod photoreceptors.

30 s likely triggers or stimulates the death of rod photoreceptors.

31 dystrophy affecting the function of cone and rod photoreceptors.

32 lity of the single-photon responses of mouse rod photoreceptors.

33 mechanism with a single-step deactivation in rod photoreceptors.

34 damage was quantified by direct counting of rod photoreceptors.

35 nositide 3-kinase and Akt survival signal in rod photoreceptors.

36 em to specifically inactivate the IR gene in rod photoreceptors.

37 early expressed in the inner segments of the rod photoreceptors.

38 peripapillary involvement resembles that of rod photoreceptors.

39 f-family transcription factor NRL to augment rod photoreceptors.

40 2+) homeostasis and synaptic transmission in rod photoreceptors.

41 light microscope was used to measure loss of rod photoreceptors.

42 unds, leads to a functional retina with only rod photoreceptors.

43 receptor degeneration and dysfunction of the rod photoreceptors.

44 st notably a block in the differentiation of rod photoreceptors.

45 in three cell classes: Muller glia, cone and rod photoreceptors.

46 Rhodopsin is thus a functional biomarker for rod photoreceptors.

47 ntered transcriptional regulatory network in rod photoreceptors.

48 ein Dendra2 and expressing in Xenopus laevis rod photoreceptors.

49 h by the morphology and number of integrated rod-photoreceptors.

50 Rod photoreceptors accomplish this task through the use

51 ependent insulin receptor (IR) activation in rod photoreceptors against dephosphorylation by protein

52 the end product of chromophore bleaching in rod photoreceptors, all-trans retinol, is part of a feed

53 ective subunit composition of the complex in rod photoreceptors allowed us to study the molecular und

54 However, rod photoreceptors also provide support that partially p

55 11-cis-retinol is not a useful substrate for rod photoreceptors although it is for cone photoreceptor

56 tween two siblings in the murine retina, the rod photoreceptor and bipolar interneuron.

57 ncodes visual information in dim light using rod photoreceptors and a specialized circuit: rods-->rod

58 ions, which were biased toward production of rod photoreceptors and amacrine cell interneurons.

59 s required to produce the full complement of rod photoreceptors and amacrine cells in mouse.

60 Retinal responses to photons originate in rod photoreceptors and are transmitted to the ganglion c

61 rmal retinal development led to apoptosis of rod photoreceptors and bipolar (BP) interneurons, wherea

62 eting to knock down Rac1 expression in mouse rod photoreceptors and found protection against light-in

63 is deficit resulted from a reduced number of rod photoreceptors and inner nuclear layer cells.

64 eotide-gated (CNG) channels are expressed in rod photoreceptors and open in response to direct bindin

65 Transient responses utilize input from rod photoreceptors and output by the classical neurotran

66 Finally, we dissected the roles of rod photoreceptors and RPE for dark adaptation of M-cone

67 blotting that SynCAM 1 is expressed on mouse rod photoreceptors and their terminals in the outer nucl

68 gulators of Cav1.4 channel function in mouse rod photoreceptors and thus synaptic activity.

69 investigation of therapies to rescue mutant rod photoreceptors and to preserve cone photoreceptors i

70 To determine how aging affects rod photoreceptors and to test the retinoid-deficiency h

71 ers are bound by hyperSUMOylated proteins in rod photoreceptors, and blocking SUMOylation in photorec

72 ere obtained that expressed cone arrestin in rod photoreceptors, and each was bred into the arr1-/- b

73 is widely expressed, including expression in rod photoreceptors, and encodes a 75 kDa protein of the

74 , and retinal microglia responses to induced rod photoreceptor apoptosis.

75 ydrophobic 11-cis retinal to the interior of rod photoreceptors appears to be retarded by transit acr

76 tion to vesicle release at synaptic ribbons, rod photoreceptors are capable of substantial slow relea

77 Rod photoreceptors are electrically coupled through gap

78 Rod photoreceptors are exquisitely sensitive light detec

79 that affect calcium homeostasis (Ca(2+)) in rod photoreceptors are linked to retinal degeneration an

80 tal-lined cups acting as macroreceptors, but rod photoreceptors are positioned behind these reflector

81 The outer segments of vertebrate rod photoreceptors are renewed every 10 d.

82 However, as rod photoreceptors are saturated in bright light, the co

83 Rod photoreceptors are specialized neurons that mediate

84 hat for light-induced retinopathies in mice, rod photoreceptors are the primary site of toxic retinoi

85 ate retina, light responses generated by the rod photoreceptors are transmitted to the second-order n

86 In dim light, rod-photoreceptors are active, but colour vision is impo

87 RNA levels of the mouse ortholog (Plk1s1) in rod photoreceptors, as well as its decreased expression

88 sion when an ancestral cone evolved into the rod photoreceptor at an unknown stage preceding the last

89 g pathway, resulted in the overproduction of rod photoreceptors at the expense of Muller glial cells.

90 This mechanism may explain how the rod photoreceptor balances the quantity of discs added a

91 gned to be perceptible to the cone-, but not rod-, photoreceptor based visual systems.

92 Both cone- and rod-photoreceptor-based vision could be demonstrated in

93 later, including later-born amacrine cells, rod photoreceptors, bipolar cells and Muller glia.

94 re expressed by using promoters specific for rod photoreceptors, bipolar cells, amacrine cells, Mulle

95 ines forming predominantly before birth, and rod photoreceptors, bipolars, and Muller glia differenti

96 demarcation of POS tips is not intrinsic to rod photoreceptors but requires activities of the RPE as

97 id vision loss and near complete ablation of rod photoreceptors by day 12.

98 cance of PI3K was investigated in vertebrate rod photoreceptors by deleting its regulatory p85alpha p

99 Activation of rod photoreceptors by light induces a massive redistribu

100 Conditional deletion of PTP1B in rod photoreceptors by the Cre-loxP system resulted in en

101 ns of rhodopsin, the glycoprotein pigment of rod photoreceptors, cause misfolding resulting in retini

102 n the retinal pigment epithelium and not the rod photoreceptor cell because 11- cis-retinol can act a

103 rochemistry were observed after the onset of rod photoreceptor cell death.

104 er, the P23H protein failed to accumulate in rod photoreceptor cell endoplasmic reticulum but instead

105 ne zipper (Nrl) is a critical determinant of rod photoreceptor cell fate and a key regulator of rod d

106 odopsin is the photosensitive pigment in the rod photoreceptor cell.

107 player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential ro

108 e Phlp1 gene in mouse (Mus musculus) retinal rod photoreceptor cells and measured the effects on G-pr

109 Mature rod photoreceptor cells contain very small nuclei with t

110 Rod photoreceptor cells depend completely on the output

111 Retinal rod photoreceptor cells have double membrane discs locat

112 ts indicate that reduced expression of IR in rod photoreceptor cells increases their susceptibility t

113 The functional role of IR in rod photoreceptor cells is not known.

114 o drive expression of mouse cone arrestin in rod photoreceptor cells of rod arrestin knockout (arr1-/

115 iated protein complex, and that apoptosis of rod photoreceptor cells triggered by protein mislocaliza

116 Rod photoreceptor cells were more sensitive to loss of i

117 nduced tyrosine phosphorylation of the IR in rod photoreceptor cells, and we hypothesized that IR act

118 known about the function of DICER1 in mature rod photoreceptor cells, another retinal cell type that

119 in the rhodopsin gene, which is expressed in rod photoreceptor cells, are a major cause of the heredi

120 tors and TUNEL labeling of fragmented DNA in rod photoreceptor cells, demonstrating that the damage o

121 The cGMP phosphodiesterase of rod photoreceptor cells, PDE6, is the key effector enzym

122 in these cilia, as well as in cilia of mouse rod photoreceptor cells, was reduced significantly when

123 To determine the importance of ARL3 in rod photoreceptor cells, we generated transgenic mice ex

124 ine whether IR has a neuroprotective role on rod photoreceptor cells, we used the Cre/lox system to s

125 he regulation or function of these lipids in rod photoreceptor cells, which have highly active membra

126 r termination of photoactivated rhodopsin in rod photoreceptor cells.

127 pressing exclusively the mutant rhodopsin in rod photoreceptor cells.

128 transcriptional regulator of homeostasis in rod photoreceptor cells.

129 hoinositide 3-kinase/Akt survival pathway in rod photoreceptor cells.

130 membranes rather than to plasma membranes of rod photoreceptor cells.

131 rhodopsin and protects IR phosphorylation in rod photoreceptor cells.

132 enger cGMP in the outer segments of cone and rod photoreceptor cells.

133 eonine protein kinase B) survival pathway in rod photoreceptor cells.

134 phosphoinositide 3-kinase and Akt pathway in rod photoreceptor cells.

135 all-trans-retinal and all-trans-retinol from rod photoreceptor cells.

136 TN3 associate in the outer segments of mouse rod photoreceptor cells.

137 ceptor-bound protein 14 (Grb14) may modulate rod photoreceptor cGMP-gated channels by decreasing chan

138 ient retinae; CrxGFP is a marker of cone and rod photoreceptor commitment.

139 Rod photoreceptors consist of an outer segment (OS) and

140 Rod photoreceptors contribute to vision over an approxim

141 In rod photoreceptors, deactivation of the light-activated

142 ases of the eye and is associated with early rod photoreceptor death followed by secondary cone degen

143 Rod photoreceptor death is characterized by apoptotic fe

144 to an indirect 'bystander effect' caused by rod photoreceptor death or a direct role for AIPL1 in co

145 without overexpression of total opsin in the rod photoreceptor decreased rod cell contribution to the

146 Signaling of single photons in rod photoreceptors decreases the concentration of the se

147 unfolded protein response (UPR), leading to rod photoreceptor degeneration and autosomal dominant re

148 ptor cells after cyclic light-mediated acute rod photoreceptor degeneration in a transgenic P23H muta

149 RIP1 kinase significantly prevented cone and rod photoreceptor degeneration in Irbp(-/-) mice.

150 ller glia and the ganglion cell layer during rod photoreceptor degeneration in rd1/Tcf-LacZ mice.

151 Our previous observations suggest that rod photoreceptor degeneration in retinas lacking AIPL1

152 adult rods into cones, via knockdown of the rod photoreceptor determinant Nrl, could make the cells

153 ic zebrafish experience a continual cycle of rod photoreceptor development and degeneration throughou

154 er transcription factor NRL is essential for rod photoreceptor development and functional maintenance

155 PKC-gamma as isoforms that are essential for rod photoreceptor differentiation in mouse retinas.

156 Rod photoreceptor differentiation requires the basic mot

157 The process by which rod photoreceptor discs are formed has been controversia

158 study provides 3D data of nascent and mature rod photoreceptor disk membranes at unprecedented z-axis

159 endoplasmic reticulum but instead disrupted rod photoreceptor disks.

160 Riggs CSNB demonstrates selective rod photoreceptor dysfunction and occurs due to mutation

161 Rod photoreceptor dysfunction is observed in Reep6-/- mi

162 Mutation of rod photoreceptor-enriched transcription factors is a ma

163 is dependent on kinesin-II in cone, but not rod photoreceptors, even though rods and cones share sim

164 Cyclic nucleotide-gated (CNG) channels from rod photoreceptors exhibit a 3:1 stoichiometry of CNGA1

165 are characterized by the progressive loss of rod photoreceptors followed by loss of cones.

166 In the mammalian retina, rod photoreceptors form selective contacts with rod ON-b

167 n a diminished progenitor pool available for rod photoreceptor formation.

168 adult zebrafish retina continuously produces rod photoreceptors from infrequent Muller glial cell div

169 uscin and A2E, we analyzed RPEs and isolated rod photoreceptors from mice of different ages and strai

170 3K), which the authors have shown to protect rod photoreceptors from stress-induced cell death.

171 We demonstrate that the recovery of rod photoreceptors from the ambient saturating levels of

172 ceptor rhodopsin on disk membranes of living rod photoreceptors from transgenic Xenopus laevis.

173 nder the control of Crx promoter can restore rod photoreceptor function and suppress cone gene expres

174 rate that ERRbeta is a critical regulator of rod photoreceptor function and survival, and suggest tha

175 To study whether cone or rod photoreceptor function was involved in the pathway t

176 opic threshold elevation led by worsening of rod photoreceptor function.

177 Rhodopsin is the rod photoreceptor G protein-coupled receptor responsible

178 ound, Photoregulin3 (PR3) that also inhibits rod photoreceptor gene expression, potentially though Nr

179 Rod photoreceptors generate amplified, reproducible resp

180 Rod photoreceptors generate measurable responses to sing

181 In vertebrate eyes, the rod photoreceptor has a modified cilium with an extended

182 rial transport of rhodopsin is essential for rod photoreceptor health and function.

183 d by mutations in genes that are specific to rod photoreceptors; however, blindness results from the

184 BP removes all-trans-retinol from individual rod photoreceptors in a concentration-dependent manner.

185 outer segment (OS) and inner compartments of rod photoreceptors in a light-dependent manner thereby c

186 ses of retinal architecture indicated intact rod photoreceptors in all patients but abnormalities in

187 Rod photoreceptors in areas of the retina that always ha

188 this hypothesis, we looked for transitioning rod photoreceptors in Blimp1 conditional knock-out (CKO)

189 Here, we show that rod photoreceptors in mice rely on glycolysis for their

190 ssessed the arrangements of retinal cone and rod photoreceptors in six nocturnal, three cathemeral an

191 a, exacerbated by the high O2 consumption of rod photoreceptors in the dark, is a primary cause of DR

192 Development of rod photoreceptors in the mammalian retina is critically

193 specification and functional maintenance of rod photoreceptors in the mammalian retina.

194 monstrate that, analogous to what happens to rod photoreceptors in the rd1 mouse model, loss of cone

195 MNU treatment or on the progressive loss of rod photoreceptors in the rd7/rd7 retina.

196 d thus assess the distribution of functional rod photoreceptors in the retina.

197 ain 3D visualization of the nascent disks of rod photoreceptors in three mammalian species, to gain i

198 phy (OCT) to measure light-driven signals of rod photoreceptors in vivo.

199 there was early-onset rapid degeneration of rod photoreceptors in young subjects with these ciliopat

200 ous mutants in vitro, and primarily affected rod photoreceptors in zebrafish mimicking cardinal featu

201 , Dendra2, and expressed in early developing rod photoreceptors, in which OSs are still cone-shaped.

202 We find that retbindin is secreted by the rod photoreceptors into the inter-photoreceptor matrix w

203 The outer segment (OS) of the rod photoreceptor is a light-sensing cilium containing ~

204 hen a substantial fraction of rhodopsin in a rod photoreceptor is exposed to bright light, the rod is

205 Exocytosis from the rod photoreceptor is stimulated by submicromolar Ca(2+)

206 Specification of retinal rod photoreceptors is determined by several different tr

207 Vesicle release from rod photoreceptors is regulated by Ca(2+) entry through

208 d receptor, most abundant protein in retinal rod photoreceptors, is glycosylated at asparagines-2 and

209 ht-sensing molecule in the outer segments of rod photoreceptors, is responsible for converting light

210 Rod photoreceptors lacking KIF3A degenerated rapidly bet

211 Mutations primarily in genes expressed in rod photoreceptors lead to early rod death, followed by

212 rative disease, in which the death of mutant rod photoreceptors leads secondarily to the non-cell aut

213 mal RPE and neural retina but showed reduced rod photoreceptor light responses, indicating that lack

214 rized by early loss of rod function and slow rod photoreceptor loss with a secondary decline in cone

215 m survival and, in some cases, expressed the rod photoreceptor marker, rhodopsin.

216 The rod photoreceptors may be more susceptible than cone pho

217 ethod for Gt purification from native bovine rod photoreceptor membranes without subunit dissociation

218 small RNA sequencing analysis, we identified rod photoreceptor miRNAs of the miR-22, miR-26, miR-30,

219 mechanism by which rhodopsin mislocalizes in rod photoreceptor neurons is not well understood.

220 ly stages of diabetes are not exacerbated by rod photoreceptor O2 consumption in the dark.

221 d by exon 5 and is specifically expressed in rod photoreceptors of developing and mature retina.

222 n of PhLPs, we expressed this protein in the rod photoreceptors of mice and found that this manipulat

223 enically expressed hAIPL1 exclusively in the rod photoreceptors of the Aipl1(-/-) mouse.

224 the strength of electrical coupling between rod photoreceptors of the retina is regulated by the tim

225 alpha) for rod transducin alpha (rTalpha) in rod photoreceptors of transgenic mice, which also expres

226 In rod photoreceptors of wild-type mice, background light p

227 By comparison, rod photoreceptors only exhibit isotropic absorbance.

228 In its absence, rod photoreceptor outer and inner segment length was red

229 n by rhodopsin to a change in current at the rod photoreceptor outer segment plasma membrane.

230 ponsible for impeding their transport to the rod photoreceptor outer segment.

231 esence of vacuolar structures that distorted rod photoreceptor outer segments and became more promine

232 ve aldehyde all-trans retinal is released in rod photoreceptor outer segments by photoactivated rhodo

233 Light detection by vertebrate rod photoreceptor outer segments results in the destruct

234 ng night (i.e., scotopic) vision in mammals, rod photoreceptor output is conveyed to ganglion cells (

235 outer segments (OSs) and connecting cilia in rod photoreceptors, overlapping with Rp1.

236 d cells, including bovine and Xenopus laevis rod photoreceptors, P/rds was robustly sensitive to endo

237 requisite component of the high-sensitivity rod photoreceptor pathway.

238 pathway in the TKO retina that originates in rod photoreceptors, potentially a rare subset of rods wi

239 Dysfunction or death of rod photoreceptors precedes cone loss in many retinal an

240 In mice lacking Mpp4, PMCAs were lost from rod photoreceptor presynaptic membranes.

241 d pluripotent stem cells (iPSCs) from murine rod photoreceptors (r-iPSCs) and scored their ability to

242 In human retinal degeneration, rod photoreceptors reactively sprout neurites.

243 be partially reversed, with regeneration of rod photoreceptors recovering normal morphology (includi

244 ents were identified as the likely source of rod photoreceptor regeneration in the P23H retinas.

245 a, and c-myb in both retinal development and rod photoreceptor regeneration.

246 investigating the molecular determinants of rod photoreceptor regeneration.

247 duction of retinal ganglion cells (RGCs) and rod photoreceptors, respectively.

248 cluding Beclin1 systemically or Atg7 in only rod photoreceptors resulted in increased susceptibility

249 rer to ancestral pigments than the dim-light rod photoreceptor rhodopsin.

250 removal of scaffolding proteins RIM1/2 from rod photoreceptor ribbon synapses causes a dramatic loss

251 Here we provide insight from studying rod photoreceptor ribbon-type active zones after disrupt

252 Rod photoreceptor (S(rod), R(rod)) and rod-driven postre

253 logical concentrations of IGF-1 can increase rod photoreceptor sensitivity in mammalian retinas.

254 for efficient enrichment of rhodopsin within rod photoreceptor sensory cilia, inhibited enrichment of

255 In rod photoreceptors, several phototransduction components

256 um entry mechanism that extends the range of rod photoreceptor signalling into light-adapted conditio

257 However, reduced IR expression in rod photoreceptors significantly decreased retinal funct

258 increasing the signal-to-noise ratio of the rod photoreceptor single-photon response in a transgenic

259 ously reported the identification of a novel rod photoreceptor specific isoform of Receptor Expressio

260 death was observed when retinas lacking the rod photoreceptor-specific Atg7 gene were coincubated wi

261 tions that cause retinitis pigmentosa are in rod photoreceptor-specific genes, cone photoreceptors al

262 Rod photoreceptor-specific inactivation of numb in vivo

263 ly transcription factor NRL is essential for rod photoreceptor specification in the mammalian retina

264 The lack of phenotype in pik3r1 KO rod photoreceptors suggests a redundant role in controll

265 igment epithelium (RPE) and is essential for rod photoreceptor survival.

266 uggesting that miRNAs play a primary role in rod photoreceptor survival.

267 is and light-evoked neurotransmission at the rod photoreceptor synapse mediated by TRPC1.

268 velopment and/or maintenance of the cone and rod photoreceptor synapse.

269 Vision requires the generation of cone and rod photoreceptors that function in daylight and dim lig

270 Phosducin is a major phosphoprotein of rod photoreceptors that interacts with the Gbetagamma su

271 dCVF) is an inactive thioredoxin secreted by rod photoreceptors that protects cones from degeneration

272 nly observed during persistent activation of rod photoreceptors that saturate rods.

273 lation then likely triggers the apoptosis of rod photoreceptors that was observed.

274 Here we investigate in mouse rod photoreceptors the relationship between rhodopsin de

275 he light-sensing organelle of the vertebrate rod photoreceptor, the outer segment (OS), is a modified

276 icularly how they are determined relative to rod photoreceptors, the cells that initiate vision in di

277 -induced suppression of glutamate release in rod photoreceptors, thereby driving ON-BC depolarization

278 his high amplification system allows retinal rod photoreceptors to detect single photons of light.

279 n cascade and is critical for the ability of rod photoreceptors to function in low light conditions.

280 We have used mouse rod photoreceptors to investigate the generation of NADP

281 19 recognized the acylated N terminus of the rod photoreceptor transducin alpha (Talpha) subunit and

282 We present a comprehensive assessment of rod-photoreceptor transplantation across six murine mode

283 demonstrated restoration of vision following rod-photoreceptor transplantation into a mouse model of

284 ing adeno-associated virus in Xenopus laevis rod photoreceptors using a transgene and in ciliated IMC

285 ngth and motorless KIF17 constructs in mouse rod photoreceptors using adeno-associated virus in Xenop

286 itic pattern, and they connect with numerous rod photoreceptors via small spherical terminals.

287 Rod photoreceptors were present in normal numbers, and t

288 Markers for amacrine, ganglion and rod photoreceptors were present in treated but not in co

289 Rod photoreceptors were recently shown to contact 'Off'

290 LKB1 and AMPK function in rod photoreceptors where their loss leads to aberrant ax

291 membrane of photosensitive outer segments of rod photoreceptors where they generate the electrical re

292 st all newly postmitotic N1-CKO cells became rod photoreceptors, whereas wild-type (WT) cells achieve

293 tatic regulation of ER function in mammalian rod photoreceptors, whereby miR-708 may help prevent an

294 Rod photoreceptors, which mediate dim light vision, rema

295 The responses of rod photoreceptors, which subserve dim light vision, are

296 toreceptors, promotes the differentiation of rod photoreceptors while preventing rods from adopting c

297 ontrast, disruption of LINC complexes within rod photoreceptors, whose nuclei are scattered across th

298 Dystrophic rod photoreceptors with truncated rod outer segments wer

299 We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input.

300 ller glia results in reduced regeneration of rod photoreceptors without affecting injury-induced prol