ライフサイエンスコーパス: rotor

1 ss the membrane generates the turning of the rotor.

2 sociation rate on the force delivered to the rotor.

3 e central stalk and c-ring form the enzyme's rotor.

4 nstitute the membrane domain of the enzyme's rotor.

5 d TICT phenomenon and behaved like molecular rotor.

6 tween transmembrane proteins (stators) and a rotor.

7 l stalk, holding them static relative to the rotor.

8 the membrane domain constitute the enzyme's rotor.

9 olded-unfolded equilibrium of an N-arylimide rotor.

10 ator-unit modulates its association with the rotor.

11 protonates an acidic glutamate in the c-ring rotor.

12 ranged between -5 and -9 kJ mol(-1) for </=5 rotors.

13 s singularity points and visually highlights rotors.

14 d nonrotational singularity points and false rotors.

15 alyzed to study phase singularity points and rotors.

16 single mapping catheter enabled detection of rotors.

17 rroborated well with the spatial location of rotors.

18 ndent upon the formation and stability of VF rotors.

19 ronic devices based on fluorescent molecular rotors.

20 ed and investigated as redox-gated molecular rotors.

21 EES-based analysis was conducted to identify rotors.

22 to be highly efficient fluorescent molecular rotors.

23 of LGE signal intensity and the presence of rotors.

24 d to highlight high-curvature wavefronts and rotors.

25 s the magnetic flux quantum phi0 through the rotor [(0.99 +/- 0.07) x phi0].

26 (11), fluorescent pairs(12,13) and molecular rotors(14-16) have been designed to measure intracellula

27 port a loosely packed crystal of dendrimeric rotor 2 and the fast dynamics of all its aromatic groups

28 cture, and solid state dynamics of molecular rotor 3 provided with a high symmetry order and relative

29 4 rotors, duration 80+/-81 cycles; sheep: 13 rotors, 4.2+/-1.5 cycles).

30 is identified a total number of 410 electric rotors, 47.8% were located in the left atrium and 52.2%

31 the first example of the use of a molecular rotor, a BODIPY dye, to quantitatively visualize the vis

32 batic cooling due to rotor stretching during rotor acceleration and the reverse process on rotor dece

33 eloped a procedure to approximate isothermal rotor acceleration for better temperature control.

34 lse and rotor modulation (FIRM) mapping that rotors act as human atrial fibrillation sources.

35 llows for the identification of sources with rotor activity.

36 on durations predicted a higher incidence of rotors (all P<0.05).

37 ing that mutant stators not engaged with the rotor allow some proton leakage.

38 d to increase </=100% the time with detected rotors, although provoked the apparition of false rotors

39 low as 1 sample point in the vicinity of the rotors, an accuracy as high as 86% (P<0.001) was obtaine

40 mpound combining the features of a molecular rotor and a photoswitch was synthesized and was shown to

41 rectly measure the temperature of a spinning rotor and detected deviations that can translate into an

42 ine analysis revealed no differences between rotor and distant sites in dominant frequency or Shannon

43 suggesting unstable interactions between the rotor and stator.

44 terium possesses a single flagellum with one rotor and two sets of stators, only one of which can pro

45 tics of atrial electrograms used to identify rotors and describe acute procedural outcomes of FIRM-gu

46 al electrogram characteristics expected from rotors and did not differ quantitatively from surroundin

47 should define the mechanisms that stabilize rotors and evaluate whether rotor modulation may reduce

48 studies evaluating the relationship between rotors and fibrosis in patients with persistent atrial f

49 w ablation of patient-specific AF-sustaining rotors and focal sources alters the natural history of a

50 aim of this study was to analyze the role of rotors and focal sources in a large academic registry of

51 gly support the mechanistic role of biatrial rotors and focal sources in maintaining AF in diverse po

52 ution required for correct identification of rotors and focal sources is a linear function of spatial

53 Elimination of stable AF rotors and focal sources may explain freedom from AF aft

54 METHODS AND Simulations of rotors and focal sources were performed to estimate the

55 echnique to examine the relationship between rotors and LGE signal intensity in patients with persist

56 ly around frameworks, can rotate microscopic rotors and magnets fast enough to generate an electric p

57 signal morphologies around the locations of rotors and nonrotors were identified and quantified.

58 tructure in the initiation or maintenance of rotors and the ionic bases of spiral waves in the past 2

59 sic concepts and terminologies pertaining to rotors and their initiation.

60 al phase/frequency mapping methods to locate rotors and track changes induced by their ablation.

61 ability to detect organized stable drivers (rotors) and target them for therapy.

62 es of subunit a in Fo wrap around the c-ring rotor, and a total of six vertical helices assigned to s

63 Further theoretical studies of this membrane rotor, and of two others with a much stronger and a slig

64 rdiolipin in stabilizing and lubricating the rotor, and, by interacting with the enzyme at the inlet

65 nd a "turnover" in the binding rate data vs. rotor angle for angles greater than [Formula: see text]4

66 ucleotides in F1-ATPase as a function of the rotor angle is further extended in several respects.

67 tion steps have an exponential dependence on rotor angle.

68 nsional treatment, which validates the rigid-rotor approach widely used in scattering calculations.

69 by examining recent evidence suggesting that rotors are critical in sustaining both atrial and ventri

70 approaches to eliminate atrial fibrillation rotors are explained and the ablation results in latest

71 The fluorescent emissions from two of the rotors are found to originate, not from the localized ex

72 Stationary rotors are more reliably identified compared with meande

73 The structure of the two-dimensional rotor arrays contained in these surface inclusions was e

74 ture and dimensions of the ordered molecular rotor arrays dictate the correlated switching properties

75 demonstrate the use of fluorescent molecular rotors as probes for detecting biomolecular interactions

76 blation, resulting in increased attention to rotors as therapeutic targets.

77 The rotors, as fast as 10(8) Hz at 240 K, are exposed to the

78 usly prolonged action potential duration and rotors, as well as wave and wavelets in the atria, and t

79 erahertz spectroscopy of gas-phase molecular rotors at room temperature.

80 l mapping do require HDF filtering to detect rotors at the expense of a decreased specificity.

81 lly heterogeneous model of the PV-LAJ showed rotor attraction toward the PV.

82 rst study demonstrating that the presence of rotors based on NEEES analysis is not directly associate

83 We report a new class of luminescent rotors, based on the sensitized emission of a terbium(II

84 We introduce gold rotor bead tracking (AuRBT), which yields >100x improvem

85 High-resolution rotor bead tracking (RBT) measures DNA torque, twist, an

86 perties of a series of phenyl-ring molecular rotors bearing three, five, six, and seven phenyl groups

87 porous crystal architecture is sustained by rotor-bearing molecular rods which are connected through

88 ided accurate fits to measurements of stator-rotor binding over a wide range of loads.

89 lifetime imaging microscopy of the molecular rotor BODIPY C10 in the membranes of live Escherichia co

90 A molecular rotor built with a stator formed by two rigid 9beta-mest

91 on to induce single, stable, and centralized rotors by optical S1-S2 cross-field stimulation.

92 angles, slight reorientations of individual rotors can occur, resulting in the rotator arms pointing

93 a two-dimensional array of dipolar molecular rotors can undergo simultaneous rotational switching whe

94 This has the advantage of not reducing the rotor capacity and allowing for a direct temperature mea

95 partially inserts into the enzyme's central rotor cavity to block functional subunit rotation.

96 ons of FliM that mediate contacts within the rotor compose the phosphatase active sites in FliY.

97 ynamic gating for impeding CR in a molecular rotor, comprising an electron donor and acceptor directl

98 In metazoans, their rotors contain a ring of eight c-subunits consisting of

99 The fluorescence of molecular rotors contingent upon target binding makes them a versa

100 detect and track rotors when placed over the rotor core although the low-resolution basket catheter i

101 dicate that self-assembly of two-dimensional rotor crystals produces systems with correlated dynamics

102 otor acceleration and the reverse process on rotor deceleration.

103 w generation of rod-shaped dipolar molecular rotors designed for controlled insertion into channel ar

104 away from the core region resulted merely in rotor destabilization (ie, drifting).

105 ysis, to prevent misinterpretation and false rotor detection.

106 show that the quantum state of the molecular rotor determines whether or not anisotropic long-range i

107 e functions of these systems, as pendulum or rotor devices or as switchable catalysts, are described.

108 s established by the spatial location of the rotor domain (P=0.016).

109 A rotor domain was defined as an area displaying at least

110 Overall, rotor domains (9.2+/-2.2 rotations) displayed higher fre

111 Ablation of rotor domains (ablation line, 3.5+/-0.9 cm) effectively

112 Rotor domains appropriately explain long-standing persis

113 We identified 19 rotor domains in 10 patients (1.8+/-1.1 per patient; 7 i

114 was observed in 2 patients after ablation of rotor domains.

115 ation plus linear ablation of extrapulmonary rotor domains.

116 rotor network and to stabilize the switched rotor domains.

117 gradient was a rate-independent predictor of rotor drift direction.

118 le pacing protocols could be used to predict rotor drift in the PV-LAJ.

119 ionships substantiated its major role in the rotor drift.

120 simulate various conditions and investigate rotor drifting mechanisms.

121 d, the motion being activated by an internal rotor driven by a battery mechanism.

122 simulations (4 cycles) and animals (rats: 14 rotors, duration 80+/-81 cycles; sheep: 13 rotors, 4.2+/

123 rect temperature measurement of the spinning rotor during high-speed sedimentation velocity experimen

124 s, although provoked the apparition of false rotors during 100% of time.

125 The rotor dynamics could be switched off and on by I2 absorp

126 The implementation of (2)H-(13)C adiabatic rotor-echo-short-pulse-irradiation cross-polarization (R

127 uses a small fluorophore termed a "molecular rotor" embedded in the microbubble surface, whose fluore

128 ion of localized sustained re-entrant waves (rotors), followed by progressive wave breakdown and roto

129 e iButton on the counterbalance of a resting rotor, following thermal equilibration under high vacuum

130 ion and mechanistic studies to determine how rotors form, progress, and regress are needed.

131 oli is under the control of a complex on the rotor formed from the proteins FliG, FliM, and FliN.

132 The second rotor forms two different inclusions differing in crysta

133 as statistically based genotyping, using the Rotor-Gene ScreenClust HRM software to both detect the p

134 understanding of the mechanisms involved in rotor-guided ablation.

135 er for the temperature sensor located in the rotor handle.

136 Rotors have long been postulated to drive atrial fibrill

137 Rotor identification is accurate and sensitive and does

138 All patients had rotors identified (mean, 2.3+/-0.9 per patient; 72% in l

139 tural heart disease, the formation of stable rotors identifies individuals whose VF requires defibril

140 merged, which involves the identification of rotors (ie, local drivers) followed by the localized tar

141 d and the resultant switches in neighbouring rotors imaged.

142 ependent stator complexes which surround the rotor in a ring.

143 been used to drive the rotation of a simple rotor in a single direction and to move a four-wheeled m

144 etic approach to induce and locally target a rotor in atrial monolayers.

145 o do this, we measured stator-binding to the rotor in mutants in which motors reportedly develop lowe

146 d flow along an axial path using an internal rotor in the blood.

147 ed in 4 systems: (1) computer simulations of rotors in a 2-dimensional atrial sheet; (2) isolated rat

148 In summary, the initiation and sustenance of rotors in AF is linked to atrial APD heterogeneity and A

149 rk for understanding the complex dynamics of rotors in AF.

150 is review, we outline the pathophysiology of rotors in animal and in-silico studies of fibrillation,

151 Localized optogenetic targeting of rotors in atrial monolayers could lead to both stabiliza

152 e we report the use of fluorescent molecular rotors in combination with Fluorescence Lifetime Imaging

153 The dynamics of molecular rotors in deuterated MFM-180a-d16 and MFM-181a-d16 were

154 Conversely, ablation of rotors in high-excitability regions migrated spiral wave

155 We highlight the characteristics of rotors in human atrial fibrillation, now validated by se

156 Second, ablation of rotors in regions of low-excitability (from remodeling)

157 ing tunnelling microscopy enables individual rotors in the arrays to be switched and the resultant sw

158 alysis was applied to identify biventricular rotors in the first 10 s or until VF terminated, whichev

159 paroxysmal atrial fibrillation (AF) by fast rotors in the left atrium (LA) or at the pulmonary veins

160 slower upstroke and conduction velocity for rotors in the PV region than in the LA.

161 LA junction (PV-LAJ) in the localization of rotors in the PVs.

162 fibrillation (AF) show spiral wave sources (rotors) in nearly all studies including humans, while mo

163 by either disengaging or jamming the stator-rotor interaction.

164 A microautoclave magic angle spinning NMR rotor is developed enabling in situ monitoring of solid-

165 sic domain where the turning of the enzyme's rotor is generated from the transmembrane proton-motive

166 The rotor is modeled as a point mass mounted inside a spheri

167 r theoretical predictions, we find that this rotor is significantly H(+) selective, although not suff

168 xtracted modulation index-based detection of rotors is feasible with few electrodes and has greater d

169 ple of a porous molecular crystal containing rotors is presented.

170 for human atrial fibrillation, specifically rotors, is moving the field towards a unifying hypothesi

171 rotor problem indicates that Co-H2 exhibits rotor-like behavior in solution because the underlying C

172 Rotor-like re-entry with fibrillatory conduction was fou

173 activation maps demonstrated occurrences of rotor-like small-radius reentrant circuits (n=9; 1.1 per

174 Rotor localization errors are larger for electrogram dat

175 Additionally, biventricular rotor locations in sustained VF were conserved across mu

176 lectrogram signatures in the vicinity of the rotor locations suggest that 62.5% of the rotors occur a

177 as 86% (P<0.001) was obtained in separating rotor locations versus nonrotor locations.

178 Several hundred rotors made from porphyrin-based double-decker complexes

179 is proposed for single molecule imaging and rotor manipulation experiments on F1-ATPase.

180 echanistically based tool that may assist AF rotor mapping.

181 ripheral regions and thereby assist clinical rotor mapping.

182 the focal adhesion mechanism and the helical rotor mechanism, which differ in the biophysics of the c

183 A new class of low-barrier molecular rotors, metal trans-dihydrides, is suggested here.

184 for brake-off switching of the pentiptycene rotor mimics the function of an antilock braking system

185 el predicts an elastic coupling, the helical rotor model predicts a viscous coupling.

186 th the demonstration using focal impulse and rotor modulation (FIRM) mapping that rotors act as human

187 fibrillation (AF) include focal impulse and rotor modulation (FIRM) mapping, and initial results rep

188 ources, either directly by Focal Impulse and Rotor Modulation (FIRM) or coincidentally when anatomic

189 Focal impulse and rotor modulation (FIRM) with an endocardial basket cathe

190 Ablation comprised source (focal impulse and rotor modulation [FIRM]) and then conventional ablation

191 s that stabilize rotors and evaluate whether rotor modulation may reduce subsequent VF risk.

192 and targeted for ablation (focal impulse and rotor modulation) before pulmonary vein isolation.

193 brillation With or Without Focal Impulse and Rotor Modulation) trial, in which 92 consecutive patient

194 The elastic compliance resides in the rotor module that includes the membrane-embedded FO c-ri

195 taneously by reaction of precursor molecular rotor molecules with a metal surface.

196 , followed by progressive wave breakdown and rotor multiplication in both atria.

197 This is determined by the molecular rotor nature of ThT, where the direction of the ThT tran

198 essential to increase electric torque on the rotor network and to stabilize the switched rotor domain

199 e phenomenon is observed only in a hexagonal rotor network due to the degeneracy of the ground-state

200 e simultaneously rotated when in a hexagonal rotor network on a Cu(111) surface by applying biases ab

201 he rotor locations suggest that 62.5% of the rotors occur at locations where the bipolar electrogram

202 /H(+) selectivity of the ion-driven membrane rotor of an F-type ATP synthase.

203 n addition, a constant energetic penalty per rotor of approximately 5-6 kJ mol(-1) was observed in le

204 ystal structure of the Na(+)-driven membrane rotor of the Acetobacterium woodii ATP synthase, at 2.1

205 ng to three rotational states of the central rotor of the enzyme.

206 interact with FliG in the cytoplasmic C ring rotor of the flagellum.

207 cterization of two new fluorescent molecular rotors of boron derived from Schiff bases: (2,4,8,10-tet

208 scale examination of monolayers from all the rotors on a subphase and after transfer is underway and

209 e free rotation of the fluorescent molecular rotor, only observed in the binuclear compound, was decr

210 ple groove machined in a high-pressure valve rotor or by a 1 muL external sample loop, although other

211 n their application as either unidirectional rotors or as chiral multistate switches.

212 a median of 2 (interquartile range: 1 to 2) rotors or focal sources in 97.7% of patients during AF.

213 ial fibrillation (AF)-sustaining substrates (rotors or focal sources) is more durable than trigger ab

214 e) and the nitrogen inversion barrier of the rotor part (the amine residue) in the molecule, the oper

215 a four- or a two-step cycling motion of the rotor part.

216 A shaft connected to the rotor passes through the peptidoglycan and the outer mem

217 nanoscale building blocks with nanowires as rotors, patterned nanomagnets as bearings and quadrupole

218 The protocol is optimized for Singer ROTOR pinning robots, takes 3 weeks to complete and meas

219 ong-standing persistent atrial fibrillation, rotors potentially explain atrial fibrillation maintenan

220 Analysis of the 1-D rotor problem indicates that Co-H2 exhibits rotor-like b

221 changes in MotA that are transmitted to the rotor protein FliG.

222 The FliY structure resembles that of the rotor protein FliM but contains two active centers for C

223 FliY is a flagellar rotor protein of the CheC phosphatase family.

224 Using point mutations in MotA and the FliG rotor protein of the motor supports the conclusion that

225 hindrance of the core unit exerted upon the rotors proved pivotal in controlling the speed of rotati

226 e-property analysis shows that replacing the rotor pyridyl group of our typical hydrazone switch with

227 Unlike known structures, this rotor ring is a 9:1 heteromer of F- and V-type c-subunit

228 hases and pumps involving adaptations in the rotor ring.

229 sion to the dark S1 state by restricting the rotor rotation enhances fluorescence, which leads to the

230 accomplished this with crystalline molecular rotors self-assembled by halogen bonding of diazabicyclo

231 FIRM-identified rotor sites did not exhibit quantitative atrial electrog

232 no rotational activation at FIRM-identified rotor sites in 23 of 24 patients (96%).

233 100-fold with a quasi-continuous increase of rotor speed during the experiment.

234 Our results show that increasing the rotor speed from 2400rpm to 3600rpm led to a rise in oil

235 Hammer mill rotor speed is a processing variable that can be tuned t

236 the present work, the impact of hammer mill rotor speed on extraction yield and overall quality of s

237 traditionally been carried out at a constant rotor speed, which limits the range of sedimentation coe

238 cross different instruments, increasing with rotor speed.

239 ids, and triterpenoids levels increased with rotor speed.

240 A parameterized rotor-speed schedule is optimized with the goal of achie

241 The resulting rotor-speed schedule may include multiple over- and unde

242 used to further refine the prediction of the rotor-speed schedule.

243 thods to implement experiments with variable rotor speeds, in combination with variable field solutio

244 centrifugation cell assembly and spun at low rotor speeds.

245 s, which supports the existence of localized rotors (spiral waves) or focal drivers.

246 Stable AF rotors (spiral waves) or focal sources were seen in 35 o

247 ls and unipolar or bipolar electrograms) and rotor stability on resolution requirements were investig

248 lf-limiting VF, was characterized by greater rotor stability: 1) rotors were present in 68 +/- 17% of

249 F0 and F1 complexes connect via a central rotor stalk and a peripheral stator stalk.

250 on as outer water phase was prepared using a rotor stator system.

251 its N-terminal inhibitory domain at the same rotor/stator interface where the mitochondrial IF1 or th

252 h by monitoring the adiabatic cooling due to rotor stretching during rotor acceleration and the rever

253 mation was verified with the simplest of the rotor structures.

254 embrane-embedded VO region via rotation of a rotor subcomplex.

255 atalytic F1 region via rotation of a central rotor subcomplex.

256 subunit a (aNT) changes conformation to bind rotor subunit d However, insufficient resolution preclud

257 experiment with added water suppression and rotor synchronization, which deposits limited power in t

258 ower in the sample and which can be suitably rotor-synchronized at low spinning rates.

259 els of unconjugated or conjugated bilirubin (Rotor syndrome).

260 ver strongly resemble the characteristics of Rotor syndrome, suggesting that mutations in ATP11C can

261 g that mutations in ATP11C can predispose to Rotor syndrome.

262 Accurate measurements of rotor temperature are critical for the interpretation of

263 mposed of 10 copies of Atp9p, is part of the rotor that couples proton translocation to synthesis or

264 These proteins exert torque on a rotor that spans the inner membrane.

265 alse detections and may incorrectly identify rotors that are not present.

266 ify electrogram morphologies colocalizing to rotors that can be implemented on few electrograms needs

267 hat these three frameworks contain molecular rotors that exhibit motion in fast, medium, and slow reg

268 include precise localization and ablation of rotors that maintain the arrhythmia using multielectrode

269 primarily because of the development of MAS rotors that spin at frequencies of 40 to 60 kHz or highe

270 ase of the bacterial flagella, a cytoplasmic rotor (the C-ring) generates torque and reverses rotatio

271 ling and understanding the role of molecular rotors through design of organic linkers within porous M

272 d to minimize energy via crosstalk among the rotors through dipolar interactions.

273 and maintenance of VT due to less meandering rotor tip.

274 inhibition that involves locking the c ring rotor to a static subunit e and not subunit a.

275 haft to transmit torque from the cytoplasmic rotor to the external filament.

276 h the ring were brief and sufficient for the rotor to turn only a fraction of a degree in the active

277 Third, ablation may connect rotors to nonconducting anatomic orifices.

278 of arrhythmia mechanisms and the analysis of rotor trajectories with respect to the myocardial substr

279 rnumerary subunits, kept in contact with the rotor turning at speeds up to 350 Hz.

280 Rotors under such conditions drifted toward the PV and s

281 Molecular rotors undergo twisted intramolecular charge transfer up

282 alize the equal rate of rotation of both its rotor units.

283 hing properties of the internal submolecular rotor units.

284 termination of the temperature of a spinning rotor using iButton temperature loggers.

285 for the preparation of crystalline molecular rotors was devised from a set of stators and rotators to

286 Next, the core region of these rotors was specifically and precisely targeted by light

287 change rates of the mutant stator around the rotor were not significantly different from wild-type st

288 Small-radius-reentrant rotors were identified from signal analyses of the domin

289 The spatial locations of rotors were identified using phase maps constructed from

290 Rotors were present in 16 of 19 patients with VF and in

291 characterized by greater rotor stability: 1) rotors were present in 68 +/- 17% of cycles in sustained

292 isengaged and sequestered from the flagellar rotor when bound by MotI.

293 nt resolution to accurately detect and track rotors when placed over the rotor core although the low-

294 sign and dynamics of a solid-state molecular rotor with a large triptycene rotator.

295 responded to the temperature of the spinning rotor with a precision better than 0.2 degrees C.

296 the high sorption properties of a molecular rotor with no permanent voids or channels in its crystal

297 ty by incorporating a magnetically levitated rotor with wide blood-flow paths and an artificial pulse

298 e design of a crystalline array of molecular rotors with inertial diffusional rotation at the nanosca

299 heses of six triptycene-containing molecular rotors with several single-crystal X-ray diffraction ana

300 Inclusion of molecular rotors with transversely dipolar rotators into TPP chann