ライフサイエンスコーパス: role

1 ated that secreted proteins may play a major role.

2 , private insurance will likely play a major role.

3 sting that this region may play a regulatory role.

4 -type Ca(2+) channels to their physiological roles.

5 A-binding proteins with potential regulatory roles.

6 ent cell types that have distinct functional roles and are subject to different evolutionary pressure

7 ng whether carbon disulfide (CS2) may play a role as an endogenously generated bioregulator and/or ha

8 and that octamer deformation plays different roles based on the type of chromatin remodeler.

9 nd granulopoiesis, this new immunomodulatory role could explain the protection conferred by THP durin

10 In addition to its suppressive role during spontaneous cardiac fibrosis in multiple spe

11 protein likely plays unappreciated accessory roles during infection.

12 ntermediaries (Smads), we demonstrated a key role for ALK2 in the BMP9/BMP10-induced surface expressi

13 ith the CD3 co-receptor, suggests a possible role for an allosteric mechanism in TCR signalling.

14 ognized in ecological studies, reveals a key role for cryptic diversity in structuring communities of

15 These observations suggest a potential role for CT-1 in the regulation of metabolic circadian r

16 Our results reveal an unexpected role for CtsB in leukocyte extravasation and transmigrat

17 by ultraviolet light, suggesting a potential role for EAF2 in androgen regulation of DNA repair in pr

18 These results suggest a novel role for EMCN as a potent regulator of angiogenesis and

19 We explore potential regulators and find a role for HSF1 in the induction of a subset of heat shock

20 Our findings highlight a role for keratinocytes and their interplay with myeloid

21 In this study, we established a role for lncRNAs in chondrocyte differentiation.

22 ed antibody to Mac1, we demonstrate a causal role for microglia in the development, but not maintenan

23 Our findings reveal a previously unsuspected role for MZB cells in controlling the TFH-germinal cente

24 These data reveal an essential role for n1-src in amphibian neural development and sugg

25 Our findings reveal an unexpected new role for NKG2D in the regulation of B1a cell development

26 Studies by Sato et al. reveal a role for parathyroid hormone 2 receptor (PTH2R) in extra

27 This study provides in vivo indication of a role for postsynaptic factors in amphetamine-induced psy

28 in ciliary functions, confirming the central role for primary cilia in Hh signaling.

29 nactivation by AMPylation and point toward a role for protein AMPylation in the regulation of cellula

30 These data uncover a direct role for RANK in lung cancer and may explain why female

31 Together, our findings establish a role for RFRP-3 in preserving reproductive immaturity, a

32 These studies suggest a potential role for selenium supplementation as an adjuvant therapy

33 T6Gal-I expression, further substantiating a role for ST6Gal-I in cell survival.

34 a null model and reveals an underappreciated role for stochasticity in language evolution.

35 Despite emerging data indicating a role for T cells in profibrotic cardiac repair and heali

36 ase may look like and suggesting a potential role for the juxtamembrane region in enzyme activity.

37 We have explored a role for the metal transporter ZIP14 during pharmacologi

38 randial serum triglycerides, suggestive of a role for TM6SF2 in the small intestine.

39 ts potency to resolve AAI supports a crucial role for transcriptional regulation by the GR in this ce

40 chanistic investigations demonstrated causal roles for CADM1, SPHK1, and YAP/TAZ in mediating metasta

41 s with both oncogenic and tumour-suppressing roles for cancer progression, such as the insulin-like g

42 ransformation, and suggest oncogene-specific roles for DUSP5 in controlling ERK signaling and cell fa

43 Compensatory roles for global-genome (XPC-1) and transcription-couple

44 Altogether, our results support roles for non-Cas nuclease(s) during crRNA maturation an

45 ly misfolded protein, two previously defined roles for Sse1.

46 al for proper CNS function, but the relative roles for the two main sources of ATP production, glycol

47 PTH secretion in vivo and in vitro, implying roles for these specific miRNAs.

48 pplied in research studies, but its clinical role has been limited by its lack of reproducibility, it

49 berant systemic inflammation plays a primary role in ACLF progression.

50 RAG recombinase (RAG1/2) plays an essential role in adaptive immunity by mediating V(D)J recombinati

51 , and hence, are not likely to have a direct role in adipocyte metabolism or adaptive thermogenesis.

52 NM myosin II plays a critical role in airway SM contraction that is independent and di

53 DIET may also have a role in anaerobic methane oxidation coupled to sulfate r

54 Because HLA-E plays an important role in antiviral immunity by regulating natural killer

55 Ubiquitination of this site plays a role in AR stability and is critical for its transcripti

56 The IPS plays a key role in attention orienting and may contribute to the hy

57 Many ALS/FTD linked genes play a direct role in autophagy/lysosomal degradation, one of the most

58 SNF may play a role in both by supplying N to leaf tissues for acclimat

59 Vacuolar protein sorting 34 (Vps34) plays a role in both canonical and noncanonical autophagy, key p

60 information in spike timing actually plays a role in brain function.

61 onal restriction of the substrate may play a role in catalysis.

62 motypic interaction motifs (RHIM) play a key role in cell death and inflammatory signalling(1-3).

63 disordered phase, which could explain their role in cell membranes.

64 ates of an E3 holds the key to elucidate its role in cell regulation.

65 eactive oxygen species (ROS) play a critical role in cell signaling and proliferation.

66 in kinase interacting kinase-1 has a pivotal role in cocaine-induced connectivity.

67 rminants of PVEM induction and its potential role in commotio cordis-induced VF.

68 tiviral state that likely plays an important role in constraining HIV-1 transmission and contributes

69 model in which this IDR of Med13 plays a key role in controlling a molecular switch that dictates cel

70 Trafficking of mGluRs plays an important role in controlling the precise localization of these re

71 In agreement with a role in defending against pathogens, XBAT35.2 interacts

72 nts, provided insights into their regulatory role in defined modules of the JA network.

73 in the filter conformation, which play a key role in defining both selectivity and permeation.

74 molecule-and its absence-plays an essential role in determining capsid structure during the self-ass

75 Temperature plays a pivotal role in determining the distribution of these communitie

76 Genetic knockout of NRF2 demonstrates its role in developmentally regulated gamma-globin gene expr

77 Mutagenesis of Cys-298 confirmed its role in dimerization.

78 eads to a powerful approach for studying its role in disease and aging.

79 ic/genetic variation that plays an important role in disease susceptibility.

80 es of a gene is related to the gene's causal role in disease.

81 udies suggest that vestibular signals play a role in dissociating object motion and self-motion, and

82 To examine its role in endothelial cell (EC) biology, we generated mice

83 aveolae biogenesis, Cavin-2 plays a critical role in endothelial cell maintenance and function by reg

84 ent conducting electrodes play a fundamental role in far-field PhotoVoltaic systems, but have never b

85 ontractile cytoskeletal networks plays a key role in force generation, while on the tissue level the

86 e of the five identified NS proteins via its role in governing MVC pre-mRNA splicing.IMPORTANCE The P

87 ve cooling by water vapor plays an important role in governing the depth and amplitude of large-scale

88 an cells, and protein kinases play a pivotal role in health and disease.

89 Friction plays a key role in how ruptures unzip faults in the Earth's crust a

90 f its assembly, function, evolution, and its role in human disease.

91 stem control of inflammation plays a central role in hypertension.

92 TA fragments have been used to unravel their role in immunology and it is described how focused libra

93 o cytotoxic treatments can play an important role in individualized cancer medicine.

94 L37 plays an essential albeit poorly defined role in intracellular capsid trafficking.

95 gene (PBX1), a gene known to have a crucial role in kidney development.

96 We thus hypothesized that dlBST could play a role in LID hyperkinetic manifestations.

97 of intracellular stores and has an important role in many cell types.

98 ng molecules and IGF2 and plays an important role in many pathophysiological processes, including gut

99 chniques, we now show that NMDARs have a key role in mediating the effect of leptin to modulate beta-

100 ays have been demonstrated to play a crucial role in memory.

101 dings show that the sigma receptor has a key role in METH dysregulation of dopamine release and dopam

102 revealed that SLC25A46 may play an important role in mitochondrial dynamics by mediating mitochondria

103 ng of placental vitamin D metabolism and its role in modulating maternal circulating vitamin D metabo

104 first time that the Igf1r plays an important role in murine asthma, mediating both AHR and mucus secr

105 ucleoporins play an unanticipated regulatory role in NEBD, by recruiting PLK-1 to the NE thereby faci

106 wever, since CusB is an adaptor protein, its role in operating this system is significant, and should

107 esize that lipids play a so far unrecognized role in organ development.

108 71 locus is unique to eutheria, suggesting a role in placental development.

109 Thus, TRAF3 plays a negative role in platelet activation and in thrombus formation in

110 at AP-2 has a clathrin-independent essential role in polarity maintenance and growth.

111 on in CD4(+)CD8(+) thymocytes, has a crucial role in positive selection and T cell development.

112 Thus, in addition to their canonical role in protein recycling, REs also mediate forward secr

113 aterials (ETMs) used in PSCs play a critical role in PSCs performance.

114 gest that endogenous GDNF plays an important role in regulating the function of dopamine transporters

115 nflicting reports about whether it plays any role in regulating viral lytic reactivation.

116 The amygdala may, therefore, play a central role in RL.

117 Peripheral blood monocytes play a role in sarcoidosis inflammation.

118 Staphylococcus aureus plays an important role in sepsis, pneumonia, wound infections, and cystic

119 results indicate that SP110b plays a crucial role in shaping the inflammatory milieu that supports ho

120 Trace minerals (TM) play a role in skin integrity and wound healing.

121 stem, we show that RARbeta2 plays a specific role in somite number and size, restriction of the preso

122 o briefly appraised in view of their special role in special selective photocatalysis, namely epoxida

123 We conclude that EEFs can play a significant role in sustainable agricultural production but their pr

124 mportant sorbent of metal(loid)s and plays a role in the attenuation of metal(loid) uptake into highe

125 de toxins such as conotoxins play a critical role in the characterization of nicotinic acetylcholine

126 essential cofactors of COP1, but their exact role in the COP1/SPA complex is thus far unknown.

127 t theories arguing that it played a critical role in the evolution of vocal communication, in both pr

128 te that the glycosylation plays an essential role in the flagellar assembly and motility of T. dentic

129 transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cell fusion, as

130 ons with a chronic illness to take an active role in the management of their condition is a core comp

131 hat TAVR will play an increasingly important role in the management of these patients.

132 Ohr also appeared to play a central role in the peroxynitrite response, because the ohr muta

133 We have found that PDHK4 plays a role in the post-translational regulation of mutant KRAS

134 ialogue between these two areas could play a role in the regulation of emotions and in procedural mot

135 component with CSC and also plays a distinct role in the regulation of endosome dynamics during funga

136 (70)-holoenzyme (Esigma(70)) and plays a key role in the transcriptional reprogramming upon shifts be

137 or other proteins and may play an important role in the various beneficial functions of vaspin in di

138 of olfactory sensory neurons, plays a vital role in their host seeking and risk aversion processes.

139 eeds to be determined to understanding their role in these pathologies.

140 l cycle related proteins for their potential role in this process.

141 but that the striatum may have a privileged role in timing because it has a more accurate "clock" as

142 ulti-unit molecular complex that plays a key role in transferring signals from transcriptional regula

143 pects of autoimmune disorders and may play a role in triggering disease.

144 ons of mTORC1 versus mTORC2 in cancer, their role in tumor-associated blood vessels and tumor immunit

145 t human cancers, but direct evidence for its role in tumorigenesis has been lacking thus far.

146 ation from non-AUG codons plays an important role in various gene regulation programs.

147 protein in EC, was not anticipated to have a role in vascular barrier.

148 tracellular Ca(2+) buffers play an important role in vesicle recruitment in both low- and high-freque

149 in is N-myristoylated and plays an important role in virus budding.

150 ctions (PPIs) of these subunits play pivotal roles in assembling the functional polymerase complex, w

151 AtBAG7 has functional roles in both the ER and the nucleus.

152 xt-dependent tumor-suppressive and oncogenic roles in cancer.

153 able molecular machines may have significant roles in chemical synthesis and molecular manufacturing.

154 eveal that PDGFRalpha+ cells perform diverse roles in CNS repair, as multipotential progenitors that

155 geometry of lipophilic groups play important roles in compound-lipid interactions.

156 Wilms' tumour 1 (WT1), which plays multiple roles in development, tissue homeostasis and disease.

157 idence indicates that lncRNAs play important roles in directing the development of diverse immune cel

158 is severely constrained by their functional roles in engaging the host receptor and in mediating mem

159 Redox-active tyrosines (Ys) play essential roles in enzymes involved in primary metabolism includin

160 n C. hirsuta, such that LFY has more obvious roles in floral and leaf development in C. hirsuta than

161 atory cytokine signaling and plays important roles in immune function, while abnormal JAK1 activity h

162 ent and activation of immune cells and their roles in immune-related diseases.

163 rimarily in the mitochondrial matrix and has roles in inflammation and infection processes, mitochond

164 tors (GPCRs) and have opposing physiological roles in insulin release and glucose homeostasis.

165 uctures of DNA bacteriophages play essential roles in life cycles.

166 ly conserved loop regions of uS12 with known roles in maintaining the accuracy of mRNA codon translat

167 TGL)-mediated lipolysis that plays important roles in metabolism, tumor progression, viral replicatio

168 ertake different, perhaps somewhat opposite, roles in motor recovery after brain injury.SIGNIFICANCE

169 e SnRK3 family, and that they play important roles in multiple signalling pathways in vivo.

170 genes as Sox2 and Sox19 appear to play major roles in neural development.

171 ate neuroimmune function, and play important roles in neurodegeneration and brain aging.

172 raction of the human proteome play important roles in numerous cellular functions.

173 A focused ethnographic study of nurses' roles in nurse-led chemotherapy clinics, including semi-

174 g proteins, BB0238 and BB0323, play distinct roles in pathogen biology and infectivity although a sig

175 ese results delineate that C3 plays specific roles in platelet activation independent of formation of

176 with parental care previously, but all have roles in predicted behavioural precursors for parenting.

177 yzed at faster rates with potential critical roles in protein activation, including the histone acety

178 , His(85), and Arg(245) to interrogate their roles in substrate binding and catalytic activity.

179 mily of ligands and receptors play important roles in T-cell co-stimulation and co-inhibition.

180 GCN2 and ATF4 serve complementary roles in the hepatic response to asparaginase.

181 es are known to play important physiological roles in the human body.

182 s also show that PKR and OAS1 play important roles in the ISG15-mediated type I IFN sensitivity of HE

183 e RVE8 clade, RVE3 and RVE5, play only minor roles in the regulation of clock function.

184 This difference defines their distinct roles in the regulation of macrophage migration.

185 Lipids have fundamental roles in the structure, energetics, and signaling of cel

186 za A virus M1 and M2 proteins play important roles in virus assembly and in the morphology of virus p

187 ltiple paralogs that perform non-overlapping roles in vivo.

188 Critical to elucidating their physiological role is the opportunity to visualize and quantify the pr

189 s an emerging drug target, but its oncogenic role is unclear.

190 s space and time and revealing the essential role it played in maintaining stability and functionalit

191 , which underscore a potentially significant role of 5RK in exocytosis, we next amperometrically anal

192 lectrostatic gating, suggesting the possible role of a current-gain inducing mechanism similar to tho

193 We investigated the role of Act1 in keratinocyte responses to IL-17 using a

194 health might further clarify the prognostic role of aging.

195 The potential role of AMPK in this setting is widely unknown.

196 In the present study, the role of AnxA1 was investigated in L. braziliensis-infect

197 ase virus (IBDV) was used to investigate the role of autophagy in avibirnavirus replication.

198 The potential protective role of B cells in controlling cCMV-related disease and

199 The newly clarified role of Bcl11b distinguishes discrete components of comm

200 r, these findings uncover a glioma-promoting role of BCL6 and provide the rationale of targeting BCL6

201 f DT caliber and resistance analogous to the role of blood vessel tone in regulating blood flow.

202 repeat (LTR) sequences, pointing to a select role of BRD4S-BRG1 complexes in genomic silencing of inv

203 However, the role of brown adipose tissue (BAT) in regulating gestati

204 Therefore, the biological role of CCRL2 in immunity is still unclear.

205 maging in Drosophila embryos, we dissect the role of condensin I in the maintenance of mitotic chromo

206 ecent "magic ratio rules", which capture the role of connectivity in determining the electrical condu

207 ealthcare systems, priority setting, and the role of cost effectiveness.

208 To assess the role of diffusion-weighted MR imaging in differentiation

209 However, the mechanistic role of EEA1 is not yet known.

210 The role of electrostatic interactions in the formation of l

211 However, failing to recognize the additional role of environmental factors in regulating birth and mo

212 There is evidence implicating the role of female sex hormones as a major factor in determi

213 tion mediators and shedding new light on the role of fibroblasts in chronic inflammation.

214 in further elucidation of the physiological role of FPR2 in health and disease.

215 The role of germline mutations in children and adults with h

216 otential to improve our understanding of the role of global methylation in human diseases, especially

217 be used as a future guide to investigate the role of glutamate, ion concentrations, and dynamics cell

218 onverbal social behaviors, and highlight the role of human attachment in providing a template for two

219 The role of hydrogen bonding led us to the rotation of NH4(+

220 To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene kno

221 lication and highlight a positive regulatory role of IFN-induced proteins in HIV-1 infection.

222 To confirm a possible modulatory role of IL-6 on MMPs, the relationship between IL-6/MMP-

223 Our results suggest that, although the role of individual and neighborhood factors remains prev

224 Increasing evidence suggests a crucial role of inflammation in cytokine-mediated beta-cell dysf

225 asis of clonal evolution and relapse and the role of inherited genetic variants in leukemogenesis.

226 rk provides an improved understanding of the role of ionic correlations in NP assembly and design rul

227 This study aims to identify the role of IRF6 in development of exocrine glands, specific

228 The pathogenic role of ischemic heart disease (IHD) in heart failure (H

229 We then tested the role of JAK2/STAT3 in ketamine-induced plasticity in the

230 c and diabetic islets, suggesting a positive role of linagliptin in modulating alpha cell function to

231 Our findings reveal an important role of litter-leached DOC input in regulating rain-indu

232 gap in our quantitative understanding of the role of local ECM size and arrangement in cell emergence

233 ; describes existing evidence supporting the role of LOX-1 in atherogenesis and its major complicatio

234 studies should focus on better defining the role of MAC and facility and organizational factors that

235 s do not provide strong support for a causal role of maternal smoking during pregnancy in offspring d

236 hich will foster future investigation of the role of mesentery fat in colorectal diseases.

237 The role of metabolites produced from stem cell metabolism h

238 This role of midkine was linked to a paracrine activation of

239 s provide a foundation for understanding the role of multiple regulatory factors in modulating Fshb g

240 e aim of the current study is to explore the role of natural killer T cells in impaired liver regener

241 We sought to investigate the role of neutrophils and the IL-17A pathway in mediating

242 To study the role of neutrophils in LPS-induced endotoxemia, we devel

243 , our results provide novel insight into the role of Nt17 post-translational modifications in regulat

244 To understand the role of oncogenic KRAS in CRC, we engineered a mouse mod

245 Our results provide support for the role of oscillatory reinstatement in memory retrieval.SI

246 sion affects multiple brain regions, and the role of p11 has only been determined in a few of these a

247 However, the role of PET during treatment (iPET) in daily practice re

248 ally, the 2009 IAV pandemics highlighted the role of pigs in the emergence of IAVs with pandemic pote

249 Taken together, these results identify a role of PLD2-generated PA in the regulation of kinesin-1

250 , few studies have directly investigated the role of prenatal cytokine and chemokine profiles on neur

251 patients included in a trial evaluating the role of pretreatment circulating tumor markers as predic

252 Herein, we aimed to assess the potential role of protein-modifying variants in endometriosis usin

253 To test the non-tumor cell microenvironment role of RAGE, we performed syngeneic studies with orthot

254 These observations elucidate the role of roughness in colloid attachment under both favor

255 The present work shows the role of SOCS1 in murine melanoma development and the pot

256 unmanipulated NK1R(-/-) mice, suggesting the role of SP-NK1R signaling in ocular surface homeostasis

257 direct interaction with actin suggests a new role of SPARC during tissue remodeling.

258 study examines this issue by focusing on the role of stromal interaction molecule 1 (STIM1), an endo/

259 approximately 0.4-0.5) suggest an important role of sulfate in tracer formation via both physical an

260 icial for its catalytic performance, but the role of sulfur vacancies and the mechanism determining t

261 CD11c(+) cells, and highlights the important role of SWAP-70 in Cer dynamics in dendritic cells.

262 tes most centrosome-dependent processes, the role of the daughter remains poorly understood.

263 We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of

264 cal power of self-focusing, Pcr, playing the role of the fundamental number-of-particles integral of

265 c oral epithelium ( Irf6 cKO), bypassing the role of the gene in lip and palate morphogenesis and thu

266 There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences

267 These findings highlight the role of the inhibitory microenvironment and how CAR T ce

268 suggests a more complex microbial management role of the innate immune system for controlled accommod

269 The identification of the role of the JNK pathway in VZV infection of neurons reve

270 ed approach has demonstrated the significant role of the merozoite proteome during erythrocyte invasi

271 d on what has been established regarding the role of the microbiome in patients with asthma, atopic d

272 or a perpendicular magnetic field plays the role of the transverse field, thereby providing a practi

273 our analyses shed light on the physiological role of the type-B ARRs in regulating the cytokinin resp

274 To evaluate the potential role of these residues in hydrophobic gating, Leu267 and

275 tiation of P19 cells, suggesting a conserved role of this kinase in the epigenic activation of MOR in

276 We examined the role of tumor necrosis factor receptor-associated factor

277 Here we investigate the role of two gtr operons that we identified in the S Typh

278 The respective role of UH vs. individual stochasticity varies greatly a

279 al recycling and vacuolar targeting, but the role of vacuole-related proteins in BR receptor dynamics

280 We examined the role of vascular CXCR4 in atherosclerosis and plaque com

281 To date there is no clear information on the role of VEGF-A in IPF.

282 bset of T cells with cytotoxic function, the role of which in lung immunity is unclear.

283 of the OH and CF2H groups and the important roles of CF2-H...O hydrogen bonds in influencing intermo

284 Although the important roles of co-opted host proteins in RNA virus replication

285 Recently, the roles of FAM83H in tumorigenesis have been interested an

286 acute CNS injury.SIGNIFICANCE STATEMENT The roles of microglia, the phagocytosing cells of the CNS,

287 10-Csm complex toward maturation and explore roles of non-Cas nucleases in this process.

288 The roles of PCBP, ferritin, and NCOA4 in erythroid developm

289 In this study, we identify new functional roles of RASSF4.

290 yte antigen region, which suggests important roles of specific amino acid polymorphisms in the antige

291 However, the in vivo roles of TFEB in the mammalian intestinal epithelium wer

292 Replication studies and understanding the roles of these genes in keratoconus are warranted.

293 Here, we investigate the roles of tumor-associated signals in regulating endothel

294 This overview emphasizes the important role played by cross-feeding of intermediary metabolites

295 such similarities are still debated, and the role played by most organismal traits and their intraspe

296 ale, had a significant positive effect on NP role (risk ratio=2.33; 95% CI: 1.06-5.13); with a one un

297 Our results suggest that PPC plays a causal role specifically in visual decision making and may supp

298 ACSL6 mRNA in human skeletal muscle and the role that ACSL6 plays in lipid synthesis in both rodent

299 se FASTK proteins and discuss the individual role that each has in mitochondrial RNA biology.

300 assessed, focusing on one of its most vital roles: the coupling between neural activity and blood fl