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1 bitors (i.e., 4 microM GF109203X or 5 microM rottlerin).
2 egative PKCdelta, and the PKCdelta inhibitor rottlerin.
3  inhibitors including the PKCdelta inhibitor rottlerin.
4 o TRAIL either in the absence or presence of rottlerin.
5 orine (up to 0.1 mM) but can be inhibited by rottlerin.
6 appaBalpha degradation were not inhibited by rottlerin.
7  a Ca(2+)-independent PKC isoform inhibitor, rottlerin.
8 to the mammalian channel agonists NS1619 and rottlerin.
9 e have used the PKCdelta-specific inhibitor, rottlerin.
10 jority of beneficial effects associated with rottlerin.
11 e protein kinase Cdelta (PKCdelta) inhibitor rottlerin.
12 y the novel protein kinase C (PKC) inhibitor rottlerin.
13 ffect on the down-regulation of caspase-2 by rottlerin.
14 e protein kinase Cdelta (PKCdelta) inhibitor rottlerin.
15 expression of dominant-negative PKCdelta and rottlerin.
16 on of Src, which was blocked by both BIM and rottlerin.
17 he PKC inhibitors chelerythrine chloride and rottlerin.
18                     Hearts were treated with rottlerin 1 mumol/L (CP+R) (n=7) or without rottlerin (C
19                               Treatment with rottlerin 1 mumol/L significantly improved CP-induced ca
20 ression of alpha4beta2delta was decreased by rottlerin (10 muM), suggesting a role for PKC-delta.
21 ls, whereas the PKC-delta specific inhibitor rottlerin (3 microM) or knockdown of this isoenzyme with
22 mic administration of the BK channel agonist rottlerin (5 mug/g) during the challenge period reduced
23                                  Intravenous rottlerin (5 mug/g) reduced AHR within 5 min in the OVA-
24  by the PKC-delta isoform-specific inhibitor rottlerin (50 microm).
25  of conventional and novel PKC isoforms) and rottlerin (a PKCdelta-selective inhibitor) but not Go697
26 AM (an intracellular free calcium chelator), rottlerin (a protein kinase Cdelta inhibitor), and prote
27                   Inhibition of PKC-delta by rottlerin (a relatively specific inhibitor of PKC-delta)
28 uced by the selective inhibitor of PKCdelta (rottlerin), a PKCdelta-specific inhibitory peptide (delt
29 (PKC delta-KR) or pretreatment of cells with rottlerin, a chemical PKC delta inhibitor, attenuated TN
30                                              Rottlerin, a compound reported to be a PKCdelta-selectiv
31                                   Similarly, rottlerin, a novel class PKC inhibitor, abrogated PA-med
32                                              Rottlerin, a pharmacologic inhibitor of PKC-delta, suppr
33 hen the expression of p21cip1 was reduced by rottlerin, a PKC delta inhibitor, p27kip1- and BrdU-posi
34 persecretion was significantly attenuated by rottlerin, a PKC delta-selective inhibitor.
35                                              Rottlerin, a PKC-delta inhibitor, also had no effect, li
36  the protein kinase C (PKC)-delta inhibitor, rottlerin, a PKC-zeta peptide inhibitor, or by overexpre
37 nhibition variably increased apoptosis, with rottlerin, a PKCdelta inhibitor, being most effective an
38                      Treatment of cells with rottlerin, a PKCdelta inhibitor, blocked IL-13-induced 1
39 induced dense granule release was blocked by rottlerin, a PKCdelta selective inhibitor.
40 itivity of fMLP-induced O()(2) production to rottlerin, a PKCdelta-selective inhibitor.
41 indolylmaleimide (BIM), a PKC inhibitor, and rottlerin, a PKCdelta-specific inhibitor.
42 harmacologic inhibitors were used, including rottlerin, a protein kinase C delta (PKC delta) inhibito
43 rc caused transformation of these cells, and rottlerin, a protein kinase inhibitor with specificity f
44              Using the inhibitors Go6976 and rottlerin, a role for both conventional and novel PKC is
45   Blocking the PKC delta isoform with either rottlerin, a selective antagonist, or small interference
46           Among the PKC inhibitors used only rottlerin, a selective inhibitor of PKCdelta, markedly i
47                                              Rottlerin, a selective PKCdelta inhibitor, also inhibite
48 ediated TRAF1 mRNA and promoter stimulation; rottlerin, a selective PKCdelta inhibitor, had no effect
49 e findings is implicated by the finding that rottlerin, a selective PKCtheta inhibitor, blocked FasL
50 hetamine-stimulated dopamine efflux, whereas rottlerin, a specific inhibitor of PKC delta, had no eff
51                                              Rottlerin, a specific inhibitor of PKC-delta, exerted a
52 27 STAT1 phosphorylation could be blocked by rottlerin, a specific inhibitor of protein kinase C-delt
53 600125, a specific inhibitor of JNK, or with rottlerin, a specific inhibitor of protein kinase Cdelta
54                                              Rottlerin, a specific PKC-theta inhibitor, diminished p-
55                       The PKCdelta inhibitor rottlerin abolished PbTx-2-induced Src activation demons
56                            Data suggest that rottlerin affects mitochondrial function independent of
57 e protein kinase Cdelta (PKCdelta) inhibitor rottlerin also blocked the induction of p21(Cip1) protei
58                                              Rottlerin also caused a significant increase in coronary
59                                              Rottlerin also inhibited O2 production at similar doses.
60                                              Rottlerin also inhibited the activation of MAP kinase ki
61         Inhibition of PKCdelta activation by rottlerin also markedly attenuated IL-13-induced Stat3 D
62                                              Rottlerin also prevented the formation of p-CREB/p300 co
63                                              Rottlerin also reduced PMA- or human neutrophil elastase
64                                              Rottlerin, an inhibitor of novel isoforms of PKC, specif
65                                              Rottlerin, an inhibitor of nPKCdelta, blocked caspase-3
66                                              Rottlerin, an inhibitor of nPKCdelta, inhibited cAMP-ind
67                                              Rottlerin, an inhibitor of PKC delta in J774 cells, also
68                                 Furthermore, rottlerin, an inhibitor of protein kinase Cdelta (PKCdel
69 n the absence or presence of BAPTA/AM, H7 or rottlerin and (2) bile flow.
70  PKC delta, the PKC delta-specific inhibitor rottlerin and a dominant negative PKC delta mutant trans
71                                         Both rottlerin and a dominant-negative PKCdelta construct inh
72                          Interestingly, both rottlerin and EGF induced substantial increases in phosp
73  accumulate in parotid C5 cells treated with rottlerin and etoposide together, suggesting that the ca
74  of freshly isolated parotid acinar cells to rottlerin and FCCP reduced cellular ATP levels and reduc
75                                   Meanwhile, rottlerin and GF109203X markedly inhibited UVB-induced a
76 diated inhibition of Akt activation, whereas rottlerin and Go6976, inhibitors of PKCdelta and PKCalph
77 n accordance with other results showing that rottlerin and hispidin have the highest efficacy in supp
78 apoptotic factors was demonstrated only when rottlerin and TRAIL were combined, and Bcl-2 overexpress
79 BCR signaling are differentially affected by rottlerin, and by Go6976 or LY294002, respectively.
80 (2) is attenuated by the PKCdelta inhibitor, rottlerin, and by overexpression of the regulatory domai
81 on, an effect that was inhibited by PD98059, rottlerin, and protein kinase Cepsilon (PKCepsilon) inhi
82                                              Rottlerin at concentrations that block novel and atypica
83 or CGS24592, or inhibition of PKCdelta using Rottlerin at concentrations that inhibit PKCdelta but no
84                                 Furthermore, rottlerin (at doses that inhibit PKCdelta activity) inhi
85 lta by RNA interference or its inhibition by rottlerin blocked ASMase phosphorylation and membrane ta
86                                              Rottlerin blocked c-Abl activation, but the c-Abl inhibi
87                                 Furthermore, rottlerin blocked combined MGO and cisplatin-induced ROS
88  the relatively specific PKC-delta inhibitor rottlerin blocked most of the E(2)-induced Erk activatio
89         Inhibition of PKCdelta activity with rottlerin blocked the increase in SPAK kinase activity.
90 03X, and a selective inhibitor of PKC-delta, Rottlerin, blocked the TPA-induced differentiation of PK
91 phorylation, whereas the nPKCdelta inhibitor rottlerin blocks CREB phosphorylation following BCR cros
92                        Finally, we show that rottlerin blocks etoposide-induced apoptosis by inhibiti
93 on and that the PKC delta-specific inhibitor rottlerin blocks thrombin-induced PKD activation, sugges
94 effect was blocked by the PKCdelta inhibitor rottlerin but not by NAC.
95  ara-C was blocked by the PKCdelta inhibitor rottlerin but not by the PKCalpha and -beta inhibitor Go
96 d dense granule secretion was potentiated by rottlerin but was abolished by Go6976, a classical PKC i
97 tion and selective inhibition of PKCdelta by rottlerin, but not by Ca(2+)-chelators.
98 ls with the protein kinase C delta inhibitor rottlerin, but not by classical protein kinase C inhibit
99 hibited by the PKCdelta-selective inhibitor, rottlerin, but not by Go-6976, an inhibitor of conventio
100 Additionally, the protein kinase C inhibitor rottlerin, but not other kinase inhibitors, blocks both
101  or with the protein kinase Cdelta inhibitor rottlerin, but not with broad-based protein kinase C inh
102 sindolylmaleimide I, Ro-32-0432, Go6983, and Rottlerin, by the phorbol 12-myristate 13-acetate-mediat
103 tors (EIPA [5-N-ethyl-N-isoproamiloride] and rottlerin [C(30)H(28)O(8)]) and by cytochalasin D, which
104 Furthermore, down-regulation of caspase-2 by rottlerin can explain its antiapoptotic function during
105 y, inhibitors of MEK (PD98059) and PKCdelta (rottlerin) completely blocked PMA-induced monocytic cell
106 ythrine, or the putative PKCdelta inhibitor, rottlerin, completely inhibited the T-mediated increase
107                                      Optimal rottlerin concentrations caused a 70-90% inhibition of t
108  rottlerin 1 mumol/L (CP+R) (n=7) or without rottlerin (CP) (n=9), and the BK(Ca++) channel inhibitor
109          Pharmacologic inhibitors Go6976 and rottlerin demonstrate that both conventional and novel p
110                  Similarly, calphostin C and rottlerin depressed activation of p44/42 MAPK.
111                                     Finally, rottlerin did not affect SFLLRN-induced platelet aggrega
112                The inhibition of PKCdelta by rottlerin did not affect the activation of p38 MAPK by a
113 ewise, treatment of cells with the inhibitor rottlerin did not block the stimulatory effect of EtOH o
114 is, whereas the PKCdelta selective inhibitor rottlerin did not.
115               These results demonstrate that rottlerin directly uncouples mitochondrial respiration f
116               A PKCdelta-specific inhibitor, rottlerin, failed to inhibit PMA-induced PLD2 phosphoryl
117                                 In contrast, rottlerin had no effect on STAT1 phosphorylation induced
118 ivation was attenuated by (i) treatment with rottlerin, (ii) expression of a kinase-inactive PKCdelta
119                                              Rottlerin increased BK channel activity in human ASM cel
120  binding to aggregates of the small molecule rottlerin increased the deuterium exchange of all 10 rep
121                                              Rottlerin increased the QO2 of isolated rat liver mitoch
122             We made a novel observation that rottlerin induced down-regulation of caspase-2 but not o
123                                      In RKO, rottlerin induced the release of cytochrome c, HtrA2/Omi
124                   These results suggest that rottlerin induces down-regulation of caspase-2 via PKC d
125                                              Rottlerin inhibited activation and processing of caspase
126 cleotides or the PKCdelta-specific inhibitor rottlerin inhibited FGF- and NGF-induced, but not EGF-in
127                                TRO, RSG, and rottlerin inhibited PDGF-induced expression of p21(Cip1)
128             During treatment with palmitate, rottlerin inhibited phosphorylation of Mcl-1 at Ser(159)
129 minant-negative PKCdelta, PKCdelta-siRNA, or rottlerin inhibits promoter activation.
130                 The first total synthesis of rottlerin is described.
131 orm, and the preferential PKCdelta inhibitor rottlerin largely prevented EGF-induced phosphorylation
132                  Blockade of this effect via rottlerin may suggest that PKC delta is a downstream sig
133                We tested the hypothesis that rottlerin mitigates deleterious effects associated with
134        However, after 15-min incubation with rottlerin, mitochondrial membrane potential (Delta psi m
135                                      Neither rottlerin nor FCCP reduced stimuli-dependent PKCdelta ty
136                               The effects of rottlerin on mitochondrial QO2 were neither mimicked nor
137 RAIL-induced apoptosis was not influenced by rottlerin or Bcl-2 overexpression in type I (GC(3)/c1) c
138 ent of IMCD3 cells with the TonEBP inhibitor rottlerin or silencing its expression with specific shRN
139 nduced EndoMT and that imatinib mesylate and rottlerin or similar kinase inhibitor molecules may be e
140 on of protein kinase C delta (PKCdelta) with rottlerin or siRNA-mediated knockdown abrogates the oste
141 atment of cells with the PKC-delta inhibitor rottlerin or the expression of a dominant-negative PKC-d
142 aA25E is abrogated by the PKCtheta inhibitor rottlerin or the expression of the kinase-inactive form
143 tment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta ol
144 atment with the PKCdelta-selective inhibitor rottlerin or transfection with PKCdelta siRNA attenuated
145 a or pretreatment with a PKCdelta inhibitor (rottlerin) or Src kinase family inhibitor (PP2) partiall
146                                              Rottlerin, originally identified as a delta-protein kina
147 inhibitors (Go6976, bisindolylmaleimide, and Rottlerin), PKC-alpha, and PKC-delta small interfering (
148 tive protein kinase Cdelta (dn-PKCdelta) and rottlerin (PKCdelta inhibitor) completely suppressed PMA
149  PKCdelta activity with the kinase inhibitor rottlerin, PKCdelta-small interfering RNA, or with PKCde
150 otriene B4, and that process was reversed by rottlerin, presumably through the blockage of PKCdelta-d
151 all interfering RNAs or PKCdelta antibody or rottlerin pretreatment significantly suppressed the phos
152           Specific inhibition of PKCdelta by rottlerin prevented both apoptosis- and activation-induc
153           Specific inhibition of PKCdelta by rottlerin prevented IkappaBalpha degradation and NF-kapp
154      Furthermore, the PKCdelta/PKC inhibitor rottlerin prevented the effects induced by phorbol 12-my
155  of these cells with the PKC-delta inhibitor rottlerin prevented the thrombin-induced phosphorylation
156        Pretreatment of parotid C5 cells with rottlerin prior to the addition of etoposide blocks the
157 omoter deletion constructs demonstrated that rottlerin profoundly reduced COL1A1 transcription and th
158 reviously shown that the PKC delta inhibitor rottlerin protects against cisplatin-induced apoptosis a
159                              Eight of these, rottlerin, quercetin, K-252c, bisindolylmaleimide I, bis
160 n the present study, we have investigated if rottlerin regulates caspase-2 activation.
161  the use of an ex vivo lung slice technique, rottlerin relaxed acetylcholine-stimulated murine airway
162                                          The rottlerin-sensitive element is not PKCdelta, inasmuch as
163 ivated monocytes phosphorylated p47phox in a rottlerin-sensitive manner.
164              These results indicate that the rottlerin-sensitive, Lyn-dependent alternate pathway, an
165                 This COL1A1 segment imparted rottlerin sensitivity to a heterologous promoter.
166 itor cycloheximide showed that TRO, RSG, and rottlerin shortened the half-life of p21(Cip1) protein.
167                       Previous studies using rottlerin should be evaluated cautiously.
168 r digitorum longus muscles with GF109203X or rottlerin significantly attenuated increases in myocellu
169                                              Rottlerin significantly improves cardiac performance aft
170   (vi) The specific inhibitor for PKC delta, rottlerin, significantly blocked the inhibition by 5-HT.
171 PKCdelta activity with a specific inhibitor, rottlerin, significantly inhibited caspase-3 activation
172 toma cell proliferation were reduced by BIM, rottlerin, the MEK inhibitor U0126, and PKCdelta and c-S
173                                              Rottlerin, the PKC delta inhibitor, down-regulated colla
174 ed genes, was potently inhibited by the drug Rottlerin, through a mechanism independent of STAT1 acti
175 ion by calphostin C, bisindolylmaleimide, or rottlerin treatment versus activation by phorbol 12-myri
176 d myocyte contraction, which was restored by rottlerin treatment.
177                                              Rottlerin was not effective in blocking PKCdelta activit
178  41251, and the PKCdelta-selective inhibitor rottlerin were able to suppress serotonin up-regulation
179  inhibitory effects of imatinib mesylate and rottlerin were mediated by inhibition of phosphorylation
180                 Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and econo
181  MG132 reversed caspase-2 down-regulation by rottlerin, whereas calpain inhibitor had no effect.
182 tin C and by the PKCdelta-specific inhibitor rottlerin, whereas Go6976, an inhibitor of conventional
183 region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a
184 zation of a lipid soluble toxin, mallotoxin (rottlerin), which potently activates the large conductan
185 ect of PKC activators only slightly, whereas rottlerin, which inhibits PKCdelta preferentially at 5 m
186 stration of hypothalamic PKC-delta inhibitor rottlerin with OAG prevented the ability of OAG to activ
187                  These findings suggest that rottlerin, with both anti-inflammatory and ASM relaxatio

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