ライフサイエンスコーパス: sarcosine

1 ch as N-methyltryptophan or N-methylglycine (sarcosine).

2 ell as N-methylated amino acids (e.g. MeAIB, sarcosine).

3 lytes (proline, sorbitol, sucrose, TMAO, and sarcosine).

4 k cat and a 150-fold decrease in k cat/ K m sarcosine.

5 y, are required for the conversion of DMG to sarcosine.

6 oval of S-adenosylmethionine by synthesis of sarcosine.

7 ne and with the glycine transport inhibitor, sarcosine.

8 LNCaP tumor cells by excess unlabeled (cold) sarcosine.

9 n) (n =1-3), where X is glycine, alanine, or sarcosine.

10 M-) dependent methylation of glycine to form sarcosine.

11 lycine to form S-adenosyl-l-homocysteine and sarcosine.

12 sm of choline, converting dimethylglycine to sarcosine.

13 rs at less than 1% of the rate observed with sarcosine.

14 r emphasis on the reduction of the enzyme by sarcosine.

15 ependent and blocked by the GlyT-1 inhibitor sarcosine.

16 s induced in various bacteria upon growth on sarcosine.

17 thionine-dependent methylation of glycine to sarcosine.

18 et) dependent methylation of glycine to form sarcosine.

19 e-carbon donors such as serine, glycine, and sarcosine.

20 ctive surface capable of binding exclusively sarcosine.

21 o bind to SARDH and to modulate the level of sarcosine.

22 ies equivalent to a premolten globule in 1 M sarcosine.

23 he binding of a radiolabeled agonist ((125)I-sarcosine(1) Ang II) and a radiolabeled antagonist ((125

24 ng II) and a radiolabeled antagonist ((125)I-sarcosine(1), isoleucine(8) Ang II) in brain homogenates

25 -(1-7) competed with low affinity for (125)I-sarcosine(1), isoleucine(8) angiotensin II binding to AT

26 incubated with five concentrations of (125)I-sarcosine(1), isoleucine(8) angiotensin II to assess the

27 ns of choline, betaine, dimethylglycine, and sarcosine (12-46%; P </= 0.08) in both pregnant and nonp

28 unosuppressive analog of cyclosporine (CsA), sarcosine-3(4-methylbenzoate)-CsA (SmBz-CsA), we found a

29 g a k(cat) value (8700 min(-)(1)) similar to sarcosine (7030 min(-)(1)).

30 inhibition of glycine transport with excess sarcosine (a substrate for system Gly) whilst systems A

31 -1 and Capan-2 cells was similar to glycyl-L-sarcosine absorption by Caco-2 cells and a Chinese hamst

32 abidopsis and showed that pipecolate but not sarcosine accumulated 6-fold when AtSOX expression was s

33 The osmolytes, TMAO, betaine, sarcosine, alanine, glycine, and proline to varying degr

34 4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl])sarcosine (ALX 5407), and examined its activity against

35 The GlyT1 transport inhibitors sarcosine, ALX-5407, and Org-24598 were tested and shown

36 nd findings from studies showing efficacy of sarcosine, an endogenous, non-selective glycine-reuptake

37 Sarcosine, an N-methyl derivative of the amino acid glyc

38 Sarcosine, an N-methyl derivative of the amino acid glyc

39 ide to MSOX does not affect the binding of a sarcosine analogue (MTA, methylthioactetate) above the r

40 ppropriate functionalities, for example, the sarcosine analogue 9, were found to retain AMPA (IC50 =

41 rtually mirror images of those observed with sarcosine analogues (N,N'-dimethylglycine, N-benzylglyci

42 hibitors of glycine transport through GlyT1 (sarcosine and (N-[3-(4'-fluorophenyl)-3-(4'-phenylphenox

43 These analogues contained sarcosine and aminocyclopropanoic acid in place of Gly5,

44 studies show that MS-325 can displace dansyl sarcosine and dansyl-L-asparagine from HSA with inhibiti

45 sed by 85%, although formate production from sarcosine and dimethylglycine (choline metabolites) was

46 The structural similarity between sarcosine and glycine led us to hypothesize that sarcosi

47 Exposure to sarcosine and its derivative resulted in an increased co

48 stive sensory materials for the detection of sarcosine and its ethyl ester hydrochloride in water wit

49 Target metabolite analyses of sarcosine and its natural precursors, glycine and cholin

50 reductive half-reaction of ETF catalyzed by sarcosine and medium chain acyl-CoA dehydrogenases which

51 Steady-state kinetic studies with sarcosine and N-methyl-L-alanine in the absence or prese

52 hese materials for the specific detection of sarcosine and related metabolites in biological fluids.

53 n of glycine by S-adenosylmethionine to form sarcosine and S-adenosylhomocysteine.

54 Propionyl-CoA is reacted with sarcosine and the formed N-propionylsarcosine is assayed

55 Turnover with sarcosine and the limiting rate of the reductive half-re

56 effects of urea and the protecting osmolytes sarcosine and TMAO are reported on the thermally unfolde

57 e of protecting osmolytes glycerol, proline, sarcosine and trimethylamine-N-oxide (TMAO).

58 et) to methylate glycine to N-methylglycine (sarcosine) and produces S-adenosylhomocysteine (AdoHcy),

59 ontaining the proposed piezolytes glutamate, sarcosine, and betaine were used, as well as solutions c

60 f one-carbon donors such as serine, glycine, sarcosine, and dimethylglycine.

61 tes the local accumulation of urea, glycine, sarcosine, and glycine betaine and removes the minimum i

62 However, glycine, sarcosine, and glycine betaine are not necessarily local

63 The local accumulation of glycine, sarcosine, and glycine betaine at single strands relativ

64 he cosolutes ethylene glycol, urea, glycine, sarcosine, and glycine betaine at the single-stranded DN

65 concentrations of betaine, dimethylglycine, sarcosine, and methionine (13-55%; P < 0.001).

66 bonds for their maintenance in sodium lauryl sarcosine- and sodium dodecyl sulfate-insoluble complexe

67 tylproline amide) and 4 x 10(5) M(-1) s(-1) (sarcosine anhydride).

68 Other secondary amino acids (e.g., sarcosine) are oxidized at a slower rate.

69 ns of prostate cancer progression, we reveal sarcosine as a potentially important metabolic intermedi

70 Since charge transfer interaction with sarcosine as donor is possible only with the anionic for

71 n Escherichia coli, AtSOX enhanced growth on sarcosine as sole nitrogen source, showing that it has S

72 MSOX probably binds the zwitterionic form of sarcosine, as judged by the spectrally similar complexes

73 The reductive half-reaction with sarcosine at 4 degrees C exhibits saturation kinetics (k

74 The discoveries that sarcosine-based tertiary amides in the context of molecu

75 ilize exogenous sarcosine opportunistically, sarcosine being a common soil metabolite.

76 ng osmolytes, trimethylamine-N-oxide (TMAO), sarcosine, betaine, proline, glycerol, sorbitol, sucrose

77 ture of MSOX and residue conformation in the sarcosine binding cavity are unaffected by replacement o

78 contact with the si face of the flavin ring; sarcosine binds just above the re face.

79 Absorption of the model dipeptide glycyl-L-sarcosine by AsPc-1 and Capan-2 cells was similar to gly

80 atidylethanolamine methyltransferase, and of sarcosine by glycine N-methyltransferase.

81 encode a sarcosine oxidase, are required for sarcosine catabolism.

82 alpha-products was also realized with Co(II)/sarcosine catalyst.

83 The Co(II)/sarcosine catalytic system is shown to perform efficient

84 the reactions proceed via an initial enzyme.sarcosine charge transfer complex and a novel spectral i

85 ults may be due to the fact that alanine and sarcosine coelute on an HPLC reversed-phase column and t

86 at the V/K(O)()2 value is independent of the sarcosine concentration at all accessible concentrations

87 ormation exhibits a hyperbolic dependence on sarcosine concentration with a finite Y-intercept, consi

88 n displays a simple hyperbolic dependence on sarcosine concentration.

89 A sarcosine-containing con-T truncation analog, con-T[1-9/

90 nation of the relative rates of synthesis of sarcosine, creatine, and phosphatidylcholine by rapid me

91 ine or knockdown of the enzyme that leads to sarcosine degradation, sarcosine dehydrogenase, induced

92 d agreement with that observed for rat liver sarcosine dehydrogenase ( approximately 100,000 Da).

93 The predicted mass of the mature human liver sarcosine dehydrogenase (99,505 Da) is in good agreement

94 Sarcosine is then transformed to glycine by sarcosine dehydrogenase (E.C. number 1.5.99.1).

95 ll as hydroxymethylglutaryl-CoA synthase and sarcosine dehydrogenase (SarDH), are S-nitrosylated by N

96 atography and mass spectrometry, we identify sarcosine dehydrogenase (SARDH), the enzyme that convert

97 The sarcosine dehydrogenase and 5,10-methylenetetrahydrofola

98 e demonstrated production of formaldehyde by sarcosine dehydrogenase and dimethylglycine dehydrogenas

99 ogenase exhibits 89% identity with rat liver sarcosine dehydrogenase and strong homology ( approximat

100 Human sarcosine dehydrogenase exhibits 89% identity with rat l

101 mpete with the dimethylglycine dehydrogenase/sarcosine dehydrogenase family for access to electron tr

102 rain libraries, were assembled from the same sarcosine dehydrogenase gene by the use of alternate pol

103 first report of the genomic structure of the sarcosine dehydrogenase gene in any species.

104 The human sarcosine dehydrogenase gene is at least 75.3 kb long an

105 Sarcosine dehydrogenase is a liver mitochondrial matrix

106 A full-length cDNA for human sarcosine dehydrogenase was isolated from an adult liver

107 and porcine dimethylglycine dehydrogenase or sarcosine dehydrogenase were incubated together in the a

108 aminase, fructose-bisphosphatase aldolase B, sarcosine dehydrogenase, and cysteine sulfinic acid deca

109 he enzymes dimethylglycine dehydrogenase and sarcosine dehydrogenase, in which protein-bound tetrahyd

110 enzyme that leads to sarcosine degradation, sarcosine dehydrogenase, induced an invasive phenotype i

111 h rat liver dimethylglycine dehydrogenase, a sarcosine dehydrogenase-related protein from Rhodobacter

112 We developed a sarcosine derivative, (R)-(N-[3-(4'-fluorophenyl)-3-(4'-

113 However, sarcosine differed from glycine because less NMDAR desen

114 ine sarcosine N-methyltransferase (GSMT) and sarcosine dimethylglycine N-methyltransferase.

115 rms a charge transfer Michaelis complex with sarcosine (E-FAD(ox).sarcosine) that exhibits an intense

116 Protein stabilization by sarcosine eliminated the effect of urea and GdmCl on VDA

117 hed in a single step with EDTA and N-lauroyl sarcosine (ES; pH 8.5 to 9.3) incubation at 50 degrees C

118 Condensation of the aldehyde 6 and sarcosine ethyl ester hydrochloride salt gives an interm

119 ve demethylation of dimethylglycine to yield sarcosine, formaldehyde, and hydrogen peroxide.

120 ss spectrometry (LC-MS) method that resolves sarcosine from alanine isomers, allowing its accurate qu

121 h-throughput LC-MS method is able to resolve sarcosine from alpha- and beta-alanine and is useful for

122 cavitand-functionalized MCs to discriminate sarcosine from glycine in water.

123 ethyl transferase, the enzyme that generates sarcosine from glycine, attenuated prostate cancer invas

124 receptor and it was proven able to recognize sarcosine from its nonmethylated precursor, glycine, in

125 The currents evoked by 20 mM glycyl-sarcosine (Gly-Sar) at pH 5.0 were dependent upon membra

126 , and F297C-hPepT1) showed negligible glycyl-sarcosine (gly-sar) uptake activity and may play an impo

127 rbitol), five amino acids (glycine, alanine, sarcosine, glycine betaine, and proline), and urea.

128 s revealed significant stepwise increases of sarcosine, glycine, and choline tissue levels from benig

129 udes the genes encoding GB, dimethylglycine, sarcosine, glycine, and serine catabolic enzymes and the

130 tions of the 2 pathways for the formation of sarcosine (ie, N-methylglycine).

131 s also air-stable but is readily oxidized by sarcosine imine, a reaction accompanied by release of we

132 l observation of increased concentrations of sarcosine in ALF patients.

133 c defect characterized by elevated levels of sarcosine in blood and urine.

134 d beta-alanine and is useful for quantifying sarcosine in serum and urine samples.

135 e ectodomain results in a decreased level of sarcosine in the cells.

136 ealed low levels of pipecolate but almost no sarcosine in wild type Arabidopsis and showed that pipec

137 , glycine and a substrate agonist for GlyT1, sarcosine, induced voltage-dependent inward currents tha

138 homology with monomeric sarcosine oxidase, a sarcosine-inducible enzyme found in many bacteria.

139 as a peroxisomal enzyme in mammals and as a sarcosine-inducible enzyme in soil bacteria.

140 a low level throughout the plant and is not sarcosine-inducible.

141 Sarcosine is a known substrate of proton-coupled amino a

142 Conclusion:(11)C-sarcosine is a novel radiotracer for PATs and shows init

143 osine and glycine led us to hypothesize that sarcosine is also an agonist like glycine.

144 Sarcosine is an amino acid involved in one-carbon metabo

145 We found that sarcosine is an NMDAR co-agonist at the glycine binding

146 esence of tetrahydrofolate, the oxidation of sarcosine is coupled to the formation of 5,10-methylenet

147 The carboxyl group of sarcosine is essential for binding since none is observe

148 The methyl group of sarcosine is not essential but does contribute to bindin

149 The amino group of sarcosine is not essential, but binding affinity depends

150 s C (k(cat) = 24.5 min(-1)), suggesting that sarcosine is oxidized at a kinetically significant rate

151 Sarcosine is then transformed to glycine by sarcosine de

152 ate, a competitive inhibitor with respect to sarcosine, is bound at the FAD site.

153 Sarcosine levels were also increased in invasive prostat

154 Thus, sarcosine may enhance NMDAR function by more than one me

155 ults indicate that the pK(a) of enzyme-bound sarcosine must be considerably lower than the free amino

156 methylation of glycine, catalyzed by glycine sarcosine N-methyltransferase (GSMT) and sarcosine dimet

157 and catalyzes the oxidative demethylation of sarcosine ( N-methylglycine).

158 Sarcosine (N-methylglycine) and beta-alanine were also a

159 hat catalyzes the oxidative demethylation of sarcosine (N-methylglycine) and contains covalently boun

160 OX) catalyzes the oxidative demethylation of sarcosine (N-methylglycine) and contains covalently boun

161 that catalyze the oxidative demethylation of sarcosine (N-methylglycine) and N-methyl-L-tryptophan, r

162 ysteinyl)FAD] and catalyzes the oxidation of sarcosine (N-methylglycine) and other secondary amino ac

163 tly bound FAD and catalyzes the oxidation of sarcosine (N-methylglycine) and other secondary amino ac

164 hat catalyzes the oxidative demethylation of sarcosine (N-methylglycine) to yield glycine, formaldehy

165 elta, 11 kDa) and catalyzes the oxidation of sarcosine (N-methylglycine) to yield hydrogen peroxide,

166 talyzes the oxidation of the methyl group in sarcosine (N-methylglycine).

167 Met-dependent methylation of glycine to form sarcosine (N-methylglycine).

168 lycine generating S-adenosylhomocysteine and sarcosine (N-methylglycine).

169 (4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS)) reduced glycine currents by approximat

170 (4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine [NFPS]) provides a tool for evaluation of the

171 plants and that plants can utilize exogenous sarcosine opportunistically, sarcosine being a common so

172 Addition of exogenous sarcosine or knockdown of the enzyme that leads to sarco

173 n reduced form upon anaerobic reduction with sarcosine or L-proline.

174 aerobic reaction with N-methyl-L-tryptophan, sarcosine, or the carbinolamine formed with L-tryptophan

175 taining peptide from another corynebacterial sarcosine oxidase (C. sp. U-96).

176 glucose oxidase (GOX) (His516) and monomeric sarcosine oxidase (MSOX) (Lys265).

177 Monomeric sarcosine oxidase (MSOX) and N-methyltryptophan oxidase

178 Monomeric sarcosine oxidase (MSOX) and N-methyltryptophan oxidase

179 Monomeric sarcosine oxidase (MSOX) binds the L-proline zwitterion

180 Monomeric sarcosine oxidase (MSOX) catalyzes the oxidation of N-me

181 Monomeric sarcosine oxidase (MSOX) catalyzes the oxidative demethy

182 Monomeric sarcosine oxidase (MSOX) contains covalently bound FAD a

183 Monomeric sarcosine oxidase (MSOX) contains covalently bound FAD a

184 appears to be a new member of the monomeric sarcosine oxidase (MSOX) family of amine oxidizing enzym

185 Monomeric sarcosine oxidase (MSOX) is a flavoenzyme that catalyzes

186 Monomeric sarcosine oxidase (MSOX) is a flavoprotein that contains

187 Monomeric sarcosine oxidase (MSOX) is a prototypical member of a r

188 Monomeric sarcosine oxidase (MSOX) is an inducible bacterial flavo

189 The covalently bound FAD in native monomeric sarcosine oxidase (MSOX) is attached to the protein by a

190 FAD in monomeric sarcosine oxidase (MSOX) is covalently linked to the pro

191 duction and sarcosine oxidation in monomeric sarcosine oxidase (MSOX) occur at separate sites above t

192 ificantly affect the expression of monomeric sarcosine oxidase (MSOX), covalent flavinylation, the ph

193 with reference to the structure of monomeric sarcosine oxidase (MSOX).

194 ymes creatininase (CA), creatinase (CI), and sarcosine oxidase (SOx) and for separating the neutral h

195 Sarcosine oxidase (SOX) is known as a peroxisomal enzyme

196 , large subunit of putative heterotetrameric sarcosine oxidase (SoxA) and glutamine synthetase type I

197 The crystal structure of heterotetrameric sarcosine oxidase (TSOX) from Pseudomonas maltophilia ha

198 Heterotetrameric sarcosine oxidase (TSOX) is a complex bifunctional flavo

199 The reaction of heterotetrameric sarcosine oxidase (TSOX) of Arthrobactor sp. 1-IN has be

200 In situ reconstitution of sarcosine oxidase activity is achieved by assaying apoCy

201 The closest structural relatives of ThiO are sarcosine oxidase and d-amino acid oxidase.

202 Biosensors based on lactate oxidase, sarcosine oxidase and mixture of fumarase and sarcosine

203 ed for the covalently bound FAD in monomeric sarcosine oxidase and N-methyltryptophan oxidase, enzyme

204 Heterotetrameric (alphabetagammadelta) sarcosine oxidase from Corynebacterium sp. P-1 (cTSOX) c

205 Sarcosine oxidase from Corynebacterium sp. P-1 is a hete

206 Sarcosine oxidase from Corynebacterium sp. P-1 is a hete

207 amadoriase I has 22% homology with monomeric sarcosine oxidase in which FAD is also linked to a homol

208 Monomeric sarcosine oxidase is a flavoenzyme that catalyzes the ox

209 ha-(N3-histidyl)FMN found in corynebacterial sarcosine oxidase represents a novel type of covalent fl

210 arcosine oxidase and mixture of fumarase and sarcosine oxidase were used for monitoring of organic ac

211 ultienzyme system (creatininase, creatinase, sarcosine oxidase) is immobilized on top of the permsele

212 asis of its sequence homology with monomeric sarcosine oxidase, a sarcosine-inducible enzyme found in

213 hat the soxBDAG genes, predicted to encode a sarcosine oxidase, are required for sarcosine catabolism

214 gy that is most similar to that of monomeric sarcosine oxidase.

215 ygen-unreactive FAD site in heterotetrameric sarcosine oxidase.

216 subunit of TSOX is very similar to monomeric sarcosine oxidase.

217 und FAD and NAD+, similar to corynebacterial sarcosine oxidase.

218 In contrast, two monomeric sarcosine oxidases (from Bacillus sp. and an unidentifie

219 Studies with sarcosine oxidases from Arthrobacter sp. and Pseudomonas

220 causes only a modest decrease in the rate of sarcosine oxidation (9.0- or 3.8-fold, respectively), as

221 Significantly, the active sites for sarcosine oxidation and oxygen reduction are located on

222 Oxygen reduction and sarcosine oxidation in monomeric sarcosine oxidase (MSOX

223 The 15(kcat/Km) kinetic isotope effect for sarcosine oxidation is pH-dependent with a limiting valu

224 ransfer between the noncovalent FAD (site of sarcosine oxidation) and the covalent FMN (site of enzym

225 No redox intermediate is detectable during sarcosine oxidation, as judged by the isosbestic spectra

226 t is one of several plausible mechanisms for sarcosine oxidation.

227 role for His45 in covalent flavinylation or sarcosine oxidation.

228 t that Arg49 also plays an important role in sarcosine oxidation.

229 (P = 0.041), a higher urinary enrichment of sarcosine (P = 0.041), and a greater plasma enrichment r

230 duct coordinately regulate components of the sarcosine pathway.

231 background ratios (TBRs) obtained from (11)C-sarcosine PET were significantly elevated compared with

232 -3 and LNCaP tumor cells and performed (11)C-sarcosine PET with CT in the first human subject with lo

233 (11)C-sarcosine produced high-contrast images in 1 case of loc

234 cular approach for the specific detection of sarcosine, recently linked to the occurrence of aggressi

235 GlyT1 inhibitors ALX 5407 and sarcosine reduced total glycine uptake to 80% whereas th

236 Decarboxylation of the amino acid sarcosine resulted in the accumulation of significant co

237 only approximately 10% of CF recovery while sarcosine (SAR) showed insignificant effects.

238 Through combined alanine, proline, and sarcosine scans coupled with a competitive fluorescence

239 nic acid, ornithine, phenylalanine, proline, sarcosine, serine, threonine, tryptophan, tyrosine, and

240 mples from 42 subjects were used to evaluate sarcosine serum/urine correlation.

241 (11)C-sarcosine showed a favorable radiation dosimetry with an

242 the presence and absence of 6 M urea or 1 M sarcosine solution is sufficient to allow large changes

243 panel of 4(P) variants containing alanine or sarcosine substitutions along the putative alpha- or PPI

244 protecting osmolytes trimethylamine N-oxide, sarcosine, sucrose, and proline and the nonprotecting os

245 diated autaptic currents decayed faster with sarcosine suggesting that NMDAR deactivation also differ

246 blocked by the GlyT1 inhibitors ALX 5407 and sarcosine, suggesting that the high-affinity glycine upt

247 use less NMDAR desensitization occurred with sarcosine than with glycine as the co-agonist.

248 following NMDAR activation were larger with sarcosine than with glycine.

249 g larger when NMDAR activation occurred with sarcosine than with glycine.

250 steady-state kinetic patterns obtained with sarcosine that are consistent with a rapid equilibrium o

251 Michaelis complex with sarcosine (E-FAD(ox).sarcosine) that exhibits an intense long-wavelength abso

252 -carbon of serine and the N-methyl carbon of sarcosine to formate without the addition of any other c

253 plantlets slowly metabolized supplied [(14)C]sarcosine to glycine and serine.

254 ydrogenase (SARDH), the enzyme that converts sarcosine to glycine, as a TMEFF2-interacting protein.

255 combinant protein catalyzed the oxidation of sarcosine to glycine, formaldehyde, and H(2) O(2) in vit

256 course observed for conversion of E-FAD(ox).sarcosine to reduced enzyme at 25 or 5 degrees C.

257 in part by the ability of N-methyl glycine (sarcosine) to competitively inhibit glycine transport.

258 We characterized (11)C-sarcosine transport in PC-3 and LNCaP tumor cells and pe

259 rboxylic acid, competitively inhibited (11)C-sarcosine tumor cell uptake, confirming PAT-mediated tra

260 In vitro assays indicated blockage of (11)C-sarcosine uptake into PC-3 and LNCaP tumor cells by exce

261 rization of the kinetics of FAD reduction by sarcosine using stopped-flow methods.

262 and PC-3 tumors (TBR: 1.89 +/- 0.2 for (11)C-sarcosine vs. 1.34 +/- 0.16 for (11)C-choline [n = 7; P

263 line in DU-145 (TBR: 1.92 +/- 0.11 for (11)C-sarcosine vs. 1.41 +/- 0.13 for (11)C-choline [n = 10; P

264 Sarcosine was discovered to be an excellent ligand for c

265 Vmax for apical uptake of [14C]glycyl-[14C]sarcosine was increased 1.64 (+/- 0.34)-fold after incub

266 While sarcosine was recently identified as a potential urine b

267 Methods:(11)C-radiolabeled sarcosine was tested as a new PET imaging probe in compa

268 c properties of MTOX with the slow substrate sarcosine were determined.

269 V), and employ a tertiary amide derived from sarcosine, which aids in membrane localization and simul

270 ynergistic effect has also been observed for sarcosine, which can form hemiaminals but not imines.

271 an and other N-methyl amino acids, including sarcosine, which is a poor substrate.