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1 ive respiration, and cj1368-70 in nucleotide salvage.
2 e measure was eradication of seeds and globe salvage.
3 reperfused too late to expect any myocardial salvage.
4 tively delineate MaR and quantify myocardial salvage.
5 reatment associated with high rates of globe salvage.
6 e is involved in cytidine as well as uridine salvage.
7 ial proportion of patients considering focal salvage.
8 size or MVO and did not increase myocardial salvage.
9 nts with non-metastatic local regrowths were salvaged.
10 w much, if any, ischemic myocardium has been salvaged.
11 vity, suggesting that ssy5Delta increases NR salvaging.
12 ences were noted for percentage of penumbral salvaged (68% [SD 28] for the tenecteplase group vs 68%
13 ls reveals substantial remaining de novo and salvage activities, and could not eliminate the disease
15 of retinoblastoma can be managed with globe-salvaging alternatives and with visual preservation in s
16 se/pyrophosphorylase activities required for salvage and conversion of l-fucose and/or d-Arap into th
21 ent implantation on infarct size, myocardial salvage, and microvascular obstruction (MVO) in patients
24 trials evaluating the impact on survival of salvage androgen deprivation therapy with or without age
27 4 randomised patients had died at follow-up: salvage ASCT (n=31 [35%]) versus oral weekly cyclophosph
28 ed to receive either high-dose melphalan and salvage ASCT (n=89) or oral weekly cyclophosphamide (n=8
29 y malignancies were reported in 12 patients (salvage ASCT [n=7] vs oral weekly cyclophosphamide [n=5]
31 progression shows continued advantage in the salvage ASCT group compared with the weekly cyclophospha
32 tive disease progression was superior in the salvage ASCT group compared with the weekly cyclophospha
33 Median overall survival was superior in the salvage ASCT group compared with weekly cyclophosphamide
35 either high-dose melphalan (200 mg/m(2)) and salvage ASCT or weekly oral cyclophosphamide (400 mg/m(2
40 patients with relapsed multiple myeloma with salvage autologous stem-cell transplantation (ASCT) comp
41 therapeutic interventions that target NAD(+) salvage biosynthesis for the purposes of inhibiting tumo
42 encodes a nicotinamidase required for NAD(+) salvage biosynthesis, demonstrating contribution of de n
44 vention had cell salvage deployed (50.8% had salvaged blood returned; mean 259.9 ml) versus 3.9% of 1
45 y pharmacological inhibition of nicotinamide salvage, both NAD(+) and NR prevent neuronal death and A
46 itory of the middle cerebral artery, TAT.ARC salvages brain tissue when given during occlusion or 3 h
49 e deiodinase (IYD) is responsible for iodide salvage by reductive deiodination of the iodotyrosine de
53 ly arise in the developing repertoire can be salvaged by receptor editing, a central tolerance mechan
54 es that underwent insufficient light cure is salvaged by the novel self-cure mechanism, and such salv
56 y best clinical response after completion of salvage chemotherapy (complete response vs partial respo
57 ose (FDG-PET) has not been established after salvage chemotherapy (ST) and before HDT-ASCT by modern
59 -C) is an essential component of primary and salvage chemotherapy regimens for acute myeloid leukemia
61 were eventually reversed by 7 days per week salvage combinations, and 11 of 18 patients have been ba
64 % of 1,498 assigned to intervention had cell salvage deployed (50.8% had salvaged blood returned; mea
65 sion associated with the routine use of cell salvage during cesarean section was not statistically si
66 d by the novel self-cure mechanism, and such salvaging effect can be triggered by HAp released from d
70 ulticenter study was to assess the impact of salvage esophagectomy after definitive chemoradiotherapy
71 e., CblT) and a kinase (i.e., CblS) that can salvage exogenous alpha-ribazole (alpha-R) from the envi
74 ted with intravenous chemotherapy and IVM as salvage for vitreous seeding, and further to determine w
78 dality treatments initiated with IVC, 50% of salvaged Group D retinoblastoma eyes had <20/200 vision,
82 approximately 22 patients were candidates to salvage IAT during emergency relaparotomy because of pos
83 on was significantly higher in candidates to salvage IAT than in those to simultaneous IAT (78.9% vs
84 nfusion of islets was significantly lower in salvage IAT than simultaneous IAT (59.1% vs 88.9%, P = 0
86 ft survival, and insulin-free survival after salvage IAT were not different from those documented aft
87 and was related to smaller final myocardial salvage index (0.59 [IQR, 0.39-0.69] versus 0.65 [IQR, 0
88 stenting was not associated with myocardial salvage index (66%; IQR: 50% to 89% vs. 67%; IQR: 49% to
89 mained associated with both final myocardial salvage index (beta=-0.12; P=0.03) and MVO (beta=0.18; P
92 d early QW in the ECG had smaller myocardial salvage index and more extensive MVO than non-QW despite
93 sociation between baseline QW and myocardial salvage index and MVO in STEMI patients treated with pri
96 dverse cardiac event and improved myocardial salvage index, indicating that a phase III clinical tria
97 ing edema, myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, and microvascular o
98 on (edema, myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, and microvascular o
99 with Sir2 and Fob1 function, wild-type NAD+ salvage is required for calorie restriction (CR) to exte
101 myocardial infarction, with the final aim of salvaging jeopardized myocardium and preventing left ven
103 rotection was mediated by reperfusion injury salvage kinase and survivor activating factor enhancemen
104 uced infarct size via the reperfusion injury salvage kinase and survivor activating factor enhancemen
105 ated the cardioprotective reperfusion injury salvage kinase and survivor activating factor enhancemen
106 ylguanine ([18F]F-AraG), targeted toward two salvage kinase pathways preferentially accumulates in ac
108 .5% and associated with decreased myocardial salvage, larger infarcts, and more pronounced reperfusio
110 rapy with curative intent (CLRT) followed by salvage liver transplantation (SLT) in case of hepatocel
111 (HCC-cirr), upfront liver resection (LR) and salvage liver transplantation (SLT) in case of recurrenc
113 nts without these markers were followed, and salvage liver transplantation was considered upon develo
114 antigen (PSMA) HBED-CC PET/CT or PET/MR and salvage lymphadenectomy were retrospectively included.
118 es, the immediate availability of aggressive salvage measures resulted in a survival of 87.9% of pati
120 two transporters may reflect distinct purine salvage needs that the spirochete encounters throughout
121 oss cellular membranes and are essential for salvage nucleotide synthesis and purinergic signaling.
123 PLA2gamma, these results are consistent with salvage of myocardium after I/R by iPLA2gamma loss of fu
125 ylation or via internalization and metabolic salvage of wall-derived sugars to produce new precursors
126 gnosis of testicular rupture may lead to the salvaging of the testicle by prompt surgical exploration
127 When selecting combination chemotherapy salvage options, evaluation of the prior treatment and t
129 del in which L. donovani amastigotes readily salvage ornithine and have some access to host spermidin
130 h larger infarcts (P<0.001), less myocardial salvage (P<0.01), impaired LV ejection fraction (P<0.001
131 uctone dioxygenase (ARD) from the methionine salvage pathway (MSP) is a unique enzyme that exhibits d
133 Our work highlights pabA and the pyrimidine salvage pathway as potential targets for novel therapeut
134 s extend current knowledge of the nucleotide salvage pathway by revealing the metabolism of oxidized
135 duct, mammalian cells have evolved an NAD(+) salvage pathway capable of resynthesizing NAD(+) from ni
136 d nicotinamide riboside (NR) in the amidated salvage pathway despite no increase in nicotinamide phos
137 Here we show that enzymes of the nucleotide salvage pathway display substrate selectivity, effective
139 phoribosyltransferase (UPRT) is a pyrimidine salvage pathway enzyme that catalyzes the conversion of
140 rthermore, we revealed that both de novo and salvage pathway enzymes contribute to viral DNA replicat
142 Bordetella parapertussis have the recycling/salvage pathway genes pncA and pncB, for use of nicotina
143 ur results suggest that enhancing the NAD(+) salvage pathway in astrocytes could be a potential thera
145 an intrinsic mRNA-specific protein synthesis salvage pathway operative in glioblastoma (GBM) tumor ce
147 f glutaminolysis and triggers autophagy as a salvage pathway supporting leukemia cell metabolism.
148 n of NAD(+) levels by stimulating the NAD(+) salvage pathway suppressed mitochondrial protein hyperac
149 transferase, the rate-limiting enzyme in the salvage pathway that converts nicotinamide to NAD (mNAMP
150 s depleted and metabolites of the deamidated salvage pathway were reduced but intracellular NAD+ and
151 inase (TK) is a key enzyme in the pyrimidine salvage pathway which catalyzes the transfer of the gamm
152 EHYDROGENASE1 (XDH1), involved in the purine salvage pathway, and CYTOSOLIC THIOURIDYLASE SUBUNIT1 an
153 egulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression
154 me in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positro
155 tical enzyme in the mitochondrial pyrimidine salvage pathway, is essential for mitochondrial DNA (mtD
165 (ATR) reduces the output of both de novo and salvage pathways by regulating the activity of their res
166 novo has been extensively characterized, the salvage pathways have received comparatively little atte
167 fic alterations in both the NAD+ de novo and salvage pathways including striking accumulations of nic
168 e analogs to capitalize on the highly active salvage pathways of Leishmania, which are purine auxotro
170 subunit proteins of the Calvin cycle and AMP salvage pathways suggests a strong biological role in hi
171 an biosynthesize PLP de novo, they also have salvage pathways that serve to interconvert the differen
172 ing the stringent response to promote purine salvage pathways, maintain GTP homeostasis and ensure co
178 had nystagmus and 12 of 20 (60%) bilaterally salvaged patients had strabismus (n = 10 exotropia and n
180 evelopment, we engineered parasites that can salvage pyrimidines through the expression of a single b
181 statectomy may benefit from dose-intensified salvage radiation therapy (SRT) of the prostate bed.
183 iandrogen therapy with daily bicalutamide to salvage radiation therapy resulted in significantly high
187 olume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy a
188 multi-institutional nomogram of outcomes for salvage radiotherapy (SRT) following radical prostatecto
190 mes in postprostatectomy patients undergoing salvage radiotherapy and to evaluate the resulting dosim
191 ention-to-treat clinical trial for potential salvage radiotherapy for recurrent prostate cancer after
192 ention-to-treat clinical trial for potential salvage radiotherapy for recurrent prostate cancer after
198 The relatively low relapse rate and high salvage rates at relapse reduce the potential benefit of
199 se OAC after initial OAC treatment have good salvage rates, and the treatment has an acceptable ocula
200 ide regenerated from C6-ceramide through the salvage/recycling pathway, at least in part, mediated th
201 fingolimod significantly improved myocardial salvage, reduced infarct size, and improved systolic LV
202 s apoptosis, leading to increased myocardial salvage, reduced infarct size, and mitigated left ventri
203 tudy demonstrates that BeGEV is an effective salvage regimen able to induce CR in a high proportion o
205 th a favourable safety profile, is an active salvage regimen for heavily pretreated patients with rel
208 Nivo was an active and well-tolerated first salvage regimen, potentially providing patients with R/R
209 Recently, adoptive T-cell therapy has shown salvage responses in multiple refractory solid tumours.
212 nts with low GC scores are best treated with salvage RT, whereas those with high GC scores benefit fr
213 come was shown on physical Toronto Extremity Salvage Score, SF-36 Physical Component Summary, and BSI
214 trials was assessed by the Toronto Extremity Salvage Score, Short-Form Health Survey (SF-36), Brief S
218 disease recurrence, lack of robustly tested salvage strategies, and significant disease morbidity of
219 as well as the development of more effective salvage strategies, remains an important objective.
221 The phase 2 C-SALVAGE study (Hepatitis C-Salvage Study for Patients who Failed DAA/PR Therapy) de
222 genes involved in nucleic acid synthesis and salvage, such as those encoding thymidine kinase (TK), c
224 rence patterns and investigate the impact of salvage surgery on survival in patients with rectal canc
225 latinum-based therapy, were not amenable for salvage surgery or radiotherapy, and who had an Eastern
228 apse of disease may be eligible for curative salvage surgery, but the benefit of this surgery has not
230 by transferring the endogenous molecules to salvage the injured neighboring cells by regulating apop
231 Hence, there is a need to develop effective salvage therapies and combine novel agents with standard
233 alovirus (CMV) infection is challenging, and salvage therapies, foscarnet, and cidofovir, have signif
235 ACVBP (54% vs 41%; P = .08), leading to more salvage therapy (37% vs 26%; P = .07) and lower event-fr
236 e that were CD38-positive had a mean time to salvage therapy 71 months shorter than patients who were
237 should optimize efficacy and tolerability of salvage therapy by stratifying patients according to ris
238 undred fourteen patients received subsequent salvage therapy following KI discontinuation with an ORR
242 ination with immunosuppressive agents, or as salvage therapy for patients who do not respond or lose
244 e needed to confirm the potential of MSCs as salvage therapy for steroid-refractory GvHD and to ident
245 ponsive to conventional rituximab-containing salvage therapy from 12 oncology-haematology centres in
246 vide a substantial initial efficacy rate for salvage therapy in heavily antiretroviral-experienced HI
247 red in combination were evaluated as initial salvage therapy in patients with relapsed or refractory
251 -label trial that studied primary as well as salvage therapy of invasive mucormycosis showed efficacy
252 -nine (94%) patients had cHL and 27 had >/=1 salvage therapy post-allo-HCT and prior to anti-PD-1 tre
254 f positron emission tomography (PET)-adapted salvage therapy with brentuximab vedotin (BV) and augmen
256 the feasibility and activity of PET-adapted salvage therapy with brentuximab vedotin, followed by au
257 leic acids in the AH from Rb eyes undergoing salvage therapy with intravitreous injection of melphala
258 le investigating the off-label use of BDQ as salvage therapy, seven of 13 patients with Mycobacterium
264 kov model to simulate primary, adjuvant, and salvage therapy; disease recurrence; and survival in pat
265 ained HSK and threonine synthase in order to salvage these nutrients when threonine availability is l
268 es polyamine synthesis, enables nicotinamide salvage to regenerate NAD(+), and is associated with obe
271 omies were lethally irradiated and underwent salvage transplantation with either the contrast-naive o
273 erapy; immunotherapy is emerging as a viable salvage treatment for patients in whom first-line chemot
276 s indicated by the possibility of successful salvage treatment in more than 70% of PET2-positive pati
277 recurrence, or assessment for suitability of salvage treatment or as response assessment within 1-6 m
279 irst remission (<12 months vs >/=12 months), salvage treatment phase (first vs second), and age (<55
281 or PET2-positive patients (regardless of the salvage treatment they received) and 81% for PET2-negati
282 emia who were due to receive first or second salvage treatment were randomly assigned (1:1) via an in
284 splatin resistance, which requires intensive salvage treatment, and have a 50% risk of cancer-related
290 sus current standard of care without routine salvage use (control) in cesarean section among women at
291 June 2013 to 17 April 2016) of routine cell salvage use (intervention) versus current standard of ca
293 ratoprosthesis type II is a viable option to salvage vision in patients with poor prognosis for other
297 found improved coronary flow and myocardial salvage when stent implantation was deferred, the DANAMI
300 a severe Ebstein anomaly can be successfully salvaged with fenestrated right ventricular exclusion an
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