ライフサイエンスコーパス: rundown

1 petitive neurotransmitter application (i.e., rundown).

2 ed accurately despite conditions of unstable rundown.

3 m intact cells or permeabilized cells before rundown.

4 ed chromaffin cells that had been allowed to rundown.

5 acking p63 undergo a premature proliferative rundown.

6 slower acute desensitization and functional rundown.

7 ular Ca2+ concentration and underwent little rundown.

8 molecule, poly-L-lysine, accelerated channel rundown.

9 on accompanied by a parallel partial current rundown.

10 cyclosporin A or deltamethrin increases the rundown.

11 ephosphorylation events that lead to current rundown.

12 t and somewhat larger following more NBCe1-A rundown, 62% smaller in the absence of Na(+), and 90% sm

13 activates the channel directly and restores rundown activity.

14 probability of BKCa and completely inhibited rundown after activation by Bt2cGMP.

15 The channel rundown after initial excision suggested that modulation

16 We asked whether functional GABA(A) R rundown also occurs in human HH neurons.

17 GABAARs displayed an ATP-dependent rundown and a low sensitivity to Zn2+.

18 Here we examine rundown and MgADP activation of wild-type and Kir6.2-F33

19 functionally with SUR2A to modulate channel rundown and MgADP activation.

20 t of mutating the adjacent residue, G334, on rundown and MgADP activation.

21 In contrast, rundown and MgADP reactivation of wild-type and Kir6.2-G

22 egment, a region implicated in use-dependent rundown and NMDA channel inactivation.

23 The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embry

24 nhibition appeared to be a result of channel rundown and was not seen in whole-cell recordings.

25 epletion of the RRP contribute to STP during rundown, and for low stimulation rates, F2 can also cont

26 speed of end plate potential (EPP) amplitude rundown, and greatly slowed the recovery from synaptic d

27 e of A6 distal nephron cells showed a sudden rundown beginning at 4 min after forming the inside-out

28 related inhibitory peptide each prevents the rundown; blockade of the phosphatase calcineurin with ei

29 We propose that PIP(2) protects I(CAN) from rundown by interacting directly with underlying ion chan

30 hed the function of ATP-Mg in restoration of rundown channel activity, demonstrating that PIPs produc

31 P-Mg underlies ATP-induced activation of the rundown channel.

32 Thapsigargin and ryanodine each inhibit the rundown, demonstrating further a requirement for calcium

33 Manifestation of the rundown depends in part on the loss of intracellular com

34 The rundown depends on calcium influx through the receptors

35 The channel exhibits rapid rundown following patch excision with Po decreasing from

36 tly, functional GABA(A) receptor (GABA(A) R) rundown has been described in surgically resected human

37 overexpression of NCS-1 resulted in a faster rundown in exocytosis.

38 e, paired synaptic facilitation, or synaptic rundown in longer trains.

39 The resetting of rundown in the motor systems can be reformulated as an a

40 at 40-second intervals) induced GABA current rundown in Xenopus oocytes microinjected with HH membran

41 2+ channels, because a similar degree of ICa"rundown" in control cells did NOT result in fracturing o

42 d by a biphasic increase and then decrease ("rundown") in open probability.

43 lular components via dialysis because little rundown is seen if perforated patch-clamp recording is u

44 ged stimulation in inside-out patches; this "rundown" is due to PIP(2) depletion.

45 Conversion of post-rundown K[ATP] channels to the spontaneously operative c

46 g gelsolin, as a result of decreased current rundown; kainate-induced currents were similar in neuron

47 Rundown may be a marker for impaired GABAergic function

48 Rundown occurred even if PMA was applied before changing

49 s revealed that PEA selectively affected the rundown of ACh currents in epsilon-AChRs.

50 cell recordings to measure the use-dependent rundown of ACh-evoked currents.

51 5) Cytochalasin D, added after rundown of alpha,beta,gamma-rENaC activity following ATP

52 functional assays, inhibitors of PP2A block rundown of basal CFTR currents and increase channel acti

53 ion by proton currents and are unaffected by rundown of Ca2+ current.

54 ysis proved impractical because of the rapid rundown of calcium channel currents.

55 his channel found in vivo is closed to avoid rundown of cation gradients across the plasma membrane a

56 in cell-attached patches, and each prevented rundown of channel activity when the membrane patch was

57 hat helps regulate PIP5 kinases, accelerated rundown of cytoplasmic Ca(2+) oscillations, and these co

58 anisms have been shown to be involved in the rundown of different ion channels.

59 Finally, level of rundown of DRN activity co-segregates with extent of beh

60 rotransmission occurred and a faster rate of rundown of EPPs were apparent.

61 greatly attenuated or reversed the observed rundown of expressed channels.

62 Functional rundown of GABA currents was significantly attenuated by

63 lly resected human HH demonstrate functional rundown of GABA(A) R-mediated transmembrane currents in

64 nAChR blockade in hippocampal slices reduced rundown of GABAA receptor-mediated whole-cell responses,

65 n the ability of a nucleotide to prevent the rundown of IM and its ability to inhibit calcineurin pho

66 mics, testing the 'unifying hypothesis' that rundown of inhibitory SK responses at resting membrane p

67 Disappearance of the functional activity or rundown of ion channels upon patch excision in many cell

68 All three approaches indicated that rundown of Kir6.2-F333I/SUR2A channels is due to a reduc

69 chanisms have been reported to contribute to rundown of L-type channels, the mechanism of rundown of

70 n-derived neurotrophic factor alleviates the rundown of neurotransmission during high activity.

71 rundown of L-type channels, the mechanism of rundown of other types of VGCC is poorly understood.

72 pression of synaptic strength, observed as a rundown of postsynaptic potential amplitudes, can also d

73 rm minimizes problems associated with modest rundown of response amplitude during the experiment.

74 nor ATP with heat-inactivated PKC rescued a rundown of SOC.

75 inhibited UDP-induced channel activity after rundown of spontaneous channel openings.

76 , and its antagonist adenosine, regulate the rundown of swimming and we therefore proposed that ecton

77 The rundown of swimming was reset in a manner similar to tha

78 nactivation, recovery from inactivation, and rundown of the Ca(2+) current.

79 After rundown of the Ca(2+) signals following leukotriene rece

80 The rundown of the channel is prevented by lipid phosphatase

81 d wortmannin's inhibitory effect, but slowed rundown of the ImAHP and IsAHP .

82 rectifying K+ channels show an ATP-dependent rundown of their activity.

83 mate decarboxylase led to rapid and complete rundown of transmission, whereas increasing GABA synthes

84 0-second intervals) induced a time-dependent rundown of whole-cell currents in small HH neurons, wher

85 vated the human TRPV6 channels after current rundown only in the presence of Mg(2+).

86 addition, decreased open probability due to rundown or sulfonylureas caused an increase in ATP sensi

87 We examined the rundown process of the plant hyperpolarization-activated

88 aptic currents would be long-lasting but may rundown quickly under high-frequency activation.

89 The fast 'rundown rate' of the M-current recorded in rat superior

90 This rundown reflects persistent intrinsic modulation of VGCC

91 he inhibitory action of glyburide lost after rundown, suggesting that the response of the channel to

92 NBCe1-A currents exhibited time-dependent rundown that was inhibited by removing Mg(2+) in the pre

93 rty of plant shaker-type K+ channels is the 'rundown' that causes channel closure upon membrane excis

94 c alkaline phosphatase (ALP) accelerated the rundown time course.

95 which inhibits ALP activity, slowed the KAT1 rundown time course.

96 s, whereas large HH neurons showed much less rundown using the same protocol.

97 Rundown was evoked by substituting NMG+ for Na+, showing

98 nging to high [K+] solution, indicating that rundown was independent of PKC activity.

99 Functional rundown was not observed in HH neurons with repetitive e

100 This sudden rundown was prevented by addition of anionic phospholipi

101 ha7-containing receptors undergo substantial rundown when the receptors are repeatedly challenged wit

102 ments with phalloidin partially prevents the rundown, whereas collapse of actin filaments with latrun

103 conformation; this probably reflects channel rundown, which is the gradual loss of channel activity t