ライフサイエンスコーパス: scarring

1 raft detachments may reattach with interface scarring.

2 ion, in association with tarsal conjunctival scarring.

3 of 28 patients had mild tarsal conjunctival scarring.

4 tually leading to myocardial hypertrophy and scarring.

5 cal trials that promote organ repair without scarring.

6 baseline retinal dysfunction and subsequent scarring.

7 nologic advancement in the treatment of acne scarring.

8 2 inhibitor results in a marked reduction in scarring.

9 aneous wounds might contribute to pathologic scarring.

10 ural circuits or extensive right ventricular scarring.

11 e-related disease featuring progressive lung scarring.

12 ll exercise capacity, and greater myocardial scarring.

13 ound healing results in diminished cutaneous scarring.

14 CNS, which has decreased cell plasticity and scarring.

15 d widespread and confluent right ventricular scarring.

16 e that MC1R genotype may influence post-burn scarring.

17 esulting in submucosal tissue remodeling and scarring.

18 l the potential of beta2ARag to improve skin scarring.

19 regenerate injured ears without discernable scarring.

20 th aBCC and all patients with BCCNS reported scarring.

21 reduced risk of recurrence but not of renal scarring.

22 is and diplopia resulting from Tenon capsule scarring.

23 ts in the prevention and treatment of keloid scarring.

24 included participants, 199 (15.5%) had renal scarring.

25 ypertension, and urogenital inflammation and scarring.

26 tified 44.9% of patients with eventual renal scarring.

27 o statistically significant association with scarring.

28 leaving atubular glomeruli and interstitial scarring.

29 re at high risk for the development of renal scarring.

30 guishing recurrent sarcoma from postsurgical scarring.

31 collagen deposition and alignment to reduce scarring.

32 njury but also kidney regeneration and renal scarring.

33 hat can exacerbate tissue injury and lead to scarring.

34 tract infection and the development of renal scarring.

35 that can cause recurrent disease and corneal scarring.

36 rapeutic avenue to improve repair and reduce scarring.

37 h the extent of podocyte loss and glomerular scarring.

38 trimental side effects such as scotomata and scarring.

39 are associated with increased rates of renal scarring.

40 utcome while eliminating or reducing corneal scarring.

41 T can equally be used to identify myocardial scarring.

42 where it promotes wound healing and reduced scarring.

43 ng wound contraction mechanism and resulting scarring.

44 rsus lower urinary tract infection and renal scarring.

45 ty that thinning may occur with little or no scarring.

46 n with periductular inflammation and induced scarring.

47 l wound healing, stromal haze formation, and scarring.

48 from the epidermis is associated with dermal scarring.

49 ts from a muted growth response and fibrotic scarring.

50 he profibrotic response leading to excessive scarring.

51 atory-mediated podocyte death and glomerular scarring.

52 currently available to stratify the risk of scarring.

53 is a potential therapeutic target for dermal scarring.

54 evaluating myocardial function, volumes, and scarring.

55 ion, in association with tarsal conjunctival scarring.

56 9-14.38) were also associated with new renal scarring.

57 L/MpJ 'healer' mice heal similar injuries by scarring.

58 cs, bowel and bladder dysfunction, and renal scarring.

59 to minimise the development of hypertrophic scarring.

60 nephrectomy (SNx) model of progressive renal scarring.

61 station and markers of myocardial injury and scarring.

62 al of 35 children (7.2%) developed new renal scarring.

63 cacious except in 1 case with severe orbital scarring.

64 cantly different from those of postoperative scarring (0.9 mm(2)/sec +/- 0.00) and hematomas (2.34 mm

65 % vs. 15%; P = 0.01) and less likely to have scarring (17% vs. 36%; P < 0.001) or SHRM (36% vs. 48%;

66 ascularization (44%), dry eye (38%), corneal scarring (26%), ectropion (25%), blepharitis (23%), conj

67 sustained visual acuity loss included foveal scarring (44.3%), pigmentary abnormalities (27.9%), and

68 complications were hearing loss (5.4%), skin scarring (5.4%), amputation (3.4%), renal dysfunction (2

69 s with sustained visual acuity loss had more scarring (60.0% vs 41.4%, P = .007), more geographic atr

70 c membrane exerts anti-inflammatory and anti-scarring actions, we hypothesized that HC-HA/PTX3 could

71 nd known to exert anti-inflammatory and anti-scarring actions.

72 croptosis and apoptosis, followed by cardiac scarring after antibiotic therapy, in an NHP model of se

73 b GOF and inhbaa LOF both lead to unresolved scarring after cardiac injury.

74 ilizing drug, epothilone B (epoB), decreased scarring after rodent spinal cord injury (SCI) by abroga

75 l autofluorescence resolved without clinical scarring after treatment.

76 ter, adult Pparg(Delta/Delta) mice developed scarring alopecia and severe perifollicular inflammation

77 C57BL/6 mice develop dermatitis and scarring alopecia resembling human cicatricial alopecias

78 d who risk late-stage disease with permanent scarring alopecia.

79 y response that leads to progressive corneal scarring and blindness.

80 Notably, myocardial scarring and cardiac dimensions, among other variables,

81 it is a major risk factor for pyelonephritic scarring and CKD in children.

82 s directly underlying progressive glomerular scarring and decline of kidney function.

83 ent understanding of purinergic signaling in scarring and discuss its potential to prevent or decreas

84 l target of TGF-beta1 and mediates excessive scarring and fibrosis in several tissues.

85 that knocking down MRTF can lead to reduced scarring and fibrosis.

86 with subcortical calcifications; (3) macular scarring and focal pigmentary retinal mottling; (4) cong

87 functional muscle, human hearts are prone to scarring and hypertrophy, which can often lead to fatal

88 s, we quantified the prevalence of permanent scarring and identified clinical features predictive of

89 benefits were associated with suppression of scarring and infiltration of inflammatory/immune cells i

90 Conversely, scarring and levels of the profibrogenic factor TGF-beta

91 on of ADAM12, led to a dramatic reduction in scarring and more complete regeneration.

92 r mammals, wound repair typically results in scarring and nonfunctional reparation.

93 opportunity to develop strategies to reduce scarring and optimize wound healing.

94 mage, fibrosis can progress toward excessive scarring and organ failure, as in liver cirrhosis.

95 plicates many chronic liver diseases causing scarring and organ failure.

96 Glial scarring and outer limiting membrane integrity, features

97 characterized by confluent right ventricular scarring and patchy left ventricular scarring capable of

98 Microtubule stabilization reduces scarring and promotes axon growth.

99 tissue exposed to WNT-974 exhibits decreased scarring and reduced Col6 production.

100 fully regenerate as evidenced by persistent scarring and reduced wall motion.

101 erized by skin ulcers that carry significant scarring and social stigmatization.

102 The fibrotic group had marked bleb scarring and vascularization and worse logMAR visual acu

103 ute phase of SJS can prevent the devastating scarring and visual problems that characterize the chron

104 d receive urgent AMT to decrease the risk of scarring and visual sequelae.

105 ment failure (a composite of recurrences and scarring), and antimicrobial resistance.

106 patients with CCCA, pseudopelade (end-stage scarring), and controls with no alopecia were also studi

107 f Vps34 led to early proteinuria, glomerular scarring, and death within 3-9 weeks of age.

108 traditional circumcision, home birth, tribal scarring, and hepatitis B virus coinfection.

109 e common and can lead to extensive fibrosis, scarring, and loss of function.

110 to extracellular matrix accumulation, organ scarring, and loss of kidney function.

111 any, effective treatments to prevent excess scarring, and new treatment strategies are needed.

112 a significant difference in symptom control, scarring, and occurrence of vulvar carcinoma between com

113 es remain poor secondary to corneal melting, scarring, and perforation.

114 od lead to severe conjunctival inflammation, scarring, and potentially blinding inturned eyelashes (t

115 ges in the matrix are complex, but excessive scarring appears to limit the ability for recovery, and

116 an's layer level, and the absence of stromal scarring are associated with a high risk of developing c

117 reatment of febrile UTIs and permanent renal scarring are associated.

118 crobial therapy and the development of renal scarring are inconsistent.

119 from restoration to progressive liver tissue scarring are not well understood.

120 In the eye in particular, fibrosis and scarring are responsible for the pathogenesis or failure

121 In case 4 (irregular corneal thinning and scarring), AS-OCT enabled accurate decision on initial t

122 ractive outcomes in the treatment of corneal scarring associated with Bowman layer irregularities.

123 charts of 22 patients with anterior corneal scarring associated with irregularities in the Bowman la

124 undescribed pattern of interface astroglial scarring at boundaries between brain parenchyma and flui

125 h reduced mycobacterial growth but increased scarring at the vaccination site.

126 we introduce a noninvasive method to prevent scarring based on nonthermal partial irreversible electr

127 Cs into mice with liver injury reduced liver scarring based on picrosirius red staining (49.7% reduct

128 ynapses; Muller cell gliosis, migration, and scarring; blood vessel loss; and retinal pigment epithel

129 uently treated with fractionated CO2 for her scarring, but her hyperpigmentation worsened with each t

130 g in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely u

131 Effective treatment heals the skin without scarring, but typically psoriasis recurs in previously a

132 UWFI; P < .001) and chorioretinal atrophy or scarring by 116% (50 eyes [0.6%] by NMFP vs 101 eyes [1.

133 Analysis of renal scarring by Masson trichrome staining, kidney hydroxypro

134 No case showed clinical haze or scarring by month 3.

135 Excessive scarring can cause organ failure and death.

136 schemia, tubular dysfunction, and glomerular scarring can result in CKD or ESRD.

137 ricular scarring and patchy left ventricular scarring capable of sustaining a large number of re-entr

138 hibited an acute inflammatory response, with scarring characterized by stronger myeloperoxidase activ

139 gressively higher average tubulointerstitial scarring (ci+ct) from 3 to 6 to 12 months (P<0.001).

140 gressively higher average tubulointerstitial scarring (ci+ct) from 3 to 6 to 12 months (P<0.001).

141 r resolution of NASH, or develop progressive scarring, cirrhosis, and possibly liver cancer.

142 oma filtration surgery and other contractile scarring conditions in the eye.

143 for eye diseases and possibly also for other scarring conditions.

144 a disease that ranges from self-healing but scarring cutaneous lesions to fatal visceral leishmanias

145 Trabeculectomies in eyes without previous scarring decreased 52% from 54 224 in 1994 to 25 758 in

146 New renal scarring defined as the presence of photopenia plus cont

147 Symptoms or signs of VLS, scarring, development of malignant neoplasms, and advers

148 Liver fibrosis, a form of scarring, develops in chronic liver diseases when hepato

149 The occurrence of renal scarring did not differ significantly between the prophy

150 documentation of progression in conjunctival scarring disease is a clinical challenge.

151 st that genetic associations with chlamydial scarring disease may be focussed on processes relating t

152 Trachoma is a conjunctiva scarring disease, which is the leading infectious cause

153 zed to the scalp and can result in permanent scarring, disfiguration, and irreversible alopecia.

154 datasets for the assessment of conjunctival scarring disorders among all anthropological groups.

155 lmonary fibrosis encompasses a group of lung-scarring disorders that occur owing to known or unknown

156 More eyes with CME (65.3%) developed scarring during 2 years of follow-up compared with eyes

157 irregular astigmatism from anterior stromal scarring during that period.

158 r cells types are also associated with liver scarring, dysfunction, and carcinogenesis, which suggest

159 rized by alteration in the lamellar pattern, scarring, edema, loss of keratocytic nuclei, and calcifi

160 remained significantly associated with renal scarring even after adjusting for these variables.

161 fibril assembly and organization results in scarring, fibrosis, poor wound healing and connective ti

162 e by the operating microscope due to diffuse scarring following alkaline injury.

163 mice, the heart can regenerate fully without scarring following MI; however, this regenerative capaci

164 diameter was found to significantly increase scarring for glass implants, as well as increase local B

165 Chronic liver scarring from any cause leads to cirrhosis, portal hyper

166 Scarring from bacterial keratitis remains a leading caus

167 pro-fibrotic myofibroblast phenotype, limits scarring from different hepatic insults and represents a

168 cal because severe LR contracture, extensive scarring from prior strabismus surgery, or inadequate sp

169 tologic findings suggest that improvement in scarring from this treatment goes beyond remodeling of c

170 follow-up visits on the quantitative global scarring grading system.

171 ly, and significantly decreased fibrosis and scarring histologically.

172 netic determinants of post-burn hypertrophic scarring (HTS) are unknown, and melanocortin 1 receptor

173 l peel, dermabrasion, wound healing, safety, scarring, hypertrophic scar, and keloid.

174 ity and residual corneal side effects and/or scarring, if any.

175 of the infarct areas and reduced myocardial scarring in animals treated with WT, but not with A2BKO,

176 P = 0.01) in PLTR and baseline conjunctival scarring in BLTR (OR, 1.72; 95% CI, 1.06-2.81; P = 0.03)

177 ry, and imaging variables in detecting renal scarring in children and adolescents with a first urinar

178 eased 50% lethal dose, and decreased corneal scarring in ocularly infected mice compared to the NgK o

179 P-9 in particular could play a role in tubal scarring in response to gonococcal infection.

180 characteristics as an important mediator of scarring in skin and skeletal muscle after injury.

181 ausible mechanistic triggers of pathological scarring in skin wounds.

182 to the molecular pathways underlying orbital scarring in TED.

183 y of opiate use, did not have any astroglial scarring in the brain regions analysed.

184 left ventricular dysfunction, and excessive scarring in the ischemic heart.

185 left ventricular dysfunction, and excessive scarring in the ischemic heart.

186 ) is characterized by a progressive fibrotic scarring in the lung that ultimately leads to asphyxiati

187 remodeling, myofibroblast accumulation, and scarring in the orbit of affected individuals.

188 acute blast exposure showed early astroglial scarring in the same brain regions.

189 implants were found to significantly reduce scarring in vivo, compared to hard implants of identical

190 with higher 50% lethal dose and less corneal scarring in vivo.

191 Arthrofibrosis, abnormal scarring in which dense fibrous tissue prevents normal r

192 whose dysregulation may lead to pathological scarring in wounds.

193 standing why adult mammals develop extensive scarring instead of regeneration is a crucial goal for r

194 Although scarring is a component of wound healing, excessive scar

195 Scarring is a long-lasting problem in higher animals, an

196 Scarring is characterized by both excessive accumulation

197 This scarring is due to loss of podocytes, cells critical for

198 beyond the material yielding threshold, and scarring is thus a by-product of the folding dynamics th

199 nse; however, their role in wound repair and scarring is unknown.

200 Vision loss in children is from corneal scarring leading to deprivation and/or refractive amblyo

201 Myocardial scarring leads to cardiac dysfunction and poor prognosis

202 Light microscopy in one patient demonstrated scarring limited primarily to the posterior stroma; in t

203 d neovascularization, postherpetic keratitis scarring, lipid keratopathy, and limbal stem cell defici

204 chment, cystoid macular edema (CME), macular scarring, macular hole, optic neuropathy, or macular isc

205 This distinctive pattern of scarring may indicate specific areas of damage from blas

206 gnosis of LyP and were also required to have scarring, more than 10 lesions, or active lesions on the

207 y during regeneration (Acomys cahirinus) and scarring (Mus musculus), we found that both species exhi

208 Adhesions and scarring occurred during follow-up in 12 (3.4%) complian

209 e characterized by injury, inflammation, and scarring of alveoli, leading to impaired function.

210 Epithelial shedding and scarring of fallopian tube mucosa are the main consequen

211 racterized by the overgrowth, hardening, and scarring of lung tissue.

212 patient, the interface was smooth with mild scarring of the anterior lamellae.

213 cell density and mitigated inflammation and scarring of the conjunctiva.

214 s a clinical disorder characterized by focal scarring of the glomerular capillary tuft, podocyte inju

215 FSGS is characterized by segmental scarring of the glomerulus and is a leading cause of kid

216 ve kidney diseases are often associated with scarring of the kidney's filtration unit, a condition ca

217 fibrosis (IPF) is characterized by excessive scarring of the lung parenchyma, resulting in a steady d

218 mortality that is characterized by abnormal scarring of the lung parenchyma.

219 Visual acuity, dry eye severity, and scarring of the ocular surface and eyelids were assessed

220 Three of 10 had moderate scarring of the tarsal conjunctiva and lid margins and a

221 orneal irregularities and/or central corneal scarring often secondary to long-standing preoperative c

222 Determining if individuals with TT had scarring or are known to the health system was critical

223 nal lesions - congenital dysplasia, acquired scarring or both - are a common cause of childhood hyper

224 of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and p

225 ronment in zebrafish shows remarkably little scarring or expression of inhibitory molecules and regen

226 Treatment that targeted the prevention of scarring or GA may improve vision outcomes.

227 t receive transvenous leads, have epicardial scarring or have intra-atrial re-entrant tachycardia cou

228 oderate cases have a low risk of significant scarring or visual sequelae and may be monitored and tre

229 aCT1 has potential to improve scarring outcome after surgery.

230 tival corkscrew vessels (P < 0.001), corneal scarring (P = 0.01) and pingueculae under the age of 50

231 re of cardiac fibroblasts, which can lead to scarring, pathological remodelling and functional defici

232 Whereas glial scarring presents a roadblock for mammalian spinal cord

233 and confluent, indicating a dense/transmural scarring process in CC.

234 ans, myofibroblasts play a major role in the scarring process in response to injury.

235 nalysis allowed us to detect the presence of scarring processes resulting from the disappearance of o

236 In others, epicardial scarring prohibits adequate sensing and pacing threshold

237 Trabeculectomies in eyes with scarring ranged from 9054 to 13 604 between 1994-2003, b

238 which damage to the epithelium induces lung scarring remain poorly understood.

239 ells involved in tissue repair, healing, and scarring respond to both ADO and ATP.

240 Fibrosis and scarring result from chronic inflammation that interrupt

241 l acuity at referral, local therapy, macular scarring, retinal detachment, and hypotony and phthisis

242 (e.g., pathogen-killing) and negative (e.g., scarring) roles in repair.

243 The primary efficacy endpoint was average scarring score using visual analog scales evaluating inc

244 included patients with clinically diagnosed scarring secondary to inflammatory or cystic acne.

245 gard to visual acuity, dry eye symptoms, and scarring sequelae at least 3 months after the acute illn

246 No other scarring sequelae occurred.

247 10 had only mild or no dry eye symptoms and scarring sequelae.

248 (BCVA) of 20/20, no dry eye symptoms, and no scarring sequelae.

249 generally inversely related to the extent of scarring, suggesting the possibility that regeneration c

250 ould be more effective in treating excessive scarring than modulation of either therapeutic target al

251 ive explanation for some forms of pathologic scarring that are now attributed to truncated telomeres.

252 c blast exposure showed prominent astroglial scarring that involved the subpial glial plate, penetrat

253 ealing response that generates collagen-rich scarring that is at first protective but if inappropriat

254 g corneal edema can lead to anterior stromal scarring that may limit visual acuity following Descemet

255 milder and more transient HSK with variable scarring that mirrors HSK seen in most humans.

256 In case 1 (corneal scarring) the OCT images helped to guide manual dissecti

257 eta 2 adrenergic receptor (beta2AR) in wound scarring, the ability of beta 2 adrenergic receptor agon

258 r function after injury results in excessive scarring, the upstream signals remain unknown.

259 imicrobial therapy was associated with renal scarring; the median (25th, 75th percentiles) duration o

260 reflux was the strongest predictor of renal scarring, this degree of reflux was present in only 4.1%

261 argeting of soluble or cellular mediators of scarring to promote tissue regeneration.

262 phage accumulation, cytokine production, and scarring to the same extent as CV mice.

263 hase genome-wide association study (GWAS) of scarring trachoma (1090 cases, 1531 controls) that ident

264 conjunctival fibroblasts from patients with scarring trachoma and matching control individuals, and

265 We further demonstrate that scarring trachoma fibroblasts can promote Akt phosphoryl

266 We show that scarring trachoma fibroblasts substantially differ from

267 ered a distinctive molecular fingerprint for scarring trachoma fibroblasts, and identified IL-6- as a

268 Secondary outcomes were renal scarring, treatment failure (a composite of recurrences

269 ed by recurrent inflammation and progressive scarring triggered by viral release from corneal nerves.

270 ), central corneal disease (vascularization, scarring, ulceration, and conjunctivalization), history

271 as determined by the degree of conjunctival scarring (using Tauber staging), central corneal disease

272 measurements for the detection of myocardial scarring, using cardiac MR as a reference.

273 findings on clinical examination were haze, scarring, vascularization, stromal edema, pigment clumps

274 At 1 year, CDVA associated with the scarring was 20/40 versus 20/20 for the fellow-eye prima

275 y high-risk group in whom the risk for renal scarring was 30.7%.

276 otic therapy in those with and without renal scarring was 72 (30, 120) and 48 (24, 72) hours, respect

277 Within these regions, the extent of scarring was 72% (95% CI, 69% to 76% [SD, 25%]); however

278 eal hydrops, whereas the presence of corneal scarring was a preventive factor.

279 Renal scarring was defined by the presence of photopenia on th

280 wound inflammation, angiogenesis, and wound scarring was explored in HDFs, zebrafish, chick chorioal

281 Left ventricular scarring was patchy with a predilection for the basal se

282 Chorioretinal scarring was present in 3 patients (7%).

283 Myocardial scarring was quantified on each segment using delayed en

284 ost common cause of MVL (3.55%), and macular scarring was the most common cause for irreversible SVL

285 healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment effi

286 inal pigment epithelial atrophy, and macular scarring were associated with increased risk of MVL; and

287 trick skin types I through V and facial acne scarring were enrolled.

288 racteristics associated with greater risk of scarring were predominantly classic choroidal neovascula

289 nflammation, and are associated with minimal scarring when compared with equivalent cutaneous wounds.

290 mal fibroblast (HDF ) function contribute to scarring, whereas hyperpigmentation negatively affects s

291 Corneal scarring, whether caused by trauma, laser refractive sur

292 is often accompanied by reactive gliosis and scarring, which are difficult to reverse with existing t

293 position of neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons.

294 Scarring, which occurs in essentially all adult tissue,

295 tromal cysts; 5b, healing stage: pan-stromal scarring with a remaining aspect of Descemet's membrane

296 d, there is unwanted and irreversible tissue scarring with consequent organ damage, organ failure, an

297 ncentrations of mitomycin C (MMC) to prevent scarring with trabeculectomy surgery.

298 cutive keratoconic eyes without deep stromal scarring, with at least 1 postoperative examination 1 mo

299 aracterized by progressive, unrelenting lung scarring, with death from respiratory failure within 2-4

300 y is routinely used in the treatment of acne scarring, with thermal injury resulting in collagen synt