ライフサイエンスコーパス: ruffling

1 res (from purely saddled to saddled with 30% ruffling).

2 evident in podosomes and regions of membrane ruffling.

3 esulting in a substantial increase in dorsal ruffling.

4 ed with enhanced cell spreading and membrane ruffling.

5 no additive effect on the amount of membrane ruffling.

6 cell survival, transformation, and membrane ruffling.

7 0alpha also restored PDGF-dependent membrane ruffling.

8 wild-type cells retained normal PDGF-induced ruffling.

9 trafficking, glucose transport, and membrane ruffling.

10 a-/-) are defective in PDGF-induced membrane ruffling.

11 of endocytosis, actin dynamics, and membrane ruffling.

12 e D (PLD) homolog, which facilitate membrane ruffling.

13 e staining was observed in regions of active ruffling.

14 rum and PDGF, along with a reduction in cell ruffling.

15 ting that PIPKIalpha and PIP2 participate in ruffling.

16 causes transformation and leads to membrane ruffling.

17 omplexes to promote membrane protrusion over ruffling.

18 n PDGF-stimulated cells resulted in membrane ruffling.

19 stimulate actin reorganization and membrane ruffling.

20 ith increases in cell spreading and membrane ruffling.

21 nt negative fashion, preventing rounding and ruffling.

22 6-regulated membrane movement or Rac-induced ruffling.

23 ut, surprisingly, did not eliminate membrane ruffling.

24 to induce actin reorganization and membrane ruffling.

25 s but may be required downstream of membrane ruffling.

26 stems, also inhibited GH-stimulated membrane ruffling.

27 The small GTPase Rac mediates membrane ruffling.

28 actin cytoskeletal organization and membrane ruffling.

29 cytosol to the plasma membrane, and membrane ruffling.

30 o stimuli (e.g., serum) that induce membrane ruffling.

31 as endocytosis, exocytosis, and cell surface ruffling.

32 s such as PAK, JNK/SAPK kinases and membrane ruffling.

33 inant negative for another pathway, membrane ruffling.

34 NQ2/3 channel currents, and loss of membrane ruffling.

35 g actin polymerization and reducing membrane ruffling.

36 me pocket residue in IsdI implicated in heme ruffling.

37 a functional link between SOCE and membrane ruffling.

38 ctor (PDGF) and growth factor-induced dorsal ruffling.

39 ed, Abi1-KO cells exhibited decreased dorsal ruffling.

40 al organization, and reduced plasma membrane ruffling.

41 nal morphogenesis and in PDGF-induced dorsal ruffling.

42 ve GTP-bound Rac and EGF-stimulated membrane ruffling.

43 ate precisely localized cell protrusions and ruffling.

44 ciated with a combination of heme doming and ruffling.

45 amics, lamellipodia protrusion, and membrane ruffling.

46 order of magnitude smaller than the observed ruffling (1B(1u)) deformation.

47 Antigen-induced cell ruffling, a calcium-independent event, is blocked by inj

48 with a smaller amount of stress fiber and/or ruffling actin confined to the cell bottom in contact wi

49 -alpha causes pronounced defects in membrane ruffling, actin organization, and focal adhesion formati

50 le that maintains leading-edge structure and ruffling activity and that supports the chemoattractant

51 in1 and that contraction depends on cellular ruffling activity, rather than on the protrusion and ret

52 en, cAMP-elevating agents stimulate membrane ruffling, Akt phosphorylation, and p70 ribosomal S6 prot

53 ndent growth assays, cell cycle and membrane ruffling analyses showed that Akt exerts estrogen-like a

54 Eklf-deficient EryP exhibit membrane ruffling and a failure to acquire the typical discoidal

55 nnoma-derived Schwann cells exhibit membrane ruffling and aberrant cell spreading when plated onto la

56 e L. pneumophila, without affecting membrane ruffling and actin polymerization.

57 nd the actin cytoskeleton to induce membrane ruffling and bacterial internalization.

58 hese data show that SHEP1 regulates membrane ruffling and cell migration and that binding to Cas is p

59 s to induce JNK and PAK activation, membrane ruffling and cell migration, suggesting that it is defec

60 ction downstream of Arf6 to control membrane ruffling and cell migration, this pathway has not been d

61 bition of Hsp90 activity suppressed membrane ruffling and cell migration, while expression of an acet

62 cting with Crk inhibits Bmx-induced membrane ruffling and cell migration.

63 attachment-induced JNK activation, membrane ruffling and cell motility in a Rac-dependent manner.

64 e-dependent actin reorganization in membrane ruffling and cell motility.

65 4-3-3zeta to increase AngII-induced membrane ruffling and cell motility.

66 of Rac1 activation, actin-dependent membrane ruffling and cell spreading are Rac1-dependent processes

67 Abnormal ruffling and cell spreading by cells with identified NF2

68 Rac1 activation and Rac1-dependent membrane ruffling and cell spreading were restored.

69 mLDL activates macrophages inducing membrane ruffling and cell spreading, activation of ERK1/2 and Ak

70 which Neisseria gonorrhoeae elicits membrane ruffling and cellular invasion of the cervical epithelia

71 PLD may be necessary to potentiate membrane ruffling and clustering of gonococci on the cervical cel

72 l structure of haem-bound IsdI in which haem ruffling and constrained binding of oxygen is consistent

73 These data are consistent with heme ruffling and coordination geometry serving to stabilize

74 h signaling when persistent induced membrane ruffling and decreased cell motility.

75 actin-binding domain cause aberrant membrane ruffling and defective actin stress fibre formation in c

76 eletal rearrangements manifested by membrane ruffling and disruption of intercellular junctions.

77 and produced smooth T cells void of membrane ruffling and filopodia.

78 nd assayed for GH- and PDGF-induced membrane ruffling and fluid phase pinocytosis.

79 tiple cellular responses, including membrane ruffling and focal complex formation.

80 3D) retained the ability to promote membrane ruffling and focus formation.

81 not Nckalpha blocks PDGF-stimulated membrane ruffling and formation of lamellipoda.

82 ot Nckalpha blocks Rac1-L62-induced membrane ruffling and formation of lamellipodia, suggesting that

83 ed shape changes in the cells, with membrane ruffling and formation/retraction of thin actin-like pro

84 Bmx with Cas results in an enhanced membrane ruffling and haptotactic cell migration.

85 ion of MAYP decreased CSF-1-induced membrane ruffling and increased filopodia formation, motility and

86 nts encompass increased Rac-induced membrane ruffling and lamellipodia, Cdc42-initiated filopodia, an

87 ystem (T3SS), leading to pronounced membrane ruffling and macropinocytic uptake of attached bacteria.

88 Rac activity and abolishing the constitutive ruffling and macropinocytosis that characterize macropha

89 uptake in a process associated with membrane ruffling and macropinocytosis.

90 the force on the macrocycle that causes the ruffling and makes the redox potential more negative tha

91 activated Rac explains its positive role in ruffling and negative role in cell spreading and migrati

92 CV1 cells and blocked PDGF-induced membrane ruffling and nucleated actin assembly.

93 orphological alterations, including membrane ruffling and numerous pseudopodial protrusions, increase

94 r these conditions causes extensive membrane ruffling and overrides the block in membrane fusion caus

95 Arf6 and its GEFs facilitated membrane ruffling and pathogen invasion via ARNO, and triggered a

96 a functional SH2 domain, inhibited membrane ruffling and pinocytosis induced by GH and PDGF.

97 erexpression of wild-type SH2-Bbeta enhanced ruffling and pinocytosis produced by submaximal GH but n

98 ac-dependent readouts: induction of membrane ruffling and pinocytosis, stimulation of cell motility,

99 negative regulator of CSF-1-induced membrane ruffling and positively regulates formation of filopodia

100 intracellular pathways that induce membrane ruffling and promote cell survival.

101 ing was characterized by (1) plasma membrane ruffling and protrusion into the wound, (2) lamellipodia

102 ANI-1 is essential for cortical ruffling and pseudocleavage, contractile events that occ

103 Membrane ruffling and pseudopod extension via the BLTR was also c

104 yphimurium into host cells requires membrane ruffling and rearrangement of the actin cytoskeleton.

105 le was able to rescue the defect in membrane ruffling and restore the localization of a fluorescent P

106 0-750 cm(-1) region known to be sensitive to ruffling and saddling deformations, as well as increased

107 in 1B S2D mutant have attenuated PMA-induced ruffling and slower cell speed.

108 d PAO effectively inhibit antigen-stimulated ruffling and spreading in these cells, and they inhibit

109 Rac1 and RhoA regulate membrane ruffling and stress fiber formation.

110 en-like activity on cell growth and membrane ruffling and that a selective ErbB2 inhibitor, but not a

111 may be a key protein that modulates membrane ruffling and that this may involve changes in caldesmon

112 the membrane, which in turn causes membrane ruffling and the formation of cellular protrusions.

113 experiments show that activation of membrane ruffling and transcriptional activation of c-jun, SRF, o

114 ranscription factor c-Jun and cause membrane ruffling and transformation, indicating that switching i

115 with GGTIs led to the inhibition of membrane-ruffling and transforming activities of both activated a

116 cells with 2-10 muM P27 caused cell membrane ruffling and uptake of virus and polymerized forms of th

117 a recruited and activated Arf1 to facilitate ruffling and uptake.

118 filamentous actin filament into the membrane rufflings and uropods of human neutrophils.

119 4 induced Rac morphology, cell spreading and ruffling (and the formation of neurites).

120 rane trafficking, which is necessary for Rac ruffling, and another involved in protrusion formation.

121 ble to promote Cas-Crk association, membrane ruffling, and cell migration toward epidermal growth fac

122 stimulated lamellipodial extension, membrane ruffling, and chemotaxis of immortalized NLT GnRH neuron

123 tivity, disassembly of F-actin, cessation of ruffling, and decay of chemoattractant signals.

124 ranslocation, growth factor-induced membrane ruffling, and DNA synthesis, indicating that PtdIns 3,4,

125 zed with respect to catalytic activity, heme ruffling, and electrochemical properties.

126 embrane and stimulates GTP loading, membrane ruffling, and filopodia formation.

127 red for growth hormone (GH)-induced membrane ruffling, and increases mitogenesis stimulated by platel

128 tion with cortical actin filaments, membrane ruffling, and lamellipodia formation, compared with wild

129 t for cell polarity, lamellipodial assembly, ruffling, and macropinocytosis.

130 ial actin, along with defects in protrusion, ruffling, and macropinocytosis.

131 owth factor-mediated proliferation, membrane ruffling, and migration.

132 ted G-actin accumulation and plasma membrane ruffling, and Myo1c knockdown confirmed its contribution

133 hepatocyte autophagosomes, nuclear membrane ruffling, and porphyrin-containing vacuoles with endopla

134 signaling induces motility, peripheral actin ruffling, and RhoA activation in MDA-MB-231 human breast

135 that CapG is required for receptor-mediated ruffling, and that it is a major functional component of

136 MLCK at the cell periphery controls membrane ruffling, and that the spatial regulation of MLC phospho

137 rvation of ORAI1-CTTN co-localization during ruffling, and the inhibition of membrane ruffling by the

138 led to become polarized, to undergo membrane ruffling, and to migrate in response to chemokine stimul

139 in localized actin polymerization, membrane ruffling, and, ultimately, pathogen entry.

140 ided that actin-myosin assembly and membrane ruffling are regulated by distinct signaling pathways in

141 proliferation, cell morphology, and membrane ruffling are suppressed by the TRQQKRP motif deletion.

142 a regulator of the cytoskeleton at membrane ruffling areas.

143 phagocytosis process was required to inhibit ruffling as BMM from Fc gamma (-/-) mice that bound C. n

144 roblasts PAK1 localizes to areas of membrane ruffling, as well as to amiloride-sensitive pinocytic ve

145 sphorylation and blocked peripheral membrane ruffling, as well as turnover of focal adhesions and cel

146 of RalA or Sec5 results in reduced membrane ruffling at sites of attachment and impairs bacterial en

147 lipodium, a response accompanied by membrane ruffling at the cell margin.

148 ts demonstrated that SOCE regulates membrane ruffling at the leading edge of cells.

149 on of the PI(4,5)P(2) biosensor and membrane ruffling at the opposite side of the cells.

150 ack to the plasma membrane (PM) and also for ruffling at the PM induced by Rac.

151 We have developed a ruffling-based translocation reporter system that uses t

152 d Ras(V12) mutant induces prominent membrane ruffling, branching morphogenesis on three-dimensional c

153 telet-derived growth factor-induced membrane ruffling but not Bradykinin-induced filopodia formation.

154 439 and Tyr-494 inhibits GH-induced membrane ruffling but still activates JAK2.

155 t the DN construct had no effect on membrane ruffling, but dramatically inhibited stress fiber and fo

156 In contrast, membrane ruffling, but not cell contraction, requires Rac GTPase

157 6%, GLUT4 translocation by 35%, and membrane ruffling by 50%, all of which are phosphatidylinositol 3

158 Dominant-negative Akt inhibited membrane ruffling by 54%; however, R25C-Akt did not have any effe

159 tors stimulate actin remodeling and membrane ruffling by integration of signaling pathways that regul

160 control membrane protrusion, retraction and ruffling by local illumination in both COS7 cells and in

161 )-induced chemotaxis was to promote membrane ruffling by regulating phosphatidylinositol 3,4,5-trisph

162 STIM1 and ORAI1 in the promotion of membrane ruffling by showing that phospho-STIM1 localizes at the

163 ing ruffling, and the inhibition of membrane ruffling by the Ca(2+)-channel inhibitor SKF96365, furth

164 distinct linear or circular/dorsal membrane ruffling, c-Abl-null cells demonstrated dramatically red

165 y, (3) for sterically encumbered porphyrins, ruffling can actually result in hypsochromic shifts in v

166 iverse cellular functions including membrane ruffling, cell cycle progression, and transformation.

167 in Rac1 signalling, trigger optimal membrane ruffling, cell migration and invasion.

168 eading, lamellipodia formation, and membrane ruffling, cell morphologies generated by active Rac1.

169 also induces actin reorganization, membrane ruffling, cell spreading, polarization, and migration.

170 In ruffling cells, alpha 5-GFP and alpha-actinin--GFP local

171 ggested to contain a large component of heme ruffling, consistent with the imidazole-bound ferrous he

172 ious assignments of gammaa as having a large ruffling content.

173 out-of-plane deformations, mainly along the ruffling coordinate.

174 , local PI(3,4,5)P(3) synthesis and membrane ruffling could be induced, with corresponding loss of ru

175 the electron transfer rates and suggest that ruffling could play an important role in redox control.

176 This ruffling defect was quantified using a newly developed m

177 of p85alpha or p85beta rescues the membrane ruffling defect.

178 eme plane, show strong correlations with the ruffling deformation and the average twist angle of the

179 n the F7A mutant, which has nearly twice the ruffling deformation as the WT.

180 e (EPR) g-tensor at several points along the ruffling deformation coordinate.

181 Consequently, the heme ruffling deformation decreases the electronic coupling o

182 The ruffling deformation of its heme cofactor has been sugge

183 could be induced, with corresponding loss of ruffling distally to the illuminated region.

184 atives of NP4 with different degrees of heme ruffling distortion are also investigated.

185 The heme is markedly nonplanar, displaying a ruffling distortion postulated to contribute to stabiliz

186 epends quadratically on the magnitude of the ruffling distortion.

187 gest a role of N-WASP in regulating membrane ruffling downstream of phosphatidylinositol 4,5-bisphosp

188 e inhibitory effect on growth factor-induced ruffling dynamics.

189 reading and is also shown to localize to the ruffling edge of spreading cells, indicating a function

190 This was associated with decreased membrane ruffling, failure to establish cell polarity, and loss o

191 n actin-dependent processes such as membrane ruffling, filopodial protrusion, and cell motility.

192 Consistent with membrane ruffling, gonococci were found residing within macropino

193 the electronic structure and its response to ruffling has been established.

194 tin cytoskeleton reorganization and membrane ruffling in 3T3-L1 fibroblasts and Rat1 cells that stabl

195 hat FKN or CSF-1 stimulated strong transient ruffling in both LR5 cells and BMM.

196 A major relaxation of heme ruffling in cytochrome c, upon binding to the mitochondr

197 additional effects of ASAP1 on PDGF-induced ruffling in fibroblasts suggest that multiple Arf GAPs f

198 inositol-3 kinase is required for tumor edge ruffling in N and S cells, with stimulation of focal adh

199 lculations presented here show that the heme ruffling in NP2 is a consequence of the interaction with

200 he CSF1R/IRDelta960 rapidly induced membrane ruffling in Rat1 fibroblasts.

201 ekin leads to loss of Rho-dependent membrane ruffling in response to epidermal growth factor, an incr

202 null cells demonstrated dramatically reduced ruffling in response to PDGF, which was rescued by physi

203 sing the Coronin 1B S2A mutant show enhanced ruffling in response to phorbol 12-myristate 13-acetate

204 The degree of ruffling in the heme cofactor of Hydrogenobacter thermop

205 As the degree of ruffling increases, the heme methyl (1)H resonances move

206 onstitutively active RacV12 induces membrane ruffling, increases PI4KIIbeta translocation to the plas

207 whereas the knockdown of PTP-PEST increased ruffling independent of oxidase activation.

208 asma membrane did not bypass the blockade in ruffling induced by ARF6 T27N, indicating that ARF6 regu

209 s of SH2-Bbeta are shown to inhibit membrane ruffling induced by constitutively active Rac.

210 n receptor (HIRc-B), SHIP inhibited membrane ruffling induced by insulin and IGF-I by 76 +/- 3% (P <

211 there was no significant change in membrane ruffling induced by PMA in the cells expressing rPLD1-V5

212 of actin stress fibers and inhibits membrane ruffling induced by Rac.

213 SP deficient cells, CP depletion resulted in ruffling instead of filopodia.

214 Gonococcal induced ruffling is a novel finding and may be unique to the cer

215 Since cell ruffling is a prelude to chemotaxis, this observation li

216 ements on cytochrome c demonstrate that heme ruffling is correlated exponentially with the electron t

217 The degree of heme ruffling is coupled to the nature of the ligand and the

218 the modestly nonplanar porphyrins, porphyrin ruffling is found to cause a decrease in binding affinit

219 lls inhibited alpha6beta4-dependent membrane ruffling, lamellae formation, and migration.

220 bly nucleated by the Arp2/3 complex, forming ruffling lamellipodia.

221 on that showed CADTK at the leading edge and ruffling lamellipodial structures in freshly isolated, a

222 he Rho-family GTPases that promotes membrane ruffling, leading edge extension, and cell spreading.

223 e host actin cytoskeleton to induce membrane ruffling, leading to the uptake of the bacterium.

224 l polarity, lamellipodial assembly, membrane ruffling, macropinocytosis, and collective cell migratio

225 Thus, ruffling may stabilize the Fe(III)-NO state, which is re

226 iety, possibly through protein-assisted heme ruffling, may lead to a nitrosyl-heme complex that is un

227 I isoform that concentrates on endosomal and ruffling membranes and is thought to play roles in membr

228 I isoform that concentrates on endosomal and ruffling membranes and is thought to play roles in membr

229 complex is translocated from the cytosol to ruffling membranes upon cell activation by serum.

230 67phox or Noxa1) colocalize with Rac1 within ruffling membranes, independently of their ability to bi

231 ediate biological processes such as membrane ruffling, mitogenesis, and chemotaxis.

232 y by inducing membrane protrusions including ruffling movements.

233 ivity of this variant to the diminished heme ruffling observed for heme bound to this enzyme and conc

234 are interpreted on the basis of tetrapyrrole ruffling occurring on the optimization of the metallo-N

235 Heme ruffling occurs in both structures, apparently due to cl

236 Furthermore, Myo1c-induced membrane ruffling of 3T3-L1 adipocytes is also compromised follow

237 ) stimulation, regulates PDGF-induced dorsal ruffling of fibroblasts and axonal morphogenesis, and co

238 In the first, MAC induced ruffling of HEp-2 cell membrane and formation of surface

239 ization of the cell's actin cytoskeleton and ruffling of its membrane.

240 these studies indicate that (1) substantial ruffling of porphyrins has a negligible effect upon thei

241 About half of the modulation is due to ruffling of the bacteriochlorin chromophore.

242 adhesion stability that appears in increased ruffling of the cell edge, reduced adhesion size, transi

243 r carbachol caused stretching and peripheral ruffling of the cytoplasmic aprons, and formation of new

244 A thickening and ruffling of the epithelium of the airways results from i

245 mutant, ARF6(Q67L), led to a loss of AJs and ruffling of the lateral plasma membrane via mechanisms t

246 These amides are chiral due to the inherent ruffling of the macrocyclic plane.

247 ced exocytosis of melanosomes accompanied by ruffling of the melanocyte membrane.

248 Invasion was accompanied by extensive ruffling of the membranes of the HEp-2 cells.

249 10.5 have a neural-tube closure defect with ruffling of the neural fold ridges, a yolk sac erythropo

250 lipid droplets, and the rapid and transient ruffling of the nuclear periphery.

251 t of extraembryonic malformations, including ruffling of the yolk sac membrane, defective extraembryo

252 lin led to actin polymerization and membrane ruffling on cells, with the specific co-localization of

253 The effects of ruffling on the axial ligation properties of a series of

254 e assembly, and extensive protrusive lateral ruffling on TSP-1 or on syndecan-1 antibody.

255 wever, EWI-2 markedly impaired spreading and ruffling on VCAM-1.

256 h DFT retain the characteristic saddling and ruffling only if the protein matrix is taken into accoun

257 lthough Trk and EGFR each stimulate membrane ruffling, only Trk undergoes both selective and specific

258 We demonstrate correlations between the heme ruffling OOP deformation and the (13)C and (1)H nuclear

259 LPS did not induce membrane ruffling or macropinocytosis in enterocytes, excluding t

260 om Rac1 in its ability to stimulate membrane ruffling or to interact with SmgGDS and IQGAP1-calmoduli

261 2152) is required for Pak1-mediated membrane ruffling, our results suggest a novel role for RSK in th

262 ncreasing cytosolic Ca(2+) enhances membrane ruffling, PI3K activity, and F-actin accumulation.

263 sma membrane and its mobilization to dynamic ruffling protrusions at the cell front.

264 he elastic moduli of the C domain and T zone ruffling region ranged between 3-7 and 7-23 kPa, respect

265 rophage colony stimulating factor-stimulated ruffling; reintroduction of CapG protein by microinjecti

266 lating factor resulted in a reduction in the ruffling response of CapG(-/-) cells compared to the res

267 ion by sucrose treatment did not inhibit the ruffling response.

268 l locomotion, spreading, actin assembly, and ruffling responses.

269 nts also indicate significant differences in ruffling-sensitive modes, particularly the low-frequency

270 Cell ruffling, spreading, and cell adhesion were dependent on

271 es a signaling cascade leading to secretion, ruffling, spreading, and cytokine production.

272 mulated by bradykinin and in dorsal membrane ruffling stimulated by PDGF, whereas the Cdc42GAP(-/-) c

273 a dominant negative mutant, blocked membrane ruffling, suggesting that PIPKIalpha and PIP2 participat

274 hat heme binds to this enzyme with less heme ruffling than observed for wild-type IsdI.

275 1 cells but does inhibit the active membrane ruffling that is necessary for cell polarization.

276 ARF6 regulates a pathway leading to membrane ruffling that occurs after the activation and membrane a

277 Membrane ruffling then becomes polarized, leading to an elongated

278 Active TRAF4 initiated robust membrane ruffling through Rac1, PAK1, and the oxidase, whereas th

279 tion from stress fiber formation to membrane ruffling to confer an invasive phenotype.

280 irulence effectors elicit host cell membrane ruffling to facilitate pathogen invasion.

281 Salmonella species trigger host membrane ruffling to force their internalization into non-phagocy

282 tin cytoskeleton rearrangements and membrane ruffling to gain access into nonphagocytic cells, where

283 established its ability to promote membrane ruffling, transformation, and activation of c-jun transc

284 r roles in actin rearrangements and membrane ruffling, translocated effectors also affect host cell p

285 onal phagocytosis, coiling phagocytosis, and ruffling/triggered macropinocytosis.

286 and anti-PSR antibodies stimulated membrane ruffling, vesicle formation, and "bystander" uptake of c

287 inhibition of FKN- or CSF-1-stimulated cell ruffling was a direct consequence of the phagocytosis pr

288 The PDGF- and Rac1-stimulated ruffling was inhibited by expression of kinase-dead PIPK

289 This stimulated cell ruffling was inhibited by phagocytosis in an intracellul

290 The inhibition of ruffling was not simply a result of reduced membrane ava

291 d cytoskeletal rearrangement, i.e., membrane ruffling, was significantly inhibited (78 +/- 10, 64 +/-

292 telet-derived growth factor-induced membrane ruffling, we investigated whether NIH 3T3 cells stably e

293 nduce formation of lamellipodia and membrane ruffling, when transiently expressed in fibroblasts, ind

294 rapidly translocated to regions of membrane ruffling, where it colocalizes with polymerized actin.

295 e Mtss1-GFP promoted the PDGF-induced dorsal ruffling, whereas overexpression of a mutant deficient i

296 inding p47phox domain decreased VEGF-induced ruffling, whereas the active mutant p4-(S303D, S304D,S32

297 phenotypes did not correlate with peripheral ruffling, which was unaffected, Abi1-KO cells exhibited

298 induced lamellipodia formation and membrane ruffling, which was unrelated to the substrate domain ph

299 ymerization-dependent spreading and membrane ruffling while Rac1-independent BCR capping remains inta

300 icient mutant (achieved by inducing membrane ruffling with epidermal growth factor) induced this epit