ライフサイエンスコーパス: rootlet

1 the acetylated microtubules and along the D4 rootlet.

2 f the gene for rootletin, a component of the rootlet.

3 g-sought structural component of the ciliary rootlet.

4 iate preferential binding to centrioles over rootlets.

5 tly, via microtubules, to some stereociliary rootlets.

6 rrelated with shorter acetylated microtubule rootlets.

7 hereditary deafness DFNB28, is localized to rootlets.

8 number of single spindle afferents in dorsal rootlets.

9 t the ciliary base in photoreceptors lacking rootlets.

10 In the mutant, ciliated cells are devoid of rootlets.

11 It was originally cloned from human hair rootlets.

12 mal basal bodies and cytoplasmic microtubule rootlets.

13 lation of neurons among the trigeminal motor rootlets.

14 propose a model of eyespot assembly wherein rootlet and photoreceptor direct EYE2 to an area of the

15 aex8) mice develop normally but fail to form rootlets and are easier to deflect and damage.

16 ate with the basal bodies and their striated rootlets and form complexes named ciliary adhesions (CAs

17 Root mutant neurons lack rootlets and have dramatically impaired sensory function

18 functional paradigm for Nesprin1 at ciliary rootlets and suggest that the wide spectrum of human pat

19 of Nesprin1alpha with photoreceptor ciliary rootlets and the functional interaction between rootleti

20 The function of rootlets and the molecules responsible for their formati

21 ceptor patches were not restricted to the D4 rootlet, and more anterior eyespots correlated with shor

22 localizes to cilia-forming basal bodies and rootlets, and is required for ciliary adhesion complexes

23 function of the rotational stiffness of the rootlets; and 4) how the standing tension of the tip lin

24 In retinal photoreceptors where rootlets appear particularly robust, rootlets extend fro

25 Stereocilia rootlets are angled toward the center of the bundle, ten

26 Our data indicate that rootlets are composed of homopolymeric rootletin protofi

27 We show, however, that normal rootlet assembly requires centrioles.

28 Rootlet axon RFs in adult cats were used to approximate

29 e input from these same digits within dorsal rootlets bordering the lesion site.

30 s into uniquely dense bundles reminiscent of rootlets but distinct from bundles formed by espin, an a

31 ls of pejvakin-deficient mice develop normal rootlets, but hair bundle morphology and mechanotransduc

32 on of the intercentriolar linker and ciliary rootlet component rootletin, and rootletin knockdown in

33 Pejvakin binds to and colocalizes with the rootlet component TRIOBP at the base of stereocilia in i

34 the daughter four-membered (D4) microtubule rootlet, comprises an elliptical patch of rhodopsin phot

35 Some rootlets contact the tight junctions that underlie the e

36 Rootlets contain spectrin, tropomyosin, and beta- and ga

37 Dorsal rootlets containing electrophysiologically identified ax

38 in reveal, respectively, the way stereocilia rootlets contribute to the hair bundle's mechanical prop

39 ioned adjacent to the daughter four-membered rootlet (D4), a unique bundle of acetylated microtubules

40 hoot axes, and largely unbranched stigmarian rootlets developed from rhizomorphs axes.

41 e base of microvilli, including to the actin rootlet devoid of ezrin or plasma membrane.

42 s and in a mix of afferents in lumbar dorsal rootlets (dorsal root potential [DRP]) with bipolar elec

43 s where rootlets appear particularly robust, rootlets extend from the basal bodies to the synaptic te

44 e packed more densely at the base, forming a rootlet extending into the cell body.

45 The ciliary rootlet, first recognized over a century ago, is a promi

46 cilium, they are especially dependent on the rootlet for structural integrity and long-term survival.

47 radiating from the centrioles and resembling rootlets found in vivo.

48 r plate, and a severing of the hair-bundle's rootlets from the actin cores of the stereocilia.

49 The rootlets have a thick central core that widens at the an

50 developed largely unbranched, root-hairless rootlets, here we report that stigmarian rootlets were h

51 is positioned along, and adjacent to, the D4 rootlet in the absence of pigment granules.

52 oreover, pejvakin localizes to stereociliary rootlets in hair cells and is required for stereocilia m

53 cord explants and formation of "miniventral rootlets." In neonatal mice, PTN protected the facial mo

54 The striated ciliary rootlet is a prominent cytoskeleton originating from bas

55 In vitro assays suggest that the rootlet is among the least dynamic of all cytoskeletons

56 They suggest that the ciliary rootlet is involved in cellular transport and stabilizes

57 Thus, a primary function of the rootlet is to provide structural support for the cilium.

58 A robust ridged pedicle with distal rootlets is preserved, together with a lophophore and ot

59 a major structural component of the ciliary rootlet, is located at the basal bodies and centrosomes

60 Within a particular frequency region, rootlet length correlates with stereociliary height but

61 of basal stereocilia in equivalent rows, but rootlet lengths increase much less.

62 a cytoskeletal structure called the ciliary rootlet links the cilium to the cell body.

63 etain defects in basal body structure and in rootlet microtubule positioning.

64 striated fiber is incomplete in this mutant, rootlet microtubules can be misplaced, and multiflagella

65 d activity was recorded from the hypoglossal rootlet of 700- to 800-microm medullary sections.

66 , and Dvl2 has been shown to localize to the rootlet of motile cilia.

67 ure that in the algal ancestor served as the rootlet of the flagellar basal bodies is required for pa

68 protein, designated rootletin, found in the rootlets of ciliated cells.

69 aralogs Rootletin and C-Nap1, assembles into rootlets of diverse lengths among sensory neuron subtype

70 Nesprin1 are integral components of ciliary rootlets of multiciliated ependymal and tracheal cells.

71 tletin recruits Nesprin1alpha at the ciliary rootlets of photoreceptors and identify asymmetric NE ag

72 Nerve impulses were recorded from the dorsal rootlets of the L7-S1 segments of the spinal cord, and a

73 ith respect to flagellar number, microtubule rootlet organization, cleavage furrow positioning, and b

74 t a density of approximately 25,600 terminal rootlets per meter of rhizomorph, and were covered in ro

75 flections of up to +/-35 degrees, ruling out rootlet prestressing as the basis for sliding adhesion.

76 n mAb widely used as a marker for vertebrate rootlets recognizes an epitope in rootletin.

77 investigated the structure and dimensions of rootlets relative to the stereocilia in apical (low-freq

78 In contrast, dorsal rootlet rhizotomy led to a significant increase in corti

79 on; or (2) diminishing their input by dorsal rootlet rhizotomy.

80 Vagal afferent rootlet section eliminated pancreatic secretions evoked

81 physiologically 15-25 weeks after the dorsal rootlet section to define this reactivation.

82 eate nucleus at 15-25 weeks after the dorsal rootlet section, than those mapped only 7 days postlesio

83 In four others (Group 2), additional rootlets shown to innervate the middle finger and thenar

84 These data suggest that rootlets strengthen the ankle region to provide durabili

85 nk membranes may serve as part of the stable rootlet structure for anchoring the tip links of stereoc

86 ar plates and association with stereociliary rootlets suggest that this isozyme participates in rigid

87 s-positive vesicles adjacent to the striated rootlet suggests a transport role for this cytoskeletal

88 Previous studies indicated that rootlets support the long-term stability of some cilia.

89 extinct rhizomorphic lycopsids have the same rootlet system architecture.

90 After section of the dorsal rootlets that enervate the macaque's thumb and index fin

91 Stereocilia have dense rootlets that extend through the ankle region to anchor

92 root entry zone and the lateral funiculi via rootlets that had become adherent to the lateral spinal

93 neous rhythmic activity in hypoglossal (XII) rootlets that occur in synchrony with periodic bursts of

94 ortical fibers in oral apparatus and ciliary rootlets, the apical filament ring and to inner arm (14S

95 f C-NAP1, although components of the ciliary rootlet were aberrantly localized away from the base of

96 ess rootlets, here we report that stigmarian rootlets were highly branched, developed at a density of

97 ubule-based trafficking selective for the D4 rootlet, which is perturbed in mlt1 mutant cells.

98 or the XIIMN while recording from XII nerve rootlets (XIIn) as an index of respiratory motor output.