ライフサイエンスコーパス: schistosome

1 asts of planarians (free-living relatives of schistosomes).

2 localized to the outer tegument of the adult schistosome.

3 overexpressed in the gut of the adult female schistosome.

4 trate that SmNPP-5 is a virulence factor for schistosomes.

5 ial applications in the study and control of schistosomes.

6 capable of transmitting S haematobium-group schistosomes.

7 of proviral MLV retrovirus in the transduced schistosomes.

8 issues of transduced schistosomula and adult schistosomes.

9 enomic DNA was extracted from the transduced schistosomes.

10 nsporters (gpaAT), has been characterized in schistosomes.

11 ility of the car washers to reinfection with schistosomes.

12 nophilia with resistance to reinfection with schistosomes.

13 y be more important for calcium signaling in schistosomes.

14 could increase the colonisation potential of schistosomes.

15 new drug targets in S. haematobium and other schistosomes.

16 the hypothesis that the slow development of schistosome-acquired immunity is due to the slow accumul

17 luciferase transgene activity driven by the schistosome actin gene promoter was expressed in the tis

18 ed Kenyans recovered responses of B cells to schistosome Ag.

19 zation of C57BL/6 animals with bacterial and schistosome Ags also resulted in schistosome-specific IL

20 We found that crude schistosome Ags downregulate basal B cell activation lev

21 Gene expression analysis showed that schistosome albumin was induced by oxidative stress.

22 changes in IgE, IgG1, and IgG4 responses to schistosome and hookworm antigens, including the allerge

23 reens for enzyme inhibitory activity against schistosome and human HDACs.

24 The differences between schistosome and mammalian PHM suggest that it could be a

25 onship between air and water temperature and schistosome and snail development.

26 om disruption of direct interactions between schistosomes and IL-7.

27 In this article, we focus on schistosomes and metastrongylids of human and animal sig

28 We focus mainly on schistosomes and other parasites with complex life cycle

29 functional genomic-phenomic explorations of schistosomes and other parasites.

30 zed signalling domains called lipid rafts in schistosomes and propose that correct signalling to ERK

31 The life cycles of schistosomes and soil-transmitted helminths (STHs) sugge

32 factor critical for the optimal survival of schistosomes and successful parasitism.

33 n development of protective immunity against schistosomes and suggest that changes associated with HI

34 a more complete sampling of pivotal and rare schistosomes and their relatives, provide an improved fr

35 te indirect but potent effects on developing schistosomes and underscore the importance of CD4(+) T c

36 analysis of genomic DNA from the transformed schistosomes, and hybridization signals indicated that t

37 t-ligand regulated transactivation events in schistosomes, and represent potential targets for anti-s

38 E expression is developmentally regulated in schistosomes, and the GPI-anchored protein is localized

39 n with praziquantel and albendazole affected schistosome- and hookworm-specific humoral responses dif

40 tions in which only one organism is endemic; schistosome- and hookworm-specific responses were not as

41 The prophylactic efficacy of a schistosome antigen (Sm-p80) was tested in a nonhuman pr

42 Our data indicate that schistosome antigens can activate proinflammatory respon

43 Human type 2 cytokine responsiveness to schistosome antigens increases after treatment; due eith

44 The recognition of specific schistosome antigens, both in terms of the diversity of

45 ls to produce additional IL-4 in response to schistosome antigens.

46 e demonstrated transplacental trafficking of schistosome antigens; however, little is known regarding

47 Schistosomes are considered the most important of the he

48 From such studies, it is inferred that schistosomes are exclusively parasites of endotherms.

49 Schistosomes are exposed to a variety of immunological e

50 Schistosomes are human parasitic flatworms that constitu

51 Schistosomes are intravascular, parasitic flatworms that

52 Schistosomes are intravascular, parasitic helminths that

53 Schistosomes are parasitic flatworms that cause schistos

54 Schistosomes are parasitic platyhelminths that constitut

55 Collectively, S. mansoni and several other schistosomes are responsible for the infection of an est

56 In contrast, the actin filaments of schistosomes are similar to those of smooth muscles, lac

57 Little is known regarding the mechanisms of schistosome-associated hepatic fibrosis in humans, and f

58 ollagen degradation, these data suggest that schistosome-associated hepatic fibrosis results, in part

59 child-bearing age, yet little is known about schistosome-associated morbidity in pregnant women and t

60 The prospects for advances in understanding schistosome biology are highlighted.

61 re, we consider the consequences of this for schistosome biology, immunoepidemiology, and public heal

62 ovide an improved framework for interpreting schistosome biology.

63 Thus, it appears that the schistosome Ca(v) channel complex has acquired a new fun

64 on rodent and primate models has shown that schistosomes can be defeated when appropriate responses

65 Schistosomes can induce functional Bregs in humans that

66 Phylogenetically, schistosome cathepsin D appeared to be more closely rela

67 aken together, these features indicated that schistosome cathepsin D is a platyhelminth orthologue of

68 The genomic organization of schistosome cathepsin D was similar in sequence, structu

69 Schistosomes cause significant morbidity and mortality.

70 ed cDNAs from a large set of newly available schistosome cDNAs.

71 ed definitively that somatic transgenesis of schistosome chromosomes had taken place and, moreover, r

72 ealed widespread retrovirus integration into schistosome chromosomes.

73 oni and delivery of reporter transgenes into schistosome chromosomes.

74 roviral integration into human compared with schistosome chromosomes.

75 investigation of transgene integration into schistosome chromosomes.

76 The deficits in lipid metabolism that make schistosomes dependent on the host are revealed, and the

77 Schistosomes detoxify heme via crystallization into hemo

78 We demonstrate that attenuated schistosome development in the absence of IL-7 results f

79 discuss how widely used degree day models of schistosome development may not be accurate at lower tem

80 at another gamma (c) chain cytokine plays in schistosome development, demonstrating that IL-2 express

81 ukin (IL)-7 is also implicated in modulating schistosome development, we investigated whether this ef

82 importance of CD4(+) T cells in facilitating schistosome development.

83 ased or injured tissues), our data show that schistosomes display unique, constitutive, functional ex

84 s thinking on processes influencing not only schistosome diversification but also their pathogenicity

85 gain increased understanding of patterns of schistosome diversification, and their abilities to colo

86 proteins and potential new targets for anti-schistosome drug development and albumin as a novel, sac

87 Exposure to schistosomes during pregnancy can modulate infant immune

88 anges constitute a substantial alteration to schistosome ecology in that the parasites are more likel

89 Antibody responses to schistosome egg (soluble egg antigen and SmTAL2) or soma

90 f the helminth parasite Schistosoma mansoni (schistosome egg Ag (SEA)) leads to the induction of prot

91 mouse DC were copulsed with the helminth Ag, schistosome egg Ag (SEA), along with the bacterium Propr

92 cytokines IL-17, IFN-gamma, and TNF-alpha by schistosome egg Ag-stimulated mesenteric lymph node cell

93 s, but concomitant immunization with soluble schistosome egg Ags (SEA) in CFA (SEA/CFA) causes marked

94 ogy induced by concomitant immunization with schistosome egg Ags (SEA) in CFA (SEA/CFA), results from

95 eral blood mononuclear cells stimulated with schistosome egg antigen 4 weeks after PZQ treatment and

96 -pathology C57BL/6 mice by immunization with schistosome egg antigens (SEA) in complete Freund's adju

97 induced in C57BL/6 mice by immunization with schistosome egg antigens in complete Freund's adjuvant,

98 s study, we show that LNFPIII conjugates and schistosome egg antigens interact with APCs via a recept

99 LNFPIII conjugates and schistosome egg antigens, which contain the Lewis(x) tri

100 n glycomics approach in which N-glycans from schistosome egg glycoproteins were prepared, derivatized

101 obium-exposed participants was cultured with schistosome egg, adult worm, and cercaria antigens pre-

102 nt role in driving inflammatory responses to schistosome egg-induced hepatic granulomata reactions, a

103 polygyrus resulted in a marked reduction in schistosome egg-induced hepatic immunopathology, which w

104 t is essential for the development of severe schistosome egg-induced immunopathology, and its absence

105 a central role in the development of severe schistosome egg-induced immunopathology.

106 ly occurring regulatory T cells (naTregs) in schistosome egg-induced inflammation.

107 ndependent part of the regulatory network in schistosome egg-induced inflammation.

108 g two Th2 model systems, allergic asthma and schistosome egg-induced lung granulomas, we found that t

109 By comparing Th responses in schistosome egg-injected mice that lack IL-10, IL-4, and

110 Interleukin-4-inducing principle from schistosome eggs (IPSE/alpha-1) is a protein produced ex

111 infected animals was shown to be induced by schistosome eggs and directed largely against egg antige

112 the Lewis(x) trisaccharide that is found on schistosome eggs and in breast milk.

113 patic schistosomiasis, pathology arises when schistosome eggs become lodged in the host liver, evokin

114 Conversely, stimulation with schistosome eggs in the presence of exogenous IL-23 and

115 us, the natural shotgun glycan microarray of schistosome eggs is useful in identifying antigenic glyc

116 f malaria parasites through livers harboring schistosome eggs may alter host immune responses and inf

117 ripts in schistosome-infected mice, and that schistosome eggs selectively stimulate production of IL-

118 We now report that live schistosome eggs stimulate dendritic cells from high pat

119 We first demonstrate that schistosome eggs stimulate production of IL-22 transcrip

120 hich produce IL-17 when stimulated with live schistosome eggs.

121 or regulation of an inflammatory response to schistosome eggs.

122 ced Th17 cell differentiation in response to schistosome eggs.

123 escence titration analyses demonstrated that schistosome eIF4E has similar binding specificity for bo

124 rison of NMR chemical shift perturbations in schistosome eIF4E on binding m(7)GpppG and m(2,2,7)GpppG

125 intrinsic conformational flexibility in the schistosome eIF4E that enables binding to m(2,2,7)G cap.

126 Schistosomes employ proteolytic enzymes to digest host h

127 are crucial for improving birth outcomes in schistosome-endemic areas.

128 ers in human reproduction, we speculate that schistosome estrogen-like molecules may contribute to in

129 Simultaneous stimulation of schistosome-exposed C57BL/6 dendritic cells with a heat-

130 re proteins recognized by serum samples from schistosome-exposed individuals before and after curativ

131 adult worm antigens by serum antibodies from schistosome-exposed Zimbabweans aged 5-18 years.

132 demonstrates that in Xenopus extracts and in schistosome extracts SPRM1hc is associated into a high m

133 ovaries and testes from paired and unpaired schistosomes for comparative RNA-seq analyses.

134 o accumulation of infections with long-lived schistosomes from early life.

135 ansgenic lines of schistosomes, to elucidate schistosome gene function and expression, and to advance

136 o encode firefly luciferase under control of schistosome gene promoters was introduced along with 7-m

137 ion of all six exon/intron boundaries of the schistosome gene.

138 ents an approximately 8-fold coverage of the schistosome genome.

139 s feasible, given the sequencing of multiple schistosome genomes.

140 Here, progress made in schistosome genomics and post-genomics is considered.

141 achykinin A (PPT A)) was detected within the schistosome granuloma, spleen, and lamina propria macrop

142 Both schistosome granulomas and gut mucosa display an SP immu

143 Preprotachykinin C mRNA was in murine schistosome granulomas and intestinal lamina propria mon

144 us, RGS16-mediated confinement of T cells to Schistosome granulomas mitigates widespread cytokine-med

145 Introduction of exogenous transposons into schistosomes has not been reported but transposon-mediat

146 t genome sequences of two of the major human schistosomes has underscored the pressing need to develo

147 f the great neglected diseases of the world, schistosomes have unusual biological features that furth

148 Infection with schistosome helminths is associated with granulomatous i

149 ion role during hematophagy, we propose that schistosome hemozoin also provides a potent immunomodula

150 sing factors associated exclusively with the schistosome host-parasite interface, a structure called

151 n had significantly increased levels of anti-schistosome IgE and CD23(+) B cells after receiving > or

152 B cell activation and anti-schistosome IgE are associated with resistance to S. man

153 There are two paradigms that exist in schistosome immunology.

154 Strikingly, schistosomes in the bloodstream have this same set of AT

155 ely influences survival and/or maturation of schistosomes in the host to patency, as we reproducibly

156 development of techniques for investigating schistosomes in their human and snail hosts and the deve

157 -enantiomers are highly active against adult schistosomes in vitro (IC50 0.08-0.13 muM), whereas both

158 ble insights for interpreting the biology of schistosomes, including the species that cause disease i

159 which result in significant amelioration of schistosome-induced immunopathology.

160 Given that schistosome-induced, non-natural killer T (NKT) cell leu

161 Schistosomes infect 200 million individuals annually and

162 Schistosomes infect approximately 40 million women of ch

163 Currently, schistosomes infect approximately 40 million women of ch

164 Schistosomes infect hundreds of millions of people in th

165 Schistosomes infect more than 200 million of the world's

166 Schistosome-infected animals also had significantly lowe

167 Schistosome-infected Cd14(-/-) mice showed significantly

168 Significantly, schistosome-infected IL-12p40-deficient or IL-1R antagon

169 erleukin 17 upon coculture with B cells from schistosome-infected individuals only, while the convers

170 immunoglobulin G in human serum samples from schistosome-infected individuals.

171 Treatment of schistosome-infected mice with 4-phenyl-1,2,5-oxadiazole

172 hibit accumulation of IL22-BP transcripts in schistosome-infected mice, and that schistosome eggs sel

173 We demonstrate that offspring from schistosome-infected mothers that were mated in the TH1

174 d accumulation of the CD4+ memory T cells in schistosome-infected people has implications for the dev

175 diators were elevated in the cord blood from schistosome-infected pregnancies, including insulin-like

176 on by the World Health Organization to treat schistosome-infected pregnant and lactating women.

177 or Schistosoma mansoni, one of the important schistosomes infecting man.

178 gE) responses are upregulated during chronic schistosome infection and during allergy.

179 ological theory and population-level data on schistosome infection and immune responses.

180 determines the severity of pathology during schistosome infection can be influenced not only by host

181 Protective immunity against human schistosome infection develops slowly, for reasons that

182 els and two observational studies in humans, schistosome infection during pregnancy was associated wi

183 estimates suggest that the average effect of schistosome infection is quite small, although this is d

184 observational studies indicate that maternal schistosome infection might be associated with decreased

185 Here we examined the effect on the schistosome infection of a third member of the IL-12 fam

186 imal models indicate a deleterious effect of schistosome infection on maternal, fetal and neonatal ou

187 ly identifying and quantifying the impact of schistosome infection on pregnancy outcomes with well-de

188 with the induction of Th2 responses, murine schistosome infection results in an inhibition of potent

189 produce high levels of IL-17 in response to schistosome infection show increased mortality.

190 ely 200,000,000 people have schistosomiasis (schistosome infection).

191 During natural schistosome infection, the induction of T helper type 2

192 t understanding of human immune responses to schistosome infection.

193 Chronic schistosome infections are associated with T-cell hypore

194 Schistosome infections are often clinically silent, but

195 Murine studies have shown that schistosome infections can induce regulatory CD1d(hi) B

196 o the debate regarding treatment of maternal schistosome infections.

197 o present in vivo translation studies of the schistosome initiator methionine context and the effect

198 (ATP) released by host cells in response to schistosome intravascular migration.

199 The advent of transgenic schistosomes is explored in relation to the biology of t

200 r, such 'transactivation' by host factors in schistosomes is not well defined.

201 )(+) catabolizing enzyme (NACE) expressed by schistosomes is structurally most closely related to the

202 Among the outstanding features of schistosomes is their dioecious lifestyle and the pairin

203 tions confirmed their compatibility with the schistosomes isolated from patients.

204 Chemotherapy for blood-dwelling schistosomes kills the worms and exposes parasite antige

205 Schistosomes lack catalase, the main H2O2-neutralizing e

206 ort on the potential of products released by schistosome larvae (material released in the first 3 h a

207 ed significant dose-dependent killing of the schistosome larvae and markedly impaired egg laying of a

208 patibility experiments by exposing snails to schistosome larvae recovered from the urine of a locally

209 itionally screened for lethality against the schistosome larval stage using a fluorescence-based assa

210 emonstrate that SPRM1hc is expressed in each schistosome life stage examined (eggs, cercariae, schist

211 How schistosomes maintain their longevity in this immunologi

212 rted but transposon-mediated transgenesis of schistosomes might supersede current methods for functio

213 neering studies by several laboratories into schistosome molecular biology and molecular genetics.

214 hlight future interventions towards stopping schistosome morbidity and transmission within this conse

215 Schistosome mRNAs have either the typical monomethylguan

216 We conclude that schistosome muscles are hybrids, containing striated mus

217 supported by sequence comparison between the schistosome myosin II heavy chain and known striated mus

218 ene expression profiling, we find that these schistosome neoblast-like cells express a fibroblast gro

219 d skin-migratory patterns of the three major schistosomes of humans reveals major differences.

220 ion in individuals chronically infected with schistosomes or hepatitis C virus (HCV).

221 challenges in the pilot-scale production of schistosome paramyosin have hampered further studies of

222 Schistosome parasites exhibit separate sexes and with th

223 ht into the intravascular lives of the major schistosome parasites of humans.

224 In contrast with some geohelminths and schistosome parasites whose worm burdens typically exhib

225 Likewise, the remaining important human schistosome parasites, S. japonicum and S. hematobium, a

226 ogression of chronic liver disease caused by schistosome parasites.

227 dditionally, the proteolytic secretions from schistosome parasitic flatworm larvae and a pancreatic c

228 One amino acid transporter, Schistosome Permease 1 light chain, SPRM1lc, a member of

229 In this report, we characterize this schistosome permease heavy chain (SPRM1hc) gene and prot

230 le kinetics, whereas a previously identified schistosome peroxiredoxin was found to function with mor

231 The ability of schistosome peroxiredoxins to use alternative electron d

232 Transient expression of schistosome PHM (smPHM) revealed functional properties t

233 ing and functional characterisation of other schistosome/platyhelminth genomes continues to expedite

234 ity, and chromosomal assignment, of existing schistosome/platyhelminth genomes.

235 ught, and flooding could impact on snail and schistosome population dynamics.

236 the spectrum of praziquantel sensitivity of schistosome populations and for an improved knowledge of

237 We propose this as one mechanism by which schistosomes prevent their hosts from focusing immunolog

238 hared by free-living ancestors to modern-day schistosomes probably contributed to the success of thes

239 ances in our understanding of the genomes of schistosomes, progress in the development of functional

240 4E.m(7)GpppG structure demonstrates that the schistosome protein binds monomethyl cap in a manner sim

241 ts, and a chemogenomic screen has pinpointed schistosome proteins for which existing drugs may be act

242 dings that rBgGal selectively recognizes the schistosome-related sugar, lacNAc, and strongly binds to

243 Female schistosomes rely on a unique male-induced strategy to a

244 l gene expression between S. mansoni-exposed schistosome-resistant and susceptible snail lines will i

245 Infection with schistosomes results in a CD4 T cell-mediated inflammato

246 footprints in the vicinity of the endogenous schistosome retrotransposons Boudicca, SR1, and SR2.

247 , and others, as well as near the endogenous schistosome retrotransposons, the fugitive and SR1.

248 Schistosomes reveal a surprising ability to switch into

249 isation between S haematobium and the cattle schistosome S bovis had a putative role in this outbreak

250 Among the schistosomes, Schistosoma haematobium is responsible for

251 Fragments of the MLV transgene and flanking schistosome sequences recovered using an anchored PCR-ba

252 Schistosome sexual dimorphism and mating systems have su

253 ells from M. tuberculosis-infected humans to schistosome soluble egg antigen (SEA) and then profiled

254 Blood cultures were incubated with schistosome soluble worm antigen (SWA) or soluble egg an

255 sites, evolutionary conservation among other schistosome species and differential expression across f

256 Whether IPSE homologs are expressed in other schistosome species has not been investigated.

257 cuss recent findings regarding how different schistosome species infect and manipulate immune respons

258 compound was active against the three major schistosome species infecting humans.

259 Of the three main human schistosome species, only S. mansoni is sensitive to oxa

260 to date and describes novel antigens in all schistosome species.

261 cing quantitative and qualitative changes in schistosome-specific antibody responses.

262 ects were associated with distinctly altered schistosome-specific cytokine and gene expression profil

263 el treatment markedly alters polarization of schistosome-specific cytokine responses, and these chang

264 Schistosome-specific IgE from resistant, occupationally

265 sociated with a significantly lower ratio of schistosome-specific IgE/IgG4 (marker for resistance to

266 In this article, we demonstrate that schistosome-specific IL-17 induction by dendritic cells

267 This schistosome-specific IL-17 was dependent on IL-6 product

268 cterial and schistosome Ags also resulted in schistosome-specific IL-17, and this response was enhanc

269 Different studies have reported that schistosome-specific IL-4 and IL-5 responses, or posttre

270 had significantly higher baseline levels of schistosome-specific immunoglobulin E (IgE) than did chi

271 he development of natural or vaccine induced schistosome-specific protective immunity as well as for

272 RNA transfection experiments using several schistosome stages demonstrated that the flatworm SL AUG

273 n of host immune cell responses by viral and schistosome T2 enzymes, and neurological development and

274 reveal a heretofore unrecognized role of the schistosome tegument in controlling water and drug movem

275 nes and/or novel drugs targeting TEMs in the schistosome tegument.

276 Recent proteomic analysis of the schistosome tegumental membranes revealed the presence o

277 n this study we cloned and characterized the schistosome tegumental phosphodiesterase SmNPP-5 and eva

278 some key aspects of the molecular biology of schistosomes that have been reported in the intervening

279 ide, is caused by flatworms (blood flukes or schistosomes) that live in the bloodstream of humans.

280 hologies exacerbated by the long lifespan of schistosomes, that can thrive in the host for decades.

281 es, and represent potential targets for anti-schistosome therapy aimed at reducing parasite survival

282 or of schistosomula of the three major human schistosomes through mouse and human skin.

283 to treat infection caused by all species of schistosome to combat emerging resistance to current the

284 ntegrates data on 13 cytokines elicited by 3 schistosome to examine how praziquantel treatment alters

285 the cells that enable parasitic worms called schistosomes to reproduce inside snails could lead to ne

286 ers a means to establish transgenic lines of schistosomes, to elucidate schistosome gene function and

287 ng infection of their human definitive host, schistosomes transform rapidly from free-swimming infect

288 Indeed, local schistosome transmission appears firmly engrained for in

289 limitations of current models of climate and schistosome transmission, and substantial gaps in empiri

290 esent, particularly among understudied avian schistosomes, we gain increased understanding of pattern

291 data analysis also showed that the Corsican schistosomes were closely related to those from Senegal

292 Lower susceptibility was documented on adult schistosomes, with most hit compounds being tricyclic mo

293 the first time, permit visualization of live schistosomes within their living hosts.

294 reatment or were unchanged, whereas those to schistosome worm antigens (soluble worm antigen and SmTA

295 ttreatment increases in the levels of IgE to schistosome worm antigens were associated with lower Sch

296 In the present study, we show that schistosome worms also elicit systemic, antigen-specific

297 first report of killing of established adult schistosome worms by a vaccine.

298 Adult schistosome worms colonise human blood vessels for years

299 Together, our data show that schistosome worms establish an immunologic milieu where

300 In murine schistosomiasis mansoni, schistosome worms produce ova that incite focal Th2-type