ライフサイエンスコーパス: run-down

1 ations of glutamate exhibited time-dependent run down.

2 +), accounting for the use dependence of the run down.

3 e signature of a mitotic clock that does not run down.

4 t-containing GABA(A)Rs by preventing current run-down.

5 zing nicotinic currents demonstrated delayed run-down.

6 hibition is a key determinant of the rate of run-down.

7 time-dependent right-shift in V0.5 values ("run-down"); (3) speeds macroscopic current activation ki

8 found that TRPV1 activity in excised patches ran down and that MgATP reactivated the channel.

9 hslo channels in that they show very little run-down and are not modulated by the addition of DTT.

10 ard this loss of sensitivity to stimulation (run-down) and it can be inferred that they interact with

11 ve potentials, increases the rate of channel run-down, and decreases the single-channel open probabil

12 DAT-null mice expressed DISC, but this DISC ran down at a significantly higher rate than littermate

13 cterized phenomenon of Ca2+-dependent NMDA-R run down because the effect of PDGF was blocked by the p

14 The time at which run-down began ( approximately 5-30 min) was correlated

15 significantly reduced the time to glycolytic run-down by approximately 33 and 65%, respectively.

16 or 7 +/- 1.2 min before its deactivation, or running down, by approximately 60 %.

17 When GIRK1/4 channels are allowed to run down completely, they are not activated by addition

18 Synaptic NMDARs were also subject to current run-down during repeated low-frequency synaptic stimulat

19 A second component did not 'run down' during dialysis and was resistant to nicardipi

20 Channel activity declined with time (run-down) following activation by beta-NAD+ in excised p

21 e and recombinant channels was precluded by 'run-down', i.e. channel activity could be elicited for o

22 In inside-out patches, SOC activity ran down immediately upon excision but was reactivated s

23 ibited by both Ba2+ and quinidine, underwent run-down in excised patches in the absence of ATP, and w

24 nce of sensory inputs they exhibit a gradual run-down in frequency before spontaneously terminating.

25 eprivation which was dependent on a complete run-down in glycolysis and a fall in cellular energy sta

26 ulatory proteins that cause Ca(2+)-dependent run-down in hippocampal neurones.

27 Little run-down in peak current amplitude was induced provided

28 fter patch excision, suggesting that channel run-down is due, in part, to membrane depletion of PIP2.

29 The NMDAR current run-down may be mediated in part by a Ca(2+)-independent

30 (1) Time-dependent run down of mK(ATP) activity was reversed by phosphatidy

31 easurements demonstrated that Ca(2+) induced run down of the glutamate response by downregulating cat

32 Run down of the glutamate response was also voltage depe

33 gic transmitters, ATP and adenosine, control run- down of swimming in the Xenopus embryo.

34 a general feedback mechanism that underlies run-down of all episodic motor patterns in vertebrates.

35 This run-down of AMPA receptor activity was proposed to occlu

36 ection of PKA inhibitory peptides leads to a run-down of AMPA receptor responses and prevents long-te

37 SD for at least four hours and prevented the run-down of amplitudes that is typically observed and wa

38 Following run-down of Ca2+ oscillations, depolarisation briefly re

39 Run-down of cellular polyphosphoinositides by concentrat

40 tory cytokine release thereby preventing the run-down of CSD amplitudes.

41 During trains of stimuli, run-down of EPSPs was less extensive in inflamed tissue

42 PIP2 significantly attenuated the run-down of HERG channel activity that we normally obser

43 lylimidodiphosphate (AMP-PNP) to prevent the run-down of IK(IR))and the Mg2+ dependence of the ATP ef

44 The run-down of institutions, the new paradigm of recovery a

45 The model reproduced the temporal run-down of motor activity seen in the real embryo sugge

46 d, while CPA greatly speeded up, the rate of run-down of motor activity.

47 hypoxia on neuronal function is to produce a run-down of synaptic transmission, and more prolonged hy

48 recordings from Muller cells revealed that a run-down of the inwardly rectifying K+ current (IK(IR))

49 nd adenosine therefore seems to underlie the run-down of the motor pattern for swimming in Xenopus.

50 ineurin in the patch pipette accelerates the run-down of whole cell GluR6 responses in cells co-trans

51 e absence of pipette ATP, both GBa and Gquin ran down over 10 min.

52 but not KIR1.1 or KIR2.1 currents typically 'ran down' over 5 min to 60-80% of maximum amplitude.

53 tase inhibitors, we investigated whether the run-down phase was the result of dephosphorylation by an

54 od of run-up was followed by a use-dependent run-down phase.

55 Channel activity typically ran down quickly, however, and was not recovered in the

56 transients of longer duration but which then ran down quickly.

57 lease from intracellular calcium stores, and run down rapidly at resting membrane potentials when cal

58 We also hypothesize that channel run-down reflects accumulation of nAChRs in long-lived d

59 d cAMP (100 microM) restored the activity of run-down ROMK1 channels in inside-out patches in oocytes

60 is with a dynamin-inhibitory peptide reduced run-down, suggesting a role for clathrin-mediated endocy

61 in the amplitude of NMDAR currents (current run-down) that was use dependent and not readily reversi

62 open diameter of approximately 5.5 angstroms run down the membrane thickness.

63 of porphyrins in an elongated central cavity running down the center of the structure.

64 zinc-binding site lies within the vestibules running down the central axis of the receptor.

65 otherwise regular honeycomb pattern of holes running down the length of a fine silica glass fiber.

66 ide of the helix and contains a channel that runs down the helix axis.

67 avelength-scale morphological microstructure running down their length.

68 cised patches, the delayed rectifier current ran down, unmasking other K+ channels.

69 Run down was triggered, at least in part, by a rise in i

70 Although the rate of Ca2+ current run-down was not affected by 10-15 microM free Ca2+ in t

71 This run-down was prevented by okadaic acid, whereupon ICl,Ca

72 Run-down was reduced by increasing intracellular Ca(2+)

73 einyl leukotriene type I receptor activation run down when cells are pretreated with Li(+), an inhibi

74 olution but when ATP was omitted the current ran down with time.

75 Kir6.1-SUR1 currents ran down within seconds of patch excision preventing ana

76 TRPM2 currents also run down within minutes, but the molecular mechanism of