ライフサイエンスコーパス: scute

1 the Drosophila transcription factor achaete-scute.

2 d by the proneural bHLH proteins achaete and scute.

3 r Poils au dos as a repressor of achaete and scute.

4 ctivity were mapped to a 14 kb region around scute.

5 ulatory sequences common to both achaete and scute.

6 illa, owing to the inappropriate function of scute.

7 which are overlain by keratinous ectodermal scutes.

8 oth natural and abnormal variation in turtle scutes.

9 human NEUROD1, NEUROD2, NEUROD3, and ACHAETE SCUTE 1 (HASH1) in cerebellar and cerebral primitive neu

10 the somatic mesoderm that express lethal of scute [2].

11 atially restricted expression of the achaete-scute (ac-sc) genes in clusters of cells, mediated by th

12 ated control of transcription of the achaete-scute (ac-sc) genes which are expressed in small proneur

13 te expression of the proneural genes achaete-scute (ac-sc).

14 The study of achaete-scute (ac/sc) genes has recently become a paradigm to un

15 Hedgehog and Lethal of scute activate Engrailed in these anterior cells.

16 A mutation removing scute activity has been previously described; it causes

17 ed carbon film around the bones and marginal scutes along the edge of the carapace.

18 through analysis of TAGteam changes in Sxl, scute (an XSE), and the ;ventral repression element' of

19 served in genetic samples from the yellow-ac-scute and Adh regions of Drosophila melanogaster.

20 erate a null allele of achaete, which leaves scute and all cis-regulatory elements intact.

21 The proneural factors Lethal of scute and Asense differentially controlled progenitor su

22 n of a single Serine at the same position in Scute and Atonal proneural proteins governs the transiti

23 The proneural genes achaete, scute and lethal of scute are required for neural precur

24 rt by activating expression of the lethal of scute and tailup H-cell regulatory genes.

25 Drosophila orthologues of ASH1 (Achaete and Scute) and the growth factor independence-1 (GFI1) oncop

26 function of the proneural genes achaete and scute, and express elevated levels of ac protein.

27 Of the four genes at this locus, achaete and scute appear to act redundantly to specify the periphera

28 However, when the levels of Scute are limiting, then some sensory organs are missing

29 proneural genes achaete, scute and lethal of scute are required for neural precursor formation in the

30 chanosensory precursors, whereas Achaete and Scute are required for the survival of the mechanosensor

31 achaete and scute are thought to have arisen from a duplication even

32 coenia, a homolog of the Drosophila achaete-scute (AS-C) genes--which encode transcription factors t

33 Achaete-Scute basic helix-loop-helix (bHLH) proteins promote neu

34 In rescue experiments, achaete or scute, but not lethal of scute, completely restored the

35 riments, achaete or scute, but not lethal of scute, completely restored the normal MP2 identity.

36 ystem (PNS) development requires the achaete-scute complex (AS-C) and the atonal (ato) genes.

37 ession of the proneural genes of the achaete-scute complex (AS-C) is required for neurectodermal cell

38 f genes of a proneural gene cluster, achaete-scute complex (AS-C), in Drosophila larvae.

39 vey of a 110-kb region including the achaete scute complex (ASC) examined 14 polymorphic molecular ma

40 quantified the relationship between achaete-scute complex (ASC) polymorphisms and Drosophila bristle

41 nes, atonal (ato) and members of the achaete-scute complex (ASC), are required for the formation of c

42 s and R8 photoreceptors, whereas the achaete-scute complex contains proneural genes for external sens

43 These results demonstrate that the achaete-scute complex genes specify aspects of neural precursor

44 Achaete-scute complex homolog (Ascl)1(+) C cells were heterogene

45 Prior to and during this process, an achaete-scute complex homolog, CapI-ash1, is expressed in cluste

46 lly expressed imprinted gene, Ascl2 [achaete-scute complex homolog-like 2 (Drosophila)], and their de

47 elix-loop-helix transcription factor achaete-scute complex homologue 1 (ASCL1) is essential for the d

48 The achaete-scute complex of Drosophila has been the focus of extens

49 regulatory enhancer sequences at the achaete-scute complex that mediate activation at specific sites

50 sion by enhancers in the neighboring achaete-scute complex, causing an apparent absence of the block

51 2 (2.4-fold increase, P = .029) and Achaete-scute complex-like 1 (ASCL1; 2.7-fold increase, P = .023

52 ress the transcription factor ASCL1 (achaete-scute complex-like 1) as well as high levels of the neur

53 ller glia increase expression of the Achaete-scute complex-like 1a (Ascl1a) and Signal transducer and

54 ter that mediates transactivation by achaete-scute complex-like 1a (ascl1a) during retina regeneratio

55 (sc) works with its paralogs in the achaete-scute-complex (ASC) to direct neuronal development.

56 -helix (bHLH) proneural proteins Achaete and Scute cooperate with the class I bHLH protein Daughterle

57 Activation of SxlPm depends on the scute, daughterless, and runt transcription factors, whi

58 Here, we show that scutes develop from an array of patterned placodes and t

59 In an achaete-scute double mutant, MP2 formation was reduced (to 11-14

60 MP2 delaminates from a cluster of achaete-scute-expressing ectodermal cells.

61 To our surprise, we found that ectopic scute expression in the ato(1) mutant induces the format

62 induces chordotonal organ formation, ectopic scute expression produces external sensory organs but no

63 s au dos, is associated with ectopic achaete-scute expression that results in the additional bristles

64 hairy, to transcriptionally repress achaete-scute expression.

65 ed by genes of the NEUROD/atonal and ACHAETE SCUTE families.

66 m the intestinal stem-cell regulator achaete-scute family basic helix-loop-helix transcription factor

67 Although Achaete-scute family bHLH transcription factor 1 (Ascl1) plays i

68 bilizes proactivation protein Ascl1 (achaete-scute family bHLH transcription factor 1) in proliferati

69 expression of phox2b, phox2a and the achaete-scute family member zash1a/ascl1.

70 retinoblastoma) expressed NeuroD and ACHAETE SCUTE family members.

71 ctor Neurogenin/Math/atonal and Mash/achaete-scute family members.

72 n Drosophila and in vertebrates, the achaete-scute family of basic helix-loop-helix transcription fac

73 Proteins of the achaete-scute family of transcription factors play important rol

74 l lineages, and mutations in lin-32 (achaete/scute family), vab-3 (Pax-6 homolog) and egl-5 (Abd-B ho

75 ffected by mutations that remove Achaete and Scute function.

76 nsory organs (SOs) in the absence of achaete-scute gene complex function.

77 Finally, the expression of the Achaete-Scute gene complex suggests that SoxNeuro acts upstream

78 The achaete-scute genes encode essential transcription factors in no

79 The Drosophila proneural achaete-scute genes govern neural precursor formation, but their

80 , we test the role of the Drosophila achaete-scute genes in specifying neural precursor identity, foc

81 te that cash4 can substitute for the achaete/scute genes in the fly and that it also has proneural ac

82 The number of achaete-scute genes increased during insect evolution, particula

83 e comparison indicates that the four achaete-scute genes of Drosophila result from three independent

84 of a family of proneural genes, the achaete-scute genes, and to examine their genomic organization a

85 ver, the genetic regulation of the epidermal scutes has not been investigated.

86 or (FGF)-2 deprivation and mammalian achaete-scute homolog (MASH)1 transcription factor levels in an

87 ude (a) expression of the bHLH mouse achaete-scute homolog (mASH1) in normal and CR2-TAg NE cells and

88 entified two Tribolium ac/sc genes - achaete-scute homolog (Tc-ASH) a proneural gene and asense (Tc-a

89 The Achaete-scute homolog 1 (Ascl1) protein regulates a large subset

90 We determined that achaete-scute homolog 1 (ASCL1), a transcription factor required

91 e gene encoding the proneural factor Achaete-scute homolog 1 (Ascl1; also known as Mash1 in mammals)

92 ix (bHLH) transcription factor human achaete-scute homolog 1 (hASH1).

93 ral and spatial pattern of mammalian achaete-scute homolog 1 (MASH-1) expression in the developing ra

94 The mammalian achaete-scute homolog 1 (MASH1) protein is required for the earl

95 hh), its receptor ptc, and mammalian achaete-scute homolog 1 (Mash1), a pro-neuron basic helix-loop-h

96 ith other vertebrate homologs of the achaete scute homolog 1 subclass shows that the carboxyl 2/3 of

97 genic transcription factor mammalian achaete-scute homolog 1, by low doses of BMP2.

98 a Japanese pufferfish, Fugu rubripes achaete-scute homolog 1, Fash1.

99 Mechanisms regulating achaete-scute homolog expression outside of Drosophila are prese

100 s examined in an effort to correlate achaete-scute homolog expression with the generation of particul

101 It also inhibits the activity of the achaete-scute homolog lin-32 and an unidentified gene that we po

102 the isolation of a novel vertebrate achaete-scute homolog, cash4, which is expressed in the presumpt

103 study, we characterize a C. elegans Achaete-Scute homolog, HLH-14.

104 Human achaete-scute homolog-1 (hASH1) is constitutively expressed in a

105 dimers of the proneural bHLH protein achaete-scute homolog-1 and E12, leading to active transcription

106 lesions was reduced when CC10-human achaete-scute homolog-1 mice were crossed with matrilysin-1 null

107 an lesions and BOA in the CC10-human achaete-scute homolog-1 transgenic mouse model.

108 for gliadin homology, noteworthy was achaete scute homologous protein (DQ2-alpha-I-gliadin; BestFit q

109 lity=215 versus 100 for random); and achaete-scute homologous protein, which displays particularly hi

110 achaete-scute homologs (ash) regulate neural development in all

111 These data suggest that achaete-scute homologs functioned in the ancestral metazoan neur

112 Human ACHAETE SCUTE homologue (HASH1) was not expressed in medulloblas

113 iption factor encoding genes, ash1a (achaete/scute homologue 1a) and neurogenin1 (ngn1), in epiphysia

114 Here we show that expression of achaete-scute homologue 2 (Ascl2)--a basic helix-loop-helix (bHL

115 anscription factor Mash-2 (mammalian achaete/scute homologue 2), which is elevated in human cytotroph

116 ue of the fly proneural genes (chick achaete-scute homologue 4, cash4), which is expressed heterogene

117 These medial cells do not express achaete scute homologue in proneural clusters, but express colli

118 The transcription factor achaete-scute homologue-1 (ASH1) is essential for neural differe

119 The Achaete-Scute Homologue-1 (ASH1) transcription factor is critica

120 We show here that human achaete-scute homologue-1 (hASH1) is selectively expressed in no

121 elix-loop-helix transcription factor achaete-scute homologue-1 (hASH1) may stimulate both proliferati

122 ix (bHLH) transcription factor human achaete-scute homologue-1 (hASH1).

123 by increased expression of mammalian achaete/scute homologue-2 (Mash-2), which increases levels of up

124 dent evolution of multiple copies of achaete-scute homologues and argue that this might have contribu

125 Vertebrate achaete-scute homologues are expressed early during neurogenesis

126 melanogaster and Tribolium castaneum achaete-scute homologues are initially expressed in clusters of

127 In all euarthropod groups, achaete-scute homologues are required for neuroblast/neural prec

128 specified by elevated levels of the achaete-scute homologues CsASH1 and CsASH2.

129 he expression of spalt, iroquois and achaete-scute homologues from elytron-like to more typical wing-

130 r results raise the possibility that achaete-scute homologues may help specify neural precursor ident

131 to its homologs, the proneural genes achaete-scute in Drosophila.

132 s expression of the proneural gene lethal of scute in the most anterior midline daughter cells of the

133 es that are responsible for the evolution of scutes in turtles, and the regulation of these centers h

134 Remarkably, many scute-induced ommatidia lack R8 although they contain ou

135 Thus, when Scute is absent, the activity of achaete allows formatio

136 We demonstrate that Scute is phosphorylated by Sgg on a serine residue and t

137 e expression of the proneural gene lethal of scute (l'sc) is required for the development of the majo

138 sion pattern of the proneural gene lethal of scute (l'sc), as well as the pattern of brain neuroblast

139 late H-cell fate revealed that the lethal of scute [l(1)sc], tailup and SoxNeuro transcription factor

140 Achaete-scute like (ASCL)2 is a basic helix-loop-helix transcrip

141 omoter activity of a newly described Achaete-scute-like gene hlh-3.

142 s Sgn1, is a member of the mammalian achaete scute (Mash) gene family of transcription factors, which

143 The difference between achaete and scute null flies is surprising and raises the question o

144 thodenticle, by the proneural gene lethal of scute or by tailless itself.

145 ariety of skin structures: keratinous dermal scutes, protospines composed of hair-like tubules, and c

146 of developing fruit flies, achaete (ac) and scute (sc) expression defines a group of neurally-compet

147 by ectopic expression of the proneural gene scute (sc) misdirect hemocytes to these ectopic location

148 In flies, scute (sc) works with its paralogs in the achaete-scute-

149 c flies expressing chimeric genes of ato and scute (sc), a member of ASC, and found that the informat

150 sion of the proneural genes achaete (ac) and scute (sc).

151 (h) and the proneural genes achaete (ac) and scute (sc).

152 mutants, Tufted is epistatic to achaete and scute, the proneural genes that normally control the dev

153 -length polymorphism 97 bp downstream of the scute transcript.

154 e absent from a soft-shelled turtle in which scutes were lost secondarily.

155 In contrast, Atonal and Scute, which are thought to heterodimerize with Daughter

156 by inducing the proneural genes achaete and scute, which downregulate the mitosis-inducing phosphata

157 estigial, Serum Response Factor, and achaete-scute, whose products regulate morphological features th