ライフサイエンスコーパス: scission

1 and destabilizing the membrane neck, causing scission.

2 he ESCRT machinery mediates reverse membrane scission.

3 rization to the membrane to drive successful scission.

4 ro systems, endoA2 reshapes membranes before scission.

5 dynamin-like protein (DLP)-mediated membrane scission.

6 vacuole, peroxisomal fission, and endocytic scission.

7 racil loss also does not compete with strand scission.

8 bly, which facilitates membrane invagination/scission.

9 g new C-heteroatom bond formations via C-OMe scission.

10 dditional driving force for C-H and O-H bond scission.

11 dorse the nucleophilic assistance to the C-S scission.

12 -coding RNAs that catalyze single-strand RNA scission.

13 he plasma membrane to drive invagination and scission.

14 ud and constricting the neck to the point of scission.

15 bulk endosomes, indicating impaired membrane scission.

16 ding and that VP40 may be able to mediate PM scission.

17 rocycle followed by subsequent beta-hydrogen scission.

18 of prototypical dynamin in endocytic vesicle scission.

19 r the mechanism of dynamin-mediated membrane scission.

20 rane constriction and COPII-directed vesicle scission.

21 mbrane recruitment and GTP-dependent vesicle scission.

22 volvement of spiraling filaments in membrane scission.

23 efore vesicle scission and regulates vesicle scission.

24 vidence for a radical mechanism for C-C bond scission.

25 d that this has implications for budding and scission.

26 lifetimes of dynamin, a key component of CCP scission.

27 decay are consistent with homolytic O-O bond scission.

28 opologically unique membrane deformation and scission.

29 d/or 2'-OH-mediated-endonucleolytic modes of scission.

30 s of actin and N-BAR recruitment to sites of scission.

31 sts how Arf and Sar proteins work in vesicle scission.

32 e CCP and is required for ubiquitin-promoted scission.

33 operatively to efficiently catalyze membrane scission.

34 rates dynamin and N-BAR proteins at sites of scission.

35 uited in the approximately 20-30 s preceding scission.

36 ice assembly is complete but before membrane scission.

37 tween dynamin and actin at sites of membrane scission.

38 and mediates virus budding through membrane scission.

39 acent nucleotide has little effect on strand scission.

40 untered the thiol molecules, due to S-H bond scission.

41 membrane shaping, tubule stabilization, and scission.

42 proteins, which bend the membrane and drive scission.

43 nical two-metal-ion mechanism to promote DNA scission.

44 SNX18 in endocytic carrier formation and/or scission.

45 ic membrane geometry necessary for efficient scission.

46 acent nucleotide has little effect on strand scission.

47 endocytic membrane invagination and vesicle scission.

48 eins involved in actin assembly and membrane scission.

49 ng the timing of ESCRT-III-mediated membrane scission.

50 clic alcohols to linear ketones via C-C bond scission.

51 spective sites of division where it mediates scission.

52 n via stereoelectronically assisted C-C bond scission.

53 o cause the necessary curvature for membrane scission.

54 g by endoA2 and pulling-force-driven dynamic scission.

55 drial division dynamin also mediated vesicle scission.

56 UL34 are sufficient for membrane budding and scission.

57 dization that accompanies carbon-oxygen bond scission.

58 a role for the Vps1-actin interaction during scission.

59 es membrane deformation and perhaps membrane scission.

60 nificantly to the driving force for C-H bond scission.

61 MAPs in creating and/or stabilizing membrane scissions.

62 MoOx, Ir/VOx) demonstrate unusually high C-O scission activity at moderate temperatures.

63 urvature, potentially enabling Sar1 membrane scission activity to be spatially restricted to highly b

64 cascade of CI couplings facilitates N-H bond scission along the (1)pisigma* state in 170 +/- 20 fs, f

65 proximately 50% decrease in the incidence of scission, an approximately 50% decrease in the amplitude

66 hols from amides by the challenging N-C bond scission and (ii) synthesis of nitrogen-containing heter

67 helix (M2 five-point mutant, or 5PM) reduced scission and also filament formation, whereas single mut

68 echanophore that does not lead to main chain scission and an elastomeric polyurethane enabled consecu

69 T) gives insight into the mechanisms of C-Br scission and C-C coupling processes.

70 reoelectronic beta-oxygen effect on the beta-scission and consequently on the 1,8-HAT reaction has be

71 ibit distinct toxin activities including RNA scission and DNA gyrase inhibition.

72 hway that requires dynamin-mediated membrane scission and endosomal acidification but is distinct fro

73 res determine the reaction pathways via bond scission and formation among weakly adsorbed water and r

74 equivalents result in full uranium-oxo bond scission and formation of UI4(1,4-dioxane)2 with extrusi

75 ls that the histone proteins catalyze strand scission and increase the rate between 11- and approxima

76 riteria of having only a single point of S-S scission and maximizing the ratio of S-S to the electroc

77 s-based perspective for the onset of vesicle scission and predict the shapes and composition of detac

78 this inhibition, effectively triggering CCP scission and producing a receptor-containing endocytic v

79 thrin-coated pits (CCPs) just before vesicle scission and regulates vesicle scission.

80 ysin heterodimer Rvs161/Rvs167 to facilitate scission and release of vesicles.

81 T III-Vps4 complex assembly that facilitates scission and repair of the injured cell membrane.

82 eolae to the cell surface by restricting the scission and subsequent endocytosis of these membrane pi

83 nks are not intermediates en route to strand scission and that C2 deprotonation is the rate-determini

84 rin contributes to the regularity of vesicle scission and thereby to controlling vesicle size.

85 of fragments generated by backbone C-C bond scissions and with the help of reference MS(2) spectra o

86 e to a long-lived dioxetane with inefficient scission, and also reduced at high temperatures, due to

87 lates membrane trafficking through vesicular scission, and it is presumed that reducing this activity

88 conjugation-driven radical-assisted C-O bond scission applies to any catalytic surface that preserves

89 , and subsequent R-loop formation and strand scission are driven by complementary base pairing betwee

90 The structural requirements for scission are even more stringent than those for budding,

91 nucleotide and only minor amounts of strand scission are observed at the initial site of radical gen

92 ly proposed mechanisms describing amide link scission as a result of the hydrolysis of the N-chlorina

93 th S599V and S599D caused defects in vesicle scission, as shown by both live-cell imaging and electro

94 , consistent with the proposed role of M2 in scission at the end of budding.

95 ling steps, which lead to efficient membrane scission at the end of ILV biogenesis in vivo.

96 n promotes further chlorine uptake, and (vi) scission at the membrane surface is unrepresentative of

97 b-PLA micelles resisted backbiting chain end scission, based on reverse-phase HPLC analysis.

98 ls that the histone proteins increase strand scission between 130- and 550-fold.

99 e force for membrane invagination or vesicle scission, but how this force is transmitted to the plasm

100 Furthermore, GTP-dependent membrane scission by dynamin was dramatically elevated by BAR dom

101 nucleotides in DNA results in direct strand scission by generating alkali-labile fragments from the

102 is significantly more susceptible to strand scission by ionizing radiation (hydroxyl radical) than i

103 ic digestion but facilitates endonucleolytic scission by MRX with a dependence on ATP and Sae2.

104 ular details and determinants impacting NEMO scission by PEDV nsp5 delineated in this study are funda

105 ir protection of supercoiled DNA strand from scission by peroxyl and hydroxyl radicals into the nicke

106 budded vesicles, suggesting that it mediates scission by scaffolding the membrane bud and constrictin

107 d be a significant contributor to RNA strand scission by the hydroxyl radical, particularly under ana

108 ow a different mechanism, crystal growth and scission, can accurately replicate chemical sequences wi

109 by the stabilization of an enzyme-substrate scission complex via three distinct amino-acid-binding p

110 sequence of bits while mechanically-induced scission creates new growth fronts.

111 ter stages of endocytosis, consistent with a scission defect.

112 aptor protein that binds actin and modulates scission during endocytosis.

113 ggested to regulate actin-dependent membrane scission during endosomal sorting, but its cellular role

114 d protein 1 (Drp1), responsible for membrane scission during mitochondrial fission.

115 estigate the process of M2-mediated membrane scission during the budding of influenza viruses.

116 ESCRT-III executes membrane scission during the budding of intralumenal vesicles (IL

117 or transport III) filaments mediate membrane scission during the ostensibly disparate processes of mu

118 the activation energy of the CO and CH bond scission during the oxidation process.

119 The dependence of strand scission efficiency from 1 on secondary structure under

120 The dependence of strand scission efficiency from the 5,6-dihydrouridin-5-yl radi

121 FtsA may be critical for the final membrane scission event.

122 CRT proteins mediate membrane remodeling and scission events and are essential for endosomal sorting

123 Dynamin controls its own recruitment to scission events by modulating the kinetics of actin and

124 endocytosis of beta2AR occurs via quantized scission events hosted by clathrin spots and plaques of

125 The complex drives membrane scission events in a range of processes, including cytok

126 namics in vitro, a prerequisite for membrane scission events in cells.

127 and abolished actin and N-BAR recruitment to scission events.

128 ns to individual clathrin-mediated endocytic scission events.

129 s and the mechanism of DRP-mediated membrane scission events.

130 Radical cyclization and ring scission experiments are consistent with hydrogen atom t

131 They document that distinct scission factors operate in an additive manner, and pred

132 nd the I51A-Y52A A/Udorn/72 and WSN viruses, scission failed, and emerging virus particles exhibited

133 We call this mechanism friction-driven scission (FDS).

134 Sonication experiments generate limiting scissioned fibrils with a well-defined length-to-width c

135 gests the reaction mechanisms including bond scissions followed by hydrogenation, gas phase addition

136 By contrast, C-C bond scission for the linear and branched structures leads to

137 ong with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in t

138 petition studies with thiol show that strand scission from the 5,6-dihydrouridin-5-yl radical (1) is

139 On a few occasions, N-N bond scission has been observed instead.

140 in proteins such as endophilin contribute to scission has remained unexplored.

141 e, yet the molecular cues that govern strand scission have not been elucidated.

142 a proton channel but also mediates membrane scission in a cholesterol-dependent manner to cause viru

143 ate that Sar1 alone is competent for vesicle scission in a manner that depends on the concentration o

144 and RNA aptamers, as well as catalytic bond scission in a ribozyme.

145 iable features of structure required for RNA scission in BrnT and the RelE toxin family.

146 lain endocytic tubule elongation and vesicle scission in fission yeast.

147 timing of ESCRT-III recruitment and membrane scission in HIV-1 budding.

148 s a new framework for understanding membrane scission in the absence of mechanoenzymes such as dynami

149 rface is unrepresentative of volume-averaged scission in the active layer.

150 The volume-averaged amide link scission in the aromatic polyamide active layer of a rev

151 ular bonding, leading to intramolecular bond scission in the formation of secondary ions.

152 tion of the directing functionality via beta-scission in the last step of the cascade.

153 nd-order rate constants for C-H and O-H bond scission in the range of 10-10(7) M(-1)s(-1).

154 Catalysis of bond scission in these hammerhead ribozymes could be restored

155 Wet self-mending of scission in these polymers is initiated and accelerated

156 on intermediate that catalyzes carbon-carbon scission in this key enzyme.

157 toethanol (1 M) does not compete with strand scission, indicating that phosphate elimination is >10(6

158 cyclin C directs the extensive mitochondrial scission induced by the anticancer drug cisplatin or oxi

159 The oxidative chain scission induced by ultraviolet irradiation also indicat

160 cked by dynasore, dynamin-dependent endosome-scission inhibitor, at subtoxic concentrations, suggesti

161 ring the first oxidation step, with C-C bond scission instead leading to ring opening, efficient func

162 Membrane scission is a crucial step in all budding processes, fro

163 Heterolytic bond scission is a staple of chemical reactions.

164 to occur, (ii) hydroxide-induced amide link scission is a strong function of exposure to hypochlorou

165 ough the underlying molecular details of how scission is accomplished often remain unknown.

166 d by inhibition of actin polymerization, and scission is blocked by inhibiting dynamin.

167 II complexes are stabilized and ILV membrane scission is delayed by Doa4, which is the ubiquitin hydr

168 Membrane scission is essential for intracellular trafficking.

169 the alpha-ribo-furanose; therefore, the beta-scission is highly delayed, and due to the reversibly na

170 pate in both GTPase recruitment and membrane scission is not known.

171 naling at the plasma membrane before vesicle scission is poorly understood.

172 menting step, followed by loss of R-OH, beta-scission is preferred for the formation of alkoxy radica

173 The barrier for O-O bond scission is sensitive to Pd surface structure and is con

174 s suggests that the rate constant for strand scission is significantly greater than 10(6) s(-1) at pH

175 N-glycosidic bond scission is then facilitated by a backbone phosphate gro

176 dies that suggest that the barrier to strand scission is very low and that synchronous proton transfe

177 protein that is required to mediate particle scission, is recruited to HIV-1 assembly sites approxima

178 rinsic to the broad distribution of limiting scission lengths.

179 presents a complete membrane deformation and scission machinery.

180 The scission mechanism is unknown but appears to be linked t

181 ts were consistent with a free radical chain scission mechanism, supported by measurements of sub-muM

182 imulations are consistent with a heterolytic scission mechanism.

183 oxidation pathway increased the level of DNA scission mediated by both enzymes ~4-5-fold.

184 Less intramolecular scission occurred in the amorphous form, resulting in a

185 elegans Our findings indicate that membrane scission occurs on both sides of the midbody ring with r

186 Strand scission occurs preferentially in double stranded RNA an

187 Internucleotidyl strand scission occurs via beta-elimination of the 3'-phosphate

188 oxygen with the vinyl ether bond linker with scission of a dioxetane intermediate.

189 of singlet oxygen with the ethene spacer and scission of a dioxetane intermediate.

190 the intermediate 5-exo-trig product via beta-scission of a properly positioned weak C-S bond provides

191 catalyzed sequence for the formal two-carbon scission of allyl groups to carboxylic acids has been de

192 ously unrecognized role for dynamin-2 in the scission of apical carrier vesicles from AREs.

193 The scission of biological membranes is facilitated by a var

194 Scission of both types of pits was found to be dynamin-2

195 Scission of C horizontal line C covalent bonds in the br

196 her Ag(111) or Ag(110) surfaces leads to the scission of C-I bonds followed by the formation of organ

197 For ether and thioether-terminated layers, scission of C-O or C-S bonds also led to the release of

198 ite that can efficiently induce the required scission of carbon-oxygen bonds and generate carbon-carb

199 rious membrane fission events, including the scission of clathrin-coated vesicles.

200 mbrane curvature and fluidity, mediating the scission of constricted membrane necks in multiple biolo

201 dissociation from the MSW core, followed by scission of covalent bonds in the bottlebrush backbones.

202 canning large DNA molecules, and to regulate scission of double-stranded DNA.

203 en lipids and BAR-domain proteins drives the scission of elongating membrane tubules.

204 alesce, thereby leading to the detachment by scission of endocytic uptake carriers.

205 thin a single polymer chain between the bond scission of interest and the nonscissile mechanochemical

206 remains stagnated mainly due to the sluggish scission of magnesium-chloride bond and slow diffusion o

207 cs of magnesium monochloride cations without scission of magnesium-chloride bond.

208 s vacuolar protein sorting 4 (VPS4) mediates scission of microvesicles from the T-cell plasma membran

209 gagement of OCRL1 with pacsin 2 and promotes scission of MPR-containing carriers.

210 wave irradiation undergoes free radical beta-scission of N-N bond and affords diverse range of 2-O-su

211 xy)benzene (M10) molecules, dominates direct scission of O-CH2 bonds up to a temperature of approxima

212 Copper-catalyzed bond scission of pentafluorobutane-1,3-diones generates diflu

213 icating a second degradation process through scission of PES chains.

214 in vivo tracking of drug delivery and chain scission of polymeric conjugates by FRET imaging.

215 amin and actin contribute in parallel to the scission of Shiga-toxin-induced tubules.

216 ablishes the basic mechanism for budding and scission of tailored vesicles at the INM.

217 leading to an intein-succinimide product and scission of that peptide bond.

218 showed that directed expression or selective scission of the ACE2 protein had no measurable effect on

219 w the system to overcome the high barrier of scission of the actinide-oxygen bond.

220 d N-methylphthalimide (Me-phth) from beta-Me scission of the alkoxy radicals to form a methyl radical

221 ibo-derivatives gave exclusively direct beta-scission of the alkoxyl radical.

222 A complete scission of the B horizontal lineB double bond in 6 was

223 Subsequent scission of the beta'-C-H bond takes place via a proton-

224 extrusion of the plasma membrane followed by scission of the bud, resulting in severing the nascent v

225 rom eta(2)-(C,O) to eta(2)-(C,C) followed by scission of the C horizontal lineC bond, which is usuall

226 ne ring are in competition with radical beta-scission of the C4-C5 bond and formation of dehomologate

227 control the reactivity and how the concerted scission of the central sigma bond is prevented in the b

228 es developed along the backbone give rise to scission of the chains near their center.

229 to capture long-wavelength light to promote scission of the Co-C bond at wavelengths up to 800 nm.

230 ialyl hydroxylamines by reversible homolytic scission of the glycosidic bond following the dictates o

231 show several minor channels, including beta-scission of the initial radicals and cyclic ether format

232 tion proceeds via UV light-induced C-Br bond scission of the initiator, giving rise to propagating ra

233 NO-induced scission of the iron-histidine bond triggers structural

234 iation of COPII-coated vesicle formation and scission of the nascent vesicle from the endoplasmic ret

235 e cytoplasm, elongation of the invagination, scission of the new vesicle from the plasma membrane, an

236 that the ultrasound-induced mechanochemical scission of the oxime sulfonate mechanophore also genera

237 mediates cargo recruitment, maturation, and scission of the pit by binding cargo, clathrin, and acce

238 The self-scission of the R2 ribozyme is strongly modulated by the

239 es with 1,2-diamino ethane leads to the full scission of the triple bond with the formation of acetop

240 Oxidative scission of the vinyl substituent of this cyclobutane ga

241 and other ESCRT complex proteins to promote scission of the virus particle from the plasma membrane.

242 ar olefins in the lubricating oil and random scission of their carbon-carbon backbones; the products

243 in have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanis

244 e that can measure mechanically induced bond scission on graphene in real time with sensitivity to at

245 reoelectronic gating delays the central bond scission, opening access to the interrupted Cope rearran

246 either hydrogen atom abstraction or C-S bond scission or allowed to proceed further to the formal 6-e

247 nascent carrier from the donor membrane by a scission or membrane fission event.

248 tep for aldol cleavage shifted from C-C bond scission (or an earlier step in the pathway) for the com

249 the COPII coat to prevent premature vesicle scission, pointing to a fundamental role for GTP hydroly

250 Strand scission proceeds via a Schiff base intermediate, but th

251 ximal amphipathic helix that facilitates the scission process and is also required for filamentous pa

252 Interestingly, this strand scission process leaves an electrophilic alpha,beta-unsa

253 with random order and that completion of the scission process requires actomyosin-driven membrane rem

254 The carbohydrate undergoes a scission process that is followed by the addition of ary

255 st, which enables up to 76% yield of the C-O scission product (2-methyl furan) in catalytic transfer

256 tration with a concomitant yield decrease of scission product, protocatechuic acid.

257 Degradation of these anthocyanins formed scission products (gallic and protocatechuic acids respe

258 Scission products tentatively annotated with MS(2) and M

259 exposure times are combined, (v) amide link scission promotes further chlorine uptake, and (vi) scis

260 ates cortactin association with the membrane scission protein dynamin-2.

261 on was observed to increase the CumO(*) beta-scission rate constant in the order Li(+) > Mg(2+) > Na(

262 The scission rate constant increases linearly with the conce

263 This happens by asymmetrical scission rather than by consecutive equal divisions.

264 , provides a rationale for the carbon-carbon scission reaction catalyzed by OleT.

265 ol(-1)) has been calculated for the C-S bond scission reaction in 1(+*)-4(+*).

266 The rate constant of the bond-scission reaction was measured as a function of temperat

267 ADPH, the azobenzene linkages undergo a bond scission reaction.

268 resses are known to trigger destructive bond-scission reactions in polymers.

269 uid-phase HDH of single HACs, hydrogenolytic scission reactivity of C-X bonds decreases in order of C

270 To clarify the reason why hydrogenolytic scission reactivity of C-X bonds over Pd/C and Raney Ni

271 n mutants, affecting endocytosis and vesicle scission, resolving 100nm vesicles was delayed (>20 s).

272 Spontaneous scission results in the formation of the stable nitroxyl

273 for other genes required either for membrane scission (shibire) or for early endosome formation (Rab5

274 hes an equilibrium position, determining the scission site.

275 cle is predicted to flow through an O-O bond scission step in either H2O2 or OOH, followed by rapid H

276 ysis of the small molecule byproducts of DNA scission supports the conclusion that cleavage occurs vi

277 The calculations showed that the scission takes place by nucleophilic attack of hydroxide

278 s within the CD framework via a 1,8-HAT-beta-scission tandem mechanism.

279 and spillover but are incapable of C-C bond scission that leads to loss of selectivity and catalyst

280 on-stabilized furfuryl radical upon C-O bond scission, the strong hydroxyl affinity of oxygen vacanci

281 dependent on the presence of Drp1, and after scission they are distributed to daughter organelles, su

282 Many proteins have been associated with scission, though the underlying molecular details of how

283 embrane tension until the membrane undergoes scission through lysis.

284 sine and water as the nucleophile for strand scission, thus between productive recombination and futi

285 generating an SP radical that undergoes beta scission to form a repaired 5'-thymine and a 3'-thymine

286 showed that (i) hydroxyl ions are needed for scission to occur, (ii) hydroxide-induced amide link sci

287 ed in terms of the stabilization of the beta-scission transition state determined by Lewis acid-base

288 rengths are assessed in the context of chain scission triggered by pulsed sonication of polymer solut

289 rylmethyl, undergo facile homolytic C-N bond scission under mild conditions to give products of forma

290 g GTPase dynamin catalyzes endocytic vesicle scission via membrane insertion of its pleckstrin homolo

291 DNA scission was enhanced when thiophilic metal ions were us

292 ntional chemical reactions, the rate of bond scission was shown to decrease with temperature.

293 idpoint of the anaphase spindle that induces scission, we depleted two proteins that mark the exact m

294 cks short enough to avoid hydrodynamic chain scission (weight-average molecular weights of 400 to 100

295 sible oxygen electrodes by oxidative thermal scission, where we concurrently rupture nitrogen-doped c

296 idation followed by condensation and a minor scission which represents about 10% of degraded anthocya

297 ation of the latter occurs via beta-C-C bond scission, which is facilitated by 2c,3e through-bond int

298 in clathrin-mediated endocytosis is membrane scission, which is mediated by the large guanosine triop

299 Thermolysis is shown to affect C-N bond scission while reactions with C6Cl4O2 or (tht)AuCl affor

300 h facilitate reaction of methoxy through C-H scission with the bridge oxygen atoms that are readily a