ライフサイエンスコーパス: satellite DNA

1 were predominantly recovered near regions of satellite DNA.

2 much more recent concerted evolution of this satellite DNA.

3 ification is not a general property of alpha-satellite DNA.

4 C/EBP consensus-binding sites in centromeric satellite DNA.

5 at binds to the 17-bp DNA sequences on alpha-satellite DNA.

6 s colocalize with foci of heavily methylated satellite DNA.

7 arker chromosomes that lack detectable alpha-satellite DNA.

8 pancentromeric nor chromosome-specific alpha-satellite DNA.

9 ypes is accompanied by a loss of centromeric satellite DNA.

10 haracterized by distinct haplotypes of alpha satellite DNA.

11 ranslocations retain ribosomal genes or beta-satellite DNA.

12 in Alu repeats and in heterochromatic alpha-satellite DNA.

13 lly coincident with diverse subsets of alpha satellite DNA.

14 reas Rsp is a large pericentromeric block of satellite DNA.

15 ional de-repression of the tandemly repeated satellite DNA.

16 human neocentromere lacking repetitive alpha-satellite DNA.

17 centromeres in platypus are not enriched in satellite DNA.

18 rge ( 2 Mb) centromeres are not dominated by satellite DNA.

19 including postmitotic bridges enriched with satellite DNA.

20 tely the same rate as the adjacent non-alpha-satellite DNA.

21 ricentromeric sequence to higher-order alpha-satellite DNA.

22 some, which is comprised of repetitive alpha satellite DNA.

23 to C/EBP regulatory elements in centromeric satellite DNA.

24 ndogenous C/EBP beta from 3T3-F442A cells to satellite DNA.

25 cation of late-replicating sequences such as satellite DNAs.

26 organized nucleoli, ribosomal DNA (rDNA) and satellite DNAs.

27 cified by structural features of centromeric satellite DNA [1-3] or by specific DNA sequences, analog

28 e-specific nucleosomes are enriched in alpha-satellite DNA [8].

29 ximately 8.4% (31 kb) of the highly repeated satellite DNA (AATAT and TTCTC) was sequenced, represent

30 In MEL cells, this gamma-satellite DNA activity depends on binding of Ikaros prot

31 cleosome reconstitution studies, human alpha-satellite DNA and Lytechinus variegatus 5S DNA, and find

32 atin states, because both higher-order alpha-satellite DNA and noncentromeric DNA were enriched for m

33 n discontinuous blocks of higher-order alpha-satellite DNA and noncentromeric DNA.

34 bundance, and variation of highly repetitive satellite DNA and presents approaches to understand thei

35 omeres (ENC) are composed of large arrays of satellite DNA and surrounded by segmental duplications.

36 e immediately flanking the centromeric alpha-satellite DNA and the other targeted to the zinc finger

37 these chromosomes confirm the lack of alpha-satellite DNA and the presence of CENtromere proteins (C

38 oss of transcription of the underlying alpha-satellite DNA and to no longer efficiently recruit HJURP

39 es well and contains mouse centromeric minor satellite DNA and variable amounts of major satellite DN

40 s suggest a common origin of the Tetragnatha satellite DNAs and evolutionary constraint in the length

41 h for their characteristic repeat sequences (satellite DNA) and for being epigenetically defined.

42 fruit fly Drosophila melanogaster shows that satellite DNA, and corresponding small non-coding RNA, h

43 e.g. GAATG, classical satellites e.g. alpha satellite DNA, and locus specific VNTR arrays.

44 with neocentromeres lacking detectable alpha-satellite DNA, and the lack of CENP-A association with a

45 embled genomic regions enriched with complex satellite DNA, and we further demonstrate the utility of

46 Satellite DNAs are known for an unusual and nonuniform e

47 ear microchromosomes contain exogenous alpha satellite DNA, are mitotically and cytogenetically stabl

48 ast centromeres, interspersed in centromeric satellite DNA arrays [4,5].

49 We show that human gamma-satellite DNA arrays allow a transcriptionally permissiv

50 intenance and/or organization of centromeric satellite DNA arrays rather than a more direct involveme

51 Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome sp

52 are defined by megabases of homogenous alpha-satellite DNA arrays that are packaged into specialized

53 In addition, satellite DNA as a nuclear marker suggests that hybridiz

54 Recent studies have implicated alpha-satellite DNA as an integral part of the centromere, imp

55 C/EBP alpha (p42 and p30 forms) can bind to satellite DNA as homo- or heterocomplexes in vitro.

56 O-2 or the SUMO E2 ligase Ubc9 reduces alpha-satellite DNA association with nucleoli.

57 At least for such marker chromosomes, alpha-satellite DNA at levels detectable by FISH appears unnec

58 nd Prod shift from low affinity sites within satellite DNA back to euchromatic sites as a self-assemb

59 ne cells, during nurse cell growth the major satellite DNAs become highly under-represented by a mech

60 n little recombination and homogenization of satellite DNA between these two sets of centromeres.

61 In both cases the loss of alpha-satellite DNA binding coincided with an elevation in the

62 role of RNAPII in the transcription of alpha-satellite DNA, binding of centromere protein C, and the

63 We have constructed a fluorescent alpha-satellite DNA-binding protein to explore the motile and

64 During mitosis in Drosophila, satellite DNA binds proteins that, during interphase, bi

65 focus corresponds to an unusual decondensed satellite DNA block, and both active genes and the XNP f

66 ally within an island are well resolved with satellite DNA but much less so with mtDNA.

67 nto C/EBPalpha that reduces binding to alpha-satellite DNA but permits normal binding to sites in som

68 is responsible for the production of a small satellite DNA called msDNA.

69 e transcriptases (RT) to synthesize peculiar satellite DNAs called multicopy single-stranded DNA (msD

70 Ectopic expression of satellite DNA can phenocopy BRCA1 loss in centrosome amp

71 ts demonstrate for the first time that alpha-satellite DNA can seed de novo centromeres in human cell

72 specialized chromatin that consists of alpha satellite DNA complexed with epigenetically modified his

73 sequencing to analyze cmDNA and showed that satellite DNAs consisting of both of simple (CCATT)(N) r

74 B1 and B2, both strands of near-centromeric satellite DNAs consisting of tandem repeats, and multipl

75 The study also reveals gain-loss of satellite DNA copies during species diversification.

76 Satellite DNA de-repression was also observed in mouse a

77 orphometric analysis revealed that the alpha-satellite DNA domain bound by CENPB-GFP becomes elongate

78 fferent heterochromatic properties appear on satellite DNA during successive embryonic division cycle

79 long-range physical map of centromeric alpha-satellite DNA (DXZ1) by pulsed-field gel analysis, as we

80 Here, we have used two kinds of alpha satellite DNA, DXZ1 (from the X chromosome) and D17Z1 (f

81 sample and it mapped to a highly repetitive satellite DNA element on chromosome 1.

82 Adding to their interest, satellite DNA elements evolve at high rates; among Droso

83 Tandemly repeating satellite DNA elements in heterochromatin occupy a subst

84 in the light of current life-cycle models of satellite-DNA evolution.

85 Because satellite DNAs evolve in a concerted manner, we use thes

86 of satellite repeats and identified 12 novel satellite DNA families.

87 SarkOne is a genus-specific satellite-DNA family, isolated from the genomes of the s

88 In this paper we use satellite DNAs for phylogenetic analysis of a rapidly ev

89 linking of linearized PACs containing alpha satellite DNA from chromosomes X and 17 with sizes of 12

90 ey possess regions of sequence similarity to satellite DNA from several bivalve species.

91 the major centromeric repetitive DNA, alpha-satellite DNA, has been extensively sequenced and shown

92 mitotically stable chromosomes lacking alpha-satellite DNA have been reported.

93 While several types of alpha satellite DNA have been used to assemble de novo centrom

94 CENP-A nucleosomes contain centromeric alpha satellite DNA, have equimolar amounts of H2A, H2B, CENP-

95 Cancer-linked satellite DNA hypomethylation was independent of RNA lev

96 d DNMT3B deficiency causing juxtacentromeric satellite DNA hypomethylation.

97 underreplication we estimated the amount of satellite DNA in each of these species.

98 Here, replication of alpha-satellite DNA in endogenous human centromeric regions an

99 eviously been profiled and the role of alpha-satellite DNA in initiation of DNA replication has not y

100 Given our discovery of gamma-satellite DNA in pericentromeric regions of most human c

101 An insertion of heterochromatic satellite DNA in the euchromatic brown (bw) gene of Dros

102 made up of highly repetitive DNA sequences (satellite DNA) interspersed with middle repetitive DNA s

103 demonstrate for the first time that complex satellite DNA is a structural component of the kinetocho

104 g to the concerted-evolution pattern of this satellite DNA is a time-dependent process by which new m

105 Satellite DNA is an enigmatic component of genomic DNA w

106 This satellite DNA is composed of repeats with a consensus le

107 Further, because complex satellite DNA is evolutionarily unconserved, these resul

108 The overwhelming majority (97%) of alpha-satellite DNA is found to be assembled with histone H3.1

109 Classical satellite DNA is normally heavily methylated at cytosine

110 which is composed exclusively of centromeric satellite DNA, is hypomethylated compared with the peric

111 structures in simple and complex centromeric satellite DNAs leads us to suggest that these centromeri

112 yielded infections with significantly higher satellite DNA levels.

113 mon ancestor forming what has been called a 'satellite DNA library'.

114 omprise megabase-size arrays of 171 bp alpha-satellite DNA monomers.

115 Two rDNAs and a satellite DNA (PaB6) from regular chromosomes were mappe

116 consists of higher-order repeat (HOR) alpha-satellite DNA packaged into two chromatin domains: the k

117 The satellite DNA present in heterochromatin contains multip

118 lutionary studies indicate that, while alpha satellite DNA present throughout the pericentromeric reg

119 ion, cycE01672, that increases the amount of satellite DNA propagated in nurse cells.

120 BRCA1 binds to satellite DNA regions and ubiquitylates H2A in vivo.

121 osophila contain multi-megabase stretches of satellite DNA repeats and a handful of protein-coding ge

122 egabase chromosomal regions containing alpha-satellite DNA repeats, which contain binding sites for t

123 intain integrity of the long arrays of alpha-satellite DNA repeats.

124 heir natural location, we suggest that gamma-satellite DNA represents a unique region of the function

125 to a 17 bp CENP-B box motif common to alpha-satellite DNA, resulted in enrichment of alpha-satellite

126 Highly repetitive satellite DNA (satDNA) repeats are found in most eukaryo

127 of about 158 bp and 312 bp are organized as satellite DNAs (Sau3A satellites I and II), whereas the

128 The Rsp locus comprises repeated copies of a satellite DNA sequence and Rsp copy number correlates wi

129 resenting the largest data set of Drosophila satellite DNA sequence to date.

130 obes, specific for human chromosome 17 alpha satellite DNA sequence variants, that distinguish cytoge

131 Highly repetitive satellite DNA sequences are main components of heterochr

132 We conclude that satellite DNA sequences may potentially be very useful f

133 The present study characterizes the satellite DNA sequences of three endemic Hawaiian spider

134 with primary localization to certain AT-rich satellite DNA sequences within heterochromatin.

135 nd two nuclear markers and that deduced from satellite DNA (stDNA) sequences suggests that the differ

136 tionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may

137 of 404 kb encompassing long tracts of alpha satellite DNA, telomeric sequences, and the human hypoxa

138 atogenesis, the maintenance and evolution of satellite DNAs, the possible roles of small interfering

139 ation and sites of array transition into non-satellite DNA, typically defined by transposable element

140 common bean (Phaseolus vulgaris) centromeric satellite DNA using genomic data, fluorescence in situ h

141 The reduction in C/EBPalpha binding to alpha-satellite DNA was induced by the co-expression of the tr

142 This YAC, which also included non-alpha satellite DNA, was modified to contain human telomeric D

143 the normal functioning centromere and alpha-satellite DNA, we have studied eight accessory marker ch

144 satellite DNA and variable amounts of major satellite DNA which probably comprise the functional cen

145 unusually low abundance of highly repetitive satellite DNA, which allowed us to determine its sequenc

146 ducing C/EBPalpha binding to the major alpha-satellite DNA, which elevated the concentration of C/EBP

147 meres are composed of tandem arrays of alpha-satellite DNA, which spans up to several megabases.

148 s of near-identical tandem repeats, known as satellite DNAs, which offer a limited number of variant

149 have combined long synthetic arrays of alpha satellite DNA with telomeric DNA and genomic DNA to gene

150 ppressive effect of co-injecting mouse alpha satellite DNA with the transgene.

151 defined by uninterrupted higher-order alpha-satellite DNA, with human artificial chromosomes that co

152 ting the rapid divergence of the centromeric satellite DNA within the Glycine genus.

153 uced by mtDNA and allozymes, except that the satellite DNA yields much longer branches, with higher l