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1 ng cycle, featuring two enzymes and a single scaffolding protein.
2 tial for tumor growth through one individual scaffolding protein.
3 interaction with Ajuba, an actin binding and scaffolding protein.
4 cascade without the involvement of the RACK1 scaffolding protein.
5 of regulating Gbetagamma signaling through a scaffolding protein.
6 n of G protein-coupled receptor signaling by scaffolding proteins.
7 natorial interactions among many enzymes and scaffolding proteins.
8 ion, triggered by limited proteolysis of the scaffolding proteins.
9 ytic enzymes with regulatory, accessory, and scaffolding proteins.
10 G proteins and an MAPK cascade via the RACK1 scaffolding proteins.
11 arallel to the Scribble module of junctional scaffolding proteins.
12 endrites by interaction with AKAP5 and other scaffolding proteins.
13 TSET is a heterohexamer, with two associated scaffolding proteins.
14 heir interaction with a variety of signaling/scaffolding proteins.
15 tor) family of PSD-95/Discs-large/ZO-1 (PDZ) scaffolding proteins.
16 eneous aberrant structures in the absence of scaffolding proteins.
17 ibitory, and experimentally evolved coat and scaffolding proteins.
21 d G protein-coupled receptors coupled by the scaffolding protein A-kinase-anchoring protein (AKAP)79/
22 Synapse-associated protein 102 (SAP102) is a scaffolding protein abundantly expressed early in develo
23 During varphiX174 assembly, the external scaffolding protein acts like a coat protein, self-assoc
24 ins constitute a highly conserved network of scaffolding proteins, adaptors and enzymes that form and
27 smaller than a Golgi subdomain positive for scaffolding protein AKAP450, which is thought to recruit
28 re depletion and brings calcineurin, via the scaffolding protein AKAP79, to calmodulin tethered to Or
30 guanylate kinase (MAGUK) family of synaptic scaffolding proteins anchor glutamate receptors at CNS s
32 ite for the dynamic functions of IQGAP1 as a scaffolding protein and a critical mechanism in temporal
33 apsid') built by multiple copies of coat and scaffolding protein and by one dodecameric portal protei
34 8 is also implicated in the interaction with scaffolding protein and is involved in capsid size deter
35 dditionally, we explored the function of the scaffolding protein and main component of caveolae, cave
37 ges in glutamate receptors, their associated scaffolding proteins and certain signaling molecules wit
38 an be affected by the relative expression of scaffolding proteins and components of signaling cascade
39 ion, we observed marked loss of postsynaptic scaffolding proteins and reduced complexity of the sub-s
40 as associated with reduced recruitment of TZ scaffolding proteins and reduced Smoothened levels at ci
42 RI holoenzyme has a weaker affinity for most scaffolding proteins and tends to localize in the cell b
43 nding of CCCTC-binding factor, a chromosomal scaffolding protein, and increases histone and DNA methy
44 of protein levels of PSD-95, a postsynaptic scaffolding protein, and the AMPAR subunits GluR1 and Gl
45 olytic metabolon is dependent on presynaptic scaffolding proteins, and disruption of the glycolytic m
46 ls, including enzymes, channels, adaptor and scaffolding proteins, and proteins of uncharacterized fu
52 r components of the node is the cytoskeletal scaffolding protein, ankyrin G (AnkG), which interacts w
54 elatively weak interactions between coat and scaffolding proteins are capable of driving correctly sh
59 at appears to contain substantial amounts of scaffolding protein as well as DNA, suggesting that DNA
60 lements, two recent reports implicate kinase-scaffolding proteins as active participants in signal re
61 taining for PSD-95 and gephyrin postsynaptic scaffolding proteins as proxies for excitatory and inhib
63 ule dynamics at both locations, but how this scaffolding protein assembles microtubule nucleation mac
64 ne-associated guanylate kinase, is the major scaffolding protein at excitatory postsynaptic densities
65 K3 (also known as PROSAP2) is a postsynaptic scaffolding protein at excitatory synapses in which muta
67 n-immunoreactive (IR) puncta, a postsynaptic scaffolding protein at inhibitory synapses used here as
70 ociated guanylate kinases (MAGUKs) are major scaffolding proteins at the PSD in glutamatergic excitat
72 bstitutions ranged from inefficient internal scaffolding protein B binding to faulty procapsid elonga
77 ing from plasma and endosomal membranes: the scaffolding proteins beta-arrestin (betaARRs) 1 and 2 an
80 a interaction protein (GSKIP) is a cytosolic scaffolding protein binding protein kinase A (PKA) and g
81 The C domain instead appears to serve as a scaffolding protein, bringing the catalytic YcaO domain
83 r compartmentalization of kinase function by scaffolding proteins, but how this is accomplished is no
85 ly related cavin proteins cooperate with the scaffolding protein caveolin to form membrane invaginati
88 ventricular myocyte with a reduction in the scaffolding protein caveolin-3 (Cav-3), altered Ca(2+) c
90 nalling domain interacts with the chemotaxis scaffolding proteins CheV and CheW, and comparative geno
91 called MAGI-2), which encodes a postsynaptic scaffolding protein controlling synaptic AMPA receptor l
94 ent and requiring different ubiquitin ligase scaffolding proteins (CUL2-RBX1 instead of CUL5-RBX2).
95 74 morphogenesis, 240 copies of the external scaffolding protein D organize 12 pentameric assembly in
96 assembly intermediates, whereas the external scaffolding protein D organizes 12 of these intermediate
98 neuromuscular junction (NMJ), the endocytic scaffolding protein Dap160 colocalizes during the SV cyc
99 multiple ankyrin repeat domains 3 (SHANK3B) scaffolding protein, defective expression of which has b
100 -CDF) of CaV1.3 channels that depends on the scaffolding protein densin and CaMKII and that outlasts
101 orted interaction among CaV1.3 channels, the scaffolding protein densin, and CaMKII could generate a
102 ty (PSD) was independently remodeled, as PSD scaffolding proteins did not change their amount and loc
103 HTT forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodies
106 ndicate that fibulin-4 serves as a potential scaffolding protein during collagen maturation in the ex
107 mine the dynamics and function of the apical scaffolding protein E3KARP/NHERF2, which consists of two
108 tute for the function of the closely related scaffolding protein EBP50/NHERF1 in the formation of int
110 eotide exchange factor Myoblast City and its scaffolding protein ELMO, downstream of cell-surface cel
113 experiments showed that RGS6 functions as a scaffolding protein for both Dnmt1 and Tip60 and is requ
116 tein likely acting as a dynamic cell surface scaffolding protein for the assembly of different signal
117 reveal a cooperative interaction of multiple scaffolding proteins for appropriately timed delivery of
118 Caveolin-1 (Cav1) is an integral membrane, scaffolding protein found in plasma membrane invaginatio
119 r biogenesis by this large family of cluster scaffolding proteins found across all domains of life.
120 basolateral amygdala, the clustering of the scaffolding protein Gephyrin and of gamma-aminobutyric a
121 signaling pathway and that clustering of the scaffolding protein gephyrin is only reduced after the i
122 otein collybistin (CB) recruits the receptor-scaffolding protein gephyrin to mammalian inhibitory gly
124 ere we show that the conserved signaling and scaffolding protein Girdin localizes to the proximal reg
125 cteriophage P22, only coat protein (gp5) and scaffolding protein (gp8) are needed to assemble a proca
126 iscover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinase
127 microvillar protocadherins interact with the scaffolding protein, harmonin, and myosin-7b, which prom
132 lg1) is generally considered to be a modular scaffolding protein implicated in the control of cell po
133 lyposis coli (APC) is a microtubule plus-end scaffolding protein important in biology and disease.
134 domain and PHD finger-containing) family are scaffolding proteins important for the recruitment of hi
135 eodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment of hi
136 came aware of this issue in our studies of a scaffolding protein in microvilli, which forced us to re
137 rtant new insights into the role of FAK as a scaffolding protein in molecular complexes that regulate
138 omplementation group A (XPA) is an essential scaffolding protein in the multiprotein nucleotide excis
139 nteract with beta-arrestin, implicating this scaffolding protein in the receptor's subcellular redist
146 w that Dedicator of cytokinesis 8 (DOCK8), a scaffolding protein involved in cytoskeletal rearrangeme
147 STATEMENT: Integrin-linked kinase (ILK) is a scaffolding protein involved in integrating signals from
148 ozygous mutations in CARD11, which encodes a scaffolding protein involved in lymphocyte receptor sign
149 1; also known as p62) encodes a multidomain scaffolding protein involved in various key cellular pro
150 CD13 was constitutively associated with the scaffolding protein IQGAP1, and CD13 cross-linking induc
151 our capsids, aided by the discovery that the scaffolding protein is exceptionally prone to radiation-
156 guanylate kinase (MAGUK) family of synaptic scaffolding proteins is critical for localization of glu
157 ts suggest that enzyme sequestration through scaffolding proteins is exploited by evolution to genera
159 ighly conserved double-PDZ domain-containing scaffolding protein, is robustly expressed in human-deri
160 Previous studies found that Asl acts as a scaffolding protein; its N terminus binds Plk4's tandem
162 l autophagosome transport is mediated by the scaffolding protein JIP1, which not only inhibits antero
165 ptors (L-AChRs) requires the muscle-secreted scaffolding protein LEV-9, a multidomain factor containi
166 oteins like occludin and the claudin family; scaffolding proteins like ZO-1; and some cytoskeletal, s
167 es, MAP17 is known to interact with PDZK1, a scaffolding protein linked to other transporters, includ
168 which otoferlin acts as a calcium-sensitive scaffolding protein, localizing SNARE proteins proximal
169 also called AKAP450/CG-NAP/AKAP9) is a large scaffolding protein located at both the centrosome and G
170 Here, we show that loss of function of a scaffolding protein Mask, also known as ANKHD1 (Ankyrin
171 ned with RNA-induced phase separation of key scaffolding proteins, may be a general mechanism for con
172 sis of human metastatic genes identified the scaffolding protein metastasis suppressor 1 (MTSS1) as a
174 DZ-binding motif allowing for binding of the scaffolding proteins Na(+)/H(+) exchanger regulatory fac
175 Mutations in NBEAL2, the gene encoding the scaffolding protein Nbeal2, are causal of gray platelet
177 immunofluorescence is coassociated with the scaffolding protein NHERF-1 and PLCbeta2 in microvilli.
178 nsically disordered tail of the multi-domain scaffolding protein NHERF1, which affects the intracellu
179 coding for caveolin-3, the major constituent scaffolding protein of cardiac caveolae, have been assoc
180 ptic scaffold organized by gephyrin-the main scaffolding protein of GABAergic synapses, which anchors
181 milar to mice overexpressing PSD-95, a major scaffolding protein of postsynaptic density involved in
182 Disrupted in Schizophrenia 1 (DISC1) is a scaffolding protein of significant importance for neurod
184 teins BAZ2A and BAZ2B constitute the central scaffolding protein of the nucleolar remodeling complex
185 ere we used tagged gephyrin, one of the main scaffolding proteins of the postsynaptic density at GABA
189 MAGUK (membrane-associated guanylate kinase) scaffolding proteins or NMDA receptors, it is necessary
197 lation of GluN2B Y1472, whereas the synaptic scaffolding protein postsynaptic density protein 95 (PSD
198 findings reveal that modular regulation by a scaffolding protein provides a simple, yet effective, me
199 s a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors
201 m increase in the expression of the synaptic scaffolding proteins PSD-95 and SAP90/PSD-95-associated
202 hemical localization of a major postsynaptic scaffolding protein, PSD-95, in striatal neurons from WT
203 where it associates with and stabilizes the scaffolding protein PSD95, promoting dendritic spine mat
207 and IFs via direct interaction with the AChR-scaffolding protein rapsyn in an isoform-specific manner
209 containing GTPase-activating protein (IQGAP) scaffolding proteins regulate many essential cellular pr
211 eomic and MS study, we demonstrate that this scaffolding protein regulates a shift in protein kinase
212 ogene required for development, and DCAF7, a scaffolding protein required for craniofacial developmen
213 ermined that there is a single amino acid in scaffolding protein required for P22 procapsid assembly,
214 with poor patient prognosis, and BRPF1 is a scaffolding protein required for the assembly of histone
216 4 is shown by cross-linking to interact with scaffolding protein residue R293 and, thus, is intimatel
217 rangement of the coat protein and release of scaffolding protein, resulting in dramatic procapsid lat
219 me through direct interaction with the large scaffolding protein RPN2 within the 19S regulatory parti
222 roteins 1 and 2 and with the multifunctional scaffolding protein sequestosome-1 (SQSTM1/p62) confirme
224 of the HDAC interaction domain (HID) of the scaffolding protein Sin3A through a bipartite motif comp
226 ises the NAD-dependent deacetylase Sir2, the scaffolding protein Sir4, and the nucleosome-binding pro
229 and show that CpmB competes with the 80alpha scaffolding protein (SP) for a binding site on the capsi
230 rrent study, we identify the multifunctional scaffolding protein spinophilin as a novel Group I mGluR
231 capacity, but altering the binding with the scaffolding protein spinophilin upon neurotransmitter ac
232 cultured astrocytes, suggesting that the DLG scaffolding protein stabilizes EAAT2b at the surface.
235 ignal through Gi/o-coupled G-proteins and/or scaffolding proteins, such as beta-arrestin, we find tha
238 isoform was recruited to nascent AZs by the scaffolding proteins Syd-1 and Liprin-alpha, and Unc13A
240 ed cardiac phenotype signal through a common scaffolding protein termed tumor necrosis factor recepto
243 ta-arrestin (betaarr)-2 is a multifunctional scaffolding protein that binds G-protein-coupled recepto
245 y reported that the immunophilin FKBP51 is a scaffolding protein that can enhance PHLPP-AKT interacti
246 ation of the Mdm2 pathway degrades PSD-95, a scaffolding protein that clusters NMDARs at the synapse
247 s sigma-1 receptor) is a unique chaperone or scaffolding protein that contributes to cellular protein
248 signaling is negatively regulated by Axin, a scaffolding protein that controls a rate-limiting step i
249 network, we believe Gib2 to be a key adaptor/scaffolding protein that drives the formation of various
251 -associated protein (CD2AP) is a multidomain scaffolding protein that has a critical role in renal fu
252 chizophrenia 1 (DISC1) is a multi-functional scaffolding protein that has been associated with neurop
254 in signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates G protein and mitoge
255 (JNK-associated leucine zipper protein) is a scaffolding protein that interacts with various signalin
257 tor 4 gamma 1 translation initiation complex scaffolding protein that is mediated by the key transcri
258 Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functio
262 ptic density 95 (PSD-95) is a major synaptic scaffolding protein that plays a key role in bidirection
263 cells by knocking down ANLN, a cytoskeletal scaffolding protein that regulates cytokinesis and might
264 associated with its binding partner Homer, a scaffolding protein that regulates mGlu5 localization to
265 tor-interacting protein (GRIP) is a neuronal scaffolding protein that stabilizes GluA2 AMPARs at syna
266 a physical model in which utrophin acts as a scaffolding protein that stabilizes lipid microdomains a
267 n together, our data suggest that CPTL2 is a scaffolding protein that tethers CPT3 on endoplasmic ret
268 ling a major capsid protein with an internal scaffolding protein that then exits from the assembled s
269 ) exchanger regulatory factor (NHERF) family scaffolding proteins that are required for many aspects
271 regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor traffic
272 s enriched in sphingolipids, cholesterol and scaffolding proteins; they serve as a platform for signa
273 exclusively to wag31, a gene that encodes a scaffolding protein thought to orchestrate cell elongati
274 alizes and interacts with the tight junction scaffolding proteins TJP1 and TJP2 in polarized epitheli
275 t RA T cells abundantly express the podosome scaffolding protein TKS5, which enables them to form tis
277 igher-order protein complexes containing K-H scaffolding protein to gain insight into its cellular fu
278 hus, F11 acts as a functional PDZ-containing scaffolding protein to inhibit RhoA signaling by binding
280 tem, coat protein interacts with an internal scaffolding protein, triggering the assembly of an inter
281 4-3-3 proteins, a family of highly conserved scaffolding proteins ubiquitously expressed in all eukar
282 al cellulosome assembly, including conserved scaffolding proteins unique to the Neocallimastigomycota
284 hagy consists of the lipid kinase VPS34, the scaffolding protein VPS15, the tumor suppressor BECN1, a
285 nhibitor, pointed to a mechanism involving a scaffolding protein, Wag31, involved in polar elongation
287 mer1, a gene encoding a postsynaptic density scaffolding protein, was selected for further study.
288 e activating protein, and SHANK3, a synaptic scaffolding protein, were chosen because of mounting evi
290 hogen effectors by partnering with different scaffolding proteins, which can each recognize distinct
291 se in the presence of oxygen include HupK, a scaffolding protein with a moderate sequence similarity
293 Here, we investigate the interaction of scaffolding protein with acidic residues in the N-arm of
294 e relevant to Parkinson's disease, encodes a scaffolding protein with both GTPase and kinase activiti
295 se disorders are those encoding postsynaptic scaffolding proteins with roles in synaptic transmission
296 mplex comprising DNA ligase IIIalpha and the scaffolding protein X-ray repair cross-complementing pro
297 ng of DNA from the histone octamer; that the scaffolding protein XRCC1 enhances the ligation; that th
299 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in he
300 y a novel functional complex of the junction scaffolding protein ZO-1 and the F-BAR-domain protein TO
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