ライフサイエンスコーパス: safeguard

1 ries exert an important function as promoter safeguards.

2 ects and appropriateness of current protocol safeguards.

3 ividuals with schizophrenia for a variety of safeguards.

4 ed and eliminated, and tissue homeostasis is safeguarded.

5 Which genes safeguard accurate progression through meiosis is largel

6 nant coral species on reefs, and may help to safeguard affected reefs from potential local and global

7 called "critical propagule," which acts as a safeguard against accidental release.

8 sential telomere 'capping' proteins act as a safeguard against ageing and cancer by inhibiting the DN

9 To safeguard against an imbalance between supply and demand

10 Relapse was strictly defined to safeguard against assigning patients with venlafaxine XR

11 has long been recognized for its ability to safeguard against atherosclerosis.

12 f care (facilitate informed decision-making, safeguard against coercion, ensure psychological safety,

13 These data suggest that PTEN may safeguard against developing malignant tumors in patient

14 Natural killer (NK) cells safeguard against early tumor formation by destroying tr

15 replication processivity factor, PCNA, as a safeguard against error-prone translesion synthesis (TLS

16 , but more importantly it provides effective safeguard against false connections at the same time ach

17 Telomeres, the ends of linear chromosomes, safeguard against genome instability.

18 We propose that LKB1 acts as a safeguard against HPV-stimulated aerobic glycolysis and

19 iated chromatin insulation acts as a crucial safeguard against hyperactivation of angiogenesis.

20 ae and preserve long-term renal function and safeguard against ill-effects of hypertension.

21 and it may therefore act as a cell-intrinsic safeguard against inappropriate CTL differentiation and

22 Plants use autophagy to safeguard against infectious diseases.

23 rrelevant auxiliary information, providing a safeguard against inflated false-discovery rates due to

24 at the pre-B cell receptor checkpoint and a safeguard against leukemogenesis.

25 ysiology of the lung, but may also provide a safeguard against life-threatening anaphylaxis during ma

26 d that the C-terminal peptide functions as a safeguard against misfolding or mislocalization prior to

27 vity, identify homologous recombination as a safeguard against off-target AID action, and have implic

28 UF1-induced immunoregulation, which safeguard against proinflammatory diseases, including NE

29 e long-term immunological responses that can safeguard against recurrences.

30 gents have emerged as promising therapies to safeguard against relapse.

31 iple bacterial products has been viewed as a safeguard against stealth infections; however, this hypo

32 es internal bodily homeostasis and acts as a safeguard against the detrimental effects of stress.

33 ude that annexin A5 might act as a molecular safeguard against the formation of toxic amyloid aggrega

34 We discover a "rule of thumb" to safeguard against the long-term catch depletion of parti

35 To safeguard against the resulting loss of power, some have

36 he complement system is tightly regulated to safeguard against tissue damage that results from unwant

37 re, regulation by NK cell licensing helps to safeguard against TNFSF14 production in response to heal

38 ity orchestrating two distinct networks that safeguard against whole chromosome instability and revea

39 s discriminated by intended communicants and safeguarded against the ecological pressures of social e

40 OS regulation promotes differentiation while safeguarding against a hybrid stem-epithelial-B-cell phe

41 processes in physiological angiogenesis and safeguarding against aberrant angiogenic responses.

42 y108 may censor self-reactive B cells, hence safeguarding against autoimmunity.

43 omains of BubR1 in preventing aneuploidy and safeguarding against cancer.

44 the quiescent state of muscle stem cells by safeguarding against cell-cycle entry and lineage progre

45 he importance of protein immune chaperone in safeguarding against immune pathology.

46 36l1/l2 therefore act as posttranscriptional safeguards against chromosomal instability and replicati

47 In contrast, transcription-coupled repair safeguards against DNA damage, contingent upon the abili

48 This local feedback loop safeguards against excessive activin signaling and maint

49 e DNA repair with chromosome segregation and safeguards against genome destabilization.

50 ion should be given to developing additional safeguards against ICU errors, particularly during drug

51 We conclude that HES1 safeguards against irreversible cell cycle exit both dur

52 fosters direct monetary relationship with no safeguards against mutual exploitation.

53 specialized type-I polymerase, POLIB, act as safeguards against plastid genome instability in Arabido

54 aints on DSB formation provide two different safeguards against recombination failure during meiosis.

55 Therefore, the cell has many safeguards against such misregulation.

56 myocardial excitability and conduction that safeguards against temperature-sensitive conduction fail

57 Thus, mammalian N-glycan branching safeguards against the formation of an endogenous immuno

58 e-tune the Wnt pathway and provides multiple safeguards against tumorigenesis.

59 g by CRISPR/Cas9 revealed that OCT4 and SOX2 safeguard an accessible chromatin neighborhood to assist

60 l stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt

61 ons will occur under research protocols with safeguards and criteria mandated by the National Institu

62 erials will facilitate maintenance of proper safeguards and ensure safe and efficient processing of m

63 While engineered safeguards and personal protective equipment can reduce

64 he importance of ensuring that the necessary safeguards and policies are in place.

65 taste is a basic taste modality, required to safeguard animals against consuming toxic substances.

66 RA-based signaling system with robustness by safeguarding appropriate RA concentration despite natura

67 hing consequences on marine food webs unless safeguards are in place to avoid depleting forage fish t

68 hat, although multiple layers of immunologic safeguards are in place to prevent the development of se

69 l data are available and adequate regulatory safeguards are instituted, caution in the use of generic

70 Safeguards are needed to protect participants' privacy a

71 t therefore focus equally on strategies that safeguard biodiversity and ecosystems.

72 anting targeted conservation partnerships to safeguard biodiversity in an era of global change.

73 on species distributions hamper prospects of safeguarding biodiversity and ecosystem services, and ad

74 nment of particular levels of diversity when safeguarding biodiversity and ecosystems that provide es

75 at concerns about land degradation, poverty, safeguarding biodiversity, and protecting the culture of

76 tual property disputes and in monitoring and safeguarding biosecurity.

77 -seq analyses, we conclude that TET proteins safeguard bivalent promoters from de novo methylation to

78 hormonal exposure of the cone to levels that safeguard both cone survival and the patterning of opsin

79 ionary pressure on the organism to eject the safeguard by spontaneous mutagenesis or horizontal gene

80 Eukaryotic genomic integrity is safeguarded by cell cycle checkpoints and DNA repair pat

81 genome integrity of stem/progenitor cells is safeguarded by mechanisms involving molecules beyond the

82 s, whereas genes with CpG-poor promoters are safeguarded by methylation.

83 iological circumstances, this trafficking is safeguarded by the competency of intercellular tight jun

84 lity of chromosome segregation in mitosis is safeguarded by the precise regulation of kinetochore mic

85 ntigen concentrations binary IL-2 expression safeguards by its spatial distribution selective STAT5 a

86 ions suggests that kinetic barriers exist to safeguard cell-type identity.

87 es, consistent with the role of occlusion in safeguarding cell identities.

88 The mechanisms that safeguard cells against chromosomal instability (CIN) ar

89 evolved as a DNA damage-sensing mechanism to safeguard cells against DNA damage-induced mutagenesis.

90 Cell-cycle checkpoints safeguard cells from such catastrophes by impeding cell-

91 dent deacetylase, slows renal senescence and safeguards cells in the renal medulla.

92 heme sensor would normally protect cells by safeguarding cellular energy and nutrients during acute

93 ty according to brain perfusion levels, thus safeguarding cellular homeostasis by preventing mismatch

94 How the five proteins work together to safeguard chromosome ends and promote telomere length ho

95 Here, we show that Tif1p safeguards chromosomes from DNA damage in the mitotic mi

96 -generation anthrax vaccines is important to safeguard citizens and the military.

97 id not include the full range of options and safeguards considered here.

98 ng both transcriptional and recombinational "safeguard" control of essential gene function.

99 the safety of these products, but additional safeguards could be implemented, and unlike drugs, there

100 ce or the state is an important mechanism to safeguard current and future human participants.

101 indicate robust compensatory mechanisms that safeguard cytoskeleton dynamics at the synapse.

102 Efforts are underway to streamline and safeguard data use.

103 edures used operationally include additional safeguards designed to minimize errors.

104 enzymes that play a special protective role, safeguarding DNA from DNDGIC, display a classical half-o

105 y of whole blood donation exist primarily to safeguard donor health.

106 enges and clarifying the need to monitor and safeguard donor safety.

107 l for maintaining adequate collections while safeguarding donor health.

108 for "ethical risk," and specific measures to safeguard donors should be considered.

109 escence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenoc

110 ts, protect drinking water reservoirs and to safeguard ecosystem health.

111 the registration of systemic insecticides to safeguard ecosystem integrity.

112 uring their registration process in order to safeguard ecosystem integrity.

113 tion, protecting agricultural production and safeguarding ecosystem services.

114 This safeguards efferent MOC firing during high-intensity sou

115 containment strategy containing overlapping 'safeguards'-engineered riboregulators that tightly contr

116 arget genes, demonstrating a role of EZH1 in safeguarding ESC identity.

117 species and regions of particular value for safeguarding evolutionary diversity.

118 without the need for genetic engineering to safeguard feed and food supply for the generations to co

119 preservation can be considered an option for safeguarding fertility.

120 t effective way to control plant diseases to safeguard food and feed production.

121 ovide novel solutions that can contribute to safeguarding food for the rapidly growing human populati

122 Thus, At-FANCM is not only a safeguard for genome stability in somatic cells but is a

123 tion established a novel role for Prdx1 as a safeguard for the lipid phosphatase activity of PTEN, wh

124 programs governing cell fate will permit new safeguards for engineered organisms and will further the

125 rkgroup and the creation of ground rules and safeguards for gift-giving.

126 , remote protected areas are thought to best safeguard forest elephants by supporting large populatio

127 ey are to secure adequate water supplies and safeguard functioning freshwater ecosystems for future g

128 ths during the remainder of this century and safeguard future generations from the ravages of tobacco

129 he pivotal BRCA1 tumor suppressor disrupts a safeguard gene network that opposes cell proliferation a

130 the need for efficient cellular programs to safeguard genetic fidelity.

131 checkpoints are surveillance mechanisms that safeguard genome integrity.

132 ent mechanism to silence retrotransposons to safeguard genome stability while undergoing rapid cell p

133 on can be separated from a novel function in safeguarding genome integrity.

134 ions in maintaining ES cell pluripotency and safeguarding genome integrity.

135 archaea to humans, of this important pathway safeguarding genome stability.

136 In its DNA repair role, TDP2 safeguards genome integrity by hydrolyzing 5'-tyrosyl DN

137 onent of this fork protection pathway, which safeguards genome stability after replication stress.

138 strate that Hst3-regulated H3K56 acetylation safeguards genome stability by controlling the S phase D

139 ral control of DSB repair in heterochromatin safeguards genome stability by preventing aberrant excha

140 In addition, SMC1B safeguards genome stability following irradiation wherea

141 labor among all family members: p63 and p53 safeguard germ line fidelity, whereas TAp73 ensures fert

142 y that represses transposable elements, thus safeguarding germ cell genomes.

143 Although safeguards have been designed to control cell growth by

144 This is of special relevance to safeguard human health considering Palythoa species are

145 conservation plans should include efforts to safeguard hundreds of direct-developing amphibian specie

146 Hya was also required to safeguard Hyb hydrogen oxidation activity after exposure

147 of the commons," shared environments will be safeguarded if international cooperation succeeds and de

148 ole for Bak and an ancillary role for Bax in safeguarding immunological tolerance and prevention of a

149 The staged approach to safeguard implementation revealed mechanisms of escape a

150 ted to halting human-induced extinctions and safeguarding important sites for biodiversity by 2020, b

151 th MeV eradication vaccine programs and as a safeguard in oncolytic viral therapy.

152 do suggest approaches for the development of safeguards in gene therapy vector design.

153 surrogate consent, research risks, and other safeguards in research involving incapacitated adults.

154 Boards interpret the Common Rule's call for safeguards in research involving incapacitated adults.

155 Emerging findings pertinent to protocol safeguards in schizophrenia research suggest general sup

156 r inhibit ASMase restore both these critical safeguards in the RPE and avert complement-induced mitoc

157 ft upward, shallow wells may warrant special safeguards, including a mandatory registry of locations,

158 potential bias; scientific designs; protocol safeguards; influences on research participation decisio

159 We have unveiled this risk, and identified safeguards instituted against it, during strand cleavage

160 ese and future experiments under appropriate safeguards is likely to allow critical understanding of

161 deconvolutes multiple layers of control that safeguard junD gene expression and functional activity.

162 Thus, commensal enteric fungi safeguard local and systemic immunity by providing tonic

163 re prioritised, and hence disproportionately safeguard localised species that are not protected effec

164 These multilayered safeguards maintain robust growth in permissive conditio

165 While the importance of safeguarding marine biodiversity is recognised by policy

166 ns to Mars and other places, and the need to safeguard martian scientific sites and potential resourc

167 MeaB also safeguards MCM, which uses radical chemistry, against in

168 ss of cell fate decision, and they provide a safeguard mechanism against stem cell proliferation indu

169 of chromosomes to microtubules, an important safeguard mechanism ensuring faithful chromosome segrega

170 Autophagy is an important innate safeguard mechanism for protecting an organism against i

171 at MOV10L1 functions as a key component of a safeguard mechanism for the genetic information in male

172 ropose that autophagy may act, in part, as a safeguard mechanism that degrades and thereby maintains

173 us through protein-protein interaction and a safeguard mechanism that relies on a SHR/SCR-dependent p

174 esults demonstrate that quiescence acts as a safeguard mechanism to ensure survival of the HSC pool d

175 essing non-RGC differentiation programs as a safeguard mechanism.

176 le assembly checkpoint (SAC) is an essential safeguarding mechanism devised to ensure equal chromosom

177 tations and decreasing the efficiency of DNA safeguard mechanisms by targeting of cell-cycle regulato

178 How cellular safeguarding mechanisms prevent such potentially toxic e

179 fficient process, suggesting the presence of safeguarding mechanisms that counteract cell fate conver

180 oadly accepted that protected intact habitat safeguards more biodiversity and generates greater ecosy

181 With its dual function in safeguarding mtDNA integrity and preserving mtDNA functi

182 hereas the newly designed Somah solution has safeguarded myocyte and endothelial integrity and functi

183 regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.

184 ale and illustrates their strategic value in safeguarding native biodiversity.

185 se additional herbivore functional groups in safeguarding natural controls of algal growth in times o

186 biodiversity and carbon storage suggest that safeguarding natural habitats for biodiversity protectio

187 and accurately informing development of site-safeguard networks.

188 n by which, PLZF represses retrotransposons, safeguarding normal progenitor homeostasis.

189 Thus, the ATM-p53 pathway safeguards not only DNA damage but also aneuploidy.

190 des unique insights into the mechanisms that safeguard notochord and spine development.

191 we uncover a potential mechanism of how PTEN safeguards NSCs, and establish a cellular platform to id

192 onizes actomyosin contractility, as proteins safeguarding nuclear integrity.

193 Identification and safeguarding of patients at risk of violence should be p

194 Safeguarding of structure and function of cardiomyocytes

195 RecQ family helicases function as safeguards of the genome.

196 imary nucleotide sequence archival resource, safeguarding open nucleotide data access, engaging in wo

197 a controlled environment within the brain to safeguard optimal neuronal function.

198 Therefore, establishing and safeguarding optimal health from early life must become

199 thods applied in, for example, international safeguards or nuclear forensics.

200 ay be used to identify mitigation options to safeguard orchard production against the risk of pollina

201 The immune system safeguards organ integrity by employing a balancing act

202 e and chemotherapeutics are being created to safeguard our future.

203 s called exception reporting, is intended to safeguard patients against inappropriate treatment by ph

204 Interventions are needed to safeguard patients and prevent serious complications of

205 However, how do we safeguard personal privacy of innocent victims and famil

206 and use the Proton Gradient Regulation 5 to safeguard photosystem I, the cyanobacterial homolog of P

207 athogens continue to challege our ability to safeguard plant health worldwide.

208 regulator Cdx2, suggesting that Sox21 helps safeguard pluripotency.

209 The molecular mechanisms that safeguard podocyte foot process architecture and maintai

210 major target of miR-92a that constitutively safeguards podocyte cell cycle quiescence.

211 d management responses can be implemented to safeguard pollinators and sustain pollination services.

212 ted, kappa editing and anergy are additional safeguards preventing 2F5 V(H)/V(L) expression by immatu

213 and associated chromatin-modifying complexes safeguard proper and robust differentiation.

214 processes and requires control mechanisms to safeguard proper and timely action.

215 Despite its importance in safeguarding proper chromosome segregation, how hMps1 is

216 , needing control and certainty of outcomes, safeguarding psychological wellbeing), justifying donor

217 the food chain may be an invaluable tool to safeguard public health.

218 propose changes in ASH policy that may help safeguard public trust as well as preserve the access of

219 f a nuclear facility or nuclear material for safeguarding purposes.

220 to enforce legislation and to implement and safeguard reliable measurements.

221 dictions call for conservation strategies to safeguard relict tree populations and anticipate how man

222 tion, and with it cyclin A/CDK2 activity, to safeguard replicative fidelity and control neuronal diff

223 mic epithelial cells (mTECs) is essential to safeguard self-tolerance.

224 These molecular safeguards should enable the development of safe CRISPR

225 tion is an effective but underused method to safeguard spermatozoa.

226 can be protective and should be increased to safeguard sportsmen from physical damage.

227 ling and growth test suggest high fitness of safeguarded strains, an important characteristic for wid

228 Our safeguarding strategy is modular and employs conserved m

229 A fourth and fifth safeguard subject has been identified: recognizing the r

230 They result in three safeguard subjects: the Asset of Natural Resources, thei

231 The stem cells that safeguard synovial joints in adulthood are undefined.

232 genetics postulate that XNA could be used to safeguard synthetic biology organisms by storing genetic

233 Our studies identify an elaborate safeguarding system that prevents individual Sm proteins

234 g a strategy to optimize CTL responses while safeguarding TCR diversity.

235 volving IL-33, decidual B cells and PIBF1 in safeguarding term pregnancy and suggest new therapeutic

236 The mitotic checkpoint is a cellular safeguard that prevents chromosome missegregation in euk

237 , whereas noncancer cells contain additional safeguards that prevent DNA re-replication.

238 he pathogenesis of ITP, and with appropriate safeguards, THD may benefit patients with ITP.

239 Two mechanisms safeguard the bipolar attachment of chromosomes in mitos

240 a single four-electron transfer reaction to safeguard the cell from the formation of reactive oxygen

241 TC-PTP is therefore shown to be required to safeguard the dynamic transcriptome necessary for effici

242 Tumour suppressors safeguard the fidelity of the mitotic checkpoint by tran

243 range chromatin regulatory interactions that safeguard the finely-balanced transcriptional programs u

244 s the replisome, but how these modifications safeguard the fork is not understood.

245 DNA glycosylases safeguard the genome by locating and excising chemically

246 ur data therefore suggest that Daxx and Atrx safeguard the genome by silencing repetitive elements wh

247 The extent to which checkpoints monitor and safeguard the genome differs between sexes and may contr

248 on heterochromatin is tightly suppressed to safeguard the genome, and in ccRCC cells, JARID1C inacti

249 Cell cycle checkpoints are implemented to safeguard the genome, avoiding the accumulation of genet

250 Interventions are needed to safeguard the health of women after fistula repair.

251 Thus, Scratch2 appears to safeguard the homeostasis of postmitotic primary neurons

252 their functions into ERA testing schemes to safeguard the integrity of aquatic ecosystems.

253 Addition of NaCl did not safeguard the katB mutant from H2O2, suggesting that Kat

254 of hemostasis that functions with the LVV to safeguard the lymphatic vascular network throughout life

255 ress TB vigorously to save patient lives, to safeguard the massive investment in HIV treatment, and t

256 n of efficient photoprotection mechanisms to safeguard the photosynthetic machinery.

257 o further elucidate regulatory pathways that safeguard the somatic state, we performed two comprehens

258 destruction of vessel-encasing tumors while safeguarding the encased vessel.

259 rdian of genome" duties at least in part via safeguarding the epigenome of ESCs.

260 ors and pathways underlies the importance of safeguarding the genome through multiple means.

261 ions cause brain developmental disorders, in safeguarding the genome through S phase during early ste

262 ATR) kinase is a master checkpoint regulator safeguarding the genome.

263 our study reveals a function of the nuage in safeguarding the germline genome against deleterious ret

264 to repress transposon transcription, thereby safeguarding the germline genome.

265 g self from non-self plays a crucial role in safeguarding the germlines of metazoa from mobile DNA el

266 nhancing research and public education while safeguarding the health of captive animals and the publi

267 med at maximizing the organ donor pool while safeguarding the interests of potential living donors.

268 characteristic; it initially contributes in safeguarding the malignant cell survival, whereas long-l

269 By safeguarding the molecules from the intensity of the max

270 d by feedback excitation among CA3 pyramids, safeguarding the network from possible runaway excitatio

271 e privilege of professional practice and for safeguarding the public well-being.

272 Disabilities (CRPD) is a major milestone in safeguarding the rights of persons with disabilities.

273 le, these new findings have implications for safeguarding the safety of normal individuals.

274 e transcription factor Nanog and its role in safeguarding the stem cell pluripotency, which can be un

275 in this care might play an important role in safeguarding the trust of adolescents.

276 t on a new and critical task of Ste24, which safeguards the essential process of translocation.

277 regulated, pluripotency-specific lncRNA that safeguards the hESC state by disrupting SIRT6 activity.

278 erstood as a bona fide tumor suppressor that safeguards the integrity of the genome via regulating nu

279 Proper regulation of RAG1/2 expression safeguards the ordered assembly of Ag receptors and the

280 3 in the region, as one of the pathways that safeguards the silent state of genes.

281 from boys undergoing treatment for cancer to safeguard their germ line.

282 Cancers adopt diverse strategies to safeguard their survival, which often involve blinding o

283 eeded to boost the resilience of ecosystems, safeguard their wildlife, and protect their capacity to

284 e lymphocytes with a cellular "fitness" that safeguards their persistence later in life during episod

285 uncover a critical role of Ovol proteins in safeguarding this intricate process.

286 ases Parp1 and Parp7 play a critical role in safeguarding this state by occupying key pluripotency ge

287 With appropriate safeguards, this novel and emerging field of research of

288 1-ETO coexpressing FLT3-ITD, SIRT1 acts as a safeguard to counteract oncogene-induced stress, and leu

289 Hif2a acts as a safeguard to initiate sinusoidal reconstruction only upo

290 es by using RNA surveillance mechanisms as a safeguard to protect their transcriptome profiles.

291 We suggest safeguards to be adopted in assessing and reporting the

292 encompassed the perceived necessity of legal safeguards to determine legitimacy of relationships, ens

293 ard practices on surrogate consent and other safeguards to protect incapacitated adults in research.

294 at proper regulation of miR-27 is pivotal to safeguarding Treg-mediated immunological tolerance.

295 ify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurit

296 d from bone marrow megakaryocytes (MKs) that safeguard vascular integrity but may also cause patholog

297 d from bone marrow megakaryocytes (MKs) that safeguard vascular integrity.

298 It is unclear if this is a mechanism of safeguard via redundancy or if it serves other functiona

299 s and regional food production while helping safeguard vital ecosystem services and globally signific

300 ir causes, frequency, severity, and existing safeguards were identified.