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1 (95% CI, 64%-93%) against moderate to severe rotavirus.
2 t protection through reduced transmission of rotavirus.
3 other enteropathogens, with the exception of rotavirus.
4 hea, and controls were children negative for rotavirus.
5 000 for Cryptosporidium, and 1 in 118000 for rotavirus.
6 thogens, which include influenza viruses and rotaviruses.
10 tions and emergency department visits due to rotavirus AGE were reduced by a median of 67% overall an
12 assess the impact of vaccine introduction on rotavirus and acute gastroenteritis (AGE) hospitalizatio
13 cination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) duri
17 Mirpur, Dhaka) as part of the performance of rotavirus and oral polio vaccines in developing countrie
20 haracterization of the confrontation between rotaviruses and their host cells has allowed us to learn
22 among children whose stool was positive for rotavirus antigen (cases) and children whose stool was n
24 talized for AGE have stool sample tested for rotavirus antigen, was used to assess trends in rotaviru
27 athogens Campylobacter, Cryptosporidium, and rotavirus as conservative risk proxies for infections vi
28 sing children with AGE who test negative for rotavirus as controls for the rotavirus-positive cases.
29 e gastroenteritis (AGE) hospitalizations and rotavirus-associated hospitalizations during the prevacc
30 We studied trends in admissions specific to rotavirus at one hospital that had undertaken active rot
37 rmed a case-control study of VE by comparing rotavirus case patients with test-negative controls.
38 ased diarrheal surveillance used to identify rotavirus cases but who test negative for rotavirus (tes
40 fectiveness was 59% (95% CI, 4%-83%) against rotavirus caused by G2P, the most common (37%) circulati
41 ore susceptible to infections from P[8]-type rotaviruses compared with nonsecretors (95% CI, 8.3-85.0
42 nt for more than half the global deaths from rotavirus, concerns remain about the performance of oral
43 confidence interval, 74.3%, 83.0%) >/=2-dose rotavirus coverage among participants eligible for publi
45 Globally, we estimated that the number of rotavirus deaths in children <5 years of age declined fr
48 of children with AGE who tested positive for rotavirus declined from 53% (645/1223) in prevaccine yea
49 VE estimate is consistent with the observed rotavirus decrease and with efficacy estimates from else
50 acity that is characteristic of RNA viruses, rotavirus dedicates substantial resources to avoiding th
54 RV5 were similarly effective against severe rotavirus diarrhea caused by a heterotypic strain in Gua
55 o determine the effectiveness of RV1 against rotavirus diarrhea hospitalization using a case-control
58 E of 2 RV1 doses against hospitalization for rotavirus diarrhea was 57% (95% confidence interval, 14%
59 patients (children with laboratory-confirmed rotavirus diarrhea) and nonrotavirus "test-negative" dia
62 immunization program to reduce the burden of rotavirus disease (documented to cause 38% of acute gast
63 Rotavirus vaccine is effective in preventing rotavirus disease in Rwandan children who began their ro
65 use, both RV1 and RV5 are effective against rotavirus disease, supporting the World Health Organizat
70 VH1-46 mAbs previously isolated from PV and rotavirus-exposed individuals indicates that cross-react
72 rcentage of hospital admissions positive for rotavirus fell from 45% in the prevaccine period to 25%
73 rcentage of hospital admissions positive for rotavirus fell from 48% in the prevaccine period to 28%
74 ength of naturally acquired immunity against rotavirus gastroenteritis (RVGE), mirroring vaccine unde
75 first episode of laboratory-confirmed severe rotavirus gastroenteritis (Vesikari score, >/=11) beginn
77 cacy analysis, there were 31 cases of severe rotavirus gastroenteritis in the vaccine group and 87 ca
79 ce interval [CI], 31%-91%) effective against rotavirus gastroenteritis requiring hospitalization or a
82 e found 2 significant positive interactions: rotavirus + Giardia (odds ratio (OR) = 23.91, 95% confid
84 wo-dose VE was 79% (95% CI, 62%-88%) against rotavirus hospitalization and 84% (95% CI, 64%-93%) agai
85 ctions of 40%, 46%, and 69% in the number of rotavirus hospitalizations among infants in 2013, 2014,
87 n infants <1 year who accounted for 84.4% of rotavirus hospitalizations prior to vaccine introduction
88 Armenian children and substantially reduced rotavirus hospitalizations shortly after introduction.
89 ough indirect protection; overall in year 3, rotavirus hospitalizations were reduced by 69% among chi
93 ultures from multiple individuals with human rotavirus (HRV) and assessed the host epithelial respons
94 bella antibody seroconversion and evaluating rotavirus IgA/IgG seroresponses in MR + HRV recipients.
95 odds ratio [OR], 0.77; P = .002) and lack of rotavirus immunoglobulin A (IgA) seroconversion (OR, 1.9
96 rial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3
99 We assessed vaccine effectiveness against rotavirus in Guatemala, where both the monovalent (RV1;
101 of admissions to hospital for diarrhoea and rotavirus in Rwanda fell substantially after rotavirus v
103 ric viral pathogens, including norovirus and rotavirus, in both preventing and curing infection.
107 iral response is specific to the pancreas of rotavirus-infected mice, similar to the autoimmunity ass
109 ses were found to correlate with the risk of rotavirus infection and all P[8]/P[4] rotavirus infected
112 omposing the incidence rate into the rate of rotavirus infection and the risk of RVGE given infection
113 od of a 12-month increment, and detection of rotavirus infection by enzyme immunoassay in at least 10
114 multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in site
117 As childhood nutrition improves worldwide, rotavirus infection may remain a public health challenge
119 s crucial for the immune response to enteric rotavirus infection, a proposed etiological agent for T1
123 estimated the impact on laboratory-confirmed rotavirus infections and hospitalizations for all-cause
127 ving childhood vaccines for pneumococcal and rotavirus infections while greatly expanding coverage of
128 rstood, but in analogy to Gardia lamblia and rotavirus infections, secondary lactose maldigestion (LM
129 mechanisms that host cells employ to prevent rotavirus invasion and the countermeasures that these vi
132 and reduces pathogenicity in mice.IMPORTANCE Rotavirus is the leading cause of diarrhea in humans.
135 ns, and monitor vaccine impact, we estimated rotavirus mortality for children <5 years of age from 20
137 hia coli (EPEC, n = 21), norovirus (n = 21), rotavirus (n = 15), sapovirus (n = 9), and Salmonella (n
139 ine (33/44 [73%] unvaccinated) compared with rotavirus-negative children (81/136 [59%] unvaccinated)
142 ere >88% for Shigellaspp.,Campylobacterspp., rotavirus, norovirus genotype 1/2 (GI/GII), and adenovir
143 health burdens for Giardia, Cryptosporidium, rotavirus, norovirus, and adenovirus infections resultin
149 the following question: what fraction of the rotavirus particles that penetrate into the cell make ne
153 sis underlying inter-segment interactions in rotaviruses, paving the way for delineating similar RNA-
154 evaluate the efficacy of a live, oral bovine rotavirus pentavalent vaccine (BRV-PV, Serum Institute o
158 est reduction was noted in infants, with the rotavirus positivity rate in this age group declining fr
160 ich are a common beginning in articles about rotaviruses, reflects the fact that these viruses have e
161 ovel insights into the mechanisms underlying rotavirus regulation of different interferons and are li
165 act of vaccine introduction in this setting, rotavirus remained the leading etiology of diarrhea requ
168 ugh the identified human G9P[19] and G9P[13] rotaviruses represented minority strains, the repeated d
169 of 2-3 doses of a rotavirus vaccine against rotavirus requiring emergency department visit or hospit
170 -specific inter-segment interactions between rotavirus RNAs, taking place in a complex RNA- and prote
173 The murine model of BA, employing rhesus rotavirus (RRV), parallels human disease and has been us
176 Temperature-sensitive (ts) mutants of simian rotavirus (RV) strain SA11 have been previously created
183 Declines were most prominent during the rotavirus season (May-October) and among infants <1 year
184 s, with greater declines observed during the rotavirus season compared with non-rotavirus season mont
185 ed mortality and hospitalizations during the rotavirus season months were considerably diminished in
188 us, kobuvirus, parechovirus, parvovirus, and rotavirus sequences were frequently detected but were no
189 D45(-) PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19(-) PC
191 participants who met study criteria and had rotavirus stool testing performed and vaccine status con
192 n both in vitro and in vivo In addition many rotavirus strains are resistant to the actions of differ
194 ains, the repeated detection of porcine-like rotavirus strains in Taiwanese children over time justif
195 nding that the sequence is specific to those rotavirus strains that cause obstructive cholangiopathy.
197 World Health Organization (WHO)-coordinated rotavirus surveillance network between 2008 and 2013 tha
198 rotavirus mortality rates and deaths through rotavirus surveillance will aid in monitoring the impact
201 fy rotavirus cases but who test negative for rotavirus (test-negative controls) can be considered a s
202 re, we focus on the transmission dynamics of rotavirus, the main diarrheal disease in infants and you
205 Although the potential health benefits of rotavirus vaccination are huge in low-income African cou
206 separately, we propose a design to estimate rotavirus vaccination coverage using controls from a rot
208 bing the impact and effectiveness of routine rotavirus vaccination in developing countries that were
209 This supports broader implementation of rotavirus vaccination in low-income countries where >90%
210 ts that could result in countries that adopt rotavirus vaccination into their national immunization p
212 roups within 1 year of introducing an infant rotavirus vaccination program are far greater than expec
218 d encourage other countries to adopt routine rotavirus vaccination to reduce the health burden of sev
222 itionally, the effectiveness of programmatic rotavirus vaccination, including possible indirect effec
227 e significantly less likely to have received rotavirus vaccine (33/44 [73%] unvaccinated) compared wi
228 tiveness of a two-dose schedule of the human rotavirus vaccine (HRV; Rotarix) given early at 6 and 10
229 vaccine effectiveness (VE) of a pentavalent rotavirus vaccine (RotaTeq) against rotavirus diarrhea.
230 a surveillance to evaluate monovalent G1P[8] rotavirus vaccine (RV1) efficacy and understand variable
237 declined from 54.8% (95% CI, 48.3%-61.5%) in rotavirus vaccine age-ineligible children to 20.0% (95%
238 Plasma IgA levels specific for antigens in rotavirus vaccine and oral polio vaccine containing poli
239 nd immunogenicity of the P2-VP8-P[8] subunit rotavirus vaccine at different doses in South African to
242 l study at 6 public sector sites to estimate rotavirus vaccine effectiveness (VE) in age-eligible chi
245 MA) to identify observational evaluations of rotavirus vaccine impact among children <5 years of age
246 rotavirus in Rwanda fell substantially after rotavirus vaccine implementation, including among older
247 pilot introduction of the Rotarix live, oral rotavirus vaccine in all public health facilities in Lus
248 Together with the demonstrated impact of rotavirus vaccine in reducing population hospitalization
249 countries in sub-Saharan Africa to introduce rotavirus vaccine into its national immunization program
250 in the Newly Independent States to introduce rotavirus vaccine into its national immunization program
251 ome African country to introduce pentavalent rotavirus vaccine into its routine national immunisation
252 recommendation that all countries introduce rotavirus vaccine into their national immunization progr
254 us vaccine introduction (2009-2011) and post-rotavirus vaccine introduction (2013-2014) periods were
257 hospitalizations, temporally associated with rotavirus vaccine introduction, was observed in children
267 n and immune activation were correlated with rotavirus vaccine responses in 68 human immunodeficiency
271 Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baselin
281 level of protection detected for the current rotavirus vaccines in low-income versus high-income sett
288 strain replacement after the introduction of rotavirus vaccines, particularly in developing countries
291 s vaccination coverage using controls from a rotavirus VE test-negative case-control study and to exa
293 mation of the spatiotemporal distribution of rotavirus VP7 (G) and VP4 (P) genotypes have shown evide
298 To predict the proportion of diarrhea due to rotavirus, we constructed a multiple linear regression m
299 ed in 75 (28%) of 266 fecal samples and P[8] rotaviruses were found to be the predominant genotype.
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