ライフサイエンスコーパス: sclera

1 f the lamina cribrosa (LC) and peripapillary sclera.

2 edictive of a stiffer response and a thinner sclera.

3 pigmented epithelium, iris/ciliary body, and sclera.

4 s) in the healthy human retina, choroid, and sclera.

5 nt-yielding a fiber orientation map for each sclera.

6 eason for an ARP is the birefringence of the sclera.

7 (ECM) that controls the extensibility of the sclera.

8 eling that controls the extensibility of the sclera.

9 eratan sulfate (KS) was detected only in the sclera.

10 the material properties of the peripapillary sclera.

11 ng treatments that strengthen the cornea and sclera.

12 terior (outward) bowing of the peripapillary sclera.

13 ometry and material properties of the LC and sclera.

14 atment prevented expansion of the cornea and sclera.

15 ructural organization of the human posterior sclera.

16 yde also increased magnetization transfer in sclera.

17 r orientation were mapped for each posterior sclera.

18 ical behavior in porcine and human posterior sclera.

19 ization of the choroid, lamina cribrosa, and sclera.

20 egulating this biomechanical property of the sclera.

21 glycosaminoglycan synthesis in the posterior sclera.

22 cornea and (6.18 +/- 1.08) x 10(-6) cm/s in sclera.

23 e biomechanical property (creep rate) of the sclera.

24 ly displaced relative to the more peripheral sclera.

25 egulated in adult relative to juvenile mouse sclera.

26 n tissues of the irido-corneal angle and the sclera.

27 solutes and in a more dramatic way than does sclera.

28 ignificant barrier to drug transport than is sclera.

29 rough the RPE and infiltrate the choroid and sclera.

30 s, and global layers (GLs), inserting on the sclera.

31 corneal endothelium, corneal stroma and the sclera.

32 lthy monolayer of RPE resting on choroid and sclera.

33 ed in cornea, lens, retina, optic nerve, and sclera.

34 e of lumican core protein in the aging human sclera.

35 er MMP gene transcription changes within the sclera.

36 uced corneal thickness, keratoconus and blue sclera.

37 y transmission of light through the iris and sclera.

38 n in retina, retinal pigment epithelium, and sclera.

39 rface and arose with a gentle slope from the sclera.

40 ion, and age-related changes in the anterior sclera.

41 oidal location, and higher radiation dose to sclera.

42 val of TM and obvious injury to the adjacent sclera.

43 in stresses and strains in the midposterior sclera.

44 myelinated optic nerve axons adjacent to the sclera.

45 nts of fiber orientation in whole normal rat scleras.

46 er tensile strain (1.2%) than mid-peripheral sclera (0.95%) for a 40 mm Hg IOP elevation (P < 0.00001

47 The melanocytosis involved the sclera (92%), iris (17%), choroid (12%), eyelid (8%), an

48 CsA implants placed in the deep sclera adjacent to the suprachoroidal space resulted in

49 d in the supraciliary space and the anterior sclera after 10 minutes and in the anterior choroid and

50 the supraciliary space and the supraciliary sclera after 10 minutes and in the anterior sclera after

51 r 10 minutes and in the anterior choroid and sclera after 20 and 60 minutes, but not in the posterior

52 sclera after 10 minutes and in the anterior sclera after 60 minutes of perfusion.

53 ells of the conjunctiva, cornea, retina, and sclera after subconjunctival delivery.

54 , high IOP induced up to an 8% strain in the sclera and a 15% strain in the cornea of rabbit kit eyes

55 e I collagen, subunit alpha1 was assessed in sclera and choroid by Western blot analysis.

56 Partitioning of the solutes into bovine sclera and choroid-Bruch's layer was also determined.

57 ss the optic nerve canal at the level of the sclera and consisted of collagen types I, III, IV, V, an

58 Tissues from sclera and cornea (type I collagen) and lens capsule (ty

59 cation of diffusion of different analytes in sclera and cornea of rabbit eyes.

60 M/Ch was cholesteryl oleate-enriched, unlike sclera and cornea.

61 lly rely on the morphologically unique human sclera and have been shown to operate even in the absenc

62 the perforating vessel's course through the sclera and its termination in the choroid, directly bene

63 Given that the biomechanics of the sclera and lamina cribrosa probably influence retinal ga

64 ssues (specifically within the peripapillary sclera and lamina cribrosa) in response to intraocular p

65 eeper ONH tissues, such as the peripapillary sclera and lamina cribrosa.

66 HNOEL-iso gene was expressed in the iris and sclera and less actively in the trabecular meshwork, ret

67 unctiva is a mucous membrane that covers the sclera and lines the inside of the eyelids.

68 These effects were specific to the human sclera and not seen in response to polarity-inverted eye

69 essed in all ocular tissues tested including sclera and optic nerve head.

70 nt 100-kVp photon beams entering through the sclera and overlapping on the macula cumulating in a the

71 scleritis showed increased thickness of the sclera and presence of intrascleral hyporeflective areas

72 The sclera and RPE were permeable in vitro, ex vivo, and in

73 the permeability coefficients (Papp) across sclera and sclera-choroid-Bruch's layers in bovine and p

74 The thicknesses of the sclera and SCRPE and the melanin content in choroid-RPE

75 ong enough to penetrate into human cadaveric sclera and that the drug coating rapidly dissolved off t

76 changes in the mechanical properties of the sclera and the axial elongation rate.

77 e analyzed to determine the thickness of the sclera and the presence or absence of scleral hyporeflec

78 ntophoresis protocol, the ion penetrated the sclera and traveled as far as 1.5 mm from the electrode-

79 Understanding the permeability properties of sclera and underlying layers would be beneficial in desi

80 Low IOP elicited negligible creep of the sclera and very gradual creep of the cornea.

81 lthy monolayer of RPE resting on choroid and sclera) and the supernatants were removed after 24 hours

82 sile strain than the adjacent mid-peripheral sclera, and 2) strains are significantly higher in the t

83 ed in retrocorneal membranes, underneath the sclera, and adjacent to uveal tissue (ciliary body, iris

84 ocular and orbital tissues--retina, choroid, sclera, and extraocular muscles--exists.

85 were manually segmented (prelamina, choroid, sclera, and lamina cribrosa [LC]).

86 bles excellent visualization of the choroid, sclera, and lamina cribrosa.

87 e obtained: cornea, equatorial and posterior sclera, and posterior pole containing the optic nerve he

88 he concentrations of melanin in choroid-RPE, sclera, and retina of BN rats were 200 +/- 30, 12 +/- 4,

89 1a) receptor subtype in the cornea, choroid, sclera, and retina.

90 etinal vein (CRV), peripapillary choroid and sclera, and subarachnoid space around the optic nerve, w

91 rs; the inner, global layer inserts into the sclera, and the outer, orbital layer inserts into the co

92 nning, posterior bowing of the peripapillary sclera, and thinning and expansion of the scleral canal

93 lastic isotropic segments--iris, cornea, and sclera--and a two-component anisotropic segment represen

94 ; inserted into nonpreserved human cadaveric sclera; and imaged.

95 owever, at the nevus margin, the choroid and sclera appeared normal.

96 aking a circumferential incision through the sclera approximately 7 mm posterior to the limbus.

97 tal sections were collected from a region of sclera approximately midway between the limbus and optic

98 material properties of monkey peripapillary sclera are altered by exposure to moderate, short-term,

99 Lumican was present in the human sclera as a 70- to 80-kDa core protein with short unsulf

100 Animal studies of chemical cross-linking of sclera as a potential treatment for progressive myopia h

101 oid after 10 minutes and in the supraciliary sclera at 20 minutes.

102 The transition from the cornea to sclera at the limbus was marked by a change in collagen

103 ning of the scleral flange and peripapillary sclera at the onset of confocal scanning laser tomograph

104 robulbar vessels were found to perforate the sclera at the site of the lacquer crack.

105 c lenses, with the zonule, ciliary body, and sclera attached, inside an environmental scanning electr

106 remodeling, the mechanical properties of the sclera, axial elongation, and refractive state.

107 While the peripapillary sclera became thinner in both mouse types with glaucoma,

108 NH with the scleral flange and peripapillary sclera being thinnest nasally.

109 ural differences were found in the posterior sclera between African American and Caucasian donors.

110 pigment epithelium (RPE) layer and the inner sclera border.

111 as aligned, and then the scleral canal wall, sclera, border tissue of Elschnig, Bruch's membrane, lam

112 eability and partition coefficients of human sclera both significantly decline with increasing donor

113 roportion to accommodative amplitude and the sclera bows inward with increasing age in both species.

114 be efficiently delivered into and across the sclera by iontophoresis for drug delivery.

115 rks-Bruch's membrane opening (BMO), anterior sclera canal opening (ASCO), anterior laminar insertion

116 es in multiple eye tissues, but particularly sclera, causing progressive myopia.

117 fferent strain response in the peripapillary sclera characterized by a stiffer meridional response.

118 of photoreceptor-like cells was detected in "sclera+choroid+RPE" eyecup explants derived from adult a

119 Explant culture of "sclera+choroid+RPE" eyecup was used to examine whether c

120 ed that nonendothelial LYVE-1(+)cells in the sclera, choroid, and iris included CD11b(+)F4/80(+) macr

121 red, and celecoxib levels in ocular tissues (sclera, choroid-RPE, retina, vitreous, lens, and cornea)

122 bility coefficients (Papp) across sclera and sclera-choroid-Bruch's layers in bovine and porcine mode

123 ial cells (HCECs) and across isolated bovine sclera-choroid-RPE (SCRPE).

124 days, and retinal pigment epithelium-choroid-sclera (choroidal) flat mounts were prepared.

125 WDR36 gene expression in lens, iris, sclera, ciliary muscles, ciliary body, trabecular meshwo

126 vement was measured using surgically removed sclera clamped in a modified Ussing chamber and connecte

127 mponents of the RPE-Bruch's membrane-choroid-sclera complex were major contributors of vascular endot

128 retinas were separated from the RPE/choroid/sclera complex.

129 Choroid sclera complexes, after laser-induced CNV, were examined

130 The sclera contained regions lacking TPAF and CARS fluoresce

131 ose of this study was to examine whether the sclera contains mesenchymal stem/progenitor cells.

132 This study indicates that the sclera contains multipotent mesenchymal stem cells.

133 cantly different between the two strains for sclera, cornea, and lens.

134 Da in ocular tissues including ciliary body, sclera, cornea, and retina.

135 on of TGIF in RNA samples derived from human sclera, cornea, optic nerve, and retina.

136 ow-velocity ballistic trauma to the inferior sclera created a reproducible retinal injury, with centr

137 A biomechanical property of the sclera, creep rate, increases; during recovery from indu

138 Ex vivo trans-sclera drug delivery in porcine eyes is demonstrated by

139 sulfated and sulfated GAG composition of the sclera during compensation for a -5 diopter (D) lens and

140 emonstrate gene expression profiles in mouse sclera during ocular growth.

141 binding proteins secreted by the choroid and sclera during visually guided ocular growth.

142 ma and in retinal pigment epithelium/choroid/sclera, establishing that human CFH regulates activation

143 cision reduced recurrence compared with bare sclera excision alone in most studies of primary or recu

144 Evidence indicates that bare sclera excision of pterygium results in a significantly

145 Fifty-one studies comparing bare sclera excision, conjunctival or limbal autograft, intra

146 For all eyes, the posterior sclera exhibited inhomogeneous, anisotropic, nonlinear b

147 The posterior sclera exhibited inhomogeneous, anisotropic, nonlinear m

148 Overall, the peripapillary sclera exhibited significantly higher tensile strain (1.

149 Human posterior sclera exhibits complex regional mechanical behavior in

150 r collagenous layer of submacular BM-choroid-sclera explants generated from aged and AMD human donor

151 India ink to the suprachoroidal space below sclera, following injection.

152 Significant stiffening of the sclera follows exposure to moderate IOP elevations in mo

153 n were measured in strips of human cadaveric sclera for up to 1 week.

154 The sclera forms the fibrous outer coat of the eyeball and a

155 s also examined in tissue-cultured pieces of sclera from additional marmosets.

156 Trephined ONH and peripapillary sclera from both eyes of four monkeys were serially sect

157 Trephinated ONH and peripapillary sclera from both eyes of nine monkeys that were perfusio

158 Trephined ONH and peripapillary sclera from both eyes of six monkeys, each perfusion fix

159 Trephinated ONH and peripapillary sclera from both eyes of six normal monkeys were serial

160 The trephinated ONH and peripapillary sclera from both eyes of three early glaucoma (EG) monke

161 The trephinated ONH and peripapillary sclera from both eyes of three monkeys with early glauco

162 Trephinated ONH and peripapillary sclera from both eyes of three monkeys with early glauco

163 Peripapillary sclera from the early-glaucoma eyes exhibited an equilib

164 Diffusion of CsA across the sclera from the episcleral space was not a feasible meth

165 Posterior-temporal scleras from 75 right eyes were procured at an average d

166 e wall of SC with the channel going into the sclera, from which quantitative measurements were made.

167 ayer of hyaline cartilage within the fibrous sclera giving an extra degree of support to the eyeball.

168 cted in the conditioned medium of choroid or sclera had an apparent Mr of 27,000 Da.

169 Aged human sclera had relatively high fluorescence due to nonenzyma

170 verall, the scleral flange and peripapillary sclera immediately surrounding the ONH were posteriorly

171 collagen solubility profile of the posterior sclera in a canine model of primary open-angle glaucoma

172 ral GAG synthesis in tissue-cultured primate sclera in a dose-dependent manner after several days.

173 cells regulates the growth of the equatorial sclera in a vision-dependent manner.

174 eral flap and connected them to the adjacent sclera in all 53 patients.

175 Compared with the wild-type sclera, the sclera in all null mutants was significantly thinner wit

176 Less than ~20% of DEX was released from the sclera in approximately 2h after cathodal iontophoretic

177 Peripapillary sclera in CD1 controls had significantly greater tempora

178 anization, at five regions of the cornea and sclera in chickens developing high myopia and astigmatis

179 ed by cells in the fibrous and cartilaginous sclera in equatorial regions of the eye.

180 l strain of peripapillary and mid-peripheral sclera in normal eyes from elderly human donors.

181 OCT was performed over the anterior sclera in the inflamed area on all cases.

182 l measurements by bonding a PMMA ring to the sclera in the region of the ciliary body after the conju

183 iomechanical response of the human posterior sclera in vitro and to estimate the effects of age and g

184 e-by-side diffusion cells with excised human sclera in vitro.

185 It is technically possible to stiffen the sclera in vivo using collagen cross-linking techniques a

186 (apposition group) or tightly to indent the sclera (indentation group) and (2) flexible refillable s

187 to impose small deformations on fresh bovine sclera, iris, crystalline lens, kidney fat, orbital pull

188 Drug delivery via the sclera is a promising approach to retinal disorder treat

189 lateral diffusion of sulforhodamine in human sclera is slow and localizes to the site of administrati

190 Rat sclera is structurally anisotropic with several consiste

191 Results indicate 1) the peripapillary sclera is subjected to significantly higher tensile stra

192 m and 3.15 +/- 3.07 mum; and for the choroid-sclera junction was -3.90 +/- 15.93 mum and 21.39 +/- 10

193 position of the outer RPE border and choroid-sclera junction was consistent with the manual delineati

194 o-called bowl or convex shape to the choroid-sclera junction, and the thickest point of the choroid w

195 outer border of the RPE band and the choroid-sclera junction.

196 (LD-BM decrease) compared with the anterior sclera (LD-AS decrease) reference plane (hazard ratio, 3

197 from a Bruch's membrane (LD-BM) or anterior sclera (LD-AS) reference plane were measured with optica

198 ne activation including cells in the retina, sclera, lung, kidney, and abundant activation in the neo

199 xpression of all three genes in the superior sclera (Mann-Whitney tests, all p </= 0.05), as well as

200 2 expression in the central cornea and nasal sclera (Mann-Whitney tests, both p </= 0.05).

201 to suggest that stiffening the peripapillary sclera may be protective against the development of glau

202 control breakdown of matrix proteins in the sclera may contribute to the development of simple myopi

203 iomechanical response of normal and glaucoma sclera may represent baseline properties that contribute

204 Age-related stiffening of the sclera may significantly influence ONH biomechanics and

205 oglycan synthesis was assessed on punches of sclera obtained immediately after extraction of supracho

206 dulation of the mechanical properties of the sclera occur during lens compensation.

207 Eye-specific baseline models of the LC and sclera of both eyes of three normal monkeys were constru

208 sed to reconstruct the ONH and peripapillary sclera of four pairs of eyes fixed at 10 mm Hg.

209 ate [C6S], and dermatan sulfate [DS]) in the sclera of groups of tree shrews (n = 5 per group) that w

210 Posterior sclera of old monkeys is significantly stiffer than that

211 anoacrylate glue was applied to the anterior sclera of six Dutch-belted rabbits before open-sky vitre

212 3D eye-specific models of the lamina and sclera of the eyes of three normal monkeys were construc

213 sed to reconstruct the ONH and peripapillary sclera of three pairs of unilateral EG eyes fixed at 10

214 onitored and quantified in rabbit cornea and sclera of whole eyeballs.

215 -2, MMP-3, TIMP-1, TIMP-2, and TIMP-3 in the scleras of tree shrews that had received either 1, 2, 4,

216 ice, impermeable on one side and open to the sclera on the other, that contained compressed pellets o

217 branches through the emissary canals in the sclera, or both were visualized in 120 (86%) eyes.

218 OCT, the dome-shaped lesion arises from the sclera, outer choroid, or both and the overlying choroid

219 cation, consistent with direct trauma to the sclera overlying the injured retina.

220 e inner to the outer layers of the posterior sclera (P < 0.001).

221 horoid (P = .004) and tended to have thicker sclera (P = .067) and greater bulge height (P = .079).

222 , and radiation dose >/= 400 Gy to the outer sclera (P = 0.0455).

223 study examined lateral diffusion within the sclera parallel to the scleral surface.

224 eation specimen contained tumor cells within sclera, pars plana, or pars plicata.

225 (PC5), and forces through the peripapillary sclera (PC3).

226 tissue (PC4), rotation of the peripapillary sclera (PC5), and forces through the peripapillary scler

227 Sclera, pericardium, dura mater and cornea are available

228 The most frequent sign was symmetric brown sclera pigmentation present in 82.5 percent of the patie

229 scein and CsA penetrated the in vitro equine sclera poorly; however, low but detectable levels of CsA

230 ese abnormal eyeballs, cornea anteriorly and sclera posteriorly, are regulated by region-specific mol

231 a in vitro, removed from the RPE/choroid and sclera, produces 11-cis retinoids upon light exposure, i

232 rong and consistent with the concept of "the sclera pulls the lamina taut" as IOP increases.

233 sa depth should be measured from an anterior sclera reference plane to reduce the influence of choroi

234 h the Bruch's membrane, but not the anterior sclera, reference plane (LD-BM decrease without LD-AS de

235 icrotubular-like structures found within the sclerad region of the inner nuclear layer of the retina.

236 5.96 +/- 2.69 kJ/m(3) for porcine and human sclera respectively; P > 0.05).

237 litates diffusion of fluorescein through the sclera resulting in high levels in the retina and poster

238 f retinal pigmented epithelium (RPE)-choroid sclera revealed that the expression of CFH was down-regu

239 cut from the scleral surface of the eyeball, sclera, RPE-choroid, retina, lens, and ciliary body.

240 hese large proteins can traverse through the sclera-RPE to reach the retina.

241 nsport of eight beta-blockers across excised sclera/sclera-choroid-RPE (SCRPE) of albino rabbit, pigm

242 in the 3-D architecture of the peripapillary sclera, scleral canal wall, and lamina cribrosa were pre

243 ough different in magnitude between species, sclera/SCRPE transport can be correlated between species

244 der affecting development of the choroid and sclera segregating in several breeds of dog, including r

245 e view that the human eye with its prominent sclera serves critical communicative functions during hu

246 aucoma, and (2) Bruch's membrane or anterior sclera should be used as a reference plane when measurin

247 Porcine sclera showed a nonlinear reduction in solute permeabili

248 retinal cells are involved in the retina-to-sclera signaling cascade causing myopia.

249 ites from type I collagen chains was high in sclera, similar to tendon.

250 However, the drug delivered onto the sclera subjects to vigorous clearance by episcleral and

251 ll-diameter fibrils in the fibromodulin-null sclera suggests a key role for fibromodulin in the matur

252 The sclera synthesizes and secretes TGFBIp, which may functi

253 troma (SCT) than the vascular lumen (VCT) or sclera (TCT).

254 umferential creep rates in the peripapillary sclera than normal eyes.

255 ion of the lamina cribrosa and peripapillary sclera that are minimal to modest in magnitude.

256 model yielded 3-D deformations of posterior sclera that matched well with those observed experimenta

257 fillable silicone exoplants also open to the sclera that were secured by suturing, to form a sealed e

258 other conditions, such as for thin and stiff sclera, the association was opposite to the tautening.

259 In recent studies using sclera, the authors observed that short-chain aliphatic

260 Compared with the wild-type sclera, the sclera in all null mutants was significantly

261 g studies of transverse diffusion across the sclera, this study examined lateral diffusion within the

262 M experiments conducted with conjunctiva and sclera tissue in Franz diffusion cells suggested vasodil

263 Imaging proceeded from the surface of the sclera to a depth of approximately 60 mum.

264 ertaken to determine whether exposure of the sclera to prostaglandin (PG)F(2alpha) or to the PGF(2alp

265 rate of delivery of bioactive factors to the sclera to regulate the rate of glycosaminoglycan synthes

266 cribrosa, scleral flange, and peripapillary sclera, to determine the position and thickness of these

267 roid stroma, and (3) the inner border of the sclera, to measure the vascular choroidal thickness (VCT

268 omal CT [StCT]), and (3) inner border of the sclera (total CT [TCT]).

269 se types with glaucoma, the remainder of the sclera uniformly thinned in CD1, but thickened in B6.

270 antenna of the implant were sutured onto the sclera using an encircling silicone band.

271 Sclera was also clamped between two hemichambers, and tr

272 ent ratio of bovine choroid-Bruch's layer to sclera was approximately 1, 1.5, 1.7, 2, and 3.5, respec

273 Inflation testing of posterior sclera was conducted, and circumferential and meridional

274 ryl ester composition of BrM/Ch, cornea, and sclera was determined by ESI/MS.

275 scent signal from collagen fibers within the sclera was evident in the TPAF channel; the scleral coll

276 or small eyecup but angle narrowing when the sclera was indented by a large eyecup.

277 Each posterior sclera was mounted on a pressurization apparatus, IOP wa

278 weaker and biochemically distinct posterior sclera was observed in dogs with the G661R missense muta

279 Human sclera was permeable to compounds with a molecular weigh

280 Sclera was reconstructed with allogenic scleral grafts.

281 Drug release from the sclera was significantly prolonged with the micellar car

282 The sclera was significantly thinner (P = 0.038) and tangent

283 Starting at 0 load, the sclera was symmetrically stretched to 2 mm in 0.25-mm st

284 tion of (35)SO4 into CPC-precipitable GAG in scleras was taken as a measure of the rate of synthesis

285 ces of the lamina cribrosa and peripapillary sclera were delineated in 40 serial radial (4.5 degrees

286 Circular pieces of sclera were either immediately preserved in a stabilizat

287 he lens, capsule, zonules, ciliary body, and sclera were mounted in an optomechanical lens-stretching

288 he lens, capsule, zonules, ciliary body, and sclera were mounted in an optomechanical lens-stretching

289 es from the conjunctiva, cornea, retina, and sclera were performed to determine the distribution and

290 terior laminar surface and the peripapillary sclera were reconstructed from serial horizontal EDI-OCT

291 The scleras were cleaned of intra- and extraorbital tissues

292 and inferior quadrants of the peripapillary sclera, which may contribute to the increased prevalence

293 epending on the properties of the lamina and sclera, which shows that it is critical to consider the

294 Select studies were performed using porcine sclera with and without choroid-Bruch's layer.

295 regulation of 4884 gene transcripts in mouse sclera with less than 5% false-discovery rate (FDR) was

296 stroma, near the limbus, and throughout the sclera, with lower expression in the TM.

297 n the bovine and porcine eyes) more than the sclera, with the impedance increasing with lipophilicity

298 nic), were determined across freshly excised scleras, with or without the underlying choroid-Bruch's

299 the tumor periphery directly adjacent to the sclera within the eye, more often in tumors of the epith

300 edles were designed to penetrate through the sclera, without penetrating into the choroid/retina, in