ライフサイエンスコーパス: ryanodine receptor

1 CaMKIIdelta-dependent phosphorylation of the ryanodine receptor.

2 mediated by enhanced phosphorylation of the ryanodine receptor.

3 nal released from internal ER stores via the ryanodine receptor.

4 arcoendoplasmic reticulum calcium ATPase and ryanodine receptor.

5 that these phenotypes are caused by a leaky ryanodine receptor.

6 consistent with no major modification of the ryanodine receptor.

7 ge of the APP-ICD and involves activation of ryanodine receptors.

8 te-mediated ER-calcium efflux occurs through ryanodine receptors.

9 lization via inositol-1,4,5-triphosphate and ryanodine receptors.

10 state of calcium release channels, i.e. the ryanodine receptors.

11 binds with high affinity and selectivity to ryanodine receptors.

12 re protocadherins, homeobox genes, MAPKs and ryanodine receptors.

13 nt, indicating the recruitment of peripheral ryanodine receptors.

14 nhanced by Ca(2+)-induced Ca(2+) release via ryanodine receptors.

15 proteins is to inhibit calcium release from ryanodine receptors.

16 g), an effect dependent on the activation of ryanodine receptors.

17 ic Ca(2+) release via activation of neuronal ryanodine receptors.

18 Mutations in ryanodine receptor 1 (RyR1) are often associated with my

19 e tubule membrane and Ca(2+) release channel ryanodine receptor 1 (RyR1) in the sarcoplasmic reticulu

20 Total ophthalmoplegia can result from ryanodine receptor 1 (RYR1) mutations without overt asso

21 Furthermore, ryanodine receptor 1 (the sarcoplasmic reticulum Ca(2+)

22 nocked out for MTM1 show severe reduction of ryanodine receptor 1 mediated calcium release but, since

23 by recessive RYR1 mutations is a decrease of ryanodine receptor 1 protein content in muscle.

24 a significant decrease in expression of the ryanodine receptor 1, a decrease in muscle-specific micr

25 lipid on the skeletal muscle calcium channel ryanodine receptor 1, a negative effect on the structure

26 sis and calcium release mediated through the ryanodine receptor 1, though they do affect myotube size

27 stic insight into the causes of this reduced ryanodine receptor 1.

28 ion (AF) risk has been associated with leaky ryanodine receptor 2 (RyR2) Ca release channels.

29 the sarcoplasmic reticulum (SR) that include ryanodine receptor 2 (RyR2) clusters.

30 calmodulin-protein kinase (CaMKII) activity, ryanodine receptor 2 (RyR2) phosphorylation and sarcopla

31 either 1a or 1b shRNA, but native KCNE1 and ryanodine receptor 2 (RYR2) transcripts were unaffected.

32 Mutations in ryanodine receptor 2 (RyR2), a Ca(2+) release channel lo

33 regulates the cardiac Ca(2+) release channel/ryanodine receptor 2 (RyR2), and mutations in CaM cause

34 mic reticulum Ca(2+)-ATPase 2b (SERCA2b) and ryanodine receptor 2 (RyR2).

35 and spark activity, a cellular phenotype of ryanodine receptor 2 activation.

36 ytes isolated from mutant mice that have the ryanodine receptor 2 calcium and calmodulin-dependent pr

37 to evoke arrhythmogenic Ca disturbances via ryanodine receptor 2 dysregulation, which explains the a

38 Conversely, a gain-of-function ryanodine receptor 2 mutant or pharmacological treatment

39 protein kinase A-dependent phospholamban and ryanodine receptor 2 phosphorylation (-42+/-9% for P-pho

40 FRD-S2814A mice, in which the CaMKII site on ryanodine receptor 2 was ablated.

41 hosphorylation of CaMKII, phospholamban, and ryanodine receptor 2 was detected in the postarrest peri

42 (C-protein), glycogen debranching enzyme and ryanodine receptor 2 were also identified.

43 ng this notion, we found expression of RYR2 (Ryanodine Receptor 2) and SERCA2 further increased by co

44 PKP2 reduces expression of Ryr2 (coding for Ryanodine Receptor 2), Ank2 (coding for Ankyrin-B), Cacn

45 o phosphorylation not only of phospholamban, ryanodine receptor 2, and histone deacetylase 4, but als

46 urement of CaM-Ca(2+) (Ca)-binding affinity, ryanodine receptor 2-CaM binding, Ca handling, L-type Ca

47 % for P-phospholamban-S16 and -22+/-7% for P-ryanodine receptor 2-S2808; P<0.05).

48 us WT-CaM), but did not alter CaM binding to ryanodine receptor 2.

49 ent phosphorylation of phospholamban and the ryanodine receptor 2.

50 ed "leaky" gain-of-function mutations in the ryanodine receptor-2 (RyR2) gene in both SUDEP and sudde

51 ivity increased in cardiomyocytes, and (iii) ryanodine receptor-2-mediated calcium oscillations incre

52 TRAIL-DR-mediated ryanodine receptor activation and endocytosis is depende

53 aMKIIdelta binding and CaMKIIdelta-dependent ryanodine receptor activation in adult cardiac myocytes.

54 from the cortical endoplasmic reticulum via ryanodine receptor activation.

55 olved in maintaining ER Ca(2+) by inhibiting ryanodine receptor activity and playing a role in termin

56 exor digitorum brevis (FDB) fibers, either a ryanodine receptor agonist (4-chloro-meta-cresol) or dep

57 n of skeletal muscle proteins, including the ryanodine receptor and calcium (Ca(2+)) release channel

58 , reduced InsP3R1 expression restored normal ryanodine receptor and cAMP response element-binding pro

59 ion of key Ca2+ handling proteins, including ryanodine receptor and phospholamban.

60 not subject to retrograde coupling with the ryanodine receptor and that the retrograde coupling mech

61 y response, due to biphasic behaviour of the ryanodine receptor and the combined effect of the rapid

62 s reduced by blocking the Ca(2+) release via ryanodine receptors and abolished by blocking the IP3 re

63 (2+) channels and endoplasmic reticulum (ER) ryanodine receptors and another between ryanodine recept

64 unolabeling demonstrated close apposition of ryanodine receptors and BK channels.

65 h, but not all, of the SR Ca leak occurs via ryanodine receptors and can be exacerbated in pathologic

66 (ER) ryanodine receptors and another between ryanodine receptors and large-conductance, voltage- and

67 I phosphorylation of L-type Ca(2+) channels, ryanodine receptors and phospholamban to basal levels.

68 horylation of L-type Ca(2+) channels (LCCs), ryanodine receptors and sodium (Na(+)) channels.

69 ates such as phosphodiesterase-4D3 (PDE4D3), ryanodine receptor, and protein phosphatase 2A (PP2A) to

70 The fluorescence pattern, affinity for ryanodine receptors, and competition by untagged FKBP12.

71 of IP3 IP3 potentiation was also blocked by ryanodine receptor antagonist.

72 s are obtained if CaMKII effects on LCCs and ryanodine receptors are considered separately.

73 Ca release channels such as IP3 receptors or ryanodine receptors arranged in clusters (release units)

74 AIPR-1 is physically associated with the ryanodine receptor at synapses.

75 ersecretion are reversed by mutations in the ryanodine receptor but not in the voltage-gated calcium

76 perthermia-triggering agent halothane or the ryanodine receptor Ca channels agonist 4-chloro-m-cresol

77 with and disrupt the function of the cardiac ryanodine receptor Ca(2+) release channel (RyR2) in the

78 nnel dihydropyridine receptor (DHPR) and the ryanodine receptor Ca(2+) release channel.

79 ), leading to diminished BKCa activation via ryanodine receptor Ca(2+) release channels (RyRs), causi

80 in 12.6/1b (FKBP1b), a negative regulator of ryanodine receptor Ca(2+) release, reverses aging-induce

81 Mice with an I4895T mutation in the type 1 ryanodine receptor/Ca(2+) release channel (RyR1) display

82 the sarcoplasmic reticulum (SR) through the ryanodine receptor/Ca(2+)-release channel RyR1 can be en

83 The ryanodine receptor/Ca(2+)-release channels (RyRs) of ske

84 potential M2 channel, and the intracellular ryanodine receptor calcium release channels.

85 n Ca(2+) release from the ER via the IP3 and ryanodine receptors, CaMKII that is activated enters a c

86 ion of different approaches including single ryanodine receptor channel recording, optical imaging (C

87 Ryanodine receptor channels (RyR) are key components of

88 lasmic reticulum (SR) Ca(2+) release through ryanodine receptor channels gated by conformational coup

89 aves originating from random fluctuations of Ryanodine receptor channels, and which occur after much

90 e to the activation of reticulum endoplasmic ryanodine receptor channels.

91 for the myospryn complex in the assembly of ryanodine receptor clusters in striated muscle.

92 t-system structure, density, and distance of ryanodine receptor clusters to the sarcolemma, including

93 exit from the ER further depends on IP3 and Ryanodine receptor-controlled Ca(2+) release as well as

94 uction of priming by an EsRalpha agonist was ryanodine receptor-dependent and prevented by the IP3 an

95 in chronification in the rat, is mediated by ryanodine receptor-dependent calcium release.

96 lar Zn(2+) induces a significant increase in ryanodine receptor-dependent cytosolic Ca(2+) transients

97 sult also leads to Kv2.1 redistribution in a ryanodine receptor-dependent fashion.

98 odine, and the ERalpha agonist, PPT, induced ryanodine receptor-dependent priming.

99 ate a profound regulatory role of ERalpha in ryanodine receptor-dependent transition to chronic pain.

100 yperpolarization-activated current (I f) and ryanodine receptor-derived diastolic local subsarcolemma

101 man atrial cardiomyocyte indicated that both ryanodine receptor dysregulation and enhanced SERCA2a ac

102 ed to phospholamban hyperphosphorylation and ryanodine receptor dysregulation as underlying mechanism

103 hosphorylation was unaltered in pAF, whereas ryanodine receptor expression and single-channel open pr

104 Ryanodine receptor fractional phosphorylation was unalte

105 doplasmic reticulum Ca(2+) ATPase levels and ryanodine receptor function modulation, leading to norma

106 e addressed whether Zn(2+) modulates cardiac ryanodine receptor gating and Ca(2+) dynamics in isolate

107 severe muscle weakness, and mutations in the ryanodine receptor gene (RYR1) represent the most freque

108 RATIONALE: Mutations in the cardiac Ryanodine Receptor gene (RYR2) cause dominant catecholam

109 ssociation of the Calstabin protein from the ryanodine receptor has been shown to result in reduced m

110 ripartite motif family-like PRY SPla and the RYanodine Receptor immune recognition domain.

111 tion and packing strategy of purified type 1 ryanodine receptors in lipid bilayers is determined by t

112 Local activation of ryanodine receptors in terminals with a spatially confin

113 he majority of SR Ca(2+) leak occurs through ryanodine receptors in the junctional SR that are locate

114 also reduced expression of Ca(2+) pumps and ryanodine receptors, increased expression of inositol-1,

115 ignificantly potentiated calcium release via ryanodine receptors induced by caffeine.

116 engers downstream of PKCepsilon, such as the ryanodine receptor, induces priming in both sexes.

117 x through CaV3.2 could repetitively activate ryanodine receptor, inducing discrete Ca(2+)-induced Ca(

118 ncreases in [Ca(2+)]i were attenuated by the ryanodine receptor inhibitor ryanodine, as well as pyruv

119 ITX-Lw1a targets and activates the mammalian ryanodine receptor intracellular calcium release channel

120 The ryanodine receptor ion channel RyR1 is present in skelet

121 odulate intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal

122 alter binding affinity and selectivity among ryanodine receptor isoforms.

123 eration of the Ca transient due to increased ryanodine receptor leakiness and/or sarco/endoplasmic re

124 R function was impaired either by making the ryanodine receptor leaky (with caffeine or ryanodine) or

125 localize to discrete microdomains and drive ryanodine receptor-mediated Ca(2+) sparks, enabling larg

126 We show that TRAIL stimulation activates ryanodine receptor-mediated calcium release from endopla

127 action between endoplasmic reticulum IP3 and ryanodine receptor-mediated calcium signaling is present

128 Recent research suggests that the diastolic ryanodine-receptor-mediated release of Ca(2+) (J(leak))

129 ults suggest that improving the stability of ryanodine receptors might be useful to treat atrial fibr

130 ng voltage-gated Na and Ca channels, cardiac ryanodine receptors, Na/Ca-exchanger, and SR Ca-ATPase a

131 ), a calcium channel that interacts with the ryanodine receptor, on myocardial function.

132 tes Ca(2+) spark parameters, a reflection of ryanodine receptor open probability, consistent with the

133 the protein expression of SERCA2a, PLN, and ryanodine receptor or in the PLN phosphorylation status.

134 pon inhibition of Ca(2+) release through the ryanodine receptors or inositol 1,4,5-trisphosphate rece

135 phosphate receptors but not by inhibition of ryanodine receptors or removal of extracellular Ca(2+).

136 ease channels of the sarcoplasmic reticulum (ryanodine receptors or RyR2s) and the Ca(2+)/calmodulin-

137 calcium homeostasis via the 2-pore channel, ryanodine receptor, or transient receptor potential M2 c

138 protein modifications, which cause increased ryanodine receptor phosphorylation and downregulation of

139 /calmodulin-dependent protein kinase II and ryanodine receptor phosphorylation, were reduced by lept

140 We found that knockin alanine replacement of ryanodine receptor PKA (S2808) or CaMKII (S2814) target

141 In animals, cADPR targets the ryanodine receptor present in the sarcoplasmic/endoplasm

142 eased class II HDAC expression and decreased ryanodine receptor protein and miRNAs expression were al

143 c reticulum Ca(2+)ATPase, phospholamban, and ryanodine receptor proteins, as well as beta-adrenergic

144 Within these discrete structures, CaV3.2 and ryanodine receptor resided in close apposition to one an

145 The amino acid mutations in ryanodine receptor (RyR) and elevated activity of detoxi

146 Intracellular Ca(2+) release through ryanodine receptor (RyR) and inositol trisphosphate rece

147 Intracellular Ca2+ release through ryanodine receptor (RyR) and inositol trisphosphate rece

148 ated that TCS disrupts signaling between the ryanodine receptor (RyR) and the dihydropyridine recepto

149 nase A (PKA)-mediated phosphorylation of the Ryanodine Receptor (RyR) at a single serine (RyRS2808) i

150 locate the biosensor peptide DPc10 bound to ryanodine receptor (RyR) Ca(2+) channels, we developed a

151 , because dantrolene does not inhibit single ryanodine receptor (RyR) Ca(2+) release channels in lipi

152 2+) -induced Ca(2+) release (CICR) from j-SR ryanodine receptor (RyR) Ca(2+) release channels.

153 are juxtaposed to clusters of intracellular ryanodine receptor (RyR) Ca2+ -release channels in mouse

154 e in direct competition with each other, the ryanodine receptor (RyR) calcium channel preferentially

155 a(2+) oscillations in neurons by stabilizing ryanodine receptor (RyR) calcium release channels in the

156 Ryanodine receptor (RyR) calcium release channels showed

157 The ryanodine receptor (RyR) channel pore is formed by four

158 inositol triphosphate receptor (InsP3 R) and ryanodine receptor (RyR) channels blocked ICC Ca(2+) tra

159 eletal muscle, and is localized closely with ryanodine receptor (RyR) channels in the SR terminal cis

160 m release from the endoplasmic reticulum via ryanodine receptor (RyR) channels is critical in stimula

161 ic reticulum, mediated by both the IP3R1 and ryanodine receptor (RyR) channels, requires physiologica

162 oscopy revealed subcellular heterogeneity of ryanodine receptor (RyR) density and the transverse tubu

163 1,4,5-trisphosphate receptor (IP3R) but not ryanodine receptor (RyR) expression was high in enamel c

164 hough these alkaloids are believed to affect ryanodine receptor (RyR) gating in a "caffeine-like" man

165 Cardiac ryanodine receptor (RyR) gating in rats and sheep was re

166 ined by including a biophysical model of the ryanodine receptor (RyR) in the computer model.

167 he 20 parameters tested, only decreasing the ryanodine receptor (RyR) inactivation rate constant (kiC

168 Calcium leak from the ryanodine receptor (RyR) is regulated by reactive oxygen

169 normal to long-lasting sparks can occur when ryanodine receptor (RyR) open probability is either incr

170 ect and analyze the structural dynamics of a ryanodine receptor (RyR) peptide bound to calmodulin (Ca

171 from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca

172 Ryanodine receptor (RyR) refractoriness played a key rol

173 on both refilling and the sensitivity of the ryanodine receptor (RyR) release channels that produce s

174 on both refilling and the sensitivity of the ryanodine receptor (RyR) release channels that produce s

175 (1,4,5)-trisphosphate receptor (IP(3)R) and ryanodine receptor (RyR) represents a critical component

176 al studies reveal that the central domain of ryanodine receptor (RyR) serves as a transducer that con

177 the formation of disulfide bonds between two ryanodine receptor (RyR) subunits, referred to as inters

178 lycine to glutamic acid mutation (G4946E) in ryanodine receptor (RyR) was highly correlated to diamid

179 These diamides act on the ryanodine receptor (RyR), a large endoplasmic calcium re

180 itol-1,4,5-triphosphate receptor (IP3R), and Ryanodine receptor (RyR), plays a major role in agonist-

181 Fourthly, a mutation in the Drosophila ryanodine receptor (RyR), which inhibits activity-induce

182 s is challenged, such as with suppression of ryanodine receptor (RyR)-evoked calcium signaling.

183 ular determinant of axonal growth, through a ryanodine receptor (RyR)-mediated Ca(2+) release mechani

184 om elevated L-type Ca2+ channel activity and ryanodine receptor (RyR)-mediated Ca2+ release, but unde

185 The latter is activated by ryanodine receptor (RyR)-mediated calcium (Ca(2+) ) rele

186 Alteration of ryanodine receptor (RyR)-mediated calcium (Ca(2+)) signa

187 apped Ca(2+) indicator demonstrated enhanced ryanodine receptor (RyR)-mediated sarcoplasmic reticulum

188 transient receptor potential A1 (TRPA1) and ryanodine receptor (RyR).

189 arises from mutations on the skeletal muscle ryanodine receptor (RyR).

190 Ryanodine receptors (RyR) are calcium release channels,

191 although evidence suggests they may regulate ryanodine receptors (RyR) via multiple mechanisms.

192 a(2+)) spark, which arises from a cluster of ryanodine receptors (RyR).

193 the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of th

194 Activation of the skeletal muscle ryanodine receptor (RyR1) complex results in the rapid r

195 motifs (EF1 and EF2) in the skeletal muscle ryanodine receptor (RyR1) functions as a Ca(2+) sensor t

196 lasmic reticulum (SR) Ca(2+) release channel/ryanodine receptor (RyR1) in the diaphragm.

197 een CaV1.1 in the plasma membrane and type 1 ryanodine receptor (RyR1) in the sarcoplasmic reticulum

198 The type-1 ryanodine receptor (RyR1) is an intracellular calcium (C

199 The type 1 ryanodine receptor (RyR1) mediates Ca(2+) release from t

200 v1.1, as well as the Ca(2+) release channel, ryanodine receptor (RyR1), are essential for excitation-

201 gated Ca(2+) channel (CaV1.1) and the type 1 ryanodine receptor (RyR1).

202 ate the intracellular calcium channel type 1 ryanodine receptor (RyR1).

203 tage-gated calcium channels (CaV1.1) and the ryanodine receptor (RyR1).

204 Inhibitors of ryanodine receptors (RyR1) and L-type Ca(2+) channels pr

205 ions at which the DHPRs interact with type 1 ryanodine receptors (RyR1) in the sarcoplasmic reticulum

206 We also show that drugs that target ryanodine receptors (RyR1: dantrolene, tetracaine, S107)

207 Type 1 ryanodine receptors (RyR1s) release Ca(2+) from the sarc

208 ) constitutive pseudo-phosphorylation of the ryanodine receptor RyR2 at Ser2814 (S2814D(+/+) mice) ex

209 tabolite, doxorubicinol, bind to the cardiac ryanodine receptor (RyR2) and to the sarco/endoplasmic r

210 Activation of the cardiac ryanodine receptor (RyR2) by elevating cytosolic Ca(2+)

211 Phosphorylation of the cardiac ryanodine receptor (RyR2) by protein kinase A (PKA) at S

212 CaM binds to and inhibits ryanodine receptor (RyR2) Ca release channels in the hea

213 Cardiac ryanodine receptor (Ryr2) Ca(2+) release channels and ce

214 quire spontaneous Ca(2+) release via cardiac ryanodine receptor (RyR2) channels affected by gain-of-f

215 ng region (the proposed gate) of the cardiac ryanodine receptor (RyR2) completely abolishes luminal,

216 purifies with myospryn and the major cardiac ryanodine receptor (RyR2) from heart.

217 minal region (residues 1-543) of the cardiac ryanodine receptor (RyR2) harbors a large number of muta

218 The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on t

219 Cardiac ryanodine receptor (RyR2) is a homotetramer of 560 kDa p

220 ngle-channel level, oxidation of the cardiac ryanodine receptor (RyR2) is known to activate and inhib

221 Calstabin2 is a component of the cardiac ryanodine receptor (RyR2) macromolecular complex, which

222 intracellular Ca(2+) release via the type 2 ryanodine receptor (RyR2) that promotes AF.

223 eticulum (SR) Ca(2+) release through cardiac ryanodine receptors (RyR2) aggravate cardiac remodeling

224 f the combined actions of direct blockade of ryanodine receptors (RyR2) and Na(+) channel inhibition.

225 +) delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) to the inner mitochondrial me

226 en cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin

227 2+ binding to ligand-gated channels known as ryanodine receptors (RyR2).

228 The cardiac Ca(2+) release channel (ryanodine receptor, RyR2) plays an essential role in exc

229 els like the cardiac Ca(2+) release channel (ryanodine receptor, RyR2), and it appears that attenuate

230 CaM also modulates NaV1.5 and the ryanodine receptor, RyR2.

231 pression levels of calcium release channels (ryanodine receptors, RyR2) in the sarcoplasmic reticulum

232 Ca2+ release channels on cardiac SR: type 2 ryanodine receptors (RyR2s) and type 2 inositol 1,4,5-tr

233 diastolic calcium (Ca) release due to leaky ryanodine receptors (RyR2s) has been recently associated

234 t ventricular myocytes indicated that type 2 ryanodine receptors (RYR2s) were not positioned in a wel

235 The cytosolic Ca(2+) sensitivity of the ryanodine receptor (RyRs) Ca(2+) release channel is low

236 odelling, including increased sensitivity of ryanodine receptors (RyRs) and decreased inward rectifyi

237 Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosph

238 Ca(2+) release mechanisms involve both ryanodine receptors (RyRs) and inositol triphosphate rec

239 ease from the endoplasmic reticulum (ER) via ryanodine receptors (RyRs) and, while they often remaine

240 Ryanodine receptors (Ryrs) are a family of calcium relea

241 However, when a fraction of ryanodine receptors (RyRs) are blocked by tetracaine or

242 The ryanodine receptors (RyRs) are high-conductance intracel

243 Ryanodine receptors (RyRs) are intracellular membrane ch

244 t, which is initiated at dyads consisting of ryanodine receptors (RyRs) at sarcoplasmic reticulum app

245 Ryanodine receptors (RyRs) form calcium release channels

246 Metaplastic activation of ryanodine receptors (RyRs) in these neurons reestablishe

247 Inositol trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs) mediate release of Ca(2+) fro

248 Ryanodine receptors (RyRs) mediate the rapid release of

249 lar changes include increased sensitivity of ryanodine receptors (RyRs) to Ca(2+) release and down-re

250 Ryanodine (Ryd) irreversibly targets ryanodine receptors (RyRs), a family of intracellular ca

251 Pharmacological regulation of ryanodine receptors (RyRs), L-type voltage-dependent Ca(

252 Activation of ryanodine receptors (RyRs), which can lead to activation

253 conformation-sensitive activators of insect ryanodine receptors (RyRs).

254 ted localised Ca(2+) events originating from ryanodine receptors (RyRs).

255 and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively).

256 Ca(2+) regulates ryanodine receptor's (RyR) activity through an activatin

257 Ejection fraction in patients with pre-LVAD ryanodine receptor-sarcolemma distances >1 microm did no

258 sity was reduced in HF, leading to increased ryanodine receptor-sarcolemma distances (0.96+/-0.05 ver

259 Low ryanodine receptor-sarcolemma distances at the time of L

260 1 channel modulation in this process is also ryanodine receptor-sensitive.

261 RAD, a concave surface of the Ash2L SPIa and ryanodine receptor (SPRY) domain binds to a cluster of a

262 ase measured by Ca sparks and promoted RyR2 (ryanodine receptor) structural organization.

263 ing protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular compl

264 dent, reciprocal interaction between IP3 and ryanodine receptors that contributes to sex differences

265 Ca) signaling between L-type Ca channels and Ryanodine receptors that occurs mainly at the cell bound

266 ion channels, including the closely related ryanodine receptor, the cytosolic carboxy termini are un

267 channels in close proximity to intracellular ryanodine receptors, the t-tubules enable synchronous Ca

268 istent with the contribution of Ca(2+)-gated ryanodine receptors to EC coupling.

269 ating stochastic openings of Ca channels and ryanodine receptors to investigate the effects of Ca-vol

270 we examined the effects of BPA and TBBPA on ryanodine receptor type 1 (RyR1), dihydropyridine recept

271 c reticulum (SR) Ca(2+) release channel, the ryanodine receptor type 1 (RyR1).

272 with different forms of AF, have implicated ryanodine receptor type 2 (RyR2) dysfunction and enhance

273 coplasmic reticulum (SR) Ca(2+) leak via the ryanodine receptor type 2 (RyR2) has been observed as a

274 rate is thought to be due to an increase in ryanodine receptor type 2 (RyR2) open probability by dir

275 analysis of immunoprecipitated JMC proteins ryanodine receptor type 2 and junctophilin-2 (JPH2) foll

276 analysis of immunoprecipitated JMC proteins ryanodine receptor type 2 and junctophilin-2 (JPH2) foll

277 n severe Ca(2+) leakage through destabilized ryanodine receptor type 2 Ca(2+) release channels.

278 The ryanodine receptor type 2 channel protein is modulated b

279 As a result of increased activity of mutant ryanodine receptor type 2 channels, sarcoplasmic reticul

280 neous Ca(2+) release events from hyperactive ryanodine receptor type 2 channels.

281 The PKA activation destabilized ryanodine receptor type 2 channels.

282 Deficiency of the protein induces ryanodine receptor type 2 dysfunction by a mechanism tha

283 Increased PKA signaling in turn promotes ryanodine receptor type 2 hyperphosphorylation, which co

284 ular, the potential involvement of increased ryanodine receptor type 2 phosphorylation in the pathoge

285 arch in this area, the functional effects of ryanodine receptor type 2 phosphorylation remain dispute

286 Cardiac ryanodine receptor type 2 plays a key role in excitation

287 9) expressing miRYR2-U10 in correcting RyR2 (Ryanodine Receptor type 2 protein) function after in viv

288 levels of Ca(2+)-cycling proteins including ryanodine receptor type 2.

289 anced sarcoplasmic reticulum Ca(2+)-leak via ryanodine receptor type-2 (RyR2) contributes to the path

290 sion was increased, and PKA sites Ser2808 in ryanodine receptor type-2, Ser16 in phospholamban, and S

291 ulin (CaM) for binding to intact, functional ryanodine receptors type I (RyR1) and II (RyR2) from ske

292 a prevention of the hyperphosphorylation of ryanodine receptors under isoproterenol administration i

293 current modulation by interactions with the ryanodine receptor using a chimeric CaV1.1e construct in

294 CaMKII target sites on phospholamban and the ryanodine receptor using genetically modified mice.

295 The cardiac ryanodine receptor was not altered in transcript, protei

296 ophy, but decreased in failing hearts, while ryanodine receptor was unchanged in either group.

297 toplasmic penetration, and distance from the ryanodine receptor were not indicative of ongoing atroph

298 initially involves SR release of Ca via the ryanodine receptor, which is regulated by its interactin

299 cytes was related to hyperphosphorylation of ryanodine receptors, which was blunted in Nod1(-/-)-PMI

300 in kinase II, through phosphorylation of the ryanodine receptor would lead to Ca leak from the sarcop