ライフサイエンスコーパス: scope

1 of therapy significantly narrow its clinical scope.

2 ces and structures of proteins classified in SCOPe.

3 larization, and relatively limited substrate scope.

4 yet been investigated with an international scope.

5 ave higher-level recipient intuitions out of scope.

6 ranes remain both challenging and limited in scope.

7 n is easy to perform, efficient and broad in scope.

8 highly regioselective with a broad substrate scope.

9 d, and economic with a broad range substrate scope.

10 however, has been challenging and limited in scope.

11 ester-linked systems and with broad monomer scope.

12 SCOPe 2.06 contains 77,439 Protein Data Bank entries, do

13 could be determined without compromising the scope, accuracy, and dynamic range of full-lipidome quan

14 SCOPe also incorporates and updates the ASTRAL compendiu

15 The scope and accessibility of sequence-controlled multibloc

16 ure providing the greatest aerobic metabolic scope and body condition across all treatments.

17 romo carbonyl compounds with broad substrate scope and compatibility.

18 uctures, thereby significantly expanding the scope and complexity of ChB host systems, we also demons

19 nization of international studies of similar scope and complexity.

20 es are becoming increasingly limited in both scope and efficacy.

21 nted general character in terms of substrate scope and employment.

22 atalyst was utilized to enhance the reaction scope and enable silylated nucleophiles to be efficientl

23 This method has a broad scope and enables both the synthesis of isolable silanes

24 are not well understood, and contain gaps in scope and enforceability.

25 This protocol features broad substrate scope and excellent functional-group tolerance.

26 job with dual segmentation reduces the size, scope and execution time of each task.

27 ates in a rat model to better understand the scope and extent of tissue deposition following multiple

28 LD approach offers significant advantages in scope and flexibility for the preparation of stable surf

29 , and settings, with diversity noted in both scope and focus.

30 accessed on gram scale with broad substrate scope and functional group tolerance.

31 This reaction enjoys broad scope and functional group tolerance.

32 Experimental data is limited in scope and generally corresponds to averages over both ti

33 The chemistry exhibits broad substrate scope and good scalability, providing a convenient route

34 The reaction has an excellent substrate scope and is compatible with a wide range of functional

35 This protocol features a broad substrate scope and is compatible with heterocylic coupling partne

36 This protocol exhibits a broad substrate scope and is compatible with symmetrical and unsymmetric

37 Scope and limitations are also reported for variation of

38 We review the scope and limitations of liquid crystal templating and l

39 The scope and limitations of the distal N-group were investi

40 report a comprehensive study to explore the scope and limitations of the DP4+ methodology in the ste

41 matode neuropeptide research, and assess the scope and limitations of the tools and techniques for no

42 In addition to details on the cross-coupling scope and limitations, full screening efforts and mechan

43 This review details the scope and mechanism of nature's halogenation and dehalog

44 perties of MiPs are likely needed, given the scope and need to correct large amounts of muscle in the

45 otes with small genomes, they are limited in scope and obviously secondary.

46 is clinical diagnosis was used to define the scope and order of the molecular investigations that wer

47 Herein, we describe a study into the scope and origin of an enantiodivergent effect in the pa

48 To characterize the scope and potential impact of this problem, we assessed

49 s show that statistical modeling extends the scope and potential of transcriptome-wide structure prob

50 The scope and potential uses of time-domain terahertz imagin

51 eveloped protocol exhibits a broad substrate scope and provides access to valuable, stereochemically

52 To broaden the scope and reduce the number of steps required for monoph

53 The reaction is scalable and the scope and robustness of the reaction is thoroughly exami

54 e fitness impacts of mosaicism depend on its scope and severity.

55 th conventional diagnostic methods limit the scope and sustainability of newborn screening for sickle

56 r critical thermal limits, aerobic metabolic scope and thermal preference.

57 ction proceeds at mild conditions with broad scope and wide functional group tolerance.

58 bill is criticized for being too limited in scope, and also for discouraging the development of biod

59 This review discusses the mechanism, scope, and applications of the reactions of alpha-imino

60 This reaction offers a broad substrate scope, and both symmetrical and unsymmetrical alkynes ca

61 tion occurs at mild temperature, is broad in scope, and does not require a separate anion exchange st

62 Due to its efficiency, scope, and flexibility, the newly developed SNP array wi

63 e to its short reaction time, wide substrate scope, and gram-scale synthesis.

64 account of our catalyst discovery, substrate scope, and mechanistic experiments for quinoline-directe

65 of pathways represented, their geographical scope, and the vaccine-pathogen combinations assessed.

66 ous glycoside nucleophiles, a broad reaction scope, and uniformly high transfer of anomeric configura

67 mplicity, inexpensive reagents, and enhanced scope as evidenced by examples in the realm of peptide c

68 ymes, catalysts with complementary substrate scope as well as selectivity can be identified.

69 viscoelastic properties has been limited in scope by the nature of most microrheological methods, wh

70 raits (such as extracellular pCO2 or aerobic scope) cannot be distinguished.

71 -acyl-2-aminoimidazoles with broad substrate scope, circumventing the problematic regiospecific acyla

72 SCOPe classifies the majority of protein structures rele

73 We did a systematic review with a scoping component of relevant studies published between

74 The current protocol shows a broad substrate scope, delivering more than 25 siloxanes with siloxy or

75 The protocol is simple to perform, broad in scope, efficient (up to 99 % yield), and has been succes

76 The substrate scope encompasses a variety of N-H and N-alkylated pyrid

77 ly available resources are either limited in scope, encompassing only organisms from specific domains

78 eptides, we greatly extend its potential and scope, especially given the frequency with which such mo

79 ected 50 children from the Cork Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurolog

80 ds has been reinvestigated and the substrate scope extended to benzyl carbonyl compounds.

81 XVXL interaction model and expand the search scope for additional CSD binding partners.

82 unprecedented detail and opens up tremendous scope for analysing cell cycle dynamics and developing i

83 mark in biotechnological H2O2 reduction with scope for applications in fuel cells and biosensors.

84 val of the auxiliary as well as its superior scope for both ketones and (hetero)aryl iodides overcome

85 ellent chemoselectivity and a wide substrate scope for both oxyamines and sulfenylation reagents.

86 in electrophysiological experiments, and the scope for continuously recording large amounts of data f

87 gies that broaden the feasibility of and the scope for delivering virus-specific T cells to patients

88 be achieved, providing an uncommon level of scope for diarylmethine desymmetrizations.

89 The reaction has broad scope for different variations of the aroyl source and t

90 We investigated the scope for enhancing the protective efficacy of a single

91 ter Rule, which clarified the jurisdictional scope for federally protected waters.

92 Scope for improved prevention at older ages was consider

93 s and mammals is currently protected and the scope for improvement.

94 roject: Cancer Biology suggest that there is scope for improving reproducibility in pre-clinical canc

95 The scope for loss associated with the destruction of coral

96 m transfer (HAT) conditions, and an expanded scope for the coupling of alkenes with N-methoxy pyridin

97 -CD-based ditopic cation and POM open a wide scope for the design of hybrid materials that accumulate

98 namic covalent chemistry offers considerable scope for the design of new stimulus-responsive copolyme

99 l interventions were considered to be out of scope for this review.

100 This suggests considerable scope for unique trait combinations to evolve in respons

101 ssociated with plasmonic nanostructures, the scope for use in reflective pixel technology for increas

102 There is significant scope for yield and quality improvement in these largely

103 The mild conditions give unprecedented scope from abundant and complex aryl chloride starting m

104 standing of CARs was used to expand reaction scope, generating biocatalysts for amide bond formation

105 effect of the masking group and the reaction scope have been delineated.

106 n vascular plant KNOX proteins, the narrower scope having evolved progressively as lycophytes, ferns

107 gy-based annotations in the remainder of the SCOPe hierarchy.

108 uranium(V/VI) complexes, it has had limited scope in an area with few unifying rules.

109 The reaction has a broad scope in terms of its amine, aldehyde, and isocyanide na

110 d on this model, though currently limited in scope in terms of the biology it represents, supports th

111 lead to a substantially increased substrate scope in that they render even 1,3-enynes, arylalkynes,

112 SCOPe is a database of relationships between protein str

113 e synthetic optimizations, a broad substrate scope is achieved and functional groups, such as ester,

114 Broad substrate scope is demonstrated (up to 99:1 Z:E) together with evi

115 A broad substrate scope is demonstrated for both quinazolinone as well as

116 ndipitous discovery to its general synthetic scope is detailed, highlighting the roles of water, CO,

117 Substrate scope is very broad under simple, user-friendly conditio

118 The approach has excellent substrate scope, is amenable to diverse guanidine-containing subst

119 ary amides to tertiary amines, with a useful scope, is demonstrated for the first time by use of this

120 As profiling campaigns expand in scope, it is important to homogenize, summarize, and ana

121 In addition, a scoping literature review and environmental scan were do

122 n the chosen set than these other similar in scope models: CSC-TD, MS-TD, Learning to Time and Modula

123 cal thermal limit, neither aerobic metabolic scope nor thermal preference exhibited such plasticity.

124 study, participants were recruited from the SCOPE (Observational Study of the Consequences of the Pr

125 s and could feasibly be completed within the scope of a single PhD thesis.

126 only improves accuracy but also broadens the scope of absolute cell fraction predictions from tumor g

127 contributed to significant expansion of the scope of accessible aerobic oxidation reactions.

128 hypervalent iodine reagents will expand the scope of aerobic oxidation chemistry in chemical synthes

129 ubstitution scheme can enhance the synthetic scope of alpha-methylisoserine-derived sulfamidates, swi

130 We have, therefore, widened the scope of analysis to include in vitro-induced T-cell res

131 al applications of this method cover a broad scope of antibody-related research, including the develo

132 We discuss the scope of applicability of most commonly used measurement

133 quids, helping the reader to distinguish the scope of application of different methods of calculation

134 vious limitations in terms of generality and scope of application.

135 We furthermore discuss the current scope of applications for 2D vibrational surface spectro

136 sitions are promising candidates for a broad scope of applications in electronics, optoelectronics, t

137 SNAPCAR-produced ssDNA will expand the scope of applications in nanotechnology, gene editing, a

138 l connections between metabolites limits the scope of applications of such tools.

139 duction of a useful azide group onto a broad scope of arenes and heteroarenes.

140 The scope of aryl halides and thiol partners includes over 6

141 Further optimization and representative scope of azide arylation is demonstrated in yields that

142 supervised clustering approaches outside the scope of bio-medical research, with the additional abili

143 manipulating boron in cells could expand the scope of boron chemistry in living systems.

144 es and imines have dramatically expanded the scope of carbonyl and iminyl chemistry by facilitating r

145 The reaction displays a broad scope of carboxylic acid and alkyne coupling partners, a

146 requirements, credentialing and privileging, scope of care, quality, and responsibility and liability

147 adly applicable strategy that can expand the scope of catalyst-controlled stereoselective olefin meta

148 nanostructures, holds promise to expand the scope of chemical reactions possible with plasmonic phot

149 erapy clinics, based on nurses' autonomy and scope of clinical practice.

150 cal properties of molecules but the chemical scope of compounds with known rate constants for racemiz

151 This paper summarizes the scope of CVD nonadherence, describes key U.S. Food and D

152 enhance access to these data, to extend the scope of data content and visualizations, and to provide

153 radiographs, representing a greatly enhanced scope of data than could be measured in surface-based st

154 unctions, that enable the full combinatorial scope of dimeric signaling receptors encoded within the

155 data collection often limit the breadth and scope of ecological study.

156 These studies enhance the scope of electrophiles for nitroarene arylations and ben

157 Collectively LOTUS-V extends the scope of excitable cell control and simultaneous voltage

158 e limitations are the inadequate quality and scope of existing evidence, incomplete understanding of

159 tensometer (ACME), which greatly expands the scope of existing methods for measuring mechanical prope

160 Future studies should broaden the scope of focal consumers, particularly in understudied t

161 henomena under scrutiny should be within the scope of formal methods.

162 ernal vaccination, are needed to enhance the scope of global prevention of GBS disease.

163 aking informed decisions about the speed and scope of government interventions.

164 y by Wrangham et al.[1] reduced the cultural scope of grooming-handclasp behavior by showing that gro

165 re carried out for 13 reactions, to test the scope of heavy-atom tunneling in organic chemistry, and

166 This study expands the scope of heterodyned 2D IR spectroscopy to tissues.

167 These results expand the scope of heterogeneous-backbone foldamer design to a new

168 Further, we extended the scope of hippocampal phase precession to include object

169 mpson considered genetics to lie outside the scope of his work, even though genetics was a growing di

170 e widespread implications for increasing the scope of human genetic variation that can be detected be

171 ); leadership support (5 reviews/overviews); scope of implementation (5 reviews/overviews); organizat

172 ntercalation compounds, but also extends the scope of investigation on high-capacity electrodes.The r

173 n of uniform field ion mobility for a narrow scope of isomers with variations in both bond coordinati

174 oducts in an isothermal reaction extends the scope of isothermal amplification to enable more useful

175 ent to secondary lymphoid tissues expand the scope of known adjuvant effects of PorB on the immune sy

176 cids is receiving significant attention, the scope of known reactions that directly exploit the polar

177 pectra without compromising the accuracy and scope of lipid identification and quantification.

178 The scope of lipids as taxonomic markers in microbial ecolog

179 ast cancer patients is increasing beyond the scope of locally advanced disease.

180 However, the scope of metacognition impairment among drug users in ge

181 establish awareness of the competencies and scope of nickel(I) compounds.

182 ondensations, the investigation of a broader scope of nucleophiles and some kinetic studies are prese

183 y to have a notable effect on broadening the scope of olefin metathesis, as the stability of methylid

184 by generating a reduced dataset to limit the scope of orthology search for each gene of interest.

185 ucts and pathways would have been beyond the scope of our initial brief report [3].

186 eizures because these topics were beyond the scope of our objective.

187 We limited the scope of our review to large RCTs of supplementation wit

188 Our findings broaden the scope of phenotypes caused by mutations in NFKB1 and sug

189 Given the scope of physiological disruption, we conclude that seis

190 ly seen as a detriment, has now expanded the scope of plasmonic applications to exploit the generated

191 hape the platelet transcriptome and the full scope of platelet translation have remained elusive.

192 has revealed new insight into the scale and scope of population-level variation in recombination rat

193 re based on optical techniques, limiting the scope of potential applications of such powerful screeni

194 inic, operational aspects, nurses' autonomy, scope of practice and clinical decision-making abilities

195 Our unpredictability metric expands the scope of quantitative biomechanical studies to include n

196 report describes the development, synthesis, scope of reaction, bioconjugation, and synthetic compari

197 insights into RNA structure and widened the scope of RNA studies.

198 Wide substrate scope of RPA1163 in such hydrolytic kinetic resolutions

199 opments in 2D IR that continue to expand the scope of scientific problems that can be accessed in the

200 ein we report a significant expansion to the scope of substitution reactions for the dodecaborate ion

201 principles and classic predictions about the scope of TCR cross-reactivity.

202 The scope of temperate AC research and application has been

203 This nano-gating membrane expands the scope of temperature-responsive membranes and has great

204 However, the scope of that control remains unknown: it remains unclea

205 nce may have contributed to the severity and scope of the 2013-16 EBOV epidemic.

206 The scope of the alkyne and hydrosilane partners is substant

207 These results extend the scope of the already very versatile Suzuki-Miyaura react

208 This Editorial describes new enhanced scope of The American Journal of Pathology and introduce

209 This article discusses the scope of the antibiotic misuse in surgery for surgical p

210 The scope of the chirality transfer [2+2] cycloaddition is a

211 ge of aldehydes were employed to examine the scope of the cyclization.

212 two interatomic potentials and to extend the scope of the DFT studies.

213 genesis, and transmission potential, and the scope of the epidemic was largely hidden, owing to gener

214 esting hampers our ability to understand the scope of the epidemic, implications for vaccine implemen

215 with low bone mineral density is beyond the scope of the guideline.

216 Here, we used RNA sequencing to uncover the scope of the H2O2 (peroxide)-stress regulon and to furth

217 These results broaden the scope of the invariant recognition framework for underst

218 This method extends the scope of the library to include spectra of "nearest-neig

219 The scope of the method was enlarged to 35 GC and 63 LC amen

220 A novel protocol for extending the scope of the Mitsunobu reaction to include amine nucleop

221 The scope of the new method for the synthesis of 2H-1,4-oxaz

222 e extent of donor and recipient consent, the scope of the obligation that the organization has to the

223 Due to the scope of the outbreak combined with the lack of availabl

224 Collectively, our findings unraveled the scope of the peroxide stress regulon and expand the repe

225 standing of risk factors for early death and scope of the problem could lead to prevention of these o

226 d be sensitizing in the case of Yb(III); the scope of the process extends to Ln(III) for which it has

227 The scope of the process is explored, demonstrating efficien

228 The scope of the radical precursor includes alpha-iodo keton

229 The scope of the reaction has been successfully tested with

230 The scope of the reaction is limited to unbranched aliphatic

231 The scope of the reaction is quite broad, tolerating a varie

232 The scope of the reaction was achieved from 6-(2-aminophenyl

233 l efforts culminated in the expansion of the scope of the substitution to various heteroatom-based fu

234 s hitherto limited their general use and the scope of the transformation.

235 models of category learning and broaden the scope of the transitive inference paradigm.SIGNIFICANCE

236 e a relatively low output power limiting the scope of their potential applications.

237 Despite the scope of these changes, backwards compatibility is maint

238 To better understand the scope of these changes, we recorded from pairs of mouse

239 onsiderable recent interest in expanding the scope of these reactions by developing new catalysts.

240 The scope of these transformations is discussed as well as m

241 lls with en loading, demonstrating the broad scope of this approach.

242 ionally resistant substrates, broadening the scope of this asymmetric Nazarov cyclization.

243 The scope of this meta-selective borylation is demonstrated

244 The broad scope of this method enabled the preparation and isolati

245 Studies of the scope of this method revealed that cages containing tetr

246 The broad scope of this method was demonstrated.

247 Eventually, we extrapolated the scope of this methodology to the formal total syntheses

248 The scope of this methodology was demonstrated with a range

249 However, the scope of this modification both in bacteria and in eukar

250 Substrate scope of this reaction is demonstrated with 24 examples

251 Aside from surveying the scope of this reaction, we provide details about the mec

252 The scope of this review has been limited to well-characteri

253 The scope of this review ranges from the purely fundamental

254 cessation, this is a large topic beyond the scope of this Seminar.

255 endium has revealed 13 terms relevant to the scope of this study.

256 vailable to only a few groups worldwide, the scope of this technique is unnecessarily limited.

257 labeling, should significantly increase the scope of this technology.

258 The operational simplicity and broad scope of this transformation allow for rapid access to f

259 The scope of this unprecedented enzymatic approach to non-ca

260 The scope of this unusual reaction has been investigated.

261 Hence, the scope of this workshop was to determine the basic functi

262 ch models cannot be used to achieve the wide scope of understanding that is required to create a unif

263 t 90% of the papers in PubMed are out of the scope of UniProt, that a maximum of 2-3% of the papers i

264 These results significantly expand the scope of using functionalized benzotriazinyls as stable

265 difficult to implement, and limited in their scope of utilization; the optimal solution requires a me

266 ing resources and estimates of the scale and scope of what will be available in the near future.

267 h was used to develop the list of topics: 1) scoping of literature and its appraisal, 2) a meeting of

268 Surpassing the expression analysis scope, our work also includes assessment of RNA variant-

269 This scoping review found that there is a large literature on

270 A scoping review maps research activity in a field across

271 s undertaken 12 years ago, in 2005, we did a scoping review of peer-reviewed, published articles on p

272 We conducted a scoping review of qualitative research that explored fam

273 This scoping review of the literature on requesting family co

274 A scoping review of the Rx for Change database of systemat

275 The scoping review yielded 683 qualitative studies; 228 were

276 l products now exists such that expansion of scope seems inevitable.

277 employed by chemists, because the substrate scope, selectivity and robustness of these catalysts are

278 A reaction scope showing good group variation on the substituents o

279 sfer, and the reaction has a broad substrate scope that includes complex pharmaceuticals.

280 lfonamides that is higher and with substrate scope that is broader than those of enzymes containing i

281 For each strategy, the scope, the reactivity of different C-H bonds, the positi

282 recommendations focus on 3 key domains: the scope, the stakeholders, and the consensus process.

283 On broadening scope to all rare and novel variants throughout the exom

284 While recent policies in the UK offers scope to overcome some of these challenges there is a ri

285 e identification-driven approach, limited in scope to peptides that are identified by database search

286 dealt only with loading, here we reduced the scope to the molecular characteristics alone.

287 cribed herein are expected to illuminate the scope to which synthetic chlorins can serve as surrogate

288 dentify these clusters are either limited in scope, unable to detect relationships beyond motif simil

289 drogenation of olefins with a wide substrate scope under 1 bar H2 pressure at room temperature.

290 The method scope was expanded to popcorn kernels, white maize kerne

291 The substrate scope was found to be wide and the methodology was used

292 The substrate scope was studied and included both unfunctionalized as

293 Thus, the scope was to develop a new class of advanced compounds m

294 e 2, the optimal reaction conditions and its scope were investigated.

295 Furthermore, the substrate and nucleophile scope were studied.

296 ization was characterized by ample substrate scope, whereas mechanistic studies provided support for

297 The method is distinguished by its wide scope, which includes the use of benzyl methyl ethers, v

298 eaction is operationally simple and broad in scope while providing succinct and scalable avenues to p

299 The reaction showed broad substrate scope with good to excellent yields.

300 This process features a broad substrate scope with respect to both the nitroarene and the nucleo