ライフサイエンスコーパス: rotarod

1 accelerating rotating rod (the accelerating rotarod).

2 ractivity, stereotypies, motor impairment in rotarod).

3 , which exhibited an enhanced ability on the rotarod.

4 phases of skill learning on an accelerating rotarod.

5 r firing rate while mice were running on the rotarod.

6 eneration and motor deficits, as assessed by rotarod.

7 ivity, hypothermia, and ataxia assessed on a rotarod.

8 y declining performances on the accelerating Rotarod.

9 nce upon repeated testing on an accelerating rotarod.

10 display motor impairment or sedation using a rotarod.

11 motor skill, as assessed by the accelerated rotarod.

12 mice also showed better motor skills on the rotarod 3 days after injury, and improved performance in

13 Wild-type 129/SvEv mice had the poorest rotarod ability of all groups tested, suggesting that li

14 y the screen test, static dowel, fixed-speed rotarod, accelerating rotarod, grip strength, or loss of

15 ssive dopaminergic degeneration and improved rotarod activity.

16 walking on grids, and fall off platforms and rotarods, although they do not have a jerky gait.

17 its are present, as measured by accelerating rotarod analysis, together with a progressive decrease i

18 ramatic deficits in motor performance on the rotarod and ataxia.

19 pendent impairment in motor tasks, including rotarod and balance beam performance.

20 in astrocytes improves motor performance in rotarod and balance beam tests and improves cognitive fu

21 The rotarod and Barnes maze acquisition and probe tests were

22 and improved motor deficits, as assessed by rotarod and clasping behavioural tests.

23 eased motor coordination on the accelerating rotarod and deficits in working memory as measured in th

24 ved motor outcome as assessed using both the rotarod and grid test.

25 Functional deficits were tested on the rotarod and grip-strength meter at 24, 48 and 72 h after

26 ment in ability to remain on an accelerating rotarod and increased grip strength observed in the pMCA

27 vement in functional outcomes as assessed by Rotarod and Morris Water Maze and a reduction in positiv

28 M on L-DOPA efficacy was evaluated using the rotarod and the cylinder test after the establishment of

29 t in motor function on forced tasks, such as rotarod and treadmill tests, caused by substantia nigra

30 combination therapy increased latency during rotarod and wirehang testing at 12 wk, in comparison wit

31 evere motor control impairment (falling from rotarods and 1-inch wide beams).

32 bited improved behavioral outcomes in motor (rotarod) and cognitive (Morris water maze) assays compar

33 little effect on sensorimotor coordination (rotarod) and spatial cognitive functions (Y-maze).

34 Neuroinflammation, motor coordination (rotarod), and depressive behaviors (social withdrawal, i

35 ocomotion in an open field, performance on a rotarod, and grid walking were significantly impaired in

36 We found motor deficits on the rotarod, and learning deficits in the Morris water maze

37 re deficient in contact righting, wire hang, rotarod, and pole climbing tasks.

38 in the null mutants on open field activity, rotarod, and wire hang, replicating and extending previo

39 We used the accelerating rotarod as a motor learning task.

40 Using rotarod as a test for motor learning, we found that expr

41 or recovery after injury, as measured by the rotarod assay and an inclined beam-walking task, was com

42 e on the accelerating versus the fixed-speed rotarod assay can be completely dissociated under some t

43 motor deficits (quantified in beam-walk and rotarod assays) and reduced PC loss observed in untreate

44 uts, dKO mice were impaired in sensorimotor (rotarod, balance beam assays) and spatial memory tasks (

45 significantly underperformed wt controls in rotarod, balance beam, string test, pole test and cotton

46 neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age

47 izer reduced learning and performance of the rotarod behavior.

48 tor learning; acquisition and retention of a Rotarod behavioral task is significantly better in K(b)D

49 h post-MPTP in BMT-treated mice assayed by a rotarod behavioral test.

50 voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and b

51 ll (improved balance) using the accelerating rotarod compared with nonexercised mice.

52 rform a complex motor task, the accelerating Rotarod, correlated with localization of mGluR1alpha to

53 N586-82Q mice show a clear progressive rotarod deficit by 4 months of age, and are hyperactive

54 ersensitivity, hyperexploratory behavior and rotarod deficits, all pointing to changes in dopamine (D

55 t young PGC-1alpha (-/-) mice exhibit severe rotarod deficits, decreased rearing behavior, and increa

56 re and produced deficits in performance on a rotarod device for the entire duration of the study.

57 everity-related deficits in performance on a rotarod device were also found at both slow and fast acc

58 after traumatic brain injury by the use of a rotarod device.

59 a faster recovery of motor incoordination in rotarod experiments and a shorter sedative effect in los

60 s C) for 2 h, and forced motor activity on a rotarod for 30 min, failed to alter extracellular 5-hydr

61 tic dowel, fixed-speed rotarod, accelerating rotarod, grip strength, or loss of righting reflex tests

62 seizures (6 Hz mouse model) without typical rotarod impairment of A(1)AR agonists.

63 Motor function was evaluated by using rotarod, inclined-plane, and forelimb/hindlimb flexion t

64 non-noxious input, generated by walking on a rotarod, induces Fos in the PKCgamma interneurons.

65 Rotarod, inverted screen, and open field motor function

66 The rotarod is one of the most commonly used tests to measur

67 CN-105 treatment, as quantified by increased Rotarod latencies on Days 1-5 post-ICH, and long-term im

68 dose adeno-associated virus vector increased Rotarod latency by 75% at 4 wk, in comparison with vecto

69 The rotarod latency was >200 s at 16 RPM in all rats pre-MCA

70 overt behavioral effects and did not change rotarod latency.

71 ted gene Arc in individual M2 neurons during rotarod learning by in vivo two-photon imaging of a knoc

72 Here, neuroligin-3 mutations increased rotarod learning by specifically impeding synaptic inhib

73 Using a mouse rotarod-learning task, we showed that lesion or inactiva

74 sensorimotor behavioral deficits measured by rotarod, limb placing, and elevated body swing tests.

75 flex, visible platform Morris water maze and Rotarod measurements were conducted to test vision and v

76 e hang, grip strength), sensorimotor skills (rotarod), mechanical sensitivity (von Frey hair), and th

77 inna reflex, Digiscan open field locomotion, rotarod motor coordination, hanging wire, footprint path

78 Using rotarod motor learning as a proxy for acquired repetitiv

79 nd rats performed poorly on balance beam and rotarod motor tests 24 h later.

80 avior, but not in the control open field nor rotarod motor tests; cyclic AMP responses to stimulation

81 , with change in maximum fall latency on the rotarod (n = 17, R = .89, p = .000001), and with blood c

82 n or pain perception were observed using the rotarod or hot-plate tests, and there was no change in G

83 trained on either the standard accelerating rotarod or the motirod for four trials per day on four c

84 ampus than those trained on the accelerating rotarod or those that received no training.

85 wt mice on composite neuroscore (P < 0.001), rotarod (P < 0.05), and beam balance (P < 0.02) tests.

86 st three days post-trauma as demonstrated by rotarod (p<0.05) and beam balance test (p<0.05), respect

87 ity to learn motor skills in an accelerating rotarod paradigm.

88 ce, to identify the genetic loci controlling rotarod performance and its relationship with body weigh

89 F/AdNoggin-treated R6/2 mice sustained their rotarod performance and open-field activity and survived

90 loss, mortality and behavioral impairment in rotarod performance and spontaneous motor activity were

91 ive dose (MED) for significant impairment in rotarod performance and the MED for significant neuropro

92 S-AMPA injection led to impaired rotarod performance and widespread axonal degeneration a

93 showed more severe exercise-induced fatigue, Rotarod performance deficits, and gait anomalies than md

94 al gait and ataxia characterized by impaired rotarod performance improved by treatment with a GABA(B)

95 ed environmental enrichment slows decline in RotaRod performance in R6/2 mice, despite rapid disease

96 ed statistically significant improvements in rotarod performance in treated animals compared to AAV2.

97 For example, while rotarod performance is normal until 10 weeks, it is impa

98 male N171-82Q mice show a greater deficit in rotarod performance than female N171-82Q mice.

99 Despite persistent behavioral deficits in rotarod performance up to the time of brain extraction (

100 Body weight and rotarod performance varied widely across CC strains and

101 Rotarod performance was comparable in the 3 strains.

102 Water maze, open field, and rotarod performance was tested 2 and 8 weeks after ICH.

103 Rotarod performance was tested at days 1-5 and maze perf

104 Impaired novel object recognition and rotarod performance were consistent across cohorts of nu

105 mice demonstrate only modest alterations in rotarod performance with aging and lack reproducible alt

106 tein aggregate reduction, reduced decline in rotarod performance, and alleviation of clasping in R6/2

107 hich is aggravated by flunitrazepam, reduced rotarod performance, and reduced locomotor activity in t

108 oved motor function as indicated by improved rotarod performance, longer stride length, lower stride

109 mal gait, inability to run or swim, impaired rotarod performance, reduced neuromuscular strength, dys

110 lation, decreased striatal atrophy, improved rotarod performance, reduction of weight loss, normaliza

111 However, 45 loci affected rotarod performance, seven of which were also associated

112 able but exhibit hindlimb clutching and poor rotarod performance.

113 enetic background to open-field activity and rotarod performance.

114 ing pattern, grip strength, balance beam and rotarod performance.

115 al thalamus and improved motor impairment on rotarod performance.

116 vehicle, though these groups had comparable rotarod performances and survival times.

117 SCs, and lower spontaneous firing rates, but rotarod performances were indistinguishable.

118 lterations in body weight changes, lifespan, RotaRod performances, grip strength, overall activity an

119 med equally as well as wild-type mice in the rotarod, pole, and cagetop tests of motor coordination.

120 nding and technically-difficult version of a rotarod procedure.

121 significantly reduced retention times on the Rotarod, suggesting a role for Bergmann glia-expressed P

122 ated significantly better performance on the rotarod task after 20 days of 'rehabilitation'.

123 pendent locomotor behaviors: training on the rotarod task and locomotor sensitization to amphetamine.

124 l memory performance were assessed using the rotarod task and Morris water maze.

125 rent strains had variable performance on the rotarod task, which correlated with the expression of >2

126 stinguishably from wild-type siblings on the rotarod task.

127 ral alterations in the open field and in the rotarod task.

128 learning and memory deficits in swimming and rotarod tasks.

129 showed normal ethanol-induced ataxia on the rotarod test after administration of a 2.5 gm/kg dose.

130 formed as well as wild-type littermates on a rotarod test and had increased numbers of large-diameter

131 than wild-type controls in the accelerating rotarod test for motor coordination.

132 We show here that exactly how the rotarod test is performed can markedly alter the apparen

133 rated by comparing it with the commonly used rotarod test of motor coordination and by using eye move

134 ith well chosen parameters, the accelerating rotarod test showed very high inter- and intralaboratory

135 Body weight and motor performance on the rotarod test were significantly improved in creatine-sup

136 rm memory (LTM) contextual fear testing, and rotarod test when compared to wild type (WT) littermates

137 ased latency to fall during the accelerating rotarod test) and possess an increased sensitivity to ni

138 eliorates motor symptoms (assessed using the rotarod test) and prevents loss of body weight induced b

139 generally normal on locomotor activity, the rotarod test, acoustic startle response, prepulse inhibi

140 st, impaired coordination and balance in the rotarod test, and increased spasticity as shown by a cla

141 Using a rotarod test, we demonstrated that early BMT greatly del

142 h an improvement in neuro-behavior using the rotarod test.

143 y assessment of motor coordination using the rotarod test.

144 not produce motor impairment as measured by rotarod test.

145 says of walking gait and in the accelerating rotarod test.

146 ar to that of non-lesioned control mice in a rotarod test.

147 ounds were administered i.p. 30 min prior to rotarod testing or onset of ischemia.

148 with motor deficits assessed by accelerating rotarod testing.

149 c mice began to display motor dysfunction in rotarod testing.

150 weight loss or neurotoxicity as measured by rotarod testing.

151 In the formalin and rotarod tests ACEA-1328 and MK-801 produced both antinoc

152 Swimming and rotarod tests demonstrate that the two Dfnb31 mutants ha

153 Results from open field and rotarod tests show A53T mice develop age-dependent chang

154 otor learning in vestibulo-ocular reflex and rotarod tests, we find that deletion of HCN1 channels fr

155 eficits in both beam-walking and accelerated rotarod tests, while they did not exhibit abnormal nucle

156 ry of motor functions in both open-field and rotarod tests.

157 eficits as measured by the vertical pole and rotarod tests.

158 mice had impaired motor coordination on the rotarod that was corrected in the congenic C57BL/6 backg

159 ined to run for 40 min/day, 5 days/week on a Rotarod treadmill at 11.5 cm/s, while control animals (n

160 ABAA receptors, the observed behavior in the rotarod, water maze and peripheral nerve injury tests wa

161 ) and functional outcomes (grip strength and Rotarod) were assessed prior to sacrifice.