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1 ain cholinergic deficits (induced by 192 IgG-saporin).
2 y lesioned with an immunotoxin (IT), 192 IgG-saporin.
3 cortical infusion of the immunotoxin 192 IgG-saporin.
4 ted with the selective cytotoxin substance P-saporin.
5 n composed of basic fibroblast growth factor-saporin.
6 gic neurons in NDB unilaterally with 192-IgG-saporin.
7 oned with the cholinergic immunotoxin 192IgG-saporin.
8 cortical infusion of the immunotoxin 192 IgG-saporin.
9 rebroventricularly with 4 micrograms 192 IgG-saporin.
10  was found in aged rats treated with 192-IgG-saporin.
11 brain with the ribosome-inactivating protein saporin.
12 scular injection of cholera toxin-conjugated saporin.
13 ansported catecholamine immunotoxin, antiDBH-saporin.
14 ced after a ventricular injection of 192 IgG-saporin.
15 VDB) cholinergic neurons produced by 192 IgG-saporin.
16 droxylase antibodies conjugated to the toxin saporin.
17 used with the selective cholinotoxin 192 IgG-saporin (0.005 microgram/0.5 microliter/site) into the f
18 re induced in rats with infusions of 192 IgG-saporin (0.1 microg/0.5 microl per side).
19 y nerve growth factor receptor conjugated to saporin (192 IgG-saporin), lesioned rats were processed
20  of the highly selective immunotoxin 192 IgG-saporin (192-sap) into the ventricular system.
21 ulness were not different between hypocretin-saporin, 192 IgG-saporin, or saline-treated rats.
22  Rats received PBS or the immunotoxin 192IgG-saporin (192Sap) intracerebroventricularly at two doses
23  linked to the ribosome-inactivating protein saporin-6 (rFGF2-SAP) on vascular SMC cytotoxicity and n
24 rious concentrations of rFGF2-SAP, FGF2, and saporin-6 (SAP).
25 tibody to DBH coupled by a disulfide bond to saporin (a ribosome inactivating protein), has been show
26                     The authors used 192 IgG-saporin, a lesioning agent selective for basal forebrain
27 tion of guanidinoneomycin to the plant toxin saporin, a ribosome-inactivating agent, results in prote
28 ng the intraseptal administration of 192-IgG-Saporin, a specific cholinergic neurotoxin, we have foun
29            We studied the effects of 192 IgG-saporin, a specific immunotoxin for the NGF receptor-pos
30 ith saline or anti-dopamine-beta-hydroxylase-saporin, a toxin that destroys noradrenergic neurons of
31 roventricular anti-dopamine beta-hydroxylase/saporin, a treatment that destroys a majority of noradre
32         This protective effect of dermorphin-saporin against SNL-induced pain was blocked by beta-fun
33  made after intrathecal infusion of vehicle, saporin alone, or SP-SAP.
34 tion of 5, 10, and 20 micrograms of anti-DBH-saporin (alpha-DBH-sap) into rats.
35 -hydroxydopamine (6-OHDA), a toxin devoid of saporin, also damaged NTS catecholamine neurons but did
36 eeks after intraventricular injection of 192-saporin, an immunotoxin directed at the low affinity neu
37 a partial immunolesion to CBFNs with 192 IgG-saporin, an immunotoxin selectively taken up by p75NTR-b
38                          Data indicated that saporin and abrin II shared one pattern, while ricin and
39 e mu-opioid agonist dermorphin; unconjugated saporin and dermorphin were used as controls.
40 e loss of SPR-positive cells, a conjugate of saporin and the more potent and peptidase-resistant SP a
41  tested in combination with a protein toxin, saporin, and a significant reduction in cell viability w
42 including Ricinus communis agglutinin (RCA), saporin, and abrin II.
43 electively killed by i.c.v. injection of 192-saporin, and cerebellar Purkinje cells which are killed
44 ection of a retrogradely transported form of saporin, and examined the morphology of contralateral SN
45  rats by bilateral local injection of orexin-saporin, and polysomnography was performed to measure ba
46 to dopamine-beta-hydroxylase conjugated with saporin (anti-DBH-SAP) damages catecholamine neurons in
47 e antibody conjugated to the ribosomal toxin saporin (anti-DH-SAP).
48 body to the serotonin transporter (SERT) and saporin (anti-SERT-SAP; 1 microm) to kill serotonergic n
49           Using ribonuclease A (RNase A) and saporin as two representative cytotoxic proteins, the co
50 rtical infusions of the cholinotoxin 192 IgG-saporin, attenuated the beneficial effects of NMDA on dS
51 pressing mu-opioid receptors with dermorphin-saporin, blocked tactile and thermal hypersensitivity, a
52                               RVM dermorphin-saporin, but not dermorphin or saporin, significantly de
53             RVM microinjection of dermorphin-saporin, but not of dermorphin or saporin, in animals pr
54 log [Sar(9), Met(O(2))(11)] Substance P (SSP-saporin) caused negligible nonspecific damage at the inj
55                          However, hypocretin-saporin completely eliminated hippocampal theta activity
56                               Using an IB(4)-saporin conjugate (IB(4)-SAP), we examined the contribut
57 he neurotoxin saporin (SAP), or the orexin-2-saporin conjugate (OXSAP) in the lateral hypothalamus.
58  region (RTN/Ppy), we injected a substance P-saporin conjugate (SP-SAP; 0.1 pmol in 100 nl) to kill N
59        This ipRGC immunotoxin, consisting of saporin conjugated to a melanopsin polyclonal antibody,
60 ere targeted with a single microinjection of saporin conjugated to the mu-opioid agonist dermorphin;
61 fects of the hypocretin-saporin with another saporin conjugated toxin, 192 IgG-saporin, that lesions
62  (NK1R)-ir and were selectively destroyed by saporin conjugated with an NK1R agonist (SSP-SAP).
63 me inactivation approach through delivery of saporin-conjugated anti-vesicular GABA transporter antib
64                                    We used a saporin-conjugated antibody against CD11b to reduce the
65 blating microglia in the spinal cord using a saporin-conjugated antibody to Mac1, we demonstrate a ca
66 nally transported catecholamine immunotoxin, saporin-conjugated antiserum to dopamine-beta-hydroxylas
67 s triple lesion of these neurons using three saporin-conjugated neurotoxins.
68                       Using HLA-B*14/peptide-saporin-conjugated tetramers, we show that HLA-B*14-EL9
69 th DS (1.0 or 2.0 pmol/200 nl/side) or blank-saporin control (BS, 200 nl/side) into the VTA.
70 cular application of the mitochondrial toxin saporin, coupled to the antibody directed against dopami
71                                 We show that saporin-coupled tetramers can delete islet-specific gluc
72 ning them with antidopamine beta-hydroxylase-saporin (DBH-SAP) injected via the 4th ventricle.
73                                          192-saporin decreased the number of correct choices and incr
74                 Using intrathecal dermorphin-saporin (Derm-sap) to selectively destroy MOR-expressing
75                                      192 IgG-saporin did not affect the total daily amounts but alter
76                            RVM dermorphin or saporin did not alter SNL-induced experimental pain, and
77       RVM dermorphin, saporin, or dermorphin-saporin did not change baseline hindpaw sensitivity to n
78 pressing mu-opioid receptors with dermorphin-saporin did not prevent the onset of SNL-induced tactile
79 ction, we employed the neurotoxin dermorphin-saporin (DS) to selectively lesion VTA GABA neurons prio
80 xylase antibody conjugated to the neurotoxin saporin (DSAP) or saline vehicle was microinjected into
81     The toxin-antibody complex anti-d(beta)h-saporin (DSAP) selectively destroys d(beta)h-containing
82      When 25A11 was coupled to the cytotoxin saporin either directly or via a secondary antibody, bot
83 cells in vitro when coupled to the cytotoxin saporin either directly or via a secondary antibody.
84                                     By 10 d, saporin eliminated staining for choline acetyltransferas
85       One to 12 weeks after injection of SSP-saporin, extracellular electrophysiological field respon
86 njury in rats pretreated with RVM dermorphin-saporin failed to elicit the expected increase in sensit
87 icacy of [Sar(9), Met(O(2))(11)] Substance P-saporin for producing a selective and spatially extensiv
88 ven GABAergic lesions of the MSDB using GAT1-saporin (GAT1-SAP) and examined on spontaneous explorati
89 he selective cholinergic immunotoxin 192 IgG-saporin have demonstrated that lesions of the cholinergi
90 e medial septum had been destroyed by mu P75-saporin, human MGE-like progenitors, but not ventral spi
91                       We used the murine-p75-saporin immunotoxin (mu-p75-sap) to induce selective les
92 R agonist dermorphin conjugated to the toxin saporin in the vicinity of ITC neurons caused a 34% redu
93 dermorphin-saporin, but not of dermorphin or saporin, in animals previously undergoing SNL showed a t
94                                      192 IgG-saporin-induced lesions of basal forebrain cholinergic n
95                                              Saporin-induced septal lesions produced a significant re
96                         Simultaneously, some saporin-injected rats were given implants containing tes
97                               RVM dermorphin-saporin injection prevented the maintenance, but not the
98 atment, SNB motoneurons contralateral to the saporin injection were retrogradely labeled with horsera
99 cortical regions was seen 12 weeks after 192-saporin injection with no further change up to 100-week
100 rvated hippocampus at 4, 8 and 12 weeks post Saporin injection.
101 sterone replacement beginning at the time of saporin injection.
102 ons of the anti-neuronal immunotoxin 192-IgG saporin into either the hippocampus or the cingulate cor
103 ts of intraparenchymal injections of 192 IgG-saporin into either the MS or NB on the organization of
104 fferents as a result of infusions of 192 IgG-saporin into the basal forebrain show persistent impairm
105        Local injections of the neurotoxin SP-saporin into the basolateral amygdala (BLA) are reported
106     Injection of 100, 237.5 or 375 ng of 192-saporin into the medial septum produced dose-related def
107 ections of the selective immunotoxin 192 IgG-saporin into the medial septum/vertical limb of the diag
108 infusing the cholinergic immunotoxin 192 IgG-saporin into the NBM.
109 ion of the specific immunotoxin, anti-p75NTR-saporin into the nucleus basalis.
110           Site-specific injection of IgG 192-saporin is a useful approach to explore the functions of
111                                      192-IgG saporin is an anti-neuronal immunotoxin that combines th
112                      Ricin A-chain (RTA) and saporin-L1 (SAP) catalyze adenosine depurination of 28S
113 imics of small oligonucleotide substrates of saporin-L1 are powerful, slow-onset inhibitors when aden
114 We characterized the catalytic properties of saporin-L1 from Saponaria officinalis (soapwort) leaves,
115                Transition state analogues of saporin-L1 have potential in cancer therapy that employs
116                                              Saporin-L1 inhibition of rabbit reticulocyte translation
117 ave potential in cancer therapy that employs saporin-L1-linked immunotoxins.
118      The present experiments used the 192IgG-saporin lesion model of AD to evaluate the actions of ga
119 misphere and a 192 immunoglobulin G (192IgG)-saporin lesion of cholinergic neurons in the contralater
120 efulness was also not affected in hypocretin-saporin lesioned rats.
121 ceived intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested
122 ctor receptor conjugated to saporin (192 IgG-saporin), lesioned rats were processed simultaneously wi
123 quently, these results support the use of SP-saporin lesions as a useful technique to study the role
124 subgroups in the BLA might be targeted by SP-saporin lesions has not been established.
125 f the nBM cholinergic system through 192 IgG-saporin lesions impairs early acquisition of learning se
126 iments, the performance of rats with 192 IgG-saporin lesions of both hippocampal and neocortical chol
127            Prior studies showed that 192 IgG-saporin lesions of cholinergic input to the hippocampus
128                            Rats with 192 IgG-saporin lesions of the NBM were assessed for perseverati
129     Rats received unilateral sham or 192 IgG-saporin lesions of the NBM.
130                            Rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis (
131                  Rats with bilateral 192 IgG-saporin lesions to all basal forebrain cholinergic nucle
132                  Rats with bilateral 192 IgG-saporin lesions to the nucleus basalis magnocellularis (
133                                    Hence, SP-saporin lesions would ablate all interneurons in the BLA
134 al nerve ligation, and this was abolished by saporin linked anti-p75(NTR) treatment.
135     Others received intrathecal injection of saporin linked to an antibody to the neurotrophin recept
136 the mitotoxin basic fibroblast growth factor-saporin more than 10-fold, thus allowing tumor cell kill
137 d either by microinjecting NPY conjugated to saporin (NPY-SAP) bilaterally into the Arc to kill NPY r
138 ntracerebroventricular injections of 192 IgG-saporin, NPY-immunolabeled neurons in the hilus of the d
139 SI cholinergic lesions, induced with 192 IgG saporin, on behavioral measures of aversive states in ra
140 B(4)-SAP-treated, but not control (saline or saporin only), rats.
141  other protein synthesis inhibitors, such as saporin or cycloheximide.
142 rmance in this task, the immunotoxin 192 IgG-saporin or its vehicle was infused into the area of the
143 uction in cell viability was measured versus saporin or photosensitiser treatment alone.
144 reatment of A549 cells or control cells with saporin or Pseudomonas exotoxin A whose intracellular me
145 wing intraseptal injection of either 192-IgG-saporin or saline, testing began in a battery of behavio
146  activation is not dependent upon reduction (saporin) or only partially dependent upon it (Pseudomona
147                              RVM dermorphin, saporin, or dermorphin-saporin did not change baseline h
148 ifferent between hypocretin-saporin, 192 IgG-saporin, or saline-treated rats.
149 ucleus region was destroyed with substance P-saporin prior to lentivirus injection into the rostral v
150 croinjection of a conjugate of native SP and saporin produced significant nonspecific damage at conce
151 s, although intraseptal injection of 192-IgG-saporin produced similar reductions of ChAT activity, pe
152                              However, the BF-saporin rats were hypersensitive to oxotremorine-induced
153           Intracortical infusions of 192 IgG-saporin reduced basal cortical ACh efflux by 47% of sham
154                                      192 IgG-saporin reduced theta activity, a finding consistent wit
155  septal inputs using the immunotoxin 192 IgG-saporin reduces the number of interneurons containing ne
156     The degree of lesion produced by 192 IgG-saporin relative to controls was compared using three in
157 he selective cholinergic immunotoxin 192 IgG-saporin resulted in a >80% decrease in the number of lar
158  of these neurons by the selective toxin SSP-saporin resulted in a complete disruption of ejaculatory
159 ugation of the sialoside probes to the toxin saporin resulted in toxin uptake and toxin-mediated kill
160  a relatively small concentration of 192 IgG-saporin, resulted in a significant impairment in sustain
161  CD11b and the ribosome-inactivating protein saporin, resulted in reduced microglia staining, reducti
162 l injection of specific cholinotoxin 192-IgG saporin (SAP) +/- intraperitoneal injection of N-[chloro
163 cholaminergic neurons) was done by injecting saporin (SAP) conjugated with a selective NK1R agonist [
164 e produced by bilateral infusions of 192 IgG-saporin (SAP) into the basal forebrain and/or 6-hydroxyd
165                          The plant cytotoxin saporin (SAP) is a potent ribosome-inactivating protein.
166 received injections of 100 or 375 ng 192-IgG saporin (SAP) or artificial CSF (C) into the medial sept
167               Rats were administered 192-IgG saporin (SAP) or vehicle into the medial septum-vertical
168 e, zebrafish Kiss1 peptide was conjugated to saporin (SAP) to selectively inactivate Kiss-R1-expressi
169 forebrain cholinergic neurons by conjugating saporin (SAP), a ribosome-inactivating protein, to a rat
170       A single dose of the immunotoxin, CD45-saporin (SAP), enabled efficient (>90%) engraftment of d
171       Rats were administered saline, 192-IgG saporin (SAP), or kainic acid (KA) into the MSDB and the
172 ry secretion, we injected DSAP, unconjugated saporin (SAP), or saline bilaterally into the paraventri
173 er phosphate-buffered saline, the neurotoxin saporin (SAP), or the orexin-2-saporin conjugate (OXSAP)
174 jugated to the ribosome-inactivating protein saporin (SAP).
175 ing either quisqualic acid (QUIS) or 192 IgG-saporin (SAP).
176 d to the ribosome-inactivating protein (RIP) saporin (SAP).
177 n for neurokinin-3 expressing neurons [NK(3)-saporin (SAP)] into the rat arcuate nucleus.
178 iving intrahippocampal injections of 192 IgG-saporin (SAP-HPC), fimbria-fornix lesions (FF), or sham
179 gated soluble DC-HIL receptor with the toxin saporin (SAP; DC-HIL-SAP) and showed it to bind activate
180                                      192-IgG-saporin selectively destroys cholinergic neurons and ter
181  aged rats, intraseptal injection of 192-IgG-saporin selectively reduced ChAT activity in the hippoca
182                        Rats treated with OX7-saporin showed impaired reacquisition of excitatory cond
183 VM dermorphin-saporin, but not dermorphin or saporin, significantly decreased cells expressing mu-opi
184 he selective cytotoxin conjugate substance P-saporin (SP-SAP).
185     We injected (2 x 100 nl) (a) substance P-saporin (SP-SAP; 1 microm) to kill NK1R-expressing neuro
186 arrier impermeable toxin, stable substance P-saporin (SSP-SAP), which ablates cells expressing NK rec
187                  Injection of the neurotoxin saporin-substance P (SSP-SAP) into the retrotrapezoid nu
188 igands and the ribosome inactivating protein saporin that specifically target Substance P receptor-ex
189 th another saporin conjugated toxin, 192 IgG-saporin, that lesions only the cholinergic neurons in th
190 ed against dopamine beta hydroxylase (DbetaH-saporin), the analgesic and sedative actions of N(2)O we
191 l immunotoxin was constructed by conjugating saporin, the ribosome-inactivating protein toxin, to an
192 e used cholera toxin B-subunit conjugated to saporin to demyelinate the rat lumbar spinal cord, remov
193 th a single RVM microinjection of dermorphin-saporin to eliminate cells that drive descending facilit
194 anti-dopamine-beta-hydroxylase conjugated to saporin to lesion hindbrain catecholamine neurons.
195 tion of sleep drive by administering 192-IgG-saporin to lesion the BF cholinergic neurons and then me
196 ventricular infusions of the immunotoxin OX7-saporin to selectively destroy Purkinje cells throughout
197                                    Targeting saporin to Siglec-8 consistently caused extensive cell d
198                                  We used NMB-saporin to specifically eliminate NMBR-expressing neuron
199 ith the cytotoxin, saporin, using either CCK-saporin to target CCK receptor expressing cells, or derm
200 CCK receptor expressing cells, or dermorphin-saporin to target MOR expressing cells, resulted in conc
201                            For this purpose, saporin toxin conjugated to an antibody against DbH was
202 s of the stria terminalis (BNST), vehicle or saporin toxin conjugated to an antibody against dopamine
203                                 We utilize a saporin toxin conjugated to the hypocretin receptor bind
204 re eliminated by previous infusion of 192IgG-saporin toxin into the medial septum.
205  of either phosphate buffer (PBS) or 192 IgG-saporin (Toxin), 3.6 micrograms rat-1, a cholinergic imm
206 hese multivalent ligands with auristatin and saporin toxins are efficiently internalized via hCD22 re
207  gonadally intact saporin-treated males, and saporin-treated males who had been castrated 6 weeks pre
208 ed in normal control males, gonadally intact saporin-treated males, and saporin-treated males who had
209                                          SSP-saporin-treated rats exhibited relatively normal respons
210 issues from these DLF-lesioned or dermorphin-saporin-treated SNL rats did not exhibit enhanced capsai
211                                       DbetaH-saporin treatment eliminated nearly all of the catechola
212 havioral tests analyzed, intraseptal 192-IgG-saporin treatment had no effect in mature animals.
213                       Ten days after 192 IgG-saporin treatment, ChAT activity decreased to 35-50% of
214                             Four weeks after saporin treatment, SNB motoneurons contralateral to the
215 d cell lesion in the RVM with the cytotoxin, saporin, using either CCK-saporin to target CCK receptor
216              The ribosome-inhibiting protein saporin was conjugated to a Siglec-8-specific antibody t
217 ance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was interna
218 n selective for cholinergic neurons, 192 IgG-saporin, was examined in rats trained to perform 2 versi
219 ntracerebroventricular injections of 192 IgG-saporin were trained on object discrimination problems a
220 e selective cholinergic immunotoxin, 192-IgG-saporin, were investigated in mature (6-month-old) and a
221 he diagonal band of Broca, made with 192 IgG-saporin, were not impaired in acquiring the same olfacto
222 ellar Purkinje cells which are killed by OX7-saporin, were not killed by alpha-DBH-sap.
223 anding specificity against another biotoxin, saporin, which has mechanism of action similar to ricin.
224 -saporin, which is targeted at Thy1, and 192-saporin, which is targeted at the low affinity neurotrop
225                                 They are OX7-saporin, which is targeted at Thy1, and 192-saporin, whi
226    We contrast the effects of the hypocretin-saporin with another saporin conjugated toxin, 192 IgG-s
227               Conjugation of the plant toxin saporin with basic fibroblast growth factor has increase
228 ndicating specific interaction of dermorphin-saporin with the mu-opioid receptor.

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