ライフサイエンスコーパス: rolling

1 ternative propulsion strategy to swimming is rolling.

2 extraction of leukocytes stabilize leukocyte rolling.

3 c selectins is enabled to significantly slow rolling.

4 lial migration, without affecting neutrophil rolling.

5 a while not affecting selectin-mediated slow rolling.

6 fecting the selectin-mediated slow leukocyte rolling.

7 and potentiate selectin-dependent leukocyte rolling.

8 eas pCS caused a rapid increase in leukocyte rolling.

9 cord the molecular adhesion events from cell rolling.

10 Data were measured monthly on a rolling 12-month mean basis.

11 months after the start of the epidemic, the rolling 14-day case fatality rate was 1.0% and remained

12 calibration drift within a few days using a rolling 72 h comparison of hourly averaged data from the

13 del to assemble three-dimensional tumours by rolling a scaffold-tumour composite strip.

14 is paper, which could determine pointing and rolling accuracy of a star tracker directly.

15 le to the variety of cell types that undergo rolling adhesion and provide a quantitative picture of c

16 verage of the cell surface by knobs and that rolling adhesion becomes more stable and slower for high

17 d could accommodate the alphaLbeta2-mediated rolling adhesion of leukocytes.

18 ensity and receptor multiplicity per knob on rolling adhesion of schizonts.

19 is unusual in its ability to mediate either rolling adhesion or firm adhesion of lymphocytes on vasc

20 We find that rolling adhesion requires a homogeneous coverage of the

21 Rolling adhesion, in which cells passively roll along su

22 e at the border between transient and stable rolling adhesion.

23 n is crucial for the regulation of leukocyte rolling, adhesion and trans-vessel migration during infl

24 ter muscle that CD95 mediates leukocyte slow rolling, adhesion and transmigration upon binding of CD9

25 vel are deemed limited, mainly consisting in rolling, adhesion, and aggregate formation.

26 cular endothelial cells to mediate leukocyte rolling, adhesion, and extravasation by up-regulation of

27 ey report that murine fetal blood neutrophil rolling, adhesion, and extravasation from inflamed yolk

28 no role in the preceding steps of tethering, rolling, adhesion, and locomotion.

29 entire leukocyte adhesion cascade, including rolling, adhesion, and migration in a single assay.

30 treating neutrophils with wortmannin reduced rolling, adhesion, and migration of neutrophils to 60%,

31 inistration significantly enhanced leukocyte rolling, adhesion, and transmigration via localized diss

32 series of distinct processes, which include rolling, adhesion, extravasation, and chemotaxis.

33 the leukocyte recruitment cascade, including rolling, adhesion, postadhesion strengthening, intravasc

34 kappaB activation, vaso-occlusion, leukocyte rolling/adhesion, and heme lethality.

35 Bloch sphere is a cycloid traced by a circle rolling along an adiabatic path.

36 L-selectin regulates leukocyte adhesion and rolling along the endothelium.

37 torsion phenotype results from differential rolling and aberrant patterning of peristaltic waves of

38 fed mice there is reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, n

39 mation, there is increased monocyte specific rolling and adhesion along cerebral endothelial cells (C

40 avital microscopy revealed reduced leukocyte rolling and adhesion in P2X7-deficient mice.

41 ng revealed a dramatic increase in leukocyte rolling and adhesion in veins near the optic nerve (ON)

42 nhibitory effect of adiponectin on leukocyte rolling and adhesion in vivo.

43 man endothelial cells near bifurcations with rolling and adhesion patterns in close agreement with in

44 d Pam3CSK4 increased integrin-dependent slow rolling and adhesion to endothelium within minutes, as i

45 monstrates that histamine-induced neutrophil rolling and adhesion to the postcapillary venules in the

46 Many phagocyte behaviors, including vascular rolling and adhesion, migration, and oxidative bursting,

47 el was processed using a combination of cold-rolling and annealing of martensite.

48 orce in diverse situations such as leukocyte rolling and arrest on the vasculature, capture of nanopa

49 tion is a multistep process preceded by cell rolling and arrest on the vessel wall via the formation

50 ng anti-P-selectin mAb to prevent neutrophil rolling and arrest.

51 ranulocyte/monocyte lineage) mice and during rolling and attachment in Rac2-null (all blood cells) mi

52 Rac1 is involved in E-selectin-mediated slow rolling and crawling.

53 how that mechanisms mediating leukocyte slow rolling and emigration are impaired in Gal-3(-/-) mice,

54 t a specialization of MAdCAM to mediate both rolling and firm adhesion by binding to different alpha4

55 show that C1q-VWF complexes induced platelet rolling and firm adhesion.

56 ingly, in ERK5-EKO mice, increased leukocyte rolling and impaired vessel reactivity were resistant to

57 t (ERK5-EKO) mice showed increased leukocyte rolling and impaired vessel reactivity.

58 After multi-pass rolling and intermittent annealing at 550 degrees C for

59 neutrophils expressing DeltaANK had impaired rolling and kinase activation.

60 iological processes: E-selectin-induced cell rolling and poly(amidoamine) (PAMAM) dendrimer-mediated

61 induced signaling effects on neutrophil slow rolling and recruitment in vivo demonstrate the function

62 ts' T cells showed increased PSGL-1-mediated rolling and residual adhesion, even under VLA-4 blockade

63 at ankyrin enhances CD44-mediated neutrophil rolling and signaling.

64 Experiments further suggest that because the rolling and sliding friction coefficients differ substan

65 oggling between two types of motion, namely, rolling and sliding.

66 Furthermore, THI0019 facilitated the rolling and spreading of cells on VCAM-1 and the migrati

67 dhesion molecule 1-dependent slow neutrophil rolling and strongly reduced L- and E-selectin-dependent

68 recruitment, and GSLs stabilizing slow cell rolling and the transition to firm arrest.

69 otrusion is an important aspect of leukocyte rolling, and it should not be ignored when leukocyte rol

70 nitial rolling contact area, and the initial rolling angle were extracted after a systematic parametr

71 Methods We define the rolling-arms design with the goal of minimizing the comp

72 the potential gains of a platform design-the rolling-arms design-that adds and removes arms on a roll

73 Conclusion The rolling-arms platform design is applicable to a broad va

74 Results A rolling-arms platform design with two to five experiment

75 very if these therapies had been tested in a rolling-arms trial.

76 component analysis (PCA) revealed neutrophil rolling as an important functional phenotype in T2DM dia

77 Incorporation of a rolling assessment of patient hospitalization has potent

78 Neutrophils rolling at high shear stress (above 6 dyn/cm(2)) form te

79 1 month), time-varying (every 3 months), and rolling-average (i.e., mean for 3 months moving at 3-mon

80 HR, 1.32; 95% CI, 1.14 to 1.52; P<0.001) and rolling-average models (HR, 1.34; 95% CI, 1.13 to 1.57;

81 R, 1.78; 95% CI, 1.29 to 2.45; P<0.001), and rolling-average models (HR, 1.83; 95% CI, 1.30 to 2.57;

82 ension movements with the goal to position a rolling ball on table into a target.

83 ling of these two force fields can "push" a "rolling ball" quickly along the skeleton of a neuron, re

84 -arms design-that adds and removes arms on a rolling basis.

85 Understanding the rolling behavior of a micro-object is essential to estab

86 d neutrophils are used to characterize their rolling behavior on E-selectin, a critical step in leuko

87 Descemet membrane rolling behavior showed significant inverse correlation

88 Drosophila larvae, we found that nociceptive rolling behavior was triggered at lower temperatures and

89 d correlation between donor age and Descemet rolling behavior.

90 e tethers are critical in understanding cell rolling behavior.

91 ases as a protective alert signal to trigger rolling behaviors, allowing fast escape before the tempe

92 facile formation of reversible and fast self-rolling biopolymer microstructures from sandwiched activ

93 st prevalent forms of evolutionary movement--rolling bodies and whirls of turbulence--exhibit the sam

94 For rolling bodies, the life span (t) and the life travel (L

95 ing capacity and the molecular basis of Treg rolling can be regulated dynamically.

96 'A'a and sheet lava flows advance in a rolling caterpillar-track motion on top of the rigid, sn

97 The sling downstream of the rolling cell aligned according to the streamlines before

98 atial distribution of adhesive properties on rolling cell surfaces.

99 with no visible material extending above the rolling cell, suggesting a very low bending modulus of t

100 Most rolling cells formed 5 tethers that were 2-30 mum long.

101 The program also automatically tracks rolling cells in addition to those that are more firmly

102 extract the rotational motion of individual rolling cells.

103 Selectin-mediated slow rolling, chemokine-induced arrest, and transmigration we

104 be is served as a template for hyperbranched rolling circle amplification (HRCA) by utilizing Bst DNA

105 ion nicking reactions mediated hyperbranched rolling circle amplification (HRCA).

106 on of peptide nucleic acid (PNA) technology, rolling circle amplification (RCA) and DNAzymes.

107 optimized for both high- and low-temperature rolling circle amplification (RCA) and strand displaceme

108 Rolling circle amplification (RCA) is an isothermal enzy

109 nsitive detection of DNA using the dendritic rolling circle amplification (RCA) is introduced.

110 Isothermal rolling circle amplification (RCA) is used to detect nuc

111 Ebola cDNA was amplified by rolling circle amplification (RCA) on magnetic particles

112 In this paper, rolling circle amplification (RCA) products are detected

113 mediated isothermal amplification (LAMP) and Rolling Circle Amplification (RCA) techniques for c-MYC

114 rming large defined silver nanostructures by rolling circle amplification (RCA) using boranephosphona

115 uble-stranded barcoding error correction and rolling circle amplification (RCA)-based target enrichme

116 ed upon a padlock probe ligation followed by rolling circle amplification (RCA).

117 ibodies enhanced signals can be obtained via rolling circle amplification (RCA).

118 via padlock probe recognition and isothermal rolling circle amplification and benchmark against a com

119 Rolling circle amplification and gradient centrifugation

120 be mediated by alternative processes such as rolling circle amplification and/or homologous recombina

121 As rolling circle amplification of padlock probes can be us

122 using exhaustive in silico enzyme screening, rolling circle amplification of plasmid DNA, capillary e

123 ed off-chip by padlock probe recognition and rolling circle amplification show a different dynamics a

124 locked-nucleic acid probes is combined with rolling circle amplification to detect the presence and

125 A new colorimetric method for monitoring of rolling circle amplification was developed.

126 subjected to massive signal amplification by rolling circle amplification, leading to a sensor system

127 It employs rolling circle amplification, which enriches the full-le

128 ay multi-arrayed fiberoptics conjugated with rolling circle amplification.

129 hich are assembled in yeast and amplified by rolling circle amplification.

130 ke DNA nanoparticles that are synthesized by rolling circle amplification.

131 s of a DNA assay based on padlock probes and rolling circle amplification.

132 the change in dynamic magnetic response when rolling circle amplified DNA molecules are bound to the

133 cess we term SIRCAS (stepwise integration of rolling circle amplified segments), towards constructing

134 A molecules were assumed to be templates for rolling circle DNA-replication.

135 They replicate via a rolling circle mechanism that requires a multi-functiona

136 TVd circles are replicated via an asymmetric rolling circle mechanism to form linear multimeric RNAs.

137 al duplications are consistent with a double rolling circle mechanism.

138 ansposons, CRISPR loci, ribosomal RNA genes, rolling circle origins of replication, and areas where p

139 DNA strands and Mg2 PPi crystals during the rolling circle process, ultimately leading to the direct

140 particles are then readily formed along the rolling circle product.

141 demonstrate the fast optomagnetic readout of rolling circle products from bacterial DNA utilizing the

142 des: complementary strand replication (CSR), rolling circle replication (RCR) and recombination-depen

143 roducing tandem CpG and shRNA via concurrent rolling circle replication and rolling circle transcript

144 in a manner distinct from that of any other rolling circle replication proteins.

145 splacement mechanism, a linear adaptation of rolling circle replication that relies on the repeated f

146 brid micro/nanostructures, fabricated by the rolling circle technique.

147 t the Escherichia coli replication fork on a rolling circle template.

148 e show that large RNA molecules generated by rolling circle transcription fold into periodic-shRNA (p

149 hia coli RNAPs, human RNAPs do not carry out rolling circle transcription on circularized templates.

150 ia concurrent rolling circle replication and rolling circle transcription, (2) self-assembling CpG an

151 e porous microstructures (Multi-RNAi-MSs) by rolling circle transcription.

152 tial for processing viral transcripts during rolling circle viral replication.

153 The axis trajectory of the rolling circle, parallel to the adiabatic path, is shown

154 ent initial states outside and inside of the rolling circle, respectively.

155 ong-chain single-stranded DNA synthesized by rolling-circle amplification (RCA).

156 Here using rolling-circle amplification of gene-specific circulariz

157 mples and five cervical cancer tissues using rolling-circle amplification of total cell DNA and deep

158 plification method, based on three rounds of rolling-circle amplification, that produces nanomole amo

159 acterial plasmids replicate by an asymmetric rolling-circle mechanism that requires sequence-specific

160 They are presumed to amplify by rolling-circle replication (RCR) because some elements e

161 from long DNA building blocks generated via rolling-circle replication (RCR) of a designed template.

162 Using a rolling-circle RNA template, we have reconstituted an in

163 in vitro replication system that utilizes a rolling-circle RNA template.

164 Pol IV, Pol II is inefficient at disrupting rolling-circle synthesis by the fully reconstituted Pol

165 redundantly encoded into tandem repeats by 'rolling-circle' reverse transcription.

166 possess small genomes that replicate by the rolling-circle-like mechanism initiated by a distinct vi

167 DNA of tandem repeats, originating from the rolling circular amplification (RCA).

168 We created rolling cohorts of pediatric and adult asthmatic patient

169 for the critical rolling moment, the initial rolling contact area, and the initial rolling angle were

170 s including stress corrosion crack (SCC) and rolling contact fatigue (RCF).

171 able regions in the materials, correspond to rolling contacts that are about to slide, whose density

172 Both rolling (cooperative) and sliding particle rotations are

173 We term this motion "subunit rolling." Correspondingly, a mammalian decoding complex

174 layed 90% to 100% reduction in tethering and rolling density on all selectins.

175 , which causes the lattice elongation in the rolling direction associated with the transition upon co

176 ll's turning direction is not defined by the rolling direction.

177 on of ORMDL3 in eosinophils causes increased rolling, distinct cytoskeletal rearrangement, extracellu

178 A study of dung beetles rolling dung balls to safety reveals unexpected facets o

179 easurable orientation behavior has made ball-rolling dung beetles an attractive model organism for th

180 rce competition for food, South African ball-rolling dung beetles carve a piece of dung off a dung-pi

181 to the plasma membrane to mediate leukocyte rolling during inflammation.

182 sent comprehensive 3D data demonstrating the rolling dynamics of freely swimming sperm cells around t

183 and attachment, folding of antihelix, helix rolling, ear protrusion and antitragus size (linear regr

184 e dendrimer surface groups, and a potential "rolling" effect leading to fast interparticle kinetic tu

185 asured intrinsic honesty in an anonymous die-rolling experiment.

186 E-selectin-mediated rolling facilitates pancreatic cancer cell adhesion to h

187 acidic pH, as indicated by the greater cell-rolling flux of neutrophils and slower rolling velocitie

188 loy plates processed through continuous rheo-rolling for the first time.

189 Although the mechanics of selectin-mediated rolling have been extensively studied, little is known r

190 tyle of rotation is shown to be identical to rolling hinge footwall rotation documented recently in O

191 mediated neutrophil arrest while maintaining rolling immune-surveillance is unknown.

192 n of selectin ligands required for leukocyte rolling in dermal microvessels.

193 Tregs and proinflammatory T cells to undergo rolling in the skin remains unclear.

194 fucosylated glycan ligands mediate leukocyte rolling in the vasculature under shear forces.

195 acking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inf

196 Diminished rolling in Tph1(-/-) mice resulted in reduced firm adhes

197 Bs, or injection of serotonin normalized the rolling in Tph1(-/-) mice.

198 lectin-induced, beta2 integrin-mediated slow rolling, in sharp contrast to the defective slow rolling

199 on and growth mechanisms of room temperature rolling induced face-centered cubic titanium (fcc-Ti) in

200 mation, PSGL-1 dominated E-selectin binding, rolling, integrin activation, and extravasation of matur

201 and FUT7 only exhibited partial reduction in rolling interaction on E-selectin.

202 eered cells exhibited enhanced tethering and rolling interactions on E-selectin-bearing endothelium u

203 Tregs underwent consistent but low-frequency rolling interactions under resting and inflamed conditio

204 butes CD44, which is the primary mediator of rolling interactions.

205 rm that generates a neural plate that, after rolling into a neural tube, acts as the main source of n

206 because selectin-mediated cell tethering and rolling is a critical component of both normal immune re

207 ss the endothelium, where it is presented to rolling leukocytes.

208 How CD44 functions as a rolling ligand despite its weak affinity for E-selectin

209 ongly correlated with neutrophil activation, rolling ligand P-selectin glycoprotein ligand 1 (PSGL-1)

210 MSCs that simultaneously express functional rolling machinery (P-selectin glycoprotein ligand-1 [PSG

211 ystem, we evaluated how E-selectin-dependent rolling modulates hyaluronic acid (HA) adhesion as a fun

212 m dimensionless expressions for the critical rolling moment, the initial rolling contact area, and th

213 Previously proposed DNA revolution and rolling motions inside the connector channel are both fo

214 ocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance o

215 tem and demonstrate that in mammalia subunit rolling occurs during tRNA selection.

216 Equations describing the rolling of a spherical ball on a horizontal surface are

217 al microscopy in Foxp3-GFP mice to visualize rolling of endogenous Tregs in dermal postcapillary venu

218 exture that is commonly developed during the rolling of magnesium alloy and can even increase during

219 terol resulted in the uniform, CD44-mediated rolling of monocytes on the E-selectin-coated surfaces.

220 ing, in sharp contrast to the defective slow rolling of neutrophils lacking talin1 or expressing a ta

221 ectin, and that TIM-1 mediates tethering and rolling of T helper 1 (Th1) and Th17, but not Th2 and re

222 adopts conformations involving ratcheting or rolling of the small subunit that are distinct from thos

223 challenge model of contact hypersensitivity, rolling of Tregs and conventional CD4(+) T cells was mos

224 However, after a second challenge, rolling of Tregs but not conventional CD4(+) T cells bec

225 infold chamber revealed unaffected leukocyte rolling on anti-VWF treatment.

226 lar tissue requires neutrophil tethering and rolling on cytokine-activated endothelial cells (ECs), t

227 alphaLbeta2 (LFA-1), which can be induced by rolling on E-selectin (slowly) or by exposure to the che

228 f these changes on the mechanics of monocyte rolling on E-selectin surfaces at 1 dyn/cm(2) in microch

229 Cell rolling on E-selectin was unaltered although the number

230 We show that tumor cells rolling on E-selectin were approximately 40-fold more li

231 These functional studies show that leukocyte rolling on P- and L-selectin is ablated in cells lacking

232 ta2 integrin-dependent arrest of neutrophils rolling on selectins but impaired intraluminal crawling

233 ed, little is known regarding how tumor cell rolling on selectins facilitates adhesion to a distinct

234 During leukocyte rolling on the endothelium, surface protrusion and membr

235 the swing phase or the sensation of the foot rolling on the floor while walking.

236 ctin ligand in vitro that mediates Th17 cell rolling on the vascular endothelium and recruitment in v

237 rated that CD43(-/-) Th17 cells had impaired rolling on TNF-alpha-treated microvessels.

238 ocyte trafficking by mediating tethering and rolling on vascular surfaces.

239 However, because of challenges in rolling out the technology and weak quality assurance me

240 Neutrophil rolling over E-selectin at precise shear stress transmit

241 eakage but did not further enhance leukocyte rolling over pCS alone.

242 At the membrane, the NB undergoes a "rolling over" mechanism to expose additional higher-affi

243 Introducing a novel sequential dyadic die-rolling paradigm, we show that collaborative settings pr

244 The time-lapse analysis of flowing and rolling (patrolling) monocytes in the heart and the peri

245 Rolling phenotype can be modulated by common disease ris

246 This study shows how a self-rolling process initiated by polymerization of a micropa

247 ng the strain engineering and a self-folding rolling process.

248 0) of the National Diet and Nutrition Survey Rolling Program, we simulated the effect of fortifying w

249 from the National Diet and Nutrition Survey rolling programme (NDNS RP) from 2008-12 and British Sof

250 Furthermore, E-selectin-dependent rolling promotes adhesion to HA by both physically slowi

251 r age (range, 39-93 years) and the extent of rolling (R2 = 0.5 [P = .006]).

252 However, although neutrophil slow rolling requires talin recruitment to integrins, talin-m

253 tance in tires, where one wishes to minimize rolling resistance (normal loading) while maximizing sli

254 vehicles, VSP for OSVs is more sensitive to rolling resistance and less sensitive to aerodynamic dra

255 roach, we studied the critical conditions of rolling resistance of an elastic cylindrical micro-objec

256 of the system surprisingly revealed that the rolling resistance per unit cylindrical length can be si

257 ized ribosome profiling read coverage over a rolling series of windows along a transcript relative to

258 Dose escalation of alisertib followed the rolling six design.

259 We used a rolling six escalation design to determine the maximum t

260 22, and 24 and was escalated according to a rolling-six design.

261 and endothelial cells stabilizes neutrophil rolling, so it has been studied extensively and the forc

262 -of-care testing methodology, and neutrophil rolling speed as a functional biomarker for rapid profil

263 Higher rolling speed was observed in T2DM patients (P < 0.01) w

264 ow membrane tethers contribute to neutrophil rolling stability during the inflammatory response.

265 and it should not be ignored when leukocyte rolling stability is studied systematically.

266 n ligands to mediate the essential tethering/rolling step in cell transport and delivery that capture

267 a multistep adhesion cascade, which involves rolling, sticking, and crawling of the leukemic cells on

268 RBCs successively tumble, roll, deform into rolling stomatocytes, and, finally, adopt highly deforme

269 (tecta) function, which is disrupted in the rolling stones (rst) mutant.

270 Participants (n = 145) completed a die-rolling task where they could misreport their outcomes t

271 cass, by ripping off any fur or feathers and rolling the flesh into a rounded ball.

272 ions for the critical conditions for initial rolling; these asymptotic solutions were found in excell

273 d were subjected to stretching, folding, and rolling to demonstrate their use as stretchable displays

274 put single-cell quantification of neutrophil rolling to detect subtle differences in speed distributi

275 Transition of PMN rolling to firm adhesion critically depends on Coro1A by

276 E-selectin-mediated rolling transmits signals into neutrophils that trigger

277 electin-PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 secretion.

278 ng as well as a translation and simultaneous rolling, typically to alternate and weaker binding inter

279 ectin on activated endothelial cells mediate rolling under flow, a prerequisite for neutrophil arrest

280 ived catch-bonds that support slow leukocyte rolling under shear stress.

281 ng films can undergo reversible pH-triggered rolling/unrolling, with a variety of 3D structures formi

282 waves are associated with asymmetric embryo rolling, unveiling a new chirality marker in Drosophila

283 However, the actual processes of rolling up graphene sheets into CNTs in laboratory synth

284 The rolling up of a graphene sheet into a tube is a standard

285 cell-rolling flux of neutrophils and slower rolling velocities of L-selectin-coated microspheres, re

286 did not further reduce P-selectin-dependent rolling velocities.

287 racellular activation loop reduces leukocyte rolling velocity and stimulates adhesion.

288 ce resulted in a dose-dependent reduction in rolling velocity associated with increased numbers of ad

289 The rolling velocity of CD45E613R mutant neutrophils was dec

290 ith N-glycan truncation also increasing cell rolling velocity on L-selectin.

291 -55 mAb, resulting in a dramatic decrease of rolling velocity under flow.

292 activated endothelium encompass (1) platelet rolling via interaction of platelet glycoprotein Ib-IX-V

293 -selectin and endothelial surfaces, and this rolling was slower, steady and uniform compared to uninf

294 oxygen furnace slag (BOFS) coupled with cold-rolling wastewater (CRW) was performed in a rotating pac

295 l of contaminating particles by impacting or rolling water droplets, which implies the action of exte

296 rmediate affinity and induces slow leukocyte rolling, whereas P-Rex1 is not involved in the induction

297 no-domains develop strong texture after cold rolling, which causes the lattice elongation in the roll

298 cutting and folding is suppressed by plastic rolling, which provides kirigami LIBs excellent electroc

299 s included not updating, periodic refitting, rolling window, and dynamic logistic regression.

300 illet and fish homogenate and dynamically by rolling with cut fillet cubes.