ライフサイエンスコーパス: sarcoma cell

1 L-4 gag), D5 mouse melanoma, or MCA304 mouse sarcoma cells.

2 sensitizes DOX-induced cell killing in human sarcoma cells.

3 breast cancer cells or KS1767 human Kaposi's sarcoma cells.

4 breast cancer, RKO colon cancer, and SAOS-2 sarcoma cells.

5 l types, including acute leukemia and Kaposi sarcoma cells.

6 he motility stimulation of human soft tissue sarcoma cells.

7 py of metastasis induced by wild-type Ag104A sarcoma cells.

8 t but did not activate apoptosis in p53(-/-) sarcoma cells.

9 antibody conjugated with drugs to kill Ewing sarcoma cells.

10 erence inhibited oncogenic activity in Ewing sarcoma cells.

11 s and metastatic potential of non-epithelial sarcoma cells.

12 lysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells.

13 inhibits the transformed phenotype of Ewing sarcoma cells.

14 also in the differential phenotype of Ewing sarcoma cells.

15 to be critical for proliferation of Ewing's sarcoma cells.

16 nifest growth inhibitory properties in Ewing sarcoma cells.

17 diated nude mice before injection of Ewing's sarcoma cells.

18 and selectively blocks the survival of bone sarcoma cells.

19 derived from the Engelbreth-Holm-Swarm mouse sarcoma cells.

20 Fas ligand could only be detected in Ewing's sarcoma cells after permeabilization.

21 In sarcoma cells alone, peptides corresponding to 39 tyrosi

22 ata from a genome-wide shRNA screen in Ewing sarcoma cells also identified the proteasome as a node o

23 genesis activators and mitogens for Kaposi's sarcoma cells and B cells.

24 ient transfection experiments in rat chondro-sarcoma cells and in NIH-3T3 fibroblasts demonstrated th

25 expression of the flt-4 receptor in Kaposi's sarcoma cells, and double labeling revealed its colocali

26 formation leaves a single EWS allele in the sarcoma cells, and the contribution that the loss of EWS

27 to various subcellular compartments of mouse sarcoma cells, and the resulting cells were tested for p

28 rmine the expression and function of DDX3 in sarcoma cells, and to investigate the antitumor activity

29 We show that mouse and human synovial sarcoma cells are sensitive in vitro to ABT-263, a BH3-p

30 of tumor suppression was validated in Ewing sarcoma cells, B-cell tumors, and human keratinocytes wh

31 93T:A mtDNA in both lung carcinoma and osteo-sarcoma cell backgrounds.

32 r inhibiting its kinase activity in synovial sarcoma cells blocked rapamycin-induced phosphorylation

33 ography) reflects EWS-FLI1 activity in Ewing sarcoma cells both in vitro and in vivo.

34 susceptibility and rejection of transfected sarcoma cells by immunocompetent animals.

35 Induction of apoptosis in Ewing's sarcoma cells by ionizing radiation is accompanied by ac

36 d in primary fibroblasts and U2OS osteogenic sarcoma cells by treatment with small molecule Cdk inhib

37 of the arrest, we generated U2-OS osteogenic sarcoma cell clones in which p16 transcription could be

38 We explored this issue using osteogenic sarcoma cell clones with inducible p16INK4a expression.

39 itro, and genetic silencing of ASNS in mouse sarcoma cells combined with depletion of plasma asparagi

40 mutant mdr1 gene into drug-sensitive MES-SA sarcoma cells confers resistance to both doxorubicin and

41 The introduction of wt p53 into sarcoma cells containing mutant p53 significantly reduce

42 We observed that Ewing sarcoma cells cultured in porous 3D electrospun poly(eps

43 Interestingly, in Ewing sarcoma cells, DKK2 suppression simultaneously increased

44 YB-1 inactivation in human sarcoma cells dramatically reduces G3BP1 and SG formatio

45 gradient accurately, we examined individual sarcoma cells embedded in the O2-controllable hydrogel.

46 therapies, we assessed the tumorigenicity of sarcoma cells expressing combinations of class II, Ii, a

47 similar suppression of apoptosis in Ewing's sarcoma cells expressing EWS-Fli-1 and EWS-erg proteins

48 ells expressing wt p53 compared with CM from sarcoma cells expressing mutant p53.

49 wt p53 compared with CM from human synovial sarcoma cells expressing mutant p53.

50 conditioned medium (CM) from human synovial sarcoma cells expressing wt p53 compared with CM from hu

51 creased when cells were treated with CM from sarcoma cells expressing wt p53 compared with CM from sa

52 Using SYN-1 sarcoma cells, FMSF predominantly stimulated chemotaxis

53 ng PI3K and PKCs is important for protecting sarcoma cells from rapamycin-induced apoptosis.

54 -mediated knockdown of Mekk3 in TC71 Ewing's sarcoma cells had no effect on tumor growth or vessel de

55 including the marked sensitivity of Ewing's sarcoma cells harbouring the EWS (also known as EWSR1)-F

56 the SIRT1/2 inhibitor Tenovin-6 killed Ewing sarcoma cells in vitro and prohibited tumor growth and s

57 killed NGFR-(b)CD- and NGFR-(y)CD-transduced sarcoma cells in vitro through direct and bystander effe

58 rigelTM) by NIH 3T3, mouse fibrosarcoma, and sarcoma cells in vitro, but it has no such effect on lym

59 efficiently killed allogeneic and autologous sarcoma cells in vitro.

60 t with RK-33 was preferentially cytotoxic to sarcoma cells, including chemotherapy-resistant Ewing sa

61 nd it was chemotactic for a variety of human sarcoma cells, including fibrosarcoma, leiomyosarcoma, l

62 somerase IIalpha expression in human Ewing's sarcoma cells, increasing their apoptosis rate and enhan

63 This work extends our previous study(1) that sarcoma cells injected intravenously form intravascular

64 on did not alter the metastatic potential of sarcoma cells injected orthotopically, but the simultane

65 tumors and the differentiation of osteogenic sarcoma cells into mature osteocytes.

66 after intramedullary injection of osteolytic sarcoma cells into the femur, there was extensive bone d

67 report the impact of hypoxic O2 gradients on sarcoma cell invasion and migration.

68 antitumor effect of wt p53 overexpression in sarcoma cells is attributable not only to enhanced cell

69 s is by endocytosis, whereas entry in rat XC sarcoma cells is by surface fusion.

70 c expression of miR-483-5p in IGF2-dependent sarcoma cells is correlated with increased tumorigenesis

71 Rapamycin-induced apoptosis in sarcoma cells is inhibited by insulin-like growth factor

72 WT1 expression in Ewing sarcoma cells is up-regulated by hypoxia.

73 However, in some Kaposi sarcoma cells, KSHV undergoes a productive life cycle an

74 transduction, we engineered a parental human sarcoma cell line (2C4) as well as sarcoma cell lines th

75 osed of a low MDR1-expressing parent uterine sarcoma cell line and a daughter cell line selected for

76 Research has been hampered by limited human sarcoma cell line availability and the large number of S

77 eductase inhibitor lovastatin on the Ewing's sarcoma cell line CHP-100.

78 A variant of the multidrug-resistant human sarcoma cell line Dx5 was derived by co-selection with d

79 Studies of the human myoblast-derived RD sarcoma cell line further demonstrated that TM4SF protei

80 glioblastoma cell line TX3868 and the human sarcoma cell line OsA-CL carry hsrs containing amplified

81 rozygous 3-methylcholanthrene-induced murine sarcoma cell line to CTL immunoselection, selecting for

82 d the growth of a patient-derived clear cell sarcoma cell line whose oncogenic potential is driven by

83 CF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental

84 ultures of live tumor cells (MCA205, a mouse sarcoma cell line), NK cells, DCs, and T cells was asses

85 maintaining Igf2 expression in the synovial sarcoma cell line, and the increased IGF2 synthesis prot

86 d COL11A2 genes are expressed in the Ewing's sarcoma cell line, CADO-ES1.

87 ificantly suppressed the growth of MCA205, a sarcoma cell line, even when treatment was delayed to 7

88 Furthermore, Dicer1 null cells from a sarcoma cell line, though depleted of miRNAs, are compet

89 nt manner, in the MDM2 amplified, SJSA human sarcoma cell line.

90 ected with 5 x 10(6) cells of the A673 human sarcoma cell line.

91 arthritic cartilage as well as by a synovial sarcoma cell line.

92 t not in a comparator KIT+/PKCtheta- Ewing's sarcoma cell line.

93 32 with IC50 = 12 pM against MES SA (uterine sarcoma) cell line and 2 pM against HEK 293T (human embr

94 ed with that in edited 3'-methylcholanthrene sarcoma cell lines (i.e., some unedited cell lines expre

95 Three different human Ewing's sarcoma cell lines (TC71, RD, and A4573) were found to e

96 e associated with resistance to MTX in human sarcoma cell lines and a rat hepatoma cell line.

97 examined global tyrosine phosphorylation in sarcoma cell lines and human tumor samples.

98 of monoclonal antibody (MoAb) 8H9 to Ewing's sarcoma cell lines and normal hematopoietic cells was st

99 mmunoscreen cDNA libraries from two synovial sarcoma cell lines and normal testis, resulting in the i

100 effects of varied anti-angiogenic agents in sarcoma cell lines and tumor models.

101 ed beta-catenin and LGR5 expression in Ewing sarcoma cell lines and tumors and noted marked intra- an

102 mmunizing cell line, but also by independent sarcoma cell lines and untransformed myoblastoid cell li

103 nduced apoptosis, indicating that these bone sarcoma cell lines are dependent on Src activity for sur

104 that selectively inhibit the growth of Ewing sarcoma cell lines by inducing apoptosis.

105 in groups of unedited 3'-methylcholanthrene sarcoma cell lines compared with that in edited 3'-methy

106 he effects of dasatinib in 12 cultured human sarcoma cell lines derived from bone and soft tissue sar

107 been shown to inhibit the growth of Kaposi's sarcoma cell lines in vitro and in immunodeficient mice.

108 ne and in combination with rapamycin against sarcoma cell lines in vitro and xenograft models in vivo

109 ced expression of thrombospondins in Ewing's sarcoma cell lines inhibited the rate of tumor formation

110 ls, we have recently demonstrated that human sarcoma cell lines often inappropriately express high le

111 ASNS silencing in mouse and human sarcoma cell lines reduced the percentage of S phase cel

112 Rescue of BAF47 in BAF47-deficient sarcoma cell lines results in increased genome-wide BAF

113 interaction they identified in which Ewing's sarcoma cell lines showed an increased sensitivity to PA

114 Analysis of synovial sarcoma cell lines showed that either IGF-1R or the PDGF

115 All Ewing's sarcoma cell lines tested expressed Fas on their surface

116 tal human sarcoma cell line (2C4) as well as sarcoma cell lines that are deficient in JAK2 expression

117 describe an induction of apoptosis by p21 in sarcoma cell lines that is p53-independent and can be am

118 1 expression diminished the ability of Ewing sarcoma cell lines to proliferate and form colonies in s

119 ma, we generated stable DDX3-knockdown Ewing sarcoma cell lines using DDX3-specific small hairpin RNA

120 In addition, Ewing's sarcoma cell lines were able to serve as stimulators for

121 Moreover, treatment of Ewing sarcoma cell lines with PF-562271 induced apoptosis and

122 (HeLa, NIH3T3) and homologous cells (Ewing's sarcoma cell lines).

123 expressed on primary osteoblasts, osteogenic sarcoma cell lines, and primary fibroblasts.

124 the most in vitro activity against Kaposi's sarcoma cell lines, was selected for the clinical invest

125 In a panel of seven Ewing's sarcoma cell lines, we found transactivation of a transi

126 Utilizing various sarcoma cell lines, xenografts and human tissue microarr

127 short- and long-term rapamycin treatment in sarcoma cell lines.

128 th and migration across a series of synovial sarcoma cell lines.

129 BL6 murine melanoma and M5076 murine ovarian sarcoma cell lines.

130 class II-negative M12.C3 B lymphoma and Sal sarcoma cell lines.

131 vels, and evaluated cytotoxicity of RK-33 in sarcoma cell lines.

132 d but not wild-type bladder cancer and Ewing sarcoma cell lines.

133 important functional role in pediatric Ewing sarcoma cell lines.

134 mpaired growth and colony formation in Ewing sarcoma cell lines.

135 yses, were performed using CRL-1976 and U2OS sarcoma cell lines.

136 t target gene in human tumor-derived Ewing's sarcoma cell lines.

137 WT1 expression and VEGF expression in Ewing sarcoma cell lines.

138 arked decrease in CASP3 transcripts in Ewing sarcoma cell lines.

139 ctivity at nanomolar concentrations in these sarcoma cell lines.

140 In contrast, in the Ewing's sarcoma cells lovastatin triggered differentiation witho

141 ive tissue matrix from Engelbreth-Holm-Swarm sarcoma cells (Matrigel) modulated their phenotype: alka

142 Asparagine reliance of sarcoma cells may represent a metabolic vulnerability wi

143 Dystrophin inhibits myogenic sarcoma cell migration, invasion, anchorage independence

144 MCA205 (H2b) sarcoma cells mixed with either vIL-10-, mIL-10-, or Zeo

145 We observed that hypoxic gradients guide sarcoma cell motility and matrix remodeling through hypo

146 In Ewing sarcoma cells, NOTCH signaling is abrogated by the drive

147 o advanced bone cancer pain, osteolytic 2472 sarcoma cells or media were injected into the intramedul

148 ediated silencing of USP14 or UCHL5 in Ewing sarcoma cells produced significant growth inhibition.

149 Loss of TNC function in Ewing sarcoma cells profoundly inhibited their migratory and m

150 eting of the molecular networks that support sarcoma cell proliferation.

151 iral G protein-coupled receptor and Kaposi's sarcoma cell proliferation.

152 oteasome as a node of vulnerability in Ewing sarcoma cells, providing orthologous confirmation of the

153 y, depletion of SYT-SSX2 in primary synovial sarcoma cells resulted in loss of nuclear beta-catenin s

154 cycline-inducible expression system in human sarcoma cells (SaOs-2) that lack both functional retinob

155 e dominant-negative form of CBP into Ewing's sarcoma cells sensitizes these cells against genotoxic o

156 ating factors for recently established human sarcoma cell strains.

157 ts indicate that anchorage-independent Ewing sarcoma cells suppress anoikis through a pathway involvi

158 lective cytotoxicity of EA in human synovial sarcoma cells (SW982 cells) and investigated the mechani

159 e tumor cell lines including U2OS osteogenic sarcoma cells, SY5Y neuroblastoma cells, and MCF breast

160 In Ewing's sarcoma cells that express endogenous EWS/Fli-1, this li

161 Sarcoma cells that expressed exogenous ACTG2(R148S) inco

162 We show in human and murine synovial sarcoma cells that SS18-SSX increases BCL2 expression, b

163 mary melanocytes and melanoma and clear cell sarcoma cells through hypoxia inducible factor 1 (HIF1)-

164 EB1, GRHL2 gene regulatory network may drive sarcoma cells to a more epithelial-like state and that t

165 LIP expression significantly increased human sarcoma cells to both FasL-induced and tumor necrosis fa

166 ulted in an increased sensitivity of Ewing's sarcoma cells to chemotherapeutic agents, suggesting a r

167 tly increased the sensitivity of these human sarcoma cells to FasL- and TRAIL-induced apoptosis.

168 Exposure of Ewing's sarcoma cells to lactacystin resulted in accumulation of

169 y exposing 15 expanded populations of MES-SA sarcoma cells to paclitaxel (Taxol) at a concentration o

170 cal compounds for growth inhibition of Ewing sarcoma cells to provide the basis for the development o

171 s revealed a particular sensitivity of Ewing sarcoma cells to the inhibition of poly(ADP-ribose) poly

172 olymerase chain reaction (RT-PCR) in Ewing's sarcoma cell tumour cell lines.

173 b inhibits migration and invasion of diverse sarcoma cell types and selectively blocks the survival o

174 entical target loci present in HT-1080 human sarcoma cells were all successfully corrected by gene ta

175 DDX3-knockdown and RK-33-treated Ewing sarcoma cells were compared with wild-type cells using a

176 Osteolytic sarcoma cells were implanted into the medullary space of

177 n in vivo model where murine osteolytic 2472 sarcoma cells were injected and confined to the intramed

178 DsRed2-labeled 2472 sarcoma cells were placed in Tg/NCD osteoclastogenic cul

179 Murine 2472 (2) sarcoma cells were transduced with fusion genes containi

180 6 mice produced NO-dependent cytotoxicity in sarcoma cells, whereas macrophages from NOS II-/- C57BL/

181 a potent cytotoxic effect on human synovial sarcoma cells which is mediated by heteromeric TRPC4/C1

182 (a) While NIH 3T3, mouse fibrosarcoma, and sarcoma cells, which respond to PLA2-I stimulation, expr

183 s capable of detecting contaminating Ewing's sarcoma cells with a sensitivity of one cell in 10(6) no

184 to tumor regression and replacement of Ewing sarcoma cells with benign fat cells.

185 Treatment of synovial sarcoma cells with dasatinib led to apoptosis and inhibi

186 ed a phenotype that was reminiscent of Ewing sarcoma cells with partial EWS/ETS loss of function.

187 Sarcoma cells with upregulated IFN signaling that show h