ライフサイエンスコーパス: scleraxis

1 llular responses including the activation of scleraxis.

2 boxes that overlaps with the closely related scleraxis.

3 We have found that Scleraxis, a bHLH transcription factor, is a highly spec

4 n part by the association between Sirt-1 and scleraxis and deacetylation of NF-kappaB and PI3K.

5 /flox)) results in microglossia with reduced Scleraxis and Fgf10 expression as well as decreased myog

6 ing somite are crucial for the expression of scleraxis and Mkp3.

7 rs, and the neotendon transcription factors, Scleraxis and Mohawk.

8 lets, in contrast to tendon-associated genes scleraxis and tenascin, present in the chordae tendineae

9 (dpERK) signaling and promotes expression of scleraxis and tenascin.

10 hat promote tendon fibroblast proliferation: scleraxis and tenomodulin.

11 he level of some markers [e.g., mtwist, mf1, scleraxis, and alpha1(II) collagen] is seen in the anter

12 f biglycan, collagen V, collagen XII, PAI-1, Scleraxis, and Mohawk by TGF-beta1.

13 increased the expression of type I collagen, scleraxis, and tenomodulin.

14 nducer of the tendon progenitor (TNP) marker scleraxis both in organ culture and in cultured cells, a

15 Col5a1(flox/flox) mouse model was bred with Scleraxis-Cre mice to create a targeted tendon and ligam

16 show that tendon development is arrested in Scleraxis-Cre::Mmp14 lox/lox mice that are unable to rel

17 The induction of scleraxis-expressing TNPs is not affected in mutant embr

18 ascade and in particular, ERK1/2 to activate scleraxis expression in a population of mesenchymal prog

19 Finally, TGF-beta signaling-mediated Scleraxis expression is required for tendonogenesis in t

20 luding the limb tendons, and show that early scleraxis expression marks the progenitor cell populatio

21 endogenous BMP activity and induces ectopic scleraxis expression.

22 Using the scleraxis gene as a marker we show that these progenitor

23 d a Col2.3GFP transgene, while expression of Scleraxis-GFP was used to follow differentiation into pe

24 udes both transcriptional activators such as scleraxis, Hand2, and Dermo-1 and repressors such as Twi

25 e results reveal an essential early role for scleraxis in mesoderm formation, as well as a later role

26 Loss of scleraxis in mice leads to geometric and structural chan

27 Paraxis expression precedes that of scleraxis in the region of the somite fated to form the

28 e, TGF-beta2 beads induced the expression of Scleraxis in tongue explant cultures.

29 Scleraxis is a basic helix-loop-helix (bHLH) transcripti

30 Loss of EP4 in Scleraxis-lineage cells did not alter gliding function,

31 e three embryonic germ layers confirmed that scleraxis mutant embryos were unable to form mesoderm.

32 nerating chimeric embryos, using lacZ-marked scleraxis-null and wild-type embryonic stem cells, we ex

33 Scleraxis-null cells were specifically excluded from the

34 At the time of developmental arrest, scleraxis-null embryos consisted of ectodermal and primi

35 nction in embryonic development, we produced scleraxis-null mice by gene targeting.

36 ect transcription from an E-box found in the scleraxis promoter.

37 ct by identifying two proepicardial markers, Scleraxis (Scx) and Semaphorin3D (Sema3D), that genetica

38 at different stages of development based on scleraxis (Scx) expression.

39 The scleraxis (Scx) gene, encoding a bHLH transcription fact

40 ed to determine how the transcription factor Scleraxis (Scx) influences the development and maturatio

41 Scleraxis (Scx) is a known regulator of tendon developme

42 Scleraxis (scx) is a transcription factor required for t

43 Scleraxis (Scx), a bHLH transcription factor, marks this

44 mad2/3-mediated signaling, the expression of Scleraxis (Scx), a transcription factor specific for ten

45 n mammalian tendons and ligaments, including scleraxis (scx), collagen 1a2 (col1a2) and tenomodulin (

46 eted from the myotome induces formation of a scleraxis (Scx)-expressing tendon progenitor population

47 ived chondrogenic lineages, and suggest that scleraxis target genes mediate these processes.

48 steogenic (Runx2, OCN) and ligament-related (scleraxis transcription factor (SCXA), ELN) genes were d

49 of phosphorylated ERK result in the loss of scleraxis transcripts and the loss of distal rib develop

50 sistent with this early embryonic phenotype, scleraxis was found to be expressed throughout the embry

51 omodulin, and tenogenic transcription factor scleraxis, whereas it inhibited gene products involved i