ライフサイエンスコーパス: screen

1 s without laborious high-throughput activity screens.

2 and the full text of eligible articles were screened.

3 the synthesis without the need for extensive screening.

4 he FCR Inventory (FCRI) severity subscale at screening.

5 us and applied the strain to high-throughput screening.

6 volcanii due to electrostatic screening.

7 ee survival according to disease duration at screening.

8 screening and 181 articles during full-text screening.

9 set a timeline for implementing lung cancer screening.

10 (KQ) mutants to mimic acetylated lysines and screened 15 KQ mutants.

11 d at 10 and 12 gestational wk (GW 10-12), to screen 27 chemicals individually for their possible anti

12 For the colonisation study, we screened 2923 rectal swabs from healthy volunteers, of w

13 We screened 36,530 third-generation germline mutant mice de

14 G+ relatives diagnosed with HCM after family screening, 74 FG+/phenotype-negative relatives, and 9 wi

15 Two researchers independently screened 945 studies from PubMed, Cochrane Library, and

16 We screen a lentiviral library encoding approximately 100 m

17 ne receptors can ameliorate tau toxicity, we screened a collection of C. elegans mutations in dopamin

18 entify genes involved in MeCP2 silencing, we screened a library of 60,000 shRNAs using a cell line wi

19 Here, we screened a panel of small molecules targeting epigenetic

20 RR = 0.93), and those who spent more time in screen activities (RR = 0.98) and sleeping (RR = 0.96) h

21 firefly luciferase complementation assay to screen against this chimeric receptor.

22 onger activity than other anti-gp120 MAbs in screening against one of two gp120s and against DS-SOSIP

23 performed fragment-based and high-throughput screens against an amino-sugar acetyltransferase enzyme,

24 NAP6-defined extended panel; many failed to screen all cases for chlorhexidine 19/44 (43%) or latex

25 suggest enhanced efforts may be warranted to screen all sexually active HIV-infected adults for syphi

26 , and July 10, 2013, 95 288 individuals were screened and 32 518 (34%) were at high risk of having CO

27 ded 4,332 articles during title and abstract screening and 181 articles during full-text screening.

28 tion of screening at age 40 years, 5-year re-screening and 3-year surveillance intervals (unless shor

29 Nutrition screening and assessment are infrequently performed in p

30 wever, due to poor access and affordability, screening and diagnosis for ID is often limited to proxy

31 Measurement of high-attenuation areas by screening and diagnostic computed tomography may be warr

32 visually, beginning with an initial clinical screening and followed potentially by dermoscopic analys

33 rough a combination of rigorous experimental screening and in silico virtual screening, we recently i

34 A focused screening and lead optimization effort identified 4b (GS

35 onsiderable variation in multiple aspects of screening and management of the disease.

36 ttention in efforts to improve pretransplant screening and management protocols before and after tran

37 efore enable simultaneous transcriptome-wide screening and mechanistic investigation at large scales.

38 a systematic and efficient way to implement screening and monitoring of modifiable risks in the clin

39 ter efforts in prevention, as well as better screening and more effective and affordable treatment.

40 plant skin cancer is fundamental to targeted screening and prevention in this population.

41 Randomisation was done via a central patient screening and randomisation system with an interactive (

42 nd more modest reductions in cervical cancer screening and sexual risk behaviors.

43 The conventional hybridoma screening and subcloning process is generally considered

44 h KHK were discovered through fragment-based screening and subsequent optimization using structure-ba

45 The Hill coefficient in the screening and the shape of the dimerization curve in sma

46 ncluding emergent magnetic monopoles, charge screening and transport, as well as magnonic response.

47 factors, symptoms, and suggested options for screening and treatment are given.

48 is needed to understand the effectiveness of screening and treatment for celiac disease, accuracy of

49 s were found in 18 (7.6%) of 237 patients at screening, and there was a clear age gradient.

50 atterns may increase productivity in genetic screens, and facilitate the study of genetic variants as

51 eptor for PGE2-G, we performed a subtractive screening approach where mRNA from PGE2-G response-posit

52 e to numerous enzymes and to engineering and screening approaches to identify activators and blockers

53 rate that antigens identified by serological screening are targets of multifunctional cellular immune

54 Here, we designed a genetic screen around E. coli that identified high-affinity cyto

55 cell-essential genes identified in a CRISPR screen, as well as in genes with reported roles in cance

56 activation capacity and optimized for simple screening assays with luciferase or fluorescent reporter

57 We analyzed data from 7663 participants screened at least once and found to have a negative FIT

58 he preferred screening method, initiation of screening at age 40 years, 5-year re-screening and 3-yea

59 o the intricate interplay between the charge screening at the PZT/SNNO interface and the charge trans

60 mense potential for fast and high-throughput screening bacterial chemotaxis.

61 compounds, and a comparison of a nontargeted screening based both on the study of the most discrimina

62 f HRMS signals, a comparison of the targeted screening based on more than 100 compounds, and a compar

63 l coupling between adults and infants during screen-based and live interactions.

64 We found no difference in uptake of screening between the active choice and control groups (

65 Of these, 92% tested D816V-positive in the screening blood sample.

66 proaches have also been taken, which rely on screening broad, natural genetic diversity for metabolic

67 s remain unknown, despite many of them being screened by whole exome sequencing.

68 MMS2 (Plasmodium invasion of mosquito midgut screen candidate 2), a Plasmodium berghei protein with s

69 ed by researchers and regulators in a hazard screening capacity to assess the potential of a protein

70 direct evidence on the benefits or harms of screening children and adolescents for excess weight.

71 ules during the encoding period of the right screen condition.

72 es and false negatives under high-throughput screening conditions is particularly difficult.

73 After conducting a compound screening contest in 2014, we report results acquired fr

74 with a standardized script and mobile touch-screen data collection.

75 we applied the correction to HX-MS excipient screening data collected for a pharmaceutically relevant

76 y available, high-quality DNA, RNA, and drug screening data.

77 Moreover, we successfully apply o2n-seq to screen de novo, low-frequency mutations in human tumours

78 screening methodology, related to robustness screening described by Glorius et al., builds a broad un

79 Screen-detected gallstone disease in the general populat

80 s without prevalent (previously diagnosed or screen-detected) diabetes at baseline, with an overall i

81 ether the rates and tumor characteristics of screening-detected and interval cancers differ for two-d

82 roarray analysis of mouse prostate tissue to screen downstream targets and effectors of miR-32, we id

83 ty attributes, optimizing manufacturing, and screening drugs/biomaterials.

84 -based eligibility would improve lung cancer screening efficacy.

85 own ocular disease who desires a routine eye screening examination is eligible.

86 scaffold, which was uncovered via a virtual screen followed by testing in a fluorescence anisotropy

87 oss 12 human cancer types and systematically screen for homozygous deletions, aiming to identify rare

88 , with moderate throughput, could be used to screen for structural elements, small molecules, and hos

89 Here, we describe a screen for transcription factors (TFs) that regulate the

90 We screened for all molecules that are expressed differenti

91 ce with senescent mouse lung fibroblasts and screened for antibodies that recognized senescence-assoc

92 852 mutants was expressed in human cells and screened for antigenicity using four different monoclona

93 affected C1-INH-HAE family member should be screened for C1-INH deficiency.

94 BACKGROUND & AIMS: Among subjects screened for colorectal cancer (CRC) by the guaiac fecal

95 to a medical ICU totaling 10,216 visits were screened for delirium by means of the Confusion Assessme

96 Children were screened for delirium using the Cornell Assessment of Pe

97 Patients were screened for DSA pretransplant, monitored regularly post

98 ed, phase 3, open-label trial, patients were screened for eligibility from 52 clinical centres in Can

99 15, and July 15, 2016, 742 participants were screened for eligibility, of whom 657 were randomly assi

100 Food handlers and fishmongers were screened for enteric carriage of GBS.

101 This study screened for mutations in 322 hematology patients classi

102 erformed (Roche/454), and the sequences were screened for nucleoside and nonnucleoside RT inhibitor D

103 Various gRNAs were screened for their efficiencies against HIV provirus in

104 lar HDAC assays, four compounds were further screened for their inhibitory activity against recombina

105 3, contacts of each index case with CDI were screened for toxigenic C. difficile by culturing rectal

106 Samples positive for HPV-DNA were screened for viral oncoprotein expression using western

107 e is adequate evidence to bound the harms of screening for and treatment of preeclampsia as no greate

108 Selective use of screening for CAC might be considered in individuals wit

109 review the evidence on benefits and harms of screening for celiac disease in asymptomatic adults, ado

110 aly, were randomly assigned to be invited to screening for colorectal cancer with FS or CT colonograp

111 aria compared to algorithms that incorporate screening for danger signs.

112 In screening for host factors that interact with HIV-1 MA,

113 tified Arabidopsis pex6 and pex26 mutants by screening for inefficient seedling beta-oxidation phenot

114 valuated by clinical examination and genomic screening for mutations in SCN9A and SCN11A.

115 ompted primary care providers to perform HCV screening for patients seen in primary care clinic (1) b

116 The USPSTF recommends screening for preeclampsia in pregnant women with blood

117 ith PLA2R1-associated MN, and more intensive screening for the presence of malignancies may be warran

118 rs, presentation, optimal management of, and screening for urologic malignancies in kidney transplant

119 jected it to random mutagenesis, followed by screening for variants whose in vivo folding displays in

120 dy, we demonstrate the utility of "admixture screening" for the discovery of new multicomponent heter

121 gence-based grading algorithm can be used to screen fundus photographs obtained from diabetic patient

122 The adoption of criteria to screen HSV PCR tests in CSF represents a cost-effective

123 (IVIVE) analyses translating high-throughput screening (HTS) data to human relevance have been limite

124 In this study, we utilized high-throughput screening (HTS) in vitro data of PAHs to predict health

125 Our high-throughput genome-wide siRNA screen identified host factors that prevent reproduction

126 The screen identified multiple candidates in many cell signa

127 A whole proteome screen identified Mycobacterium tuberculosis antigens as

128 From these, the secondary chemical screen identified SETD8, the H4(K20me1) methyltransferas

129 High-throughput screening identified anthracyclines including doxorubici

130 se reporter strains, we performed an RNA-seq screen, identifying tip- and stalk-enriched gene sets in

131 apse video imaging compiled from the optical screening images revealed unexpected differences in grow

132 he findings lend support to consideration of screening imaging of the brain for patients with HER2-po

133 Here, we use an unbiased genome-wide genetic screen in near-haploid human cells to uncover cellular p

134 Through an RNAi screen in the developing Drosophila eye, we found that p

135 Plasma levels of 17 cytokines were screened in the same set of subjects.

136 his microfluidic device will facilitate drug screening in a relevant microenvironment thanks to its s

137 Heart Association (ACC/AHA) recommend lipid screening in all adults older than 20 years to identify

138 Fragment-based screening in human cells thus provides an extensive prot

139 to emphasize sun protection and skin cancer screening in individuals who tan indoors.

140 We aim to investigate the value of clinical screening in relatives of all subjects who died suddenly

141 the proportion of women who participated in screening in the study groups.

142 nefit, and there is no evidence to recommend screening in this group.

143 AKAP13 and WAC, which were identified by our screens in multiple cancer types, as new tumor suppresso

144 Most positive regulators identified in our screens, including Rab34, Pdcl, and Tubd1, were involved

145 tance to therapeutic agents, and potentially screen individuals for the early diagnosis of cancer.

146 e), and thus was used in genetic testing for screening individuals at high risk.

147 tic assays for interaction analysis and drug screening involving membrane components.

148 he putative interactions revealed in the Y2H screen is unclear.

149 Adding surveillance to FIT screening is not cost-effective based on the Dutch ICER

150 trained vs untrained PCPs are needed before screening is widely implemented in large health care sys

151 pite early detection during routine clinical screening, is associated with substantial short- and lon

152 Advances in the ability to screen, isolate, and characterize HIV-specific antibodie

153 We then screened it for pyrazinamide resistance both in vitro an

154 ential is an electric potential in the Debye screening layer of an electrolyte, which represents a ke

155 Screening led by either specialists or ICU teams was equ

156 ional and nationwide projections useful as a screening-level assessment of climate impacts on CyanoHA

157 d a platform for microfluidics-assisted cell screening (MACS) that overcomes this trade-off by tempor

158 copy could offer a rapid and high-throughput screening method for identification of Leptospermum hone

159 d be used in a manner similar to the testing/screening method for neural tube defects and common chro

160 We recommend colonoscopy as the preferred screening method, initiation of screening at age 40 year

161 luate the effectiveness of this quantitative screening method.

162 A general screening methodology, related to robustness screening d

163 ectiveness of 2 population-based skin cancer screening methods and to assess their budget effect and

164 of individuals and could supplement current screening modalities to aid early diagnosis of high-risk

165 herapeutics have been impeded by the lack of screening models that faithfully replicate prion disease

166 tify novel molecular targets and efficiently screen new compounds aimed at those targets.

167 Neither meeting criteria for screening nor history of receptive anal sex was signific

168 H3K27me3 site in EED discovered by in-house screening, Novartis scientists have now produced a compo

169 The initial screen of small molecule compound libraries identified m

170 In this study, we performed an siRNA-based screen of the kinome to identify genetic regulators of P

171 Finally, virtual screening of 29332 metabolites predicted 146 competitive

172 Screening of a 50000-member library of natural and synth

173 mine if the intervention was associated with screening of a demographically higher-risk population th

174 Initial screening of a series of over 50 newly characterized 2-a

175 Phytochemical compound screening of all Fagioli di Sarconi beans performed by f

176 Screening of all publically available V. cholerae genome

177 Screening of bacterial colonies to identify new biocatal

178 BB) models are crucial tools to enable rapid screening of brain-penetrating drugs.

179 In the largest screening of CD in the United States to date outside of

180 Routine screening of children with suspected ZIKV infection for

181 PCR screening of ETEC isolates revealed that 8.6% (n = 13) o

182 ystem is also being used for high-throughput screening of genes, gene regulatory regions, and long no

183 h the graphene polarization charge and ionic screening of ions adsorbed on the graphene as well as ch

184 Exosome based screening of key HPVOPC associated molecules could be be

185 le rounds of affinity maturation through the screening of macrocyclic peptide libraries produced in E

186 ability of the developed zebrafish model for screening of molecules with therapeutic value against th

187 noassays and was applied in this work to the screening of mycotoxins.

188 cterial and host factors and high throughput screening of novel therapeutics becoming the mainstay of

189 well suited for multiplexed single-molecule screening of protein libraries, and should enable the in

190 Advances in the synthesis and screening of small-molecule libraries have accelerated t

191 High-throughput screening of the host transcriptional response to variou

192 SIL following implementation of universal AC screening offered to all HIV-infected women.

193 Sera from 820 patients were screened on GGTA1/CMAH/B4GalNT2 KO cells and a subset wi

194 le for clinical use, we performed phenotypic screens on a NINDS small molecule library of 1040 drugs.

195 such as leaking roofs were repaired, windows screened, open eaves blocked with bricks and mortar, cem

196 ges with established implications for cancer screening or prevention.

197 t CE spectral mammography and MR imaging for screening or staging from 2010 through 2014 were include

198 ent neutralization activity based on initial screening or to evaluate neutralization magnitude-breadt

199 Here, through a biochemical and structural screening paradigm, we have identified JNJ0966, a highly

200 putational tool that simulates the impact of screen parameters on the robustness of screen results, t

201 Biochemical markers can also help in screening patients for the presence of small fibre neuro

202 xamination, it is unclear whether performing screening pelvic examinations in asymptomatic women has

203 the spectral properties of the eye-colouring screening pigments are discussed within the context of t

204 L) human cell lines and a custom CRISPR/Cas9 screening platform, we identify the H3K9 methyltransfera

205 and feasibility of implementing lung cancer screening policies based on risk prediction models shoul

206 Patients who screened positive for HER1/2 and who did not have progre

207 etecting environmental EDC contamination and screening potential NHR-targeted pharmaceuticals.

208 Screening, preventive therapy, and surveillance for tube

209 Thereby, PHA was immobilized on screen printed electrodes (SPE) through a blend formatio

210 tion of model amphipathic viral peptide on a screen-printed electrode.

211 t study, we demonstrate the development of a screen-printed potentiometric immunosensor for in vitro

212 Our search and study screening process adhered to the PRISMA Guidelines.

213 INTERPRETATION: Systematic, community-based screening programme of fracture risk in older women in t

214 ent to support the implementation of T cruzi screening programmes at primary health centres in Europe

215 hically higher-risk population than previous screening programs and if melanoma incidence and thickne

216 High-throughput methods for screening protein-protein interactions enable the rapid

217 We propose an ophthalmic screening protocol to diagnose retinitis in pediatric HS

218 To describe a skin cancer screening quality initiative in a large health care syst

219 ng vein and scutellar bristle development to screen Rab proteins predicted to be substrates for ICMT

220 population Considerations: Studies show that screening rates among children vary by race/ethnicity an

221 cord-based prompt on hepatitis C virus (HCV) screening rates in baby boomers in primary care and acce

222 Additional studies comparing screening rates, specialty referrals, and patient outcom

223 owards addressing these issues by increasing screening resolution and analyzing the effects of off ta

224 ct of screen parameters on the robustness of screen results, thereby enabling users to build intuitio

225 red in the early differential diagnosis when screening results are positive for HPA.

226 Surprisingly, genetic screening reveals that yeast FTase can modify sequences

227 fectiveness of colonoscopy surveillance in a screening setting.

228 Persons without prior screening should be considered for screening up to age 8

229 Prospective studies evaluating cancer screening strategies in adults with unprovoked VTE that

230 nd harms (e.g., overdiagnosis) of risk-based screening strategies using these models.

231 g tests in asymptomatic persons, and optimal screening strategies.

232 Here, we develop a screening strategy for modulators of ATP-PRT and identif

233 ve Orbitrap were compared by retrospectively screening surface water samples for 95 pharmaceuticals.

234 s into apoE biology and establishes a robust screening system to monitor apoE conformation.

235 and the lack of rapid, sensitive biological screening systems.

236 e diagnostic potential of this approach as a screening technique for non-Hodgkin lymphoma and melanom

237 lusion of the eyes and the conventional Hess screen test.

238 A sectors approach shows good screening test characteristics for the detection of CSME

239 and recommends specific strategies based on screening test implementation.

240 In contrast to Hess screen testing, strabismus video goggle measurements wer

241 enable for biomarker identification and drug-screening testing and led to the identification of the E

242 nd treatment for celiac disease, accuracy of screening tests in asymptomatic persons, and optimal scr

243 The objective of this study was to screen the antibacterial and antioxidant activity of thi

244 In this study, we screened the FDA-approved drug library for agents that s

245 To test this hypothesis we screened the potential enzymatic functions of hypothetic

246 pping ligand; of the eight different ligands screened, those with the shortest alkyl chain, -(CH2)2-,

247 After screening through Lipinski's rule of five filter for ora

248 Three reviewers independently screened titles and abstracts, read full-text articles,

249 Here we used a system-wide screen to address the frequency of susceptibility to gam

250 hput microfluidic platform as a quantitative screen to assess peptide activity and selectivity by pre

251 36), identified using an unbiased phenotypic screen to detect inhibitors of the HSF1 stress pathway.

252 GCs with a next-generation short hairpin RNA screen to identify GC-regulated "effector" genes that co

253 ort a nanotechnology-enabled high-throughput screen to identify small-molecule agonists of TFEB and d

254 Here we developed a genome-wide functional screen to interrogate the transcription factors and cofa

255 zed ligands from the database were virtually screened to obtain the most efficient and potent ones.

256 ble new approaches to prevent CDI, including screening to identify and isolate carriers, universal gl

257 study, we performed a novel drug-repurposing screening to identify Food and Drug Administration-appro

258 e study, we used comparative flow cytometric screening to identify ICAM-1 as a potential target for m

259 be used for high-throughput reverse genetic screens to help functionally annotate the Ae. aegypti ge

260 hanism of this process, we performed genetic screens to identify components of the sorting machinery

261 i and CRISPRa) in the context of genome-wide screens to identify components that influence resistance

262 and fast, the method can serve as a primary screening tool for TMJ pathology, before proceeding to c

263 nscription, thus making it an efficient drug screening tool that can be used for therapeutic interven

264 ical characteristics to be employed as a pre-screening tool, when combined with other data such as pa

265 s been proposed for several years as a rapid screening tool, whereby negative specimens are excluded

266 ngs also support the use of neuropathic pain screening tools in these patients and treatment algorith

267 Screening tools, such as the DN4 questionnaire, and trea

268 as well as the lack of large-scale neonatal screening tools.

269 This screen uncovered essential residues within Synaptotagmin

270 or greater and less than 170 mm Hg at second screening underwent renal angiography and were randomly

271 out prior screening should be considered for screening up to age 85, depending on age and comorbiditi

272 f differences and changes in vaccination and screening uptake by ethnicity in England, over time.

273 ted and with latent or active TB (aTB), were screened using M.tuberculosis-specific MHC class II tetr

274 Post-prostate massage urine samples were screened using the Matrix-Assisted Laser Desorption/Ioni

275 ore our findings are relevant to studies and screens using VTD to activate DRG neurons.

276 mug/kg, and exceeded the human health cancer screening value of 12 mug/kg in 48% of the national samp

277 y referral and CIN2+ detection rates for HPV-screened versus cytology-screened women in Australia's H

278 We performed screening visual fields using a calibrated iPad 2 with t

279 melanoma incidence and thickness differed in screened vs unscreened patients.

280 in using structural information for virtual screening (VS) of libraries and for structure-based drug

281 Through a forward genetic screen we found pals-22, a gene of previously unknown fu

282 further characterize genes identified by our screen, we compared the functional contributions of P. s

283 Based on an unbiased genetic screen, we found that partial genetic and pharmacologica

284 Furthermore, using a yeast two-hybrid screen, we identified the motor protein Kif15 as a poten

285 By cDNA library screening, we identified an immune cell-specific, co-sti

286 experimental screening and in silico virtual screening, we recently identified novel classes of EPIs

287 Utilizing high-throughput screens, we identify prion-curing mutants and engineer "

288 ol livers to design an "educated guess" drug screen, which led to the identification of new, deleteri

289 isk for retinoblastoma require more frequent screening, which may preferentially be examinations unde

290 Furthermore, a genome-wide forward screen with Haplobank identified PLA2G16 as a host facto

291 approach of integrating a genome-wide miRNA screen with patient-derived phospho-proteomic signatures

292 ulse after which the DC surface potential is screened with a second optical pump pulse.

293 AND Primary care attendees aged 18-65 years screened with moderately severe to severe depression on

294 a-like symptoms, determine the usefulness of screening with computed tomography coronary angiography

295 esting strategy, routine universal anorectal screening with respect to chlamydia and gonorrhea preval

296 ve combined high-throughput immunophenotypic screens with large-scale single-cell gene expression ana

297 rticipation (ie, attendance at breast cancer screening) within 90 days of the date of the first offer

298 ction rates for HPV-screened versus cytology-screened women in Australia's HPV-vaccinated population

299 Kinome-wide screening would have the advantage of providing structur

300 t formats of an enzyme-based high-throughput screen yielded two attractive chemotypes capable of inhi