ライフサイエンスコーパス: scaffolding function

1 is after assembly and appears to perform the scaffolding function.

2 r WDR62 dimerization and is critical for its scaffolding function.

3 ed by phosphorylation regulation of the Axin scaffolding function.

4 PKC signaling and activity through a direct scaffolding function.

5 al flexibility likely to be critical for its scaffolding function.

6 f the tyrosine phosphorylation cascade via a scaffolding function.

7 sent in high-order oligomers and may serve a scaffolding function.

8 S encodes a phosphorylation-dependent cyclin scaffolding function.

9 inase catalytic functions from the protein's scaffolding functions.

10 t for >80% of the mass of the APC/C, provide scaffolding functions.

11 le protein interaction motifs to achieve its scaffolding functions.

12 abetics, implicating PAK1 in islet signaling/scaffolding functions.

13 cells has considered actin largely for its 'scaffolding' function.

14 a, we discuss the insights obtained from the scaffolding function and how this non-canonical role cou

15 se that the processing of MyD88 disrupts its scaffolding function and uncouples the activation of TLR

16 oteins in the context of their enzymatic and scaffolding functions and in terms of their interactions

17 isoforms are emerging with localizations and scaffolding functions at sites away from the NE, suggest

18 ion of the downstream components of this FAK scaffolding function by Y315F endophilin A2 mutant or MT

19 vivo analyses of domains important for MAGUK scaffolding functions demonstrate that while the Vari HO

20 We show that mutations disrupting the scaffolding function do not impair endocytosis, whereas

21 We propose that beta-arrestins via their scaffolding function facilitate Amer1 interaction with P

22 These observations identify a physiologic scaffolding function for IQGAP2 and establish the presen

23 These data suggest a kinase-independent scaffolding function for Itk in the regulation of Vav lo

24 -Src, consistent with the receptor serving a scaffolding function for recruitment and activation of S

25 e concept that DARC provides a high affinity scaffolding function for surface retention of chemokines

26 This implies a common scaffolding function for tankyrases at each location, wi

27 We propose a scaffolding function for Tap42/alpha4 whereby the intera

28 er protein, termed BLNK, which serves such a scaffolding function in B cells.

29 , these results identify a novel role of FAK scaffolding function in breast cancer, which could serve

30 duced disruption of cav-1alpha chaperone and scaffolding function in PAECs likely accounts for divers

31 act with a number of proteins and may have a scaffolding function in this context.

32 ting the balance of RIP1 kinase activity and scaffolding function in vivo during development and TNF-

33 ike focal adhesion kinase (FAK) also possess scaffolding functions in intracellular signaling, but su

34 ode uses a kinase domain independent edge, a scaffolding function, in the signaling pathway leading t

35 A novel scaffolding function is described for paxillin LD4 in th

36 These YYAA mice reveal that the scaffolding function is important for normal development

37 hat the kinase activity of RIP1, but not its scaffolding function, is dispensable for viability and h

38 d this interaction appears critical for KSR1 scaffolding function, it has been argued that the kinase

39 hese findings, we propose that Brc1 provides scaffolding functions linking gammaH2A, Rhp18, and Smc5/

40 ved framework (FR) subdomains, which serve a scaffolding function maintaining the conformation of loo

41 et for inflammation and cancer, requires the scaffolding function of beta-arrestins for chemotaxis.

42 Our findings support a kinase-independent scaffolding function of CK2alpha that promotes resistanc

43 ase A anchoring protein, we suggest that the scaffolding function of E3KARP binding to both ezrin and

44 dence from recent studies implicate that the scaffolding function of enzymes could be as important in

45 on and is tailored to the dual catalytic and scaffolding function of FAK.

46 Here, we report that MinC controls the scaffolding function of FtsZ by antagonizing the mechani

47 activation loop mutant uncover an essential scaffolding function of Jak2 within the IFNGR receptor c

48 We propose that the scaffolding function of Lst1p is required to generate ve

49 domains, and these binding sites mediate the scaffolding function of MAGUK proteins.

50 osphorylation, we have demonstrated that the scaffolding function of receptor interacting protein kin

51 first molecular explanation of the essential scaffolding function of Rev1 and highlights the Rev1 CTD

52 lesion synthesis in vertebrates requires the scaffolding function of the C-terminal domain (CTD) of R

53 optotic cells and that cleavage destroys the scaffolding function of the full-length KSR1 protein and

54 repressive function may invoke a role for a scaffolding function of the protein at target genes.

55 This scaffolding function of Z rings is essential throughout

56 These responses require the scaffolding functions of beta-arrestins; however, the me

57 Scaffolding functions of obscurin may therefore prevent

58 w these findings in the context of regulated scaffolding functions of other MAGUK proteins.

59 Tight homodimerization may be central to the scaffolding functions of PRX and AHNAK2 in molecular com

60 ice, revealing distinct kinase-dependent and scaffolding functions of RIPK1.

61 iably attributed to GAP/enzymatic or non-GAP/scaffolding functions of these proteins.

62 t least two proteins that contribute to this scaffolding function; one is the maturational protease p

63 pletion suggest that OGT's glycosylation and scaffolding functions play distinct roles in the replica

64 eam signaling but may require a nonenzymatic scaffolding function provided by type II receptors to fo

65 Mechanistically, FADD/caspase-8 scaffolding function provides a post-translational signa

66 rotein depletion, indicative of catalytic or scaffolding functions, respectively.

67 inding and NC-RNA interactions serve similar scaffolding functions so that one can functionally compe

68 RAC1/PAK1 and promoted a kinase-independent scaffolding function that led to recruitment and phospho

69 sion components exhibit dual biochemical and scaffolding functions that are critically modulated by f

70 In addition to its scaffolding function, the GK domain of hCASK has been sh

71 l to the plasma membrane is required for its scaffolding function, the precise mechanism(s) regulatin

72 suppressor homologs 1/2 (LATS1/2), uses its scaffolding function to link MST1/2 with MARK3, and inhi

73 a structural role, it is believed to play a scaffolding function to organize and inactivate signalin

74 We suggest that the larger fragment serves a scaffolding function to stabilize the basement membrane

75 the unusually long Mdv1 coiled coil serves a scaffolding function to stabilize the Mdv1-Fis1 complex.

76 Conversely, bypass of the scaffolding function using the phosphorylation mimic mut

77 To address the importance of the scaffolding function, we generated a zap70 mutant mouse

78 ify motifs in ZO-1 critical for its putative scaffolding functions, we focused on the SH3-GUK module

79 While Tum/RacGAP has well-documented scaffolding functions, whether it influences Pav/kinesin