ライフサイエンスコーパス: sarcomatoid

1 en malignant mesotheliomas (10 epithelial, 1 sarcomatoid).

2 In the remainder, sarcomatoid and carcinomatous elements shared 42% of som

3 phasic-epithelioid (biphasic-E) and biphasic-sarcomatoid (biphasic-S).

4 cinar cell carcinoma, ductal adenocarcinoma, sarcomatoid carcinoma and neuroendocrine tumors, and all

5 e that developed, which progressed to lethal sarcomatoid carcinoma at approximately 6 months of age.

6 atic, with many characteristics of pulmonary sarcomatoid carcinoma, a neoplasm previously undocumente

7 splay aggressive phenotypes characterized by sarcomatoid carcinomas and metastases, which is presumab

8 thelial to mesenchymal transition in vivo to sarcomatoid carcinomas containing osseous metaplasia.

9 often included under the broader concept of sarcomatoid carcinomas.

10 Patients who have mRCC and sarcomatoid differentiation can demonstrate objective re

11 Metastatic renal cell carcinoma (mRCC) with sarcomatoid differentiation is an aggressive disease tha

12 ear-cell histology and a lower percentage of sarcomatoid differentiation may have better outcomes wit

13 BMPC cancers lacked neuroendocrine or sarcomatoid differentiation, features uncommon in human

14 were reviewed to determine the percentage of sarcomatoid differentiation.

15 Most interestingly, sarcomatoid elements acquired biallelic tumor protein p5

16 otein 1 (BAP1) were significantly mutated in sarcomatoid elements and were mutually exclusive with TP

17 These findings provide evidence that sarcomatoid elements arise from dedifferentiation of car

18 Sarcomatoid elements had a higher overall SSNV burden (m

19 t frequent SSNVs shared by carcinomatous and sarcomatoid elements were in known ccRCC genes including

20 lying clear-cell histology and less than 20% sarcomatoid elements.

21 identified four distinct molecular subtypes: sarcomatoid, epithelioid, biphasic-epithelioid (biphasic

22 The presence of sarcomatoid features in clear cell renal cell carcinoma

23 Patients who had mRCC with sarcomatoid features in the primary tumor and who were t

24 The median percentage of sarcomatoid features was 14% (range, 3% to 90%).

25 patients with epithelial (H2461 and H2591), sarcomatoid (H2373), and biphasic (MSTO-211H) MPM.

26 ORR for patients with Fuhrman grade 4 and/or sarcomatoid histology was 22% (n = 18; 95% CI, 6% to 48%

27 Some RCCs had a sarcomatoid morphology of spindle cells in whorled patte

28 cases, with lower mutation rates observed in sarcomatoid MPM (P < 0.001).

29 Forty-three patients who had sarcomatoid mRCC were identified.

30 patients (78%), including three with either sarcomatoid or biphasic MPM.

31 nce was strongly associated with an EMT-like sarcomatoid phenotype and high expression of the Abcb1b

32 eration, migration, and transition to a more sarcomatoid phenotype in subsets of mesothelioma cell li

33 if harboring pure squamous, adenocarcinoma, sarcomatoid, plasmacytoid, or micropapillary disease.

34 phic giant cells with an immunohistochemical sarcomatoid profile were present in the undifferentiated

35 We report the outcomes of 31 patients with sarcomatoid RCC treated with a combination of surgical r

36 the cases of 31 consecutive patients in whom sarcomatoid RCC was diagnosed between 1990 and 1997.

37 d classification, five chromophobe RCC, five sarcomatoid RCC, two oncocytomas, three transitional cel

38 otherapy may play a role in the treatment of sarcomatoid RCCs in select patients.

39 (i.e., high grade clear cell carcinomas and sarcomatoid renal tumors) show aberrant expression of ca

40 A146T and Q61H mutations in 2 out of 4 (50%) sarcomatoid SDC variants.

41 ied with histological reminiscences to human sarcomatoid SDC variants.

42 e sequencing of matched normal-carcinomatous-sarcomatoid specimens from 21 subjects.

43 elial differentiation (i.e., micropapillary, sarcomatoid, squamous/glandular differentiation, etc.),

44 Escaping tumors contained areas of sarcomatoid transformation with disappearance of CAFs.

45 ariate analysis, age, sex, and percentage of sarcomatoid tumor (< or >50%) did not significantly corr

46 idly and specifically target epithelioid and sarcomatoid tumor cells, demonstrating the potential of

47 Adjusting for age, sex, and percentage of sarcomatoid tumor, the relative risk of death was 10.4 t

48 n of P-glycoprotein could partly resensitize sarcomatoid tumors to the PARP inhibitor olaparib, docet

49 een patients had epithelioid tumors, two had sarcomatoid tumors, and 10 had biphasic tumors.

50 ar cell, mixed granular cell/clear cell, and sarcomatoid types) but also in papillary RCC, a less fre

51 f mesothelioma of both epithelioid (M28) and sarcomatoid (VAMT-1) origins.

52 Sarcomatoid variants of renal cell carcinoma (RCC) are a