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1 ical addition of proteins to a ribosomal RNA scaffold.
2 time response through engineered sub-micron scaffold.
3 l marine natural product bromophycoic acid E scaffold.
4 nic semiconductors was assembled using a DNA scaffold.
5 ors, with a specific focus on Gravin, a PLK1 scaffold.
6 ed into a sunflower trypsin inhibitor cyclic scaffold.
7 rapid and modular access to this privileged scaffold.
8 rt2 inhibitors based on the 1,2,4-oxadiazole scaffold.
9 mily) are derived from the C7 epimer of this scaffold.
10 )8 barrel as an inherently evolvable protein scaffold.
11 0 = 0.21 muM, selectivity index (SI) 40) and scaffold.
12 ne, an alkaloid with a structurally distinct scaffold.
13 ary vasculature in a decellularized rat lung scaffold.
14 he 5,7-trans-fused bicyclic pseudolaratriene scaffold.
15 on the hydroxyl groups of the tartaric acid scaffold.
16 radial manner from a minimal flavin-binding scaffold.
17 rmeable membranes that serve as a structural scaffold.
18 residues, despite sharing a common morphinan scaffold.
19 s using N-[3-(2-pyridinyl) phenyl] benzamide scaffold.
20 ne cells, and constructing immune-modulating scaffolds.
21 been limited to cyclopentadienyl (Cp) based scaffolds.
22 lysis of multiple assemblies of the same set scaffolds.
23 assemble 3D crystals to be used as molecular scaffolds.
24 unctional groups inserted within fluorophore scaffolds.
25 ogy has been applied to medicinally relevant scaffolds.
26 en spunbonded poly(l-lactic acid) fiber mesh scaffolds.
27 ructurally and sequentially distinct protein scaffolds.
28 arsenal of synthetic methods to obtain such scaffolds.
29 led from iron and cysteine sulfur on protein scaffolds.
30 ero-vesicle assemblies with complex DNA nano-scaffolds.
31 after the introduction of cadaveric biologic scaffolds.
32 on of saturated bicyclic and tricyclic amine scaffolds.
33 rnished the desired trisubstituted imidazole scaffolds.
34 the inner and outer regions of the biphasic scaffolds.
35 re coumarin- and chomone-3-phenylcarboxamide scaffolds.
36 catalytic use in preparing complex synthetic scaffolds.
37 ration of the peptide assemblies into tissue scaffolds.
38 otentials based on conjugated, light element scaffolds.
39 laps on which a new cell-wall segment can be scaffolded.
41 structure-activity relationship (SAR) of the scaffold 1, we synthesized 14 analogs of compound 1 whic
43 ind that ARPP-16 interacts directly with the scaffolding A subunit of the serine/threonine protein ph
45 tion (ORR) catalyzed by a cofacial porphyrin scaffold accessed in high yield (overall 53%) using coor
47 reparatory period for stem cell seeding on a scaffold and relatively invasive procedures for stem cel
48 (KOP) receptor featuring a diphenethylamine scaffold and showed the promise of these ligands as effe
49 y, HUVEC cells naturally migrated in the ECM scaffold and spontaneously repopulated the lining of dec
50 rovide novel Sirt2 inhibitors with a compact scaffold and structural insights for further inhibitor i
51 applied to a new conformationally controlled scaffold and synthesized to accurately evaluate pairwise
53 en the patients who received a bioresorbable scaffold and the patients who received a metallic stent.
54 ed in firm integrin-mediated adhesion to the scaffold and well-stratified epithelial constructs, with
55 esults indicate that the respective roles of scaffolding and coat proteins may have been redistribute
59 ity ratio of Raman bands associated with the scaffolds and HA with the spatial offset depended on the
62 for virion morphogenesis, release of the D13 scaffold, and the association of EFC proteins with viral
63 id kinase catalytic subunit VPS34, the VPS15 scaffold, and the regulatory BECN1 and ATG14 subunits.
64 fate and anthocyanin were preloaded in CaCO3 scaffold, and then microcapsules were created by coating
65 olds than these of CM/nHA-AL and PLLA/nHA/AL scaffolds, and the mechanical and degradation properties
68 sphorylated protein 1 (Cat-1) is a signaling scaffold as well as an ADP-ribosylation factor-GTPase-ac
69 ing the way to exploiting these new coumarin scaffolds as caging groups that can be removed with visi
70 nes derived from readily available terpenoid scaffolds as efficient multifunctional reagents for the
71 the ascorbic acid units within the hydrogel scaffold; as a consequence, the hydrogel framework colla
72 ods is beneficial both for the developers of scaffold assembly algorithms and for the researchers foc
74 re exist numerous methods and techniques for scaffold assembly, identifying similarities and dissimil
77 of everolimus-eluting bioresorbable vascular scaffolds (BVS) compared with everolimus-eluting stents
78 cal [AMA]) to Absorb (bioresorbable vascular scaffold [BVS]) using different experimental models.
83 nce that PSI confinements in synthetic lipid scaffolds can be used for tuning the photoexcitation cha
84 dation site-selectivity, in which the enzyme scaffold causes a specific C-H bond to be functionalized
89 ble nonsteroidal antiandrogens show a common scaffold consisting of two aromatic rings connected by a
91 eds compared to wounds treated with chitosan scaffolds containing control DNA or wounded controls.
94 fficient access to unprecedented spirocyclic scaffolds containing up to five stereocenters with high
95 medicinal chemistry on the compounds' basic scaffold could enhance the potency and selectivity for A
97 engineering intestine on vascularized native scaffolds could bridge the gap between cell/tissue-scale
98 G-protein complex (STE4), the pheromone MAPK scaffold (CST5), and the two terminal MAP kinases (CEK1/
104 blocked CAV1 phosphorylation induced by CAV1 scaffolding domain, indicating that CAV1 interaction wit
105 annulated thiophene/furan-based heterocyclic scaffolds (e.g., 4,5-dihydro-6H-thieno[2,3-c]pyrrol-6-on
106 equence remains highly fragmented, dozens of scaffolds encompassing more than one mapped gene were id
107 te epoxidation on opposite faces of the ring scaffold, evidence of competitive epoxidation pathways,
108 ta from ChEMBL20 to examine the evolution of scaffold features, such as enumerated compounds, biologi
109 ected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider o
110 he inorganic benzene as a versatile aromatic scaffold for engineering of molecular materials with tai
111 to the role of RG cells to provide a stable scaffold for neuronal migration, and suggest that the tr
113 odes filamin C-a protein that acts as both a scaffold for the assembly and organization of the centra
114 factors, and implicate Jmjd2c as a molecular scaffold for the assembly of essential enhancer-protein
119 otential applicability to the fabrication of scaffolds for cell culture, reconfigurable microfluidic
120 ed the promising application of CM-ALs (10%) scaffolds for drug delivery and bone tissue engineering.
122 this end, incorporation of suitable protein scaffolds for PSI incorporation is of great scientific a
123 dence from recent studies implicate that the scaffolding function of enzymes could be as important in
124 ost potent sweeteners combines a hydrophobic scaffold functionalized by a limited number of hydrogen
126 ce thrombosis occurred in 31 patients in the scaffold group as compared with 8 patients in the stent
129 ved great attention, and different molecular scaffolds have been selected to target CB2R subtypes.
130 tight control over pore sizes, inverse opal scaffolds have found widespread use in biomedical applic
132 y model with excitons localized on the arene scaffold, here generalized to Cn symmetry, accurately de
134 l investigational agent pretomanid (PA-824), scaffold hopping from delamanid inspired the discovery o
135 tual prevalence of pharmacophore methods for scaffold hopping, a variety of computational approaches
136 -stacks) of stained cells and three types of scaffolds (i.e., spun coat, large microfiber, and medium
137 pared with the Absorb bioresorbable vascular scaffold in an ex vivo porcine arteriovenous shunt model
138 rrounded by other side chains in the protein scaffold in biology, which may alter the apparent DeltaD
139 -pull chromophores based on a novel coumarin scaffold in which the carbonyl of the lactone function o
141 amide analogues relative to a common warhead scaffold, in both noncovalent and covalent binding state
142 correlated, we find that there are apparent scaffold induced changes in DeltaDeltaGsc(o) for more th
143 kinase at DNA lesions; however, the putative scaffold interactions involving the N-terminal BRCT doma
144 ded native de-cellularized rat parotid gland scaffolds into the renal capsule of nude mice led to the
146 Fs to the core SKP1-CUL1-F box protein (SCF) scaffold is facilitated by light signals or PIF3 phospho
148 otic genomes; however, at present additional scaffolding is needed to achieve chromosome-level assemb
149 ns and reactions have evolved from ancestral scaffolds is fundamental to understanding chemical and e
150 ent of new antibiotics around proven natural scaffolds is the best short-term solution to the rising
151 yde Probe 573 (FAP573), based on a resorufin scaffold, is the most red-shifted and FA sensitive in th
154 le of interrogating high quality and diverse scaffold libraries with verifiable folding and stability
155 ion in turning gene expression on or off and scaffold-like properties for protein and small molecule
157 ury (SCI), we demonstrated that the tailored scaffolding maintained hMSC stemness, engraftment, and l
159 ially problematic, since prior immunity to a scaffold may inhibit immune responses to the antigen-sca
161 nd fidelity, and hCMPs fabricated with these scaffolds may significantly improve recovery from ischem
166 ssembly represents >78% of the genome with a scaffold N50 of 88.8 kb that has a high fidelity to the
167 mprovements, and examined the effect of gRNA scaffold, number of gRNAs per gene and number of replica
168 phron portions of renal extracellular matrix scaffolds obtained after decellularization of human rena
174 sue engineering, autofluorescence of polymer scaffolds often lowers the image contrast, making it dif
176 arget binding by (a) truncating the original scaffold or (b) introducing a hydrophilic group to inter
180 ial pi-pi and C-H...pi interactions within a scaffold organized by multiple hydrogen bonds dictate st
181 residing at the plasma membrane in neurons, scaffolds PKA to target proteins to mediate downstream s
183 designed with 3D printing, and indicate that scaffold pore architecture is a critical variable in add
187 espectively, of the AMPA-receptor regulatory scaffold protein A-kinase anchoring protein (AKAP) 79/15
188 ctor receptor-associated factor 2 (TRAF2), a scaffold protein and E3 ubiquitin ligase important for i
189 1 to double-strand breaks (DSBs) through the scaffold protein CCDC98 (Abraxas) and facilitates DNA da
190 ransmembrane protein A17 and the capsid-like scaffold protein D13 was sufficient to form similar ER-a
191 esolution the distribution of the inhibitory scaffold protein gephyrin in response to protocols induc
193 yndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters
194 The abnormal particles retained the D13 scaffold protein of immature virions, were severely defi
197 nstructed truncated versions of the membrane scaffold protein, allowing the preparation of a range of
198 IGF-I receptor signals through an alternate scaffold protein, SHPS-1, resulting in pathophysiologic
201 bstitutions ranged from inefficient internal scaffolding protein B binding to faulty procapsid elonga
205 rtant new insights into the role of FAK as a scaffolding protein in molecular complexes that regulate
206 omplementation group A (XPA) is an essential scaffolding protein in the multiprotein nucleotide excis
208 also called AKAP450/CG-NAP/AKAP9) is a large scaffolding protein located at both the centrosome and G
209 sis of human metastatic genes identified the scaffolding protein metastasis suppressor 1 (MTSS1) as a
210 Mutations in NBEAL2, the gene encoding the scaffolding protein Nbeal2, are causal of gray platelet
212 where it associates with and stabilizes the scaffolding protein PSD95, promoting dendritic spine mat
216 cells by knocking down ANLN, a cytoskeletal scaffolding protein that regulates cytokinesis and might
217 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in he
218 multiple ankyrin repeat domains 3 (SHANK3B) scaffolding protein, defective expression of which has b
219 nhibitor, pointed to a mechanism involving a scaffolding protein, Wag31, involved in polar elongation
224 a lipid bilayer surrounded by a boundary of scaffold proteins have emerged as a powerful tool for me
226 aptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling
227 ion, we observed marked loss of postsynaptic scaffolding proteins and reduced complexity of the sub-s
228 as associated with reduced recruitment of TZ scaffolding proteins and reduced Smoothened levels at ci
229 eodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment of hi
230 ) exchanger regulatory factor (NHERF) family scaffolding proteins that are required for many aspects
232 ignal through Gi/o-coupled G-proteins and/or scaffolding proteins, such as beta-arrestin, we find tha
234 rmediates are converted to a known genotoxic scaffold, providing metabolic support of our mechanistic
235 evel of scaffolds rather than compounds, and scaffold queries increasingly abstract from chemical str
236 are increasingly carried out at the level of scaffolds rather than compounds, and scaffold queries in
238 as is the case for other alternative binding scaffolds, represent complementary affinity reagents to
239 set of high-fidelity contigs and a sequence scaffold, representing a mean 98% of the target region.
240 e, the 5-membered chiral biaryl heterocyclic scaffold represents a departure from 6-membered P,N-liga
241 structure-activity relationship of these two scaffolds, resulting in nanomolar potencies in an ATP sy
244 nalyses of scaffold properties could support scaffold selection and prioritization in small molecule
245 reated with FHs alone or in the absence of a scaffold showed disorganized collagen formation and poor
248 in vivo monitoring the mineralization in 3D scaffolds subcutaneously implanted in small animals.
249 that SMAPs act by binding to the PP2A Aalpha scaffold subunit to drive conformational changes in PP2A
250 NF-kappaB essential modulator (NEMO) is the scaffolding subunit of the inhibitor of kappaB kinase (I
251 erstood neddylation targets are the cullins, scaffold subunits of E3 ubiquitin ligases, where neddyla
256 e sustained drug release of CM-AL-containing scaffolds than these of CM/nHA-AL and PLLA/nHA/AL scaffo
257 We show that FER acts as a RALF-regulated scaffold that modulates receptor kinase complex assembly
258 data reveal intersectin as an autoinhibited scaffold that serves as a molecular linker between the s
259 ed by conformational dynamics of the protein scaffold that surrounds the active site, yet the exact n
261 ivity of functional gene groups by acting as scaffolds that promote the local assembly of tissue-spec
263 ing two sulfur atoms to a single carboxylate scaffold, the molecular solid reaches a reversible capac
264 n the current CE-mark approved bioresorbable scaffolds, their basic characteristics, and clinical res
265 hromophores and establish the use of the DNA scaffold to arrange carbon layers in homogeneous, rapidl
267 ast stem cells (TSCs) in a three-dimensional scaffold to generate structures whose morphogenesis is m
268 on laser lithography is employed for LC cell scaffolding to accurately verify theoretical predictions
269 nd high levels of interferons can be used as scaffolds to carry therapeutic oligonucleotides, while p
271 adaptive immune system, providing versatile scaffolds to display diverse antigen-binding surfaces.
272 cted scaffolds could be transferred to fresh scaffolds to establish new infections for at least three
279 is sirolimus-eluting bioabsorbable magnesium scaffold was significantly less thrombogenic compared wi
280 stimulating nerve repair in a nerve-guidance scaffold was used to explore the regenerative effect of
281 logues, novelized with high-valued bioactive scaffolds was synthesized by means of click-chemistry un
283 l and degradation properties of CM-ALs (10%) scaffolds were comparable to that of PLLA/nHA control.
286 pulp stem cells, encapsulated in a hydrogel scaffold, were injected into half the experimental teeth
287 based on the 1,4,5-trisubstituted imidazole scaffold which are appended with aliphatic linkers that
288 ed dihydropyridopyrimidine pan-BET inhibitor scaffold, which was uncovered via a virtual screen follo
289 ed us to obtain a completely acellular renal scaffold while maintaining the extracellular matrix stru
290 we report the first synthetic, ceramic-based scaffold whose architecture closely mimics that of cuttl
291 lthiazoles were reported previously as a new scaffold with antibacterial activity against an array of
292 ted the proliferation of SCAP throughout the scaffold with differentiation into odontoblast-like cell
293 e class of NIR dyes via modifying the rhodol scaffold with fused tetrahydroquinoxaline rings is descr
295 d assembly of the American alligator genome, scaffolded with in vitro proximity ligation (Chicago) da
296 possibility to repopulate naturally obtained scaffolds with cells of different sources is advancing.
298 echnique produces extracellular matrix-based scaffolds with exceptional resolution and fidelity, and
300 e identification of new Cruzipain inhibitory scaffolds within the GlaxoSmithKline HAT (Human African
301 tives of Cl-amidine, hypothesizing that this scaffold would allow access to a series of PAD2-selectiv
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