ライフサイエンスコーパス: scar

1 ace area (median 540 points collected within scar).

2 lular matrix proteins that form this fibrous scar.

3 f myofibroblasts, and formation of a fibrous scar.

4 and eventually resolve, leaving a calcified scar.

5 expressing cells persist to form a permanent scar.

6 large numbers among astrocytes in the glial scar.

7 (130 of 151) were associated with transmural scar.

8 e epidermis of human hypertrophic and keloid scar.

9 bipolar voltage (BV) may indicate epicardial scar.

10 enesis and completely abolished the fibrotic scar.

11 for delineation of IMAT dense regions within scar.

12 e photograph was assessed for each patient's scar.

13 e the main CSPG contributory factor in glial scar.

14 matrix proteins responsible for the fibrotic scar.

15 lineages to activated fibroblasts within the scar.

16 , and two had just a small residual fibrotic scar.

17 e skin inflammation and sometimes, permanent scars.

18 gh-quality macrophotographs of postoperative scars.

19 y assess the quality of postoperative linear scars.

20 n skin wounds and in normal and hypertrophic scars.

21 staining from underlying, preexisting laser scars.

22 ypical eye findings, including chorioretinal scars.

23 from the epidermis is associated with dermal scarring.

24 he profibrotic response leading to excessive scarring.

25 atory-mediated podocyte death and glomerular scarring.

26 currently available to stratify the risk of scarring.

27 is a potential therapeutic target for dermal scarring.

28 evaluating myocardial function, volumes, and scarring.

29 ion, in association with tarsal conjunctival scarring.

30 ts in the prevention and treatment of keloid scarring.

31 f vision loss were cataract (19.7%), corneal scars (15.7%), refractive error and amblyopia (12.1%), o

32 rhytides on the face (20%), multiple facial scars (20%), verruca vulgaris on the face (20%), and rhi

33 ity by 5 raters on a set of 80 total patient scars, 20 of which were analyzed for photographic equiva

34 ations included evaluation of post-treatment scar (55%) or fovea (16%), and posterior pole scanning f

35 In contrast, adults heal via fibrovascular scar, aberrant differentiation toward cartilage and bone

36 c membrane exerts anti-inflammatory and anti-scarring actions, we hypothesized that HC-HA/PTX3 could

37 nd known to exert anti-inflammatory and anti-scarring actions.

38 croptosis and apoptosis, followed by cardiac scarring after antibiotic therapy, in an NHP model of se

39 b GOF and inhbaa LOF both lead to unresolved scarring after cardiac injury.

40 l autofluorescence resolved without clinical scarring after treatment.

41 ter, adult Pparg(Delta/Delta) mice developed scarring alopecia and severe perifollicular inflammation

42 entification of epicardial right ventricular scar, an endocardial UV cutoff value of 3.9 mV is more a

43 changed in 3 eyes due to preexisting macular scar and advanced glaucoma.

44 onstrated larger epicardial than endocardial scar and core-dense (</=0.5 mV) scar areas (28 [20-36] v

45 aseline does not significantly influence VA, scar and GA outcomes in eyes with NVAMD treated with ant

46 ft ventricular ejection fraction, myocardial scar and ischemia, rate-pressure product, type of radiot

47 allowed for differentiation between ischemic scar and normal myocardium on cine MR images in both sub

48 Two healed lesions with a linear bony scar and one detached lesion were identified.

49 ng, and skin discoloration of the mastectomy scar and radiation bed.

50 ble knockout to show that cells lacking both SCAR and WASP are unable to grow, make pseudopods or, un

51 Loss of SCAR and WASP causes excessive dDia2 activity, maintaini

52 with subcortical calcifications; (3) macular scarring and focal pigmentary retinal mottling; (4) cong

53 benefits were associated with suppression of scarring and infiltration of inflammatory/immune cells i

54 tissue exposed to WNT-974 exhibits decreased scarring and reduced Col6 production.

55 fully regenerate as evidenced by persistent scarring and reduced wall motion.

56 The fibrotic group had marked bleb scarring and vascularization and worse logMAR visual acu

57 ce, and the animals developed larger infarct scars and more pronounced left ventricular remodeling co

58 uired for the production of normal cutaneous scars and place P311 immediately up-stream of TGF-betas

59 tigation focused on studying the wear tracks/scars and the tribofilms generated on the composite and

60 ts with nontuberculous mycobacteria, old PTB scar, and immune reconstitution syndrome.

61 ound healing, safety, scarring, hypertrophic scar, and keloid.

62 rolonged repolarization, electric markers of scar, and late gadolinium enhancement (all P<0.001).

63 were less likely to have fluid, FA leakage, scar, and SHRM and more likely to have GA than eyes with

64 to extracellular matrix accumulation, organ scarring, and loss of kidney function.

65 es remain poor secondary to corneal melting, scarring, and perforation.

66 liable rating scale for postoperative linear scars, and photographs may reliably be used in lieu of l

67 There was no significant difference in scar appearance between aCT1- or control-treated incisio

68 pathy, the arrhythmogenicity of the ablation scar appears to be overemphasized.

69 ocardial structure and function with reduced scar area.

70 endocardial scar and core-dense (</=0.5 mV) scar areas (28 [20-36] versus 19 [15-26] and 21 [2-49] v

71 SCAR scale but also the Patient and Observer Scar Assessment Scale and the Vancouver Scar Scale, and

72 Herein, we hypothesized that scar-associated fibroblasts may be a source of stress-in

73 paB-CCL2 signaling pathway, operating within scar-associated fibroblasts, may be therapeutically mani

74 fibrotic scar surrounded by a reactive glial scar at the lesion site.

75 Cs into mice with liver injury reduced liver scarring based on picrosirius red staining (49.7% reduct

76 0 (best possible scar) to 15 (worst possible scar), based on 6 clinician and 2 patient items was used

77 A common strategy for ablation of scar-based ventricular tachycardia is delivering multipl

78 ioning associated with thaw-induced collapse-scar bog ('wetland') expansion.

79 ph nodes, followed by an optional mastectomy scar boost of four fractions of 3.33 Gy.

80 a reparative genetic program with increased scar border vascularity, reduced fibrosis, and recovery

81 during mapping of IMAT, confined to putative scar border zones (bipolar amplitude, 0.5-1.5 mV).

82 s: (a) non-neural lesion core, (b) astrocyte scar border, and (c) surrounding spared but reactive neu

83 ized by formation of astrocytic and fibrotic scars, both of which are necessary for lesion repair.

84 g in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely u

85 No case showed clinical haze or scarring by month 3.

86 hibited an acute inflammatory response, with scarring characterized by stronger myeloperoxidase activ

87 Keloids are pathological scars characterized by excessive extracellular matrix pr

88 on leads to accelerated cardiac recovery and scar clearance after injury.

89 1 resulted in a significant decrease in skin scar collagen deposition.

90 known to the health system and cases with no scarred conjunctiva.

91 Moreover, retention of WASP together with SCAR correctly predicts alpha-motility in disease-causin

92 The Scar Cosmesis Assessment and Rating (SCAR) scale was dev

93 The SCAR scale that measures postoperative scar cosmesis, with scores ranging from 0 (best possible

94 able standard rating scale for postoperative scar cosmesis.

95 cterization of the LV epicardial/endocardial scar distribution and density in CC has not been perform

96 car-related right ventricular VT, 2 distinct scar distributions were identified: 1) scars involving t

97 we discuss the divergent roles of the glial scar during CNS regeneration and explore the possibility

98 nd elevated B-Hcg levels, the possibility of scar ectopic pregnancy should be considered.

99 ingly, after halting GCV at 14 d postinjury, scar elements and vessels entered the lesions over the n

100 Because the mammalian heart scars following cardiac injury, recent work showing that

101 diameter was found to significantly increase scarring for glass implants, as well as increase local B

102 eath, (3) cause MACE, and (4) induce cardiac scar formation after antibiotic treatment during severe

103 This injury induces scar formation and activates the proliferation of hemocy

104 ult zebrafish, allowing for visualization of scar formation and heart regeneration in the same animal

105 The corneas healed with scar formation and neovascularization.

106 sue is suspected to be a key driver of glial scar formation around neural implants.

107 of soft hydrogel coatings to modulate glial scar formation by reducing local strain.

108 of S100A12 resulted in a marked hypertrophic scar formation in a validated rabbit hypertrophic scar m

109 icacy and safety of aCT1 in the reduction of scar formation in human incisional wounds.

110 a growth-inhibitory molecule associated with scar formation in injured spinal cord.

111 Evidence of cardiac scar formation was observed only in convalescent animals

112 Wound fibrosis (i.e., excessive scar formation) is a medical problem of increasing preva

113 nes leads to dramatic inflammation and glial scar formation, affecting brain tissue's ability to repa

114 d efforts to define the role of P311 in skin scar formation.

115 s-linking and leads to tissue stiffening and scar formation.

116 of dysregulated, exaggerated inflammation in scar formation.

117 enesis, which in turn is needed for fibrotic scar formation.

118 ions, pericytes and glia, may also influence scar formation.

119 ses involved in tissue healing might lead to scar formation.

120 t provide the majority of newly proliferated scar-forming astrocytes that protect tissue and function

121 newly proliferated and molecularly confirmed scar-forming astrocytes.

122 , and the residual regenerative potential of scar-forming myofibroblasts are largely determined by th

123 NG2(+) cells may influence both scar-forming processes.

124 d skin and in gingival and hypertrophic-like scar-forming skin wound healing in a pig model, and used

125 Chronic liver scarring from any cause leads to cirrhosis, portal hyper

126 ssive valvulopathy, hypertension, and atrial scars from previous heart surgery.

127 VA; scar; geographic atrophy; retinal thickness, fluid; and

128 Although SCAR has been shown to drive pseudopod formation, WASP's

129 ectroanatomic mapping to identify epicardial scar has not been assessed in this setting.

130 eneration, beneficial functions of the glial scar have also been recently identified.

131 ly, and significantly decreased fibrosis and scarring histologically.

132 Hypertrophic scar (HTS) formation is a frequent postoperative complic

133 l peel, dermabrasion, wound healing, safety, scarring, hypertrophic scar, and keloid.

134 Adjunctive scar imaging was available in 37 (71%) patients and was

135 inium enhancement cardiac magnetic resonance scar imaging.

136 l of the uterus at the site of previous LSCS scar in a multipara female.

137 NAFLD, this study demonstrates that hepatic scar in NASH is actively remodeled even in advanced fibr

138 ge mapping serves to characterize epicardial scar in this setting.

139 P = 0.01) in PLTR and baseline conjunctival scarring in BLTR (OR, 1.72; 95% CI, 1.06-2.81; P = 0.03)

140 P-9 in particular could play a role in tubal scarring in response to gonococcal infection.

141 ausible mechanistic triggers of pathological scarring in skin wounds.

142 implants were found to significantly reduce scarring in vivo, compared to hard implants of identical

143 whose dysregulation may lead to pathological scarring in wounds.

144 tool to assess the quality of postoperative scars in clinical and research settings.

145 c cell type that may be manipulated to treat scars in humans.

146 In contrast to scars in other mammalian tissues, CNS tissue significant

147 ndaries at the reversal temperature leaving "scars" in the underlying lattice structure, giving rise

148 colocalized with late gadolinium enhancement scar, indicating a relationship with structural disease.

149 a paucity of data on the extent of molecular scars inflicted on the mouse genome.

150 Basal lateral LV scar involvement was observed in 18 of 19 patients.

151 tinct scar distributions were identified: 1) scars involving the subtricuspid right ventricle in 46 p

152 Glial scar is a significant barrier to neural implant function

153 , whereas clinically unrecognized myocardial scar is associated with a longer QT interval.

154 In Dictyostelium discoideum, loss of SCAR is compensated by WASP moving to the leading edge t

155 ns of ectopic pregnancies such as an ectopic scar is crucial for a correct diagnosis and early manage

156 This scarring is due to loss of podocytes, cells critical for

157 The origin of these scars is thought to be perivascular cells entering lesio

158 One such response, the glial scar, is a structural formation of reactive glia around

159 om), overlain by a dose-dependent astroglial scar-like formation and recruitment of phagocytic microg

160 sculoskeletal (due to atrophy and retraction scars limiting movement) or neuropathic pain.

161 morphology (nodules, abscesses, tunnels, and scars), location (axillae, inframammary folds, groin, pe

162 re, rotation occurred around a small area of scar (<0.03 mV; 12+/-6 mm diameter).

163 Scar (<1.5 mV) occupied a median 29% of the total surfac

164 usted for demographic data, risk factors for scar, LV end-diastolic volume, and LV mass.

165 confounding influence of IMAT on endocardial scar mapping.

166 Proper SCAR markers may represent a fast, sensitive, reliable a

167 , modeling the mechanical effects of infarct scar maturation, causes smooth muscle alpha-actin fiber

168 pply to the lower uterine segment, caesarean scars may heal improperly predisposing it to be a site o

169 formation in a validated rabbit hypertrophic scar model compared with saline control.

170 gnosis of LyP and were also required to have scarring, more than 10 lesions, or active lesions on the

171 y during regeneration (Acomys cahirinus) and scarring (Mus musculus), we found that both species exhi

172 In contrast, the presence of LV scar (n = 106) was associated with longer QTc (beta = 4.

173 te gadolinium enhancement-defined myocardial scar (n = 1131), T1 mapping was used to assess left vent

174 detachment, and geographic atrophy/fibrotic scar/neovascular AMD in the fellow eye.

175 The basal cytonemes required diaphanous, SCAR, Neuroglian and Synaptobrevin, and both the Hh grad

176 joint degeneration, pars defect, or presumed scar neuroma.

177 Epithelial shedding and scarring of fallopian tube mucosa are the main consequen

178 cell density and mitigated inflammation and scarring of the conjunctiva.

179 ve kidney diseases are often associated with scarring of the kidney's filtration unit, a condition ca

180 mortality that is characterized by abnormal scarring of the lung parenchyma.

181 Determining if individuals with TT had scarring or are known to the health system was critical

182 nal lesions - congenital dysplasia, acquired scarring or both - are a common cause of childhood hyper

183 of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and p

184 es as well as between disease recurrence and scars or adverse reactions after surgery or radiation th

185 aCT1 has potential to improve scarring outcome after surgery.

186 he presence and extent of epicardial bipolar scar (P<0.001).

187 tival corkscrew vessels (P < 0.001), corneal scarring (P = 0.01) and pingueculae under the age of 50

188 02), vitritis (P < 0.005), and chorioretinal scars (P < 0.02).

189 The scar pattern is particularly dense and transmural as com

190 This scar pattern may allow distinguishing exercise-induced a

191 tudy was to evaluate whether electroanatomic scar patterns related to sustained VT can distinguish ex

192 ral as compared with the more erratic/patchy scar patterns seen in other nonischemic cardiomyopathies

193 -beta1 to -beta3, each restituted the normal scar phenotype.

194 cale score (P = 0.0009), and improvements in scar pigmentation, thickness, surface roughness, and mec

195 o guide the self-assembly of defects such as scars, pleats, folds, blisters, and liquid crystal rippl

196 Left ventricular myocardial scar portends poor clinical outcomes.

197 Scar pregnancy is an extremely rare type of ectopic preg

198 and confluent, indicating a dense/transmural scarring process in CC.

199 of using photographs in lieu of live patient scar rating assessments, and to determine the interrater

200 We targeted arrhythmogenic scar regions by combining anatomical imaging with noninv

201 are at risk of sudden death, typically from scar-related abnormalities of electrical activation that

202 al model and optical mapping of ovine atrial scar-related AF.

203 CI on reentrant scar-related AT showed much lower EGM amplitude with a s

204 Accurate activation mapping of reentrant scar-related atrial tachycardias (AT) allows efficient r

205 ; 83% male) undergoing catheter ablation for scar-related right ventricular VT, 2 distinct scar distr

206 with mechanical aortic valves, who underwent scar-related ventricular tachycardia ablation, were anal

207 al mapping and ablation of right ventricular scar-related ventricular tachycardia with computed tomog

208 The cycle lengths of scar-related VTs were significantly faster in group B pa

209 fibroblasts that constitute the postinfarct scar remain controversial, in particular the potential c

210 estrained fibroblast proliferation, impaired scar remodeling, reduced fibroblast-derived collagen syn

211 e practice dermatology clinic, with assessed scars representing a range of surgical procedures includ

212 l clearance, cardiomyocyte proliferation and scar resolution.

213 l clearance, cardiomyocyte proliferation and scar resolution.

214 argely segregate into the fibrotic and glial scars, respectively; therefore, we used a thymidine kina

215 t ventricle in 46 patients (group A); and 2) scars restricted to the anterior subepicardial right ven

216 Fibrosis and scarring result from chronic inflammation that interrupt

217 l acuity at referral, local therapy, macular scarring, retinal detachment, and hypotony and phthisis

218 c subgroup, 10 were rated using not only the SCAR scale but also the Patient and Observer Scar Assess

219 ntly, no ideal valid, feasible, and reliable scar scale existed to effectively assess the quality of

220 The SCAR scale is a reliable rating scale for postoperative

221 The SCAR scale ratings using photographs were found to be la

222 The SCAR scale that measures postoperative scar cosmesis, wi

223 The SCAR scale therefore represents a reliable standard rati

224 rver Scar Assessment Scale and the Vancouver Scar Scale, and 10 were assessed twice by the same rater

225 interrater and intrarater reliability of the SCAR scale.

226 ment in scar scores over controls (Vancouver Scar Scale; P = 0.0045), a significantly higher Global A

227 The Scar Cosmesis Assessment and Rating (SCAR) scale was developed and validated as a tool to ass

228 Modeling the overall SCAR score predicted whether the rater would consider th

229 The primary efficacy endpoint was average scarring score using visual analog scales evaluating inc

230 reated incisions showed a 47% improvement in scar scores over controls (Vancouver Scar Scale; P = 0.0

231 ubepicardial right ventricular outflow tract scar serving as a substrate for fast VT in high-level en

232 Predictive model of GA vs. fibrotic scar showed sensibility of 68.89% and specificity of 72.

233 ve model of preserved macula vs. GA/fibrotic scar showed sensibility of 77.78% and specificity of 69.

234 I]: 0.24-0.44; P < .001), had larger 3-month scar size (0.39 mm; 95% CI: 0.06-0.73; P = .02), were mo

235 ac stem cells (CSCs) synergistically reduces scar size and improves cardiac function in ischemic card

236 1) and a 0.83-mm decreased infiltrate and/or scar size at 3 months after correcting for baseline valu

237 e-corrected visual acuity, and infiltrate or scar size at 3 months.

238 vealed a 1.89-mm decreased infiltrate and/or scar size at 3 weeks (95% CI, -2.69 to -1.09 mm; P < .00

239 Whereas scar size reduced to a similar degree in both groups: 20

240 ed visual acuity (BSCVA), 3-month infiltrate/scar size, corneal perforation, and re-epithelialization

241 Although both cell doses reduced scar size, only the 100 million dose increased ejection

242 BSC-treated hearts had significantly reduced scar size, smaller myocytes, and increased myocyte nucle

243 c applications including acne vulgaris, acne scars, skin rejuvenation and hair growth, and for therap

244 heterogeneity within the cells of the glial scar-specifically, astrocytes, NG2 glia and microglia.

245 Mammalian glial scars supposedly form a chemical and mechanical barrier

246 injury (SCI) induces a centralized fibrotic scar surrounded by a reactive glial scar at the lesion s

247 cars with reduced stiffness but also reduced scar tensile strength.

248 ould be more effective in treating excessive scarring than modulation of either therapeutic target al

249 ive explanation for some forms of pathologic scarring that are now attributed to truncated telomeres.

250 ealing response that generates collagen-rich scarring that is at first protective but if inappropriat

251 In inactive scars, the areas of retinal and choriocapillaris lesions

252 In keratoconic eyes without deep stromal scars, the combination of a graft larger than convention

253 properties, reduced infarct size, increased scar thickness, and attenuated LV dilatation 7 days afte

254 Fibroblasts persist within fibrotic scar tissue and exhibit considerable phenotypic and func

255 Fibrosis involves increasing amounts of scar tissue appearing in a tissue, but what drives this

256 HS-treated groups revealed persistent scar tissue for 10 weeks, while control groups were heal

257 ated and clinically relevant rabbit model of scar tissue formation after glaucoma filtration surgery

258 resent a new therapeutic strategy to prevent scar tissue formation in the eye and other tissues.

259 o cure for this, partly because cavities and scar tissue formed after injury present formidable barri

260 aimed to determine the influence of IMAT on scar tissue identification during endocardial contact ma

261 Tendon injuries heal via scar tissue rather than regeneration.

262 fibrogenesis results in the accumulation of scar tissue, which can lead to organ failure and death.

263 d of therapy may constitute eradicated tumor/scar tissue.

264 vere injury is dominated by the formation of scar tissue.

265 t minimizing the longer-term consequences of scar to the heart.

266 s, with scores ranging from 0 (best possible scar) to 15 (worst possible scar), based on 6 clinician

267 ing fire histories, consisting of 1,767 fire-scarred trees from 97 sites (from 22 degrees S to 54 deg

268 ), central corneal disease (vascularization, scarring, ulceration, and conjunctivalization), history

269 edicted whether the rater would consider the scar undesirable, with an odds ratio of association of 1

270 as determined by the degree of conjunctival scarring (using Tauber staging), central corneal disease

271 identifying molecular characteristics of the scar, very little is known about its mechanical properti

272 The glial scar was also altered in the absence of acutely dividing

273 cell populations to determine whether either scar was altered.

274 Larger preoperative RV outflow tract scar was associated with a smaller improvement in post-P

275 tural heart disease or inadvertent pacing in scar was not associated with changes in E12; however, th

276 Histologically, a small scar was observed at the outer part of the muscular laye

277 Chorioretinal scarring was present in 3 patients (7%).

278 This work shows that SCAR, WASP, and dDia2 compete for actin.

279 Pseudopods are replaced in double SCAR/WASP mutants by aberrant filopods, induced by the f

280 previously established that Rac1 signals via Scar/WAVE and Arp2/3 to effect pseudopod extension and m

281 tes actin dynamics through interactions with Scar/WAVE and Ena/VASP proteins to promote the formation

282 he actin effectors Ena/VASP proteins and the SCAR/WAVE complex.

283 Actin pseudopods induced by SCAR/WAVE drive normal migration and chemotaxis in eukar

284 ear trend: only organisms with both WASP and SCAR/WAVE-activators of branched actin assembly-make act

285 rocess that is finely tuned by the conserved SCAR/WAVE-Arp2/3 actin regulatory module.

286 r epicardial and endocardial voltages within scar were low (0.4 [0.2-0.55] and 0.54 [0.33-0.87] mV, r

287 inal pigment epithelial atrophy, and macular scarring were associated with increased risk of MVL; and

288 </=20%, n = 48) subacute or chronic ischemic scars were included.

289 e and persisted in forming hypertrophic-like scars, whereas few CD26-positive cells were present in t

290 position of neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons.

291 ase P311 levels could result in less tensile scars, which could potentially lead to higher incidence

292 iations of LV diffuse fibrosis or myocardial scar with ECG parameters (QRS voltage, QRS duration, and

293 areas of late activation associated with LV scar with high interindividual heterogeneity.

294 electrograms are associated with transmural scar with low endocardial BV, the additional use of endo

295 ociations of myocardial diffuse fibrosis and scar with surface electrocardiographic (ECG) parameters

296 A set of 20 live patient scars with associated photographs, as well as a separate

297 decrease in collagen deposition resulted in scars with reduced stiffness but also reduced scar tensi

298 cutive keratoconic eyes without deep stromal scarring, with at least 1 postoperative examination 1 mo

299 were also true in the CNS, then the fibrotic scar would depend on dividing NG2(+) pericytes.

300 dural/cosmetic dermatology, plastic surgery, scars, wound healing, acne, and isotretinoin was convene