ライフサイエンスコーパス: screening of

1 A screening of 1,000 biologically active compounds reveal

2 ding to this pattern, a ligand-based virtual screening of 1 444 880 active compounds from Chinese her

3 The HT-BST may facilitate the rapid screening of 100000 chemicals reportedly manufactured in

4 Last, screening of 101 anti-cancer compounds identifies three

5 , 78.1 years; 74% women) were included after screening of 10650 titles and abstracts and 1210 full-te

6 to a mass spectrometer for the quantitative screening of 12 different regulated sulfonamides in hone

7 Here, we present a large scale screening of 13 NPs for the analysis of two dozen small

8 After initial screening of 15 orthologues, we identified Cas13a from L

9 The two sHRP fragments, engineered through screening of 17 cut sites in HRP followed by directed ev

10 Immunohistochemical screening of 201 patients (2011-2013) identified 68 with

11 Using the optimized method, screening of 25 wine samples was performed, and the pres

12 ells into haemogenic endothelium followed by screening of 26 candidate haematopoietic stem-cell-speci

13 Finally, virtual screening of 29332 metabolites predicted 146 competitive

14 EPA commissioned screening of 320 pesticides, herbicides, fungicides, and

15 Screening of 38 additional patients on ibrutinib without

16 A screening of 400 Saccharomyces cerevisiae selected strai

17 4-dione, was obtained from a high throughput screening of 40000 compounds against KGA.

18 Screening of 414 Culicoides individuals from 29 Palearct

19 Following siRNA screening of 47 upregulated proteins indicated that the

20 The virtual screening of 68,752 natural compounds via molecular dock

21 nts), who were identified on cross-sectional screening of 741 patients, were randomly assigned to rec

22 ere identified upon cross-sectional antibody screening of 741 recipients with stable graft function a

23 Functional screening of 879 human microRNAs reveals miR-371-3p as a

24 Screening of a 50000-member library of natural and synth

25 e a high throughput platform for nontargeted screening of a broad spectrum of DoA and their metabolit

26 Screening of a carefully selected library of 5,195 small

27 Using crystallographic data and the virtual screening of a chemical library, we identified a set of

28 Screening of a Chlamydomonas insertional mutant library

29 ovel Notch1-binding protein, N9, obtained by screening of a combinatorial library based on the ultra-

30 monstrate the usefulness of synthetic lethal screening of a conditionally BCL6-deficient Burkitt lymp

31 mine if the intervention was associated with screening of a demographically higher-risk population th

32 Phenotypic screening of a GBS transposon insertion library identifi

33 Screening of a glycan array demonstrated GalNAcbeta1-4(F

34 This intervention also resulted in screening of a higher proportion of men and an older pat

35 ed without cross-contamination, allowing the screening of a huge number of saturation conditions with

36 we report the high-throughput computational screening of a large experimental metal-organic framewor

37 In silico screening of a large library of lead-like compounds iden

38 upling constants allow for fast and reliable screening of a large number of reported halogenated natu

39 n small volumes and can thus be used for the screening of a large number of samples for high-throughp

40 Screening of a library of metal-binding pharmacophores (

41 Combined HTS (11000 compounds) and in-house screening of a limited number of quinolones (50 compound

42 Screening of a miRNA library by functional proteomics in

43 Screening of a panel of mouse tissues revealed that Clec

44 ing technology allowed for a high-throughput screening of a panel of polymer carriers toward efficien

45 report the design, synthesis, and biological screening of a series of acrylate derivatives as NLRP3 i

46 Initial screening of a series of over 50 newly characterized 2-a

47 s, we performed a cell-based high-throughput screening of a small-molecule library based on TLR3-medi

48 report the discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibit

49 remote surrogates for the physician's in the screening of acute abdominal pain.

50 e single cutoff (<11.5 or 12.5 cm) for field screening of acute malnutrition did not track along the

51 en raised towards providing more insights on screening of agri-food commodities to benefit consumers.

52 Phytochemical compound screening of all Fagioli di Sarconi beans performed by f

53 These results support routine screening of all HIV-infected women regardless of human

54 rgence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasibl

55 Screening of all publically available V. cholerae genome

56 In this study, screening of an in-house compound library revealed two s

57 cently disclosed the results of a phenotypic screening of an internal library, publishing a collectio

58 In an unbiased screening of an oncology drug library, we found that sor

59 Functional screening of an optimized 10-site library (1,536 variant

60 Although similar functional screening of an optimized 30-site library (2.15 x 10(9)

61 Here we performed sequencing-based screening of an shRNA library on a panel of cancer cells

62 robust variant of CP-MIMS amenable to rapid screening of analytes in complex samples.

63 Screening of animal IAVs to monitor their potential to c

64 efore, the development of biosensors for the screening of antibiotic residues has been increasing sin

65 al) and their potential applications for the screening of antibiotic residues in food are presented.

66 nd up-to-date findings on biosensors for the screening of antibiotic residues in food products of ani

67 microfluidics will enable higher throughput screening of antibiotics.

68 Screening of antioxidant potential of dichloromethane an

69 means of its attenuation and new targets for screening of antiviral drugs.

70 s study, small interfering RNA (siRNA)-based screening of approximately 4800 druggable genes in 3-dim

71 After screening of article titles and abstracts, studies were

72 preliminary findings of a tuberculosis (TB) screening of asylum seekers performed in a reception cen

73 on tree model that compared the test option (screening of asymptomatic individuals, treatment, and fo

74 led trials demonstrating cost effectiveness, screening of asymptomatic men cannot be recommended.

75 adiation risk ratios well in excess of 1 for screening of asymptomatic women with dense breasts who a

76 METHODS AND Familial screening of at-risk relatives identified mutations in 1

77 ive rodent (Melomys burtoni) after extensive screening of Australian wildlife.

78 ized structural templates to perform virtual screening of available compound libraries for new KOR li

79 logous filoviruses, allowing high-throughput screening of B cell lines to isolate MAbs of any filovir

80 Screening of baby boomers remains low.

81 Screening of bacterial colonies to identify new biocatal

82 Here, we show that the screening of band-edge charge carriers by rotation of or

83 reated a platform for the massively parallel screening of barcoded combinatorial gene perturbations i

84 Our screening of bat samples collected in Kenya from 2007 to

85 r concentrations, it will allow for the fast screening of biomolecule binding in low volume multiwell

86 -throughput format and carried out a primary screening of both collections, followed by construction

87 BB) models are crucial tools to enable rapid screening of brain-penetrating drugs.

88 In patients undergoing TAVR, screening of CAD with invasive coronary angiography and

89 use of large-scale genomic and drug response screening of cancer cell lines depends crucially on the

90 l-drug carrier interaction studies and rapid screening of cancer drug therapeutics/carriers.

91 ectroscopy has the potential to enable rapid screening of cancers and impact next-generation cancer d

92 Screening of candidate kinases reveals a specific, dosag

93 res was developed for rapid and simultaneous screening of cardiac Troponin-I (cTnI) and cardiac-Tropo

94 In the largest screening of CD in the United States to date outside of

95 High throughput metabolite screening of cerebrospinal fluid (CSF) samples from a ca

96 e results suggest that rabies-based unbiased screening of changes in input populations can identify p

97 e level of their DRBDs using high-throughput screening of chemical libraries by homogeneous time-reso

98 The high throughput screening of chemicals for interaction with intracellula

99 eceptor signaling and its application to the screening of chemicals for interaction with targeted rec

100 Screening of childhood maltreatment history in non-suici

101 sting and counseling serves as the basis for screening of children at elevated risk for development o

102 Screening of children for multifactorial dyslipidemia ha

103 Routine screening of children with suspected ZIKV infection for

104 es the density functional theory (DFT) based screening of chiral ligands for transition-metal-catalyz

105 olecular identifiers (UMIs) that allowed for screening of clonally expanded, individually tagged cell

106 Here, through pooled shRNA screening of colorectal cancer cells, we identified trip

107 expressing large membrane protein complexes, screening of complex I homologues is limited to large ma

108 gy for the mechanistic study and therapeutic screening of complex ocular pathologies.

109 g new options for region-specific phenotypic screening of complex physiological phenomena and mitocho

110 ore model which could be used in the virtual screening of compound collections and potentially identi

111 A pharmacophore and docking-based virtual screening of compound libraries led to the selection of

112 sis and are not suitable for high-throughput screening of compound libraries.

113 phores that are suitable for high-throughput screening of compound libraries.

114 rization for microplate format, amenable for screening of compounds or interventions that alter lipid

115 Screening of compounds that bound the modeled PfHDP stru

116 The tracing and screening of contacts of known patients with leprosy pro

117 A sensitive quantitative screening of coumarin in 43 commercially available cinna

118 CSF3R and suggest the necessity for broader screening of CSF3R extracellular domain in leukemia pati

119 Using a PCR-based screening of cytokines known to play a role in the biolo

120 pproach was suitable for comprehensive urine screening of different drug classes and might be a promi

121 ts and molecular identity, and allow forward screening of distinct functional neural pathways embedde

122 pluripotent stem cells would enable in vitro screening of drug candidates for the treatment of hearin

123 Here, we show that phenotypic screening of drug libraries in zebrafish scn1 mutants ra

124 e-clinical cardiotoxicity and pro-arrhythmia screening of drugs in development.

125 contributing to HHV-6A/B integration and the screening of drugs influencing viral gene expression, as

126 Primary screening of drugs of abuse (DoA) currently relies on im

127 inic acid lactone (4-FQAL)) was used for the screening of enzymes before treatment of the coffee extr

128 PCR screening of ETEC isolates revealed that 8.6% (n = 13) o

129 Screening of FA chain length indicated that C8-C12 FA (t

130 understanding FMF and enables immunological screening of FMF mutations.

131 uide rational structure-based design and NMR screening of focused and diverse fragment libraries.

132 p the possibility to perform high-throughput screening of G-quadruplex ligands for the development of

133 ons, and isothermal titration calorimetry, a screening of ganglioside analogues together with a detai

134 agnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality

135 ystem is also being used for high-throughput screening of genes, gene regulatory regions, and long no

136 This test opens perspectives for the screening of GLUT1-DS in children and adults with cognit

137 rray for high-throughput, fluorescence-based screening of glycan-binding proteins.

138 Screening of >70000 compounds from different libraries i

139 By comprehensive screening of guanine nucleotide exchange factors (GEFs)

140 s (IDE-arrays) towards ultrafast, label-free screening of heart type-FABP and MPO.

141 spite prompt diagnosis of ID anemia (IDA) by screening of hemoglobin concentrations followed by iron

142 uggest that it should be included in routine screening of HIV-infected individuals for sexually trans

143 OTG), isolated from a large-scale expression screening of human cDNAs in zebrafish embryos.

144 in important areas, including the phenotypic screening of human genes in transgenic mice by study of

145 of six intervention strategies that involved screening of humans and pigs, antiparasitic treatment, p

146 Here, we describe the synthesis and screening of HyCoSuL for human caspases and legumain.

147 The screening of Icelandic patients clinically diagnosed wit

148 Targeted screening of individual loci identified three new unfixe

149 our identification warrants inclusion in the screening of individuals at risk for developing AD.

150 Quantitative screening of influenza A (H7N9) virus without DNA amplif

151 ing of the brain is essential for diagnostic screening of intracranial injuries in need of neurosurgi

152 h the graphene polarization charge and ionic screening of ions adsorbed on the graphene as well as ch

153 ella melitensis (B. melitensis) based on the screening of its complementary DNA target by using two d

154 Exosome based screening of key HPVOPC associated molecules could be be

155 ht the PM as a high-fidelity target for drug screening of Kv channels.

156 he aim of this web server is to automate the screening of large amounts of sequence data and to focus

157 -of-the-art methods used for high-throughput screening of large datasets to identify materials that e

158 The presented workflow allows the screening of large macrocyclic peptides with diverse mod

159 predicting material properties enables rapid screening of large numbers of materials and facilitates

160 This system can be used in rapid screening of large patient populations especially in the

161 In this study, we conducted a detailed screening of leaf growth responses to mild drought in a

162 This strategy provides a platform for the screening of libraries of modified biomolecules.

163 To date, no systematic screening of lncRNAs under abiotic stress and their regu

164 Fragment-based drug design exploits initial screening of low molecular weight compounds and their co

165 Screening of lung function in school age children may id

166 le rounds of affinity maturation through the screening of macrocyclic peptide libraries produced in E

167 academics), or used for the fully automated screening of many different interactions (for example in

168 Screening of many solute-solvent combinations shows that

169 eful in the rapid, multiplexed detection and screening of membrane-associated biological targets.

170 d the LAP was an effective indicator for the screening of MetS.

171 fluorescence, allowing ultrahigh-throughput screening of millions of variants.

172 ort a method called PRISM that allows pooled screening of mixtures of cancer cell lines by labeling e

173 Target-blind activity-based screening of molecular libraries is often used to develo

174 with therapeutic benefit, to the systematic screening of molecular libraries on whole organisms or c

175 latform for the development and pre-clinical screening of molecular therapeutics against VS.

176 vels in living cells and for high-throughput screening of molecules that modulate GTP levels.

177 ability of the developed zebrafish model for screening of molecules with therapeutic value against th

178 and recognize simple ligands identically, a screening of more than 300 bacterial polysaccharides rev

179 zooarchaeology by mass spectrometry (ZooMS) screening of morphologically uninformative bone specimen

180 The ranking and screening of MOS sensors, specific for volatile organic

181 rapid, reliable, reproducible and economical screening of most of these common alleles.

182 the literature, we do not support universal screening of mothers and the routine use of cytomegalovi

183 equipment, and thus are not well suited for screening of multiple candidate treatments, even in anim

184 say that enables the relatively fast kinetic screening of multiple compounds.

185 tumor initiating cells (TICs) often requires screening of multiple surface markers, sometimes with op

186 Here, we deployed genome-scale CRISPR-Cas9 screening of MYCN-amplified neuroblastoma and found a pr

187 noassays and was applied in this work to the screening of mycotoxins.

188 Screening of N-methylated quinolinium, isoquinolinium, p

189 electrodes showed evidence of monitoring and screening of NA released from PC12 cells under K(+) ion-

190 ghput screening method will facilitate rapid screening of nanomaterial toxicity and thus inform the r

191 mall molecules have been identified from the screening of natural products (NPs) produced by environm

192 ovides a unique platform for high throughput screening of natural products for specific glycosylation

193 Screening of neonates with elevated 17-hydroxyprogestero

194 ouse models for both mechanistic studies and screening of new cell based therapies.

195 Screening of newborn blood samples revealed a significan

196 cterial and host factors and high throughput screening of novel therapeutics becoming the mainstay of

197 By automation-assisted screening of numerous sediment samples, we detected Nean

198 proves to be very sensitive and allows rapid screening of organic molecules in dilute solutions for p

199 Following genetic screening of Parkinson's disease patients and healthy co

200 The screening of pathogenic mutations can be very challengin

201 oduced at trivial cost as a tool for initial screening of pathogens.

202 Chemical screening of patient-derived glioma cells (PDCs) shows t

203 ed QALYs (0.002-0.004), and only quadrennial screening of patients aged 55 to 69 years was potentiall

204 Genetic screening of patients diagnosed with macular dystrophy d

205 ty, suggesting the feasibility of widespread screening of patients preoperatively to identify frailty

206 alysis-Colon microsimulation model, we found screening of patients with cystic fibrosis for CRC to be

207 ion Screening Analysis-Colon model, we found screening of patients with cystic fibrosis for CRC to be

208 To maximize clinical benefits of genetic screening of patients with nephrotic syndrome (NS) to di

209 rt system to automate the identification and screening of pediatric patients at high risk for T2D can

210 Finally, Tf assay-based screening of peptides derived from two other large clost

211 pies targeted to exon 1, and for preclinical screening of personalized HTT lowering therapies in HD p

212 included using an aggregated mAb as bait for screening of phage display peptide library and identifyi

213 Next, we performed myeloma cell surface screenings of phage-displayed patient transplant immunom

214 to facilitate high-throughput toxicological screening of pharmaceutical agents and treatment regimen

215 ro myelination assays, disease modeling, and screening of pharmacological compounds potentially promo

216 he life-threatening Lemierre's syndrome, and screening of pharyngeal samples may be warranted for its

217 f IDRs in CBP, we performed yeast-two-hybrid screenings of placenta and lung cancer cDNA libraries, w

218 tive economical and eco-friendly approach is screening of plant extract for natural antioxidants.

219 tability, particularly suitable for the fast screening of plant oils.

220 In a cell-based screening of pleuromutilin derivatives against a drug se

221 ltrasound are noninferior to chest x-ray for screening of pneumothorax and accurate central venous ca

222 LRET nanoparticle assay can be exploited for screening of potential beta-amyloid aggregation inhibito

223 mer method is convenient for high-throughput screening of potential GLUT5 inhibitors and activators,

224 ns, identification of putative drug targets, screening of potential interventions, and propagation of

225 These models will allow for rapid screening of potential therapeutics to alleviate Tau agg

226 We build the case for universal screening of private well water quality around arsenic,

227 Universal screening of private well water will identify the danger

228 address this, we performed yeast two-hybrid screening of PRMT7 and identified argininosuccinate synt

229 turally sorted nanotubes and high-throughput screening of properties that are controlled by the wrapp

230 e used an inhibitory approach to perform the screening of prostanoid receptors as potential candidate

231 is of the fluorescence-labeled HyCoSuL, (ii) screening of protease P4-P2 preferences, and (iii) synth

232 ne of the analytical approaches allowing the screening of protein biomarkers in serum.

233 well suited for multiplexed single-molecule screening of protein libraries, and should enable the in

234 -doped carbon dots (N-CDs) electrode for the screening of purine metabolic disorder was described in

235 reening (CERES) for improved high-throughput screening of regulatory element activity in the native g

236 Broad screening of relatives and systematic tests, including p

237 ardiac death with negative autopsy, clinical screening of relatives identifies a high proportion of i

238 amilial hypercholesterolemia and for cascade screening of relatives, genetic testing is likely to exp

239 nd (iii) its suitability for high-throughput screening of (RGD-)peptide libraries.

240 ntal tools for high-throughput and multiplex screening of samples or cellular functions.

241 On unbiased screening of serum cytokines and other markers in a dive

242 thermodynamic profiling, XDM-CBP was used in screenings of several cancer cell lines in vitro to stud

243 lysts for this reaction was initiated by the screening of simple binary and ternary admixtures of Pd/

244 Docking tools are largely used for virtual screening of small drug-like molecules, but their accura

245 By in vitro screening of small molecule mimics of naturally occurrin

246 chemistry of RBR E3s and for high-throughput screening of small-molecule activators or inhibitors of

247 This can be utilized for the screening of small-molecule inhibitors of such protein-p

248 Advances in the synthesis and screening of small-molecule libraries have accelerated t

249 ucture, we performed structure-based virtual screening of small-molecule libraries to seek inhibitors

250 Screening of somatosensory functions in the (post-) acut

251 ith the potential for high-throughput ligand screening of some of the most challenging drug targets i

252 dology holds great promise for combinatorial screening of stem-cell and multicellular-spheroid cultur

253 The method was used for screening of synthetic Middle East respiratory syndrome

254 rin alphavbeta3 is based on two concepts: a) screening of systematically designed libraries with spat

255 In the past decade, systematic screening of T-ALL genomes by high-resolution copy-numbe

256 Polymerase chain reaction screening of T. cruzi-infected pregnant women is a usefu

257 e SERS-PLFS has great potential in assisting screening of TBI patients in the point-of-care setting.

258 Third, the arrays enabled screening of ten media compositions for inducing differe

259 Functional screening of the 'core' interactome consisting of common

260 265 papers were chosen for closer screening of the abstracts and 93 for full text evaluati

261 F materials toward rational design and rapid screening of the best electrocatalysts for a specific ap

262 les across the membrane surface allows rapid screening of the biofilm community.

263 We performed a mutational screening of the CACNA1A gene, including the promoter an

264 assessments; which consisted of first phase screening of the children for neurodevelopmental delays

265 Subsequent Mtb screening of the complete in-house quinolone library (35

266 l dichalcogenides (TMDs), reduced dielectric screening of the Coulomb interaction leads to strongly c

267 be generally applicable for high-throughput screening of the efficacy of cell-penetrating peptides.

268 60%, resulting in high frequency dielectric screening of the film by water and dissociation of Na(+)

269 into TiO2 is dominated by long-range Coulomb screening of the final states of the excitonic transitio

270 Subsequent screening of the HBV(+) cohort revealed that a remarkabl

271 High-throughput screening of the host transcriptional response to variou

272 omic evaluation of systematic Chagas disease screening of the Latin American population attending pri

273 LAS-like phenotype, and suggests the genetic screening of the MRM2 gene in patients with a m.3243 A >

274 Through virtual screening of the National Cancer Institute Diversity Set

275 Prospective screening of the participants is under way.

276 ite the uncertainty, is beneficial for broad screening of the population at risk from elevated arseni

277 Screening of the Protein Data Bank led to identification

278 In contrast, risk-based selection screening of the same number of ever-smokers (9.0 millio

279 whole-transcriptome analyses and phenotypic screenings of the marine bacterium Phaeobacter inhibens

280 holangiopathies, in disease modeling and for screening of therapeutic compounds.

281 nts demonstrates the utility of model-driven screening of therapeutic targets.

282 Biomarkers aid diagnosis, allow inexpensive screening of therapies, and guide selection of patient-s

283 Screening of these T cell hybridomas against IKEPLUS and

284 e paramagnetic interlayer V ions and a Kondo screening of these V moments.

285 Through proteomic screening of these variants, we identified ZMYM3 (zinc f

286 y metabolites and facilitates the untargeted screening of tracer derivatives from concurrently metabo

287 odels and is suitable for precision medicine screening of tumour explants, particularly in hard-to-tr

288 as a physiologically relevant model for the screening of variants of unknown function.

289 fundamental studies, and for high-throughput screening of various biomolecules for stem cell differen

290 ounds by these techniques is followed by the screening of various derivatives of these molecules.

291 results produced could guide a more reliable screening of vestibular system deterioration.

292 elding multiplicative diagnostic markers, co-screening of which can give high predictive value.

293 We identified 811 abstracts for screening, of which 254 articles underwent full-text rev

294 04 eligible individuals were invited for FIT screening, of whom 18,716 (69%) participated at least on

295 U.S. mammographic screening population, with screening of women ages 40-49 years (or premenopausal wo

296 Screening of women ages 40-49 years (or premenopausal wo

297 let microfluidics to achieve high throughput screening of yeast strains engineered for enhanced tyros

298 re an obstacle to electrocardiographic (ECG) screening of young athletes for cardiac disease.

299 the American Diabetes Association recommends screening of youths with type 2 diabetes at the time of

300 Here, through a functional screening of ZBTB genes, we identify that BCL6 is requir