ライフサイエンスコーパス: screen

1 epts of visual forms, like pixels on a video screen.

2 e on how to design and analyze CRISPR-pooled screens.

3 on the design and analysis of pooled CRISPR screens.

4 oach to facilitate image-based pooled CRISPR screens.

5 es, because the field cannot be localized or screened.

6 31, 2012, to May 16, 2017, 408 patients were screened.

7 ic CrAg-positive patients identified through screening.

8 iac disease and serve as a test bed for drug screening.

9 d improving the quality of colorectal cancer screening.

10 8.5% children, 54.4% women) underwent vision screening.

11 unds to outcomes of digital mammography (DM) screening.

12 States instead of DM alone for breast cancer screening.

13 east cancer mortality compared with stopping screening.

14 biocatalyst via ultrahigh throughput droplet screening.

15 alcifications during 20 years of mammography screening.

16 ydrophobic cavity suitable for targeted drug screening.

17 same strain as a parental strain at time of screening.

18 physicians are overdue for colorectal cancer screening.

19 (COVID-19) serological testing and antiviral screening.

20 ll-child visits, HbA(1c) testing, and cancer screening.

21 ease who were referred for colorectal cancer screening.

22 the accuracy and efficiency of breast cancer screening.

23 d; 33 of 56 839) than DM (0.9 per 1000 women screened; 0.4, 1.6 per 1000 women screened; nine of 10 5

24 s; 27 of 48 [56%] male) referred for cardiac screening 1.5-T MRI between 2014 and 2017.

25 Among 341 individuals screened (11/2016-7/2017), 200 met inclusion criteria; 5

26 Of the 1284 abstract results screened, 124 articles were assessed in full and 37 stud

27 relationship model was employed to virtually screen ~138,000 compounds, which increased the identific

28 Of the 5,467 patients that were screened, 2,007 were molecularly eligible for entry into

29 The Nutrition Risk Screening-2002 (NRS-2002), Subjective Global Assessment

30 We used HeLa cells and screened 231 FDA-approved oncology and natural substance

31 December 31, 2018, 4,247 patients underwent screening; 247 were reviewed weekly by a VIA diagnostic

32 Results We screened 2566 records from the search, assessed 52 full-

33 Screening 3-monthly was cost-effective (ICER: $4,500/QAL

34 en screened; 95% CI: 0.4, 0.8 per 1000 women screened; 33 of 56 839) than DM (0.9 per 1000 women scre

35 Two reviewers independently screened 6,666 abstracts.

36 By automated screening, 8.3% of the 180 study participants had refera

37 e slightly lower for DBT (0.6 per 1000 women screened; 95% CI: 0.4, 0.8 per 1000 women screened; 33 o

38 A RVFV inhibition ELISA was used to screen 977 cattle, 1,549 sheep and 523 goats and informa

39 We initially screened a library with a large structural variety of li

40 Specifically, we screened a naive human semisynthetic phage library again

41 eir continued movement and introduction, but screening a sufficient fraction to ensure rare infection

42 Pooled library CRISPR/Cas9 knockout screening across hundreds of cell lines has identified g

43 text, nearly all candidate inhibitors from a screen against acetylcholinesterase show detectable acti

44 (2020) conduct a focused CRISPR/Cas9 screen against NRF2 target and other redox regulatory ge

45 phenolic acids, and flavonoid compounds were screened against acetylcholinesterase, butyrylcholineste

46 II HLA molecules were selected for in vitro screening against PBMC samples from a cohort of chronic

47 dence is increasing among young adults below screening age, despite the effectiveness of screening in

48 We screened an Asian-Pacific cohort for CANVAS and identifi

49 We screened an RNAi library targeting ubiquitin E3 ligases

50 ipants, the authors sought to systematically screen and validate a wide range of potential modifiable

51 Patients were pre-screened and received their substudy assignment upon pro

52 Universal screening and convenient access to maternal health servi

53 ese features have led to many techniques for screening and diagnosis, but many are expensive, less fe

54 immunity and have clear implications for the screening and evaluation of novel adjuvants.

55 We used structure-based virtual screening and fragment-based drug discovery to identify

56 SpyCas9), we used both self-targeting CRISPR screening and guilt-by-association genomic search strate

57 oximity of a metal, which induces additional screening and hence suppresses electron interactions.

58 intestinal microbiome might be used for CRC screening and modified for chemoprevention and treatment

59 idate a patient-reported outcome measure for screening and monitoring vision-related anxiety in patie

60 Ralphabeta-Jurkat libraries enabled repeated screening and panning for antigen-reactive TCRs using pe

61 ics, suggesting their usefulness not only as screening and predictive biomarkers, but also in capturi

62 l COVID-19 disease status, the role of viral screening and serological testing, return-to-work consid

63 Community screening and therapeutic prevention strategies may redu

64 wering treatment for at least 4 weeks before screening and who had an LDL cholesterol level of 130 mg

65 cently used CRISPRi/a-based chemical-genetic screens and cell biological, biochemical, and structural

66 findings inform parameter choices of CRISPR screens and provide guidance to researchers on the desig

67 aff represent acceptable solutions to expand screening, and (iv) whether testing a large percentage o

68 Early case detection, contact screening, and chemoprophylaxis are the most promising t

69 d gene set enrichment analysis and proteomic screening, and identified substantial reprogramming of t

70 val from TRB was not improved as a result of screening, and many false-positive results required addi

71 readily deployable surrogate viral assays to screen antiviral humoral responses, define correlates of

72 starch damage increased significantly as the screen aperture size decreased.

73 g the way toward T-dependent high-throughput screening applications by HDX-MS.

74 tential for disease modeling and therapeutic screening applications.

75 A strategic screening approach led to the discovery of this novel li

76 PR2A which enables this target for NMR-based screening approaches.

77 for computer-aided diagnosis and image-based screening are being adopted worldwide by medical institu

78 meta-analysis methods when using our CRISPR screen as validation data.

79 Regional epidemiology and level of active screening (AS) both influenced the predicted time to EOT

80 Using a FRET-based high-throughput screening assay that we previously reported, we identifi

81 ivity, and establishes curation of data from screening assays, used routinely in antimalarial drug di

82 We introduce a methodology for optimizing screening, assessing potential risks, and quantifying as

83 dy assignment upon progression, or they were screened at progression and received their substudy assi

84 ic charges contribute to charge transfer and screening at oxide interfaces, triggering a thermodynami

85 via microscopy, establishing robust droplet screening at single-cell resolution.

86 rk for the analysis of NGS functionalization screens available as an R package called malacoda (avail

87 identified this antibody in a yeast display screen built from mononuclear cells isolated from the im

88 comparing IPTp with SP against intermittent screening by rapid diagnostic tests (ISTp).

89 In addition, genetic modifier screens can be used to elucidate disease mechanisms and

90 Experimental testing of 62 screening candidates yielded the discovery of 10 new ago

91 undesired variants that can quickly outstrip screening capacity.

92 on to the disease biology but are limited in screening capacity.

93 Method for the ICU, Intensive Care Delirium Screening Checklist, a focused bedside cognitive examina

94 k assessment, counseling, and decision aids; screening checklists; community engagement; and provider

95 also inspire the design of future macrocycle screening collections.

96 21 RA healthy middle-aged volunteers before screening colonoscopy.

97 romising approach to improve cervical cancer screening coverage, especially among women with limited

98 We developed screening criteria to identify a subset of potential env

99 trumentation and will be useful for antibody screening, custom assay development, biomarker detection

100 ion of significantly depleted genes, optimal screen design can nevertheless enable robust screen perf

101 gating enzyme E2 variant 1) in a genome-wide screen designed to identify novel effectors of the aggre

102 To determine trends in recall and outcome of screen-detected microcalcifications during 20 years of m

103 Approaches to prostate cancer screening, diagnosis, surveillance, treatment and manage

104 onization Group (IGHG) recommends risk-based screening echocardiograms, but evidence supporting its f

105 hensive sexually transmitted infection (STI) screening every 3-6 months for men who have sex with men

106 ve cohort study of patients who received ROP screening examinations at a level IV neonatal intensive

107 , cancer detection rate (CDR) per 1000 women screened, false-negative rate per 1000 women screened, p

108 Screening, followed by colonoscopic polypectomy (or surg

109 Our screen for admixture-enabled selection relies on the ide

110 -drug antibodies that may provide an initial screen for all therapeutic monoclonal antibodies.

111 signalling pathways driving fibrosis and to screen for anti-fibrotic compounds targeting glycogen sy

112 sors that can noninvasively and continuously screen for biochemical markers in body fluids for the pr

113 bitors from a high-throughput small-molecule screen for fragile X tremor ataxia syndrome.

114 ysis of GAL4 lines identified in an unbiased screen for increased female chasing behavior revealed th

115 The algorithm also gives the ability to screen for isomeric contributions and to follow homologo

116 oupled with the SONICC and TEM techniques to screen for microcrystal formation within living insect c

117 report on the results of a gain-of-function screen for modulators of hypotonicity-induced ATP releas

118 henotypic screening is an unbiased method to screen for novel targets and therapeutic molecules and s

119 Typically, nonspecialists such as dentists screen for oral cancer risk, and then they refer high-ri

120 We used this approach to screen for phenotypic targets of the essential mir-35-42

121 uated for serum SEVs size, concentration and screened for 95 oncomirs.

122 Patients should be screened for and counseled regarding substance abuse to

123 le fragment (scFv) phage display library was screened for binding, internalization, and transcytosis

124 collected for communicable diseases commonly screened for during the exam, including tuberculosis (TB

125 cular basis for lability of T3D/T1L L3S2, we screened for hyperstable mutants of T3D/T1L L3S2 and ide

126 ets annotated with their bound fragments was screened for local similarity to cavities from recently

127 Approximately 1000 M(2) families were screened for the segregation of pale-green seedlings in

128 ent decisions, the present evidence supports screening for and targeting of modifiable risk factors f

129 presentatives, developed a recommendation on screening for anxiety in adolescent and adult women to i

130 uggest that the benefits of population-based screening for CKD are uncertain; that there is potential

131 Traditional screening for COVID-19 typically includes survey questio

132 fever >=37.5 degrees C, necessitating urgent screening for Ebola virus, and a small number developed

133 By contrast, screening for latent tuberculosis before immune checkpoi

134 mation for risk-adapted starting ages of CRC screening for patients with diabetes, who are at higher

135 Furthermore, screening for suspects in LC-HRMS data resulted in the d

136 library containing nearly 4000 fragments and screening for target-specific binders within days.

137 l genes and pathways as well as larger-scale screens for studies of development and disease.

138 gene editing, have made possible systematic screens for synthetic lethal drug targets in human cance

139 e difference was significant in favor of the screening group (hazard ratio, 0.17; 95% CI, .03-.86).

140 Among 10,232 African Americans in the early screening group who were mailed a FIT, screening was com

141 forts should be made to improve adherence to screening guidelines, especially for vulnerable populati

142 ces, even in high-income countries; and that screening has substantial opportunity costs in low- and

143 Studies are needed on the effects of screening high-risk persons and to identify quality meas

144 High-throughput screening (HTS) research programs for drug development o

145 ore physiologically relevant high-throughput screens (HTS).

146 The screen identified several compounds that interfere with

147 second, subsequent whole-genome CRISPR-Cas9 screen identified the LITAF-like protein CDIP1 as a seco

148 Proteomics screening identified adenine nucleotide translocase 3 (A

149 High-throughput screening identified doxorubicin (DXR) as an inhibitor o

150 These screens identified 890 genes whose loss causes either se

151 in human neurons and, from a small-molecule screen, identify the mTOR inhibitors OSI-027, AZD2014 an

152 Here we performed a CRISPR-Cas9 screen in human SV589 cells for genes required for LDL-d

153 Out of 381 miRs screened in the perivascular tissues in response to Ang

154 x show promise as biomarkers for anal cancer screening in HIV+ and at-risk HIV-negative women.

155 nts are not advised for cardiometabolic risk screening in large groups.

156 screening age, despite the effectiveness of screening in older populations.

157 We suggest reinforcing the cancer screening in T2DM patients to enable the early detection

158 From genetic screens in C. elegans, we identified splicing factor RNP

159 Here we performed genome-wide CRISPR screens in Vero-E6 cells with SARS-CoV-2, Middle East re

160 ormance, we carried out parallel CRISPR-Cas9 screens in wild-type and TP53 knockout human retinal pig

161 Most screening instruments are moderately to highly accurate.

162 study shows that the integration of newborn screening into existing primary health-care immunisation

163 Cervical screening involved HPV testing at age 35 years, or at ag

164 Phenotypic screening is an unbiased method to screen for novel targ

165 esenting approximately 40% of those for whom screening is currently recommended.

166 ain; that there is potential for harms; that screening is not a wise use of resources, even in high-i

167 erium RT-PCR method provides a rapid tool to screen isolates and identify probable diphtheria cases d

168 r contrast material administration in breast screening.Keywords: Breast, MR-Diffusion Weighted Imagin

169 Broad preoperative screening led to 1 positive COVID-19 test in an asymptom

170 with established cardiovascular disease and screening lipoprotein(a) levels of at least 60 mg per de

171 Screening mammograms were double reported.

172 tudied whether or when women can safely stop screening mammography.

173 Our comprehensive screen measures thousands of pairwise trait correlations

174 broadly applicable high-throughput operando screening method for heterogeneous catalysts.

175 We have also developed a temperature-based screening method for synthetic paralysis that can be use

176 Here, we describe an arrayed CRISPR screening method, Genome engineering-based Interrogation

177 Advances in cancer screening methods have opened avenues for incidental fin

178 The use of sensitive screening modalities for early detection of lung cancer

179 1000 women screened; 0.4, 1.6 per 1000 women screened; nine of 10 511) overall (P = .30), but the dif

180 rs of Mtb-specific T cells, we carried out a screen of 3,724 distinct proteins covering 95% of Mtb pr

181 In a screen of an insertional mutant library of all 14 annota

182 Here, through a genome-wide mutant screen of human antigen-presenting cells, we show that t

183 ost no described role in cancer, our in vivo screen of inflammatory and cytokine pathway genes reveal

184 Screening of 600 Victorian clinical isolates identified

185 lase activity was isolated during functional screening of a human gut metagenomic library using Lacto

186 wever, only a few have their origin from the screening of combinatorial peptidomimetic library.

187 We have performed the parallel screening of commercially available compounds against a

188 developed a platform for rapid phage display screening of deep recombinant libraries consisting of as

189 Standard state-of-the-art techniques for screening of electrogenic bacteria are inefficient, and

190 ques to isolate effective compounds based on screening of entire compound libraries based on desired

191 Parallel (multichip) screening of ferric ion concentration gradients (0-40 mM

192 FTD/ALS syndromes and indicate that genetic screening of FTD/ALS patients for HTT repeat expansions

193 e 1990s, however, indicates that low-dose CT screening of high-risk patients enables detection of lun

194 By a loss-of-function genetic screening of individual IFN-stimulated genes (ISGs) on h

195 Guidelines suggest endoscopic screening of individuals who are at increased risk for B

196 nce for future attempts to achieve proximity screening of many-body phenomena in two-dimensional syst

197 ed ex vivo stimulation of memory T cells and screening of naive and memory T cell libraries, combined

198 and open-source OPERA application to enable screening of new chemicals with a defined applicability

199 etup shows limited ability to perform a true screening of oregano using the setup offered.

200 e searched for new agents by high-throughput screening of selected targeted compounds and identified

201 he presence of mobile ions, enabled by ionic screening of the carbon electrode.

202 Phenotypic screening of the resulting oxazonine collection identifi

203 2 patients with immune thrombocytopenia were screened, of whom 74 (80%) were randomly assigned: 38 to

204 d whether sex differences in not enrolling ("screen out") varied by various individual, trial, or sit

205 Screening outcome in the era of SFM (1997-2008), the tra

206 r prevention interventions for women include screening, partner notification, promoting condoms, and

207 Continuing annual breast cancer screening past age 75 years did not result in substantia

208 networks, have enabled the development of AF screening pathways using the ubiquitous 12-lead ECG to d

209 ometrists (61.2%) reported that they did not screen patients aged 40 years and above for cataract.

210 tial utility of the composite cTAG score for screening patients prior to biopsy to identify those sui

211 impact of cellular p53 status on CRISPR-Cas9 screen performance, we carried out parallel CRISPR-Cas9

212 screen design can nevertheless enable robust screen performance.

213 astoma, we develop a high-throughput in vivo screening platform and discover several driver variants

214 reliable and convenient ultrahigh-throughput screening platform based on flow cytometric droplet sort

215 ons prompted us to develop a high-throughput screening platform of cancer drugs in a quest to repurpo

216 lying disease mechanisms and for use as drug screening platform, particularly for reagents designed t

217 Of the 531 patients followed, 108 (20%) screened positive for any MHD: of those who screened pos

218 screened positive for any MHD: of those who screened positive for PTSD (7.9%, N = 42), all had co-mo

219 screened, false-negative rate per 1000 women screened, positive predictive value of recall (PPV1) per

220 We describe a convenient assembly for screen printed carbon electrodes (SPCE) suitable for ana

221 for Pa-positive patients with a surveillance screening program does not significantly reduce ICU-acqu

222 g contained within the National Korea Health Screening Program for Infants and Children database.

223 A surveillance screening program for Pa was implemented.

224 est set-based assessment schemes in a breast screening program has the potential to predict and ident

225 To examine the impact of a screening program to detect anal cancer precursors on th

226 Despite the existence of screening programmes worldwide, the interpretation of ma

227 of mental disorders were measured using the Screening Questionnaire for Disaster Mental Health (n =

228 terventions (n = 88) indicated higher cancer screening rates with patient navigation; telephone calls

229 rom GP databases could be used to complement screening referral decisions by identifying those at gre

230 atment and the overall cost-effectiveness of screening remains uncertain.

231 We screened repo>Dube3a flies for approved compounds that c

232 Smartphone-based fundus imaging can meet DR screening requirements in an outreach setting; however,

233 Cell surface-based loss-of-function screens reveal that ATP7A, a copper-exporter upregulated

234 A previous genome-wide screen revealed that depletion of 14 RNA splicing factor

235 Chemical screening revealed that inhibition of MEK/ERK signaling

236 r 110 bee species and 89 flower species were screened, revealing that 42% of bee species (12.2% indiv

237 Analogies to imaging, newborn screening, routine testing panels, and antibiotic sensit

238 -resistant strain (RR) derived from the F(2) screen showed a high level of resistance to Vip3Aa39 pro

239 ia, Germany, a program of primary care-based screening showed an islet autoantibody prevalence of 0.3

240 nding protein 4 (RBP4) as model proteins and screened six different polar-aprotic and polar-protic so

241 ions focused on the yield of alternative HBV screening strategies and the accuracy of tools to identi

242 t phenotypic models, as well as the chemical screening strategies most often employed.

243 lysis units and hence, assessment of current screening strategies.

244 ing a mathematical simulation, we examined 3 screening strategies: Yearly, 6-monthly, and 3-monthly,

245 y of life after SAH influenced the preferred screening strategy.

246 ducted systematic reviews of the literature, screened studies, extracted data, and summarized finding

247 proof of concept, results showed that INSeq screens successfully identified genes encoding known rec

248 Many centers are currently screening surgical patients for COVID-19 using either ch

249 ity to ototoxin in a high-content phenotypic screening system.

250 A model including the screening test result had a C-statistic of 0.860, c-slop

251 as led to the development of pharmacogenetic screening tests, such as HLA-B*57:01 in abacavir therapy

252 udies (n = 15 785) evaluated the accuracy of screening tests; across individual studies and tests, se

253 viously reported an in vivo gain-of-function screen that identified ~30 genes with a functional role

254 Therefore, this study aims to screen the antioxidant activity by six methods and deter

255 To do this we screened the E90K GnRHR mutant vs. a library of 645,000

256 r chemical hazard assessment are designed to screen thousands of molecules across hundreds of biologi

257 cation of active compounds, while decreasing screening time and resources.

258 ers independently used Covidence software to screen titles and abstracts followed by full texts.

259 ting with a high-throughput in vitro primary screen to identify inhibitors, building in silico models

260 erformed a high-throughput whole-genome RNAi screen to identify novel inhibitors of ciliogenesis in n

261 tive approach for high throughput analytical screening to discard defective cocoa samples.

262 ed approach and performed antiviral activity screening to identify compounds 29 and 30 with EC(50) va

263 cerevisiae, which allow for high-throughput screening to patient-derived cell-lines that have a clos

264 ith the application of high-resolution omics screening to populations enrolled in large-scale observa

265 he predictive value of placental sonographic screening to predict early-onset FGR.

266 mated efficiency of population-based newborn screening to prevent ketoacidosis, and enables individua

267 We apply cell-free biochemical screens to assess the protospacer adjacent motif (PAM) a

268 mic tools that are commonly used for in vivo screens to illustrate their strengths and limitations.

269 e of iterative "perturb and observe" genetic screens to uncover regulatory mechanisms driving complex

270 d by polygenic risk scoring and phenome-wide screening, to identify genetic comorbidities.

271 sk as measured by the malnutrition universal screening tool (MUST), CT derived body composition as me

272 C(4) plant, and can potentially be used as a screening tool for WUE(plant) in sorghum.

273 Real-time PCR was used as a screening tool with great accuracy, while internal trans

274 itional Status Index (CONUT) are widely used screening tools, but their efficacy has not yet been com

275 graphy images of IPNs from the National Lung Screening Trial, internally validated, and externally te

276 nerating new developments in high-throughput screening used to identify functional lncRNAs.

277 he changes in gene expression and functional screening using an in vitro mouse oocyte development sys

278 Label-free high-throughput screening using mass spectrometry has the potential to p

279 This screen utilized the most extensive genome-wide ORF colle

280 therwise be impossible by using regular flat-screen visualization programs.

281 cancer death between continuing and stopping screening was -1.0 (95% CI, -2.3 to 0.1) death per 1000

282 early screening group who were mailed a FIT, screening was completed by 33.1%.

283 Then, an accurate screening was successfully conducted in C57BL/6 primary

284 Through an RNAi screen, we identified FBXO44 as an essential repressor o

285 Using a CRISPR-mediated knockout screen, we identify SLC35B2 and myosin-7B (MYO7B) as cri

286 Here, using genome-wide screening, we find that SAT1 selectively controls nicoti

287 Using RNA sequencing and drug screening, we find that treatment of FLT3 internal tande

288 ling in vivo ribosome profiling with genetic screening, we provide direct evidence that oncogene-indu

289 Using FACS-assisted shRNA screens, we identified the cell-surface adhesion recepto

290 vices Task Force (USPSTF) for annual CT lung screening were analysed for pulmonary nodules (PN) detec

291 Data from patients with MRSA nares screening were obtained from the VA Corporate Data Wareh

292 -old men and women (most common age of first screening), which were 0.44% and 0.41%, respectively.

293 family for a total of 114 F(2) families were screened with a diagnostic concentration of 3.0 mug/cm(2

294 opoiesis in newly diagnosed MM, which can be screened with moderate sensitivity using cost-effective

295 uited from the general population to undergo screening with an implantable loop recorder.

296 Purpose To determine if screening with DBT is associated with lower FN rates, de

297 Here, we performed global metabolite screening with metabolite set enrichment coupled with tr

298 Screening with protocol biopsy was favored over biomarke

299 We next report an MS1 automatized suspect screening workflow that allows for a rapid preannotation

300 eased utilization of SFE as a part of future screening workflows of microbial natural products.

301 in addition to the Status quo (SQ, 0.7-10.3% screened/year, stratified by age).