ライフサイエンスコーパス: sculpt

1 ections to the monolayer from which they are sculpted.

2 tifying cues by which neural architecture is sculpted.

3 ntrolled separations of 0.9 nm primed for re-sculpting.

4 remodeling and BAR domain-dependent membrane sculpting.

5 as a molecular canvas for three-dimensional sculpting.

6 ntum information processing and wavefunction sculpting.

7 he basement membrane's active role in tissue sculpting.

8 ns, we show that alpha-tubulin isotype TBA-6 sculpts 18 A- and B-tubule singlets from nine ciliary A-

9 l types organize themselves into a carefully sculpted, 3D labyrinth of vessels that regulate blood fl

10 4 (Bmp2/4), and Six3-dependent pathways then sculpt a complex ciliary band territory that is defined

11 generation during development is required to sculpt a functional nervous system and is also a hallmar

12 he TRAPPI core indicates that these subunits sculpt a second RAB binding site on TRAPP apparently ind

13 proteins (EAPs) generate curvature needed to sculpt a sufficiently narrow neck to trigger Dyn2 assemb

14 s to rationally devise schemes for precisely sculpting a great variety of elementary shapes by diffus

15 process underlies post-learning information sculpting, a novel and essential consolidation step in t

16 These sculpting actions of D1R stimulation are mediated in mon

17 standing the dual host-protective and tumour sculpting actions of immunity on cancer and establishing

18 arkedly depressing and were more powerful to sculpt activity of postsynaptic neurons.

19 he main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mi

20 modulin in regulating the intrinsic membrane-sculpting activity of endocytic N-BAR domains.

21 ned with structural results reveal that ATLs sculpt alkylated DNA to create a genetic and structural

22 e examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosen

23 uit mapping and show that sensory experience sculpts an intrinsically developing template network, wh

24 ironmental cues and inflammatory stimuli can sculpt and agitate homeostasis, provides a frame of refe

25 otion detection, while most neurons serve to sculpt and enhance these feedforward pathways.

26 ted, homeostatic actions of microglia, which sculpt and refine neuronal circuitry.

27 om studying excitatory maps is that maps are sculpted and refined throughout development and/or throu

28 20 in palate mesenchyme drives palatal shelf sculpting and extension.

29 nal apoptosis, suggesting a role in cortical sculpting and plasticity.

30 synapse elimination plays a critical role in sculpting and refining neural connectivity throughout th

31 d etching of polymer films, focused ion-beam sculpting, and electron-beam lithography and tuning of s

32 ector genes modify developmental pathways to sculpt animal body parts.

33 that the importance of rigidified, precisely sculpted architectures increases with increasing pi acid

34 hort-duration signals from extrinsic cues to sculpt axon arbors within the CNS.

35 eld of drug discovery, with the potential to sculpt biological response to favor therapeutically bene

36 Our results indicate that dopamine sculpts bipolar cell performance in a type-dependent man

37 ming cues, but the key molecular events that sculpt both the phasing and magnitude of responsiveness

38 Thus, surround inhibition is sculpted both in time and space and may be an important

39 ignalling to intercellular adhesion and that sculpts both tubular and planar epithelial shape.

40 Sex and reproduction sculpt brain and behavior throughout life and evolution.

41 phur-doped pnictogen chalcogenide nanoplates sculpted by a scalable microwave-stimulated wet-chemical

42 surroundings, and reveals a complex surface sculpted by a succession of ice-sheet configurations sub

43 w the circuitry of the developing PFC can be sculpted by a wide range of pre- and postnatal factors.

44 iling view that many developing circuits are sculpted by activity-dependent competition among converg

45 vior of the modern domesticated dog has been sculpted by artificial selection for at least 14,000 yea

46 ked to CD4 T cell functionality and could be sculpted by blockade of specific inhibitory receptors.

47 tions (i.e., viral mutant swarms), which are sculpted by different evolutionary mechanisms, such as m

48 omprise many oscillator loops that have been sculpted by evolution over two trillion day-night cycles

49 tructure and function of which may have been sculpted by evolutionary selection to provide a highly t

50 olecules with conformations and interactions sculpted by force seem more likely than singular mechano

51 anet systems that are not flat and have been sculpted by Kozai-Lidov oscillations.

52 ks represents optimized solutions, precisely sculpted by natural selection; their common features are

53 ling, we demonstrate that the septin ring is sculpted by polarized exocytosis, which creates a hole i

54 e molecular repertoire of mature neurons was sculpted by SOC-related up- and down-regulation of volta

55 ganization suggests that their morphology is sculpted by specific cell to cell interactions with neur

56 ral connections in the auditory brainstem is sculpted by spontaneous and stimulus-induced neural acti

57 composition of the postsynaptic membrane is sculpted by synaptic activity.

58 cess initiates in the ER, where vesicles are sculpted by the essential COPII coat.

59 These inclusions are often sculpted by the plant into shapes required to support fu

60 The primary antigen receptor repertoire is sculpted by the process of V(D)J recombination, which mu

61 However, how the motor system is sculpted by trial-by-trial content of current sensory in

62 elix insertion, plays a key role in membrane sculpting by amphiphysin N-BAR domains.

63 th a structure consistent with gravitational sculpting by an orbiting planet.

64 on its differential additive and subtractive sculpting by two isoforms of a single auxiliary subunit.

65 res and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), re

66 of chow, fat and sucrose, insulin appears to sculpt calorie-associated desires toward foods high in f

67 select products based on safety, lifting or sculpting capability and rheological properties, such as

68 and-binding site that include the ability to sculpt cellular signaling and to respond differently in

69 r of Zn(2+) signaling and may participate in sculpting cellular response to an increase in intracellu

70 light on the stage-dependent mechanisms that sculpt chamber-specific cardiomyocytes and, therefore, h

71 competition between diffusive processes that sculpt convex hillslopes and advective processes that ca

72 tem, sensory experience is widely thought to sculpt cortical circuits during a precise critical perio

73 The basal ganglia thalamic output sculpts cortical activity by interacting with signals fr

74 isms exist that may interact to persistently sculpt corticostriatal circuits, potentially influencing

75 BAR domains are proteins that sense and sculpt curved membranes in cells, furnishing a relativel

76 show that synNotch receptors can be used to sculpt custom response programs in primary T cells: they

77 type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical pe

78 Spontaneous network activity is believed to sculpt developing neural circuits.

79 morphologies, and how they interact with and sculpt developing neuronal circuits.

80 Synaptic rearrangements are shown to help sculpt developing retinal circuits, although the mechani

81 ing for microglia in the healthy brain, from sculpting developing neuronal circuits to guiding learni

82 O functions specifically in leaves, where it sculpts developing leaflets by repressing growth at thei

83 ving the inverse problem of designing a flow sculpting device for a desired fluid flow shape remains

84 ontribute to long-term plasticity capable of sculpting direct and indirect pathway output.

85 sites, mediated by N-cadherin, coordinate to sculpt discrete sympathetic ganglia.

86 ll-to-cell differences in the rules may help sculpt distinct physiological properties.

87 anner in which distinct circuits interact to sculpt diverse rhythms remains unresolved.

88 FEN1 sculpts DNA with diffusion-limited kinetics to test DNA

89 ves neuronal activity, and neuronal activity sculpts domain formation.

90 mers of a biperylene derivative by precisely sculpted electromagnetic fields.

91 ations are thought to play a central role in sculpting embryonic tissues, maintaining organ architect

92 In contrast, microRNAs (miRNAs) sculpt endogenous mRNA expression [4].

93 site modification may be an effective way of sculpting epitope presentation in Env-based vaccines.

94 t 2AG in the VTA regulates reward seeking by sculpting ethologically relevant patterns of dopamine re

95 Numerous surveillance pathways sculpt eukaryotic transcriptomes by degrading unneeded,

96 In addition to sculpting eukaryotic transcripts by removing introns, pr

97 fer, a process considered to be a strong and sculpting evolutionary force in microbial environments.

98 ally, generating a functional diversity that sculpts excitatory transmission and behavioral function.

99 However, here we report that the membrane-sculpting F-BAR domain-containing Fer/Cip4 homology doma

100 facial rhytides, restore facial volume, and sculpt facial contours, thereby achieving an aesthetical

101 rrays with ~30 A periodicity into a membrane-sculpting filament.

102 During development, the canals are sculpted from pouches that grow out of a simple ball of

103 During development, the canals are sculpted from pouches that protrude from the otic vesicl

104 We conclude that rule learning sculpts frontal cortex interconnectivity and adjusts a t

105 insight into how early environmental events sculpt functional network architecture across developmen

106 ince each hemagglutinin mutation potentially sculpts future mutation space, drift can follow many sto

107 new insights into how DNA polymerase errors sculpt genetic variation and drive evolution.

108 e should increase through time, as selection sculpts genetic variation.

109 ular pathways through which our life stories sculpt genomic function to contribute to complex behavio

110 2 transforms flat Snf7 spirals into membrane-sculpting helices.

111 c cells could be improved if we could custom sculpt immune cell responses.

112 red landscape of the prokaryotic ribosome is sculpted in this way.

113 regions implement a set of learning rules to sculpt information processing in a given neural circuit?

114 We show here that organs can be sculpted instead by patterning anisotropic resistance wi

115 mmature pattern of connectivity that is then sculpted into the adult pattern via pruning.

116 llic and dielectric nanostructures precisely sculpted into two-dimensional (2D) and 3D nanoarchitectu

117 d apical dendrites that results in a gradual sculpting into a stellate morphology.

118 onceptually appealing mechanism for membrane sculpting is really overhyped.

119 ay be the ultimate force through which Pitx2 sculpts L-R organs.

120 Continental ice sheets typically sculpt landscapes via erosion; under certain conditions,

121 Fluid-sheared granular transport sculpts landscapes and undermines infrastructure, yet pr

122 tivities may both direct leaf initiation and sculpt leaf form.

123 y passively adsorb to membranes but actively sculpt lipid bilayers, which would result in highly curv

124 s analogous to topological quantum states to sculpt localized buckling regions in the interior of per

125 ply seen as a cargo-recognition and membrane-sculpting machine viewable from three distinct perspecti

126 The way nature evolves and sculpts materials using proteins inspires new approaches

127 on, is an important step in elucidating this sculpting mechanism.

128 Numerous proteins act in concert to sculpt membrane compartments for cell signaling and meta

129 he assembly of COPI into a cage-like lattice sculpts membrane vesicles that transport cargo from the

130 nsing, bending, and stabilizing curvature to sculpt membranes with speed.

131 and PRRs emerges as a mechanism that locally sculpts microbial assemblages in plant populations.

132 Here we introduce ion beam-sculpted microcantilevers that enable precise force-feed

133 irected signal bias offers opportunities for sculpting molecular events, with the promise of better,

134 Apoptosis is an important mechanism for sculpting morphology.

135 ebrates, Phr1 functions cell-autonomously to sculpt motor nerve terminals.

136 therapies that enhance neural plasticity and sculpt motor recovery.

137 ergetic ions, often gallium (Ga(+)), FIB can sculpt nanostructures via localised sputtering.

138 itory interneurons that gate signal flow and sculpt network dynamics.

139 optimal stimulation of dopamine D1 receptors sculpts network inputs to refine mental representation.

140 Pruning is important for sculpting neural circuits, as it removes excessive or in

141 ding to the list of mechanisms available for sculpting neural circuits.

142 present results indicate that the eCB system sculpts neural activity patterns that accompany PR perfo

143 Early visual experience sculpts neural mechanisms that regulate the balance of i

144 ss functional connections between neurons to sculpt neuronal circuits during development and througho

145 onal pruning and neuronal cell death help to sculpt neuronal connections during development, but thei

146 Voltage-gated potassium (Kv) channels sculpt neuronal excitability and play important developm

147 ranscription programs, and synaptic activity sculpt neuronal form.

148 elopment, experience plays a crucial role in sculpting neuronal connections.

149 ubthreshold sodium currents are important in sculpting neuronal discharge and have been implicated in

150 ctions in retina, but play a primary role in sculpting neuronal populations to appropriate sizes or p

151 rs and scaled additive noise can interact to sculpt noise-induced stimulus encoding uncertainty to ma

152 e during a sensitive period of embryogenesis sculpts not only the patterns of expression of genes inv

153 ized M1 to bypass spinal cord mechanisms and sculpt novel patterns of motor output that are essential

154 This observation makes it possible to sculpt nucleation pathways by tuning the distribution of

155 ylate cyclases operate in close proximity to sculpt O2 responses.

156 gens drives the immunological destruction or sculpting of a developing cancer.

157 expression by C1q may also contribute to the sculpting of an immune response to the ingested "self-Ag

158 ons in the brain is reflected in the dynamic sculpting of axonal arbors that takes place as connectio

159 ell established that BDNF contributes to the sculpting of dendrite structure and modulation of synaps

160 s that are permissive for activity-dependent sculpting of excitatory synapses via the mechanism of NM

161 lts support a potentially general concept of sculpting of glycosylases to their targets, allowing the

162 eural crest cell (NCC) invasion is a complex sculpting of individual cells into organized migratory s

163 vation of JAGGED, a key gene involved in the sculpting of lateral organs in several model species, we

164 omputer-generated holography enables precise sculpting of light and could in principle enable simulta

165 The sculpting of membranes into dynamic, curved shapes is ce

166 Glia also participate in the fine sculpting of neuronal connections by pruning excess axon

167 glial cell-dependent pathway regulating the sculpting of neuronal connectivity and synaptic circuitr

168 ork identifies key steps in the dimorphic re-sculpting of the anal depressor that are regulated by ge

169 We propose that developmental sculpting of the arcuate fasciculus determines acquisiti

170 We conclude that the ubiquitin-dependent sculpting of the chromosomal distribution of an antisile

171 framework to quantify and guide the dynamic sculpting of the curved structures that often arise in a

172 piny stellate neurons emerge by differential sculpting of the dendritic arborizations of an initial p

173 e patterns give additional insights into the sculpting of the endomembrane system.

174 ir shape and behavior to promote bending and sculpting of the epithelial sheet is not well understood

175 burst patterns during sleep represent active sculpting of the RA network, supporting auditory feedbac

176 Tissue morphogenesis involves both the sculpting of tissue shape and the positioning of tissues

177 hment of a branch from suitable vegetation; "sculpting" of a terminal hook from the nodal joint; and

178 e for shaping microfluid flow, known as flow sculpting, offers an unprecedented level of passive flui

179 aded inputs, and how learning and experience sculpt olfactory categorical perception.

180 nd post-mitotic cell expansion that together sculpt organ form.

181 ar matrix (ECM) regulates cell migration and sculpts organ shape.

182 Sculpting organism shape requires that cells produce for

183 e represents a privileged rigid template for sculpting other carbocyclic nucleosides to meet the dema

184 ated cells early in development and then (2) sculpting, patterning, and restructuring tissues during

185 rast, stronger higher-level predictions that sculpt perception into conformity with beliefs might con

186 Membrane sculpting performed by BAR domains collectively is obser

187 e uncovered novel roles for KNOX proteins in sculpting plant form and its diversity.

188 as a smoothing process, we find that erosion sculpts pointed and cornerlike features that persist as

189 ever, how these molecules are coordinated to sculpt postsynaptic structures is less well understood.

190 ts a versatile set of tools that are used to sculpt pRb in precise, but very different, ways.

191 t to explain how GABAergic neurotransmission sculpts principal cell activity in a relevant fashion.

192 that mediate topologically similar membrane-sculpting processes, including cytokinesis, retroviral e

193 of tissue surface tension drives the somite sculpting processes.

194 id phosphatase, actin assembly, and membrane-sculpting proteins leads to proper membrane shaping, tub

195 ns correlates with translocation of membrane-sculpting proteins.

196 ntroduce two modifications to the excitation sculpting pulse sequence whereby the excitation solvent

197 We also saw that patterned retinal input can sculpt recurrent activity according to a spike timing-de

198 These findings expand the membrane-sculpting repertoire of dynamin to include the regulatio

199 Organ sculpting requires directed physical force generation.

200 concert with correlated retinal activity to sculpt retinogeniculate projections.

201 nt, in addition to its important function in sculpting RNA conformation, plays an underappreciated ro

202 a simple, evolutionarily labile solution for sculpting sensory bandwidth to maximize the detection of

203 rcinogens and UV exposure, respectively, may sculpt specific mutation landscapes.

204 mechanical antagonists, and thus can act to 'sculpt' specific movement patterns out of a background o

205 ound experience can activate and potentially sculpt subplate circuits before permanent thalamocortica

206 for applications where wrinkles are used to sculpt surface topography, to measure properties of the

207 lised for waves confined to an appropriately sculpted surface.

208 c (3)He surface exposure dating of fluvially sculpted surfaces to determine the impact of extreme flo

209 neuronal populations and can differentially sculpt synaptic transmission and plasticity.

210 microenvironment and play essential roles in sculpting synaptic connections during brain development.

211 ntaneous action potentials, thus potentially sculpting synaptic connections in an activity-dependent

212 orce for Ca(2+) entry are powerful levers in sculpting synaptic efficacy.

213 Fragile X mental retardation protein (FMRP) sculpts synaptic refinement in an activity sensor mechan

214 plex shows how variable BRCT insertion loops sculpt tandem-BRCT phosphoprotein-binding pockets to fac

215 ping intracortical circuitry and thereby can sculpt thalamocortical connections.

216 Here we present a method based on light sculpting that enables unbiased single- and dual-plane h

217 Thus Hof1 tunes formins to sculpt the actin cable network.

218 ent a mechanism through which experience can sculpt the activation patterns within a neural circuit.

219 ignals received in the periphery promote and sculpt the adaptive immune response.

220 and synapse-specific form of plasticity may sculpt the balance of activity in basal ganglia circuits

221 Experiences during the critical period sculpt the circuitry within the neocortex, leading to ch

222 e of capabilities, we present sequences that sculpt the cross-sectional shape of a stream into comple

223 ive cell-cell and cell-matrix adhesions that sculpt the emerging tissue architecture are guided by dy

224 riation, identified some of the factors that sculpt the epigenome, and determined its functional rela

225 secreted and membrane-associated targets to sculpt the extracellular environment and modulate interc

226 ystemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets.

227 speculate that herpesvirus latency may also sculpt the immune response to self and environmental ant

228 l crest cell migration and colonization that sculpt the incipient ganglion into a postmitotic neurona

229 quired, leading to the proposal that FCHo1/2 sculpt the initial bud site and recruit the clathrin mac

230 versatile extracellular scaffolds that both sculpt the landscape of extracellular cues and modulate

231 We show how TARPs sculpt the ligand-binding domain gating ring, enhancing

232 axons, but many branches are later pruned to sculpt the mature pattern of connections.

233 tural insights into the way BAR proteins may sculpt the membrane as a high-order cooperative assembly

234 order assembly can define how these proteins sculpt the membrane.

235 rides any direct nutrient sensing in ISCs to sculpt the observed response to CR.

236 of a uniform material in such a manner as to sculpt the paths that rays of light follow as they trans

237 from the available microbial communities to sculpt the root microbiome.

238 integrates with other signaling pathways to sculpt the SSCs and their sensory patches is unknown.

239 Cytoskeletal proteins are known to sculpt the structural architecture of cells.

240 brain, indicating that microglia continue to sculpt the synaptic landscape in the postdevelopmental b

241 cuss recent evidence that GABAergic circuits sculpt the temporal and spatial aspects of synaptic inte

242 f adhesion-directed multicellular structures sculpt the tissue, promote its functionality, and mainta

243 9:Im9 complex demonstrates that force can re-sculpt the underlying energy landscape, providing new op

244 and electrical activity has the potential to sculpt the wiring of neural circuits and to modulate the

245 ncode and to reflect the learning rules that sculpted the information-processing system within which

246 lamo-nigral glutamatergic synapses (STN-SNr) sculpting the activity patterns of nigral neurons, the m

247 e and used here to illustrate the concept of sculpting the analytical volume associated with a nanopa

248 act upon neuromodulation as a mechanism for sculpting the behavioral repertoire of a species.

249 eveal that transcription plays a key role in sculpting the chromatin after DNA replication.

250 trol the polarized development of tissues by sculpting the cytoskeleton of individual cells.

251 Thus, AlkD acts by sculpting the global DNA conformation to achieve lesion

252 Patterns of neural activity are critical for sculpting the immature brain, and disrupting this activi

253 way epithelium facilitates carcinogenesis by sculpting the immune/inflammatory environment in the lun

254 ne cells protect against cancer formation by sculpting the immunogenicity of developing tumors.

255 vidually optimized illumination settings; 2) sculpting the light-sheet to trace complex sample shapes

256 We propose that Robo3 evolution was key to sculpting the mammalian brain by converting a receptor f

257 tic information on the processes involved in sculpting the mammary gland and demonstrate that BIM is

258 atest findings on the role of proteolysis in sculpting the nervous system through control of axonal g

259 ermines the spread of cortical activation by sculpting the precise activity patterns that underlie th

260 lements and the simple architectures play in sculpting the response dynamics of the network.

261 cell death, are the principal mechanisms of sculpting the sexually dimorphic abdomen of Drosophila.

262 afB/cJun heterodimers promoted apoptosis for sculpting the shape of the limbs.

263 The ligand is redesigned by sculpting the shifting hydration patterns of the target.

264 se that endocytosis plays a critical role in sculpting the structure of synapses, perhaps through the

265 As such, it is a potent mechanism for sculpting the synapse.

266 Branching morphogenesis sculpts the airway epithelium of the lung into a tree-li

267 that region- and pathway-specific plasticity sculpts the circuits involved in the performance of the

268 Kat-60L1 thus sculpts the class IV dendritic arbor through microtubule

269 eurons as spatial learning in the water maze sculpts the dendritic arbor of adult-born neurons even w

270 e provide the first description of how Pitx1 sculpts the forming hindlimb skeleton by localised modul

271 elopmentally regulated programmed cell death sculpts the limbs and other embryonic organs in vertebra

272 ridylation of mRNA mediated by TUT4 and TUT7 sculpts the mouse maternal transcriptome by eliminating

273 findings suggest that knowledge accumulation sculpts the neural networks associated with successful m

274 Evolution sculpts the olfactory nervous system in response to the

275 nderstanding how the PINK1-PARKIN pathway re-sculpts the proteome to support mitochondrial homeostasi

276 the 'even-toed' camel, extensive cell death sculpts the tissue around the remaining toes.

277 d indirect pathway MSNs and are important in sculpting their output to downstream basal ganglia nucle

278 d reassembling it, playing an active role in sculpting their surrounding environment and directing th

279 stable levels of activity, while experiences sculpt them.

280 ructures are dynamic and self-organize: they sculpt themselves and change their own architecture, and

281 The factors that dynamically sculpt these inter-regional correlation patterns are poo

282 on but the molecules in the active zone that sculpt this function are poorly understood.

283 it remains unclear which factors dynamically sculpt this topography as a function of brain state.

284 n II is a major driver of the movements that sculpt three-dimensional organs from two-dimensional epi

285 ize of individual astrocytes are dynamically sculpted through inhibitory or competitive astrocyte-ast

286 mouse models, we show that blood vessels are sculpted through the generation of stereotyped avascular

287 oproteinases (MMPs) are crucial mediators in sculpting tissue architecture and are required for many

288 ustness and versatility of this strategy for sculpting tissue interfaces by directing the morphogenes

289 s in our understanding of how cells actively sculpt tissues and how forces are involved in specific m

290 uit and illustrate how a circuit is flexibly sculpted to guide behavioral decisions in a context-depe

291 the aim is to provide some lift, support and sculpting to the treated area.

292 The focused ion beam can also be used as a sculpting tool to create specific specimen shapes such a

293 , in addition to destroying tumour cells and sculpting tumour immunogenicity, the immune system of a

294 r transformation, promotes tumour growth and sculpts tumour cell immunogenicity, but also as an extri

295 phase of the process, where immunologically sculpted tumours begin to grow progressively, become cli

296 additional temporal regulators may exist to sculpt vascular topology.

297 d apoptosis, plus morphogenic processes that sculpt vasculature, parenchymal cells, and mesenchyme to

298 ombining water presaturation with excitation sculpting water suppression delivers the most reproducib

299 hesia impairs normal synapse development and sculpting, which are crucial elements of developmental s

300 tified the optimal lattice type for membrane sculpting, which matches closely the lattices seen throu