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1 bitors (i.e., 4 microM GF109203X or 5 microM rottlerin).
2 egative PKCdelta, and the PKCdelta inhibitor rottlerin.
3 inhibitors including the PKCdelta inhibitor rottlerin.
4 o TRAIL either in the absence or presence of rottlerin.
5 orine (up to 0.1 mM) but can be inhibited by rottlerin.
6 appaBalpha degradation were not inhibited by rottlerin.
7 a Ca(2+)-independent PKC isoform inhibitor, rottlerin.
8 to the mammalian channel agonists NS1619 and rottlerin.
9 e have used the PKCdelta-specific inhibitor, rottlerin.
10 jority of beneficial effects associated with rottlerin.
11 e protein kinase Cdelta (PKCdelta) inhibitor rottlerin.
12 y the novel protein kinase C (PKC) inhibitor rottlerin.
13 ffect on the down-regulation of caspase-2 by rottlerin.
14 e protein kinase Cdelta (PKCdelta) inhibitor rottlerin.
15 expression of dominant-negative PKCdelta and rottlerin.
16 on of Src, which was blocked by both BIM and rottlerin.
17 he PKC inhibitors chelerythrine chloride and rottlerin.
20 ression of alpha4beta2delta was decreased by rottlerin (10 muM), suggesting a role for PKC-delta.
21 ls, whereas the PKC-delta specific inhibitor rottlerin (3 microM) or knockdown of this isoenzyme with
22 mic administration of the BK channel agonist rottlerin (5 mug/g) during the challenge period reduced
25 of conventional and novel PKC isoforms) and rottlerin (a PKCdelta-selective inhibitor) but not Go697
26 AM (an intracellular free calcium chelator), rottlerin (a protein kinase Cdelta inhibitor), and prote
28 uced by the selective inhibitor of PKCdelta (rottlerin), a PKCdelta-specific inhibitory peptide (delt
29 (PKC delta-KR) or pretreatment of cells with rottlerin, a chemical PKC delta inhibitor, attenuated TN
33 hen the expression of p21cip1 was reduced by rottlerin, a PKC delta inhibitor, p27kip1- and BrdU-posi
36 the protein kinase C (PKC)-delta inhibitor, rottlerin, a PKC-zeta peptide inhibitor, or by overexpre
37 nhibition variably increased apoptosis, with rottlerin, a PKCdelta inhibitor, being most effective an
42 harmacologic inhibitors were used, including rottlerin, a protein kinase C delta (PKC delta) inhibito
43 rc caused transformation of these cells, and rottlerin, a protein kinase inhibitor with specificity f
45 Blocking the PKC delta isoform with either rottlerin, a selective antagonist, or small interference
48 ediated TRAF1 mRNA and promoter stimulation; rottlerin, a selective PKCdelta inhibitor, had no effect
49 e findings is implicated by the finding that rottlerin, a selective PKCtheta inhibitor, blocked FasL
50 hetamine-stimulated dopamine efflux, whereas rottlerin, a specific inhibitor of PKC delta, had no eff
52 27 STAT1 phosphorylation could be blocked by rottlerin, a specific inhibitor of protein kinase C-delt
53 600125, a specific inhibitor of JNK, or with rottlerin, a specific inhibitor of protein kinase Cdelta
57 e protein kinase Cdelta (PKCdelta) inhibitor rottlerin also blocked the induction of p21(Cip1) protei
70 PKC delta, the PKC delta-specific inhibitor rottlerin and a dominant negative PKC delta mutant trans
73 accumulate in parotid C5 cells treated with rottlerin and etoposide together, suggesting that the ca
74 of freshly isolated parotid acinar cells to rottlerin and FCCP reduced cellular ATP levels and reduc
76 diated inhibition of Akt activation, whereas rottlerin and Go6976, inhibitors of PKCdelta and PKCalph
77 n accordance with other results showing that rottlerin and hispidin have the highest efficacy in supp
78 apoptotic factors was demonstrated only when rottlerin and TRAIL were combined, and Bcl-2 overexpress
80 (2) is attenuated by the PKCdelta inhibitor, rottlerin, and by overexpression of the regulatory domai
81 on, an effect that was inhibited by PD98059, rottlerin, and protein kinase Cepsilon (PKCepsilon) inhi
83 or CGS24592, or inhibition of PKCdelta using Rottlerin at concentrations that inhibit PKCdelta but no
85 lta by RNA interference or its inhibition by rottlerin blocked ASMase phosphorylation and membrane ta
88 the relatively specific PKC-delta inhibitor rottlerin blocked most of the E(2)-induced Erk activatio
90 03X, and a selective inhibitor of PKC-delta, Rottlerin, blocked the TPA-induced differentiation of PK
91 phorylation, whereas the nPKCdelta inhibitor rottlerin blocks CREB phosphorylation following BCR cros
93 on and that the PKC delta-specific inhibitor rottlerin blocks thrombin-induced PKD activation, sugges
95 ara-C was blocked by the PKCdelta inhibitor rottlerin but not by the PKCalpha and -beta inhibitor Go
96 d dense granule secretion was potentiated by rottlerin but was abolished by Go6976, a classical PKC i
98 ls with the protein kinase C delta inhibitor rottlerin, but not by classical protein kinase C inhibit
99 hibited by the PKCdelta-selective inhibitor, rottlerin, but not by Go-6976, an inhibitor of conventio
100 Additionally, the protein kinase C inhibitor rottlerin, but not other kinase inhibitors, blocks both
101 or with the protein kinase Cdelta inhibitor rottlerin, but not with broad-based protein kinase C inh
102 sindolylmaleimide I, Ro-32-0432, Go6983, and Rottlerin, by the phorbol 12-myristate 13-acetate-mediat
103 tors (EIPA [5-N-ethyl-N-isoproamiloride] and rottlerin [C(30)H(28)O(8)]) and by cytochalasin D, which
104 Furthermore, down-regulation of caspase-2 by rottlerin can explain its antiapoptotic function during
105 y, inhibitors of MEK (PD98059) and PKCdelta (rottlerin) completely blocked PMA-induced monocytic cell
106 ythrine, or the putative PKCdelta inhibitor, rottlerin, completely inhibited the T-mediated increase
108 rottlerin 1 mumol/L (CP+R) (n=7) or without rottlerin (CP) (n=9), and the BK(Ca++) channel inhibitor
113 ewise, treatment of cells with the inhibitor rottlerin did not block the stimulatory effect of EtOH o
118 ivation was attenuated by (i) treatment with rottlerin, (ii) expression of a kinase-inactive PKCdelta
120 binding to aggregates of the small molecule rottlerin increased the deuterium exchange of all 10 rep
126 cleotides or the PKCdelta-specific inhibitor rottlerin inhibited FGF- and NGF-induced, but not EGF-in
131 orm, and the preferential PKCdelta inhibitor rottlerin largely prevented EGF-induced phosphorylation
137 RAIL-induced apoptosis was not influenced by rottlerin or Bcl-2 overexpression in type I (GC(3)/c1) c
138 ent of IMCD3 cells with the TonEBP inhibitor rottlerin or silencing its expression with specific shRN
139 nduced EndoMT and that imatinib mesylate and rottlerin or similar kinase inhibitor molecules may be e
140 on of protein kinase C delta (PKCdelta) with rottlerin or siRNA-mediated knockdown abrogates the oste
141 atment of cells with the PKC-delta inhibitor rottlerin or the expression of a dominant-negative PKC-d
142 aA25E is abrogated by the PKCtheta inhibitor rottlerin or the expression of the kinase-inactive form
143 tment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta ol
144 atment with the PKCdelta-selective inhibitor rottlerin or transfection with PKCdelta siRNA attenuated
145 a or pretreatment with a PKCdelta inhibitor (rottlerin) or Src kinase family inhibitor (PP2) partiall
147 inhibitors (Go6976, bisindolylmaleimide, and Rottlerin), PKC-alpha, and PKC-delta small interfering (
148 tive protein kinase Cdelta (dn-PKCdelta) and rottlerin (PKCdelta inhibitor) completely suppressed PMA
149 PKCdelta activity with the kinase inhibitor rottlerin, PKCdelta-small interfering RNA, or with PKCde
150 otriene B4, and that process was reversed by rottlerin, presumably through the blockage of PKCdelta-d
151 all interfering RNAs or PKCdelta antibody or rottlerin pretreatment significantly suppressed the phos
154 Furthermore, the PKCdelta/PKC inhibitor rottlerin prevented the effects induced by phorbol 12-my
155 of these cells with the PKC-delta inhibitor rottlerin prevented the thrombin-induced phosphorylation
157 omoter deletion constructs demonstrated that rottlerin profoundly reduced COL1A1 transcription and th
158 reviously shown that the PKC delta inhibitor rottlerin protects against cisplatin-induced apoptosis a
161 the use of an ex vivo lung slice technique, rottlerin relaxed acetylcholine-stimulated murine airway
166 itor cycloheximide showed that TRO, RSG, and rottlerin shortened the half-life of p21(Cip1) protein.
168 r digitorum longus muscles with GF109203X or rottlerin significantly attenuated increases in myocellu
170 (vi) The specific inhibitor for PKC delta, rottlerin, significantly blocked the inhibition by 5-HT.
171 PKCdelta activity with a specific inhibitor, rottlerin, significantly inhibited caspase-3 activation
172 toma cell proliferation were reduced by BIM, rottlerin, the MEK inhibitor U0126, and PKCdelta and c-S
174 ed genes, was potently inhibited by the drug Rottlerin, through a mechanism independent of STAT1 acti
175 ion by calphostin C, bisindolylmaleimide, or rottlerin treatment versus activation by phorbol 12-myri
178 41251, and the PKCdelta-selective inhibitor rottlerin were able to suppress serotonin up-regulation
179 inhibitory effects of imatinib mesylate and rottlerin were mediated by inhibition of phosphorylation
182 tin C and by the PKCdelta-specific inhibitor rottlerin, whereas Go6976, an inhibitor of conventional
183 region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a
184 zation of a lipid soluble toxin, mallotoxin (rottlerin), which potently activates the large conductan
185 ect of PKC activators only slightly, whereas rottlerin, which inhibits PKCdelta preferentially at 5 m
186 stration of hypothalamic PKC-delta inhibitor rottlerin with OAG prevented the ability of OAG to activ
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