ライフサイエンスコーパス: sebaceous gland

1 vel found in the preputial gland, a modified sebaceous gland.

2 ytes located in the suprabasal layers of the sebaceous gland.

3 air follicles, interfollicular epidermis and sebaceous gland.

4 differentiation and lipid metabolism of the sebaceous gland.

5 ny of K5-expressing cells located within the sebaceous gland.

6 estricted to mouse skin, specifically to the sebaceous gland.

7 g effects of different substrates within the sebaceous gland.

8 omeostatic effect of Edar stimulation on the sebaceous gland.

9 ogressive transformation of the niche into a sebaceous gland.

10 opulation of fibroblasts located beneath the sebaceous gland.

11 hance the disinfecting activity of the human sebaceous gland.

12 em to form the epidermis, hair follicle, and sebaceous gland.

13 entification of histamine receptors in human sebaceous glands.

14 te a stratified epidermis, hair follicles or sebaceous glands.

15 ation program from forming hair follicles to sebaceous glands.

16 -induced abnormalities in hair follicles and sebaceous glands.

17 egenerate new hair follicles, epidermis, and sebaceous glands.

18 terfollicular epidermis, hair follicles, and sebaceous glands.

19 heart, dermis, atrophic hair follicles, and sebaceous glands.

20 striking increase both in size and number of sebaceous glands.

21 er-root sheath cells, and basal cells of the sebaceous glands.

22 iopsy punches from human facial skin rich in sebaceous glands.

23 t the effects of DGAT1 deficiency on fur and sebaceous glands.

24 expression was abundant in keratinocytes and sebaceous glands.

25 or more follicular compartments or solely to sebaceous glands.

26 rogen regulated tissues such as prostate and sebaceous glands.

27 get heated, and induce focal thermolysis of sebaceous glands.

28 mas of the forestomach, as well as tumors of sebaceous glands.

29 protoporphyrin, in human hair follicles and sebaceous glands.

30 elanocortin receptors are expressed in human sebaceous glands.

31 cells lining the epithelial root sheath and sebaceous glands.

32 pha) are also observed in hair follicles and sebaceous glands.

33 more hair follicles down to the level of the sebaceous glands.

34 errantly expressed in the tumor cells of the sebaceous glands.

35 rticles enable selective photothermolysis of sebaceous glands.

36 ed total lipoatrophy and complete absence of sebaceous glands.

37 /Delta) mice and likely were due to the lack sebaceous glands.

38 icles in prolonged telogen with hyperplastic sebaceous glands.

39 n-specific kinase expressed predominantly in sebaceous glands.

40 epithelial structure with hair follicles and sebaceous glands.

41 on with reduced effects in the uterus and in sebaceous glands.

42 g reduced effects on reproductive organs and sebaceous glands.

43 ir follicle distensions adjacent to enlarged sebaceous glands.

44 cle orientation, and increased expression of sebaceous glands.

45 lid and in cells of Meibomian and preputial (sebaceous) glands.

46 opecias, which characteristically begin with sebaceous gland ablation.

47 Sebaceous gland ACC represents an attractive therapeutic

48 ing puberty are likely due to alterations in sebaceous gland activation and sebum composition.

49 Sebaceous glands also fail to form in gamma-secretase-de

50 transcriptional regulators of the epidermal, sebaceous gland and hair follicle differentiation progra

51 E mRNA in the germinative cell layer of the sebaceous gland and in epithelial cells of the hair foll

52 sin-2 immunoreactivity was also found in the sebaceous gland and in the basal layer of the central ou

53 llow systematic annotation of hair follicle, sebaceous gland and interfollicular epidermal abnormalit

54 roscopy is a promising tool for studying the sebaceous gland and its associated disorders in three di

55 haft and in the most mature sebocytes of the sebaceous gland and preputial, meibomium, ceruminous gla

56 cles, with FABP5 being a prominent marker of sebaceous glands and anagen follicle bulbs.

57 e keratin 15 (K15) promoter and targeted the sebaceous glands and base of the follicle (bulb) with a

58 ill microbes and have been detected in human sebaceous glands and cell lines.

59 The new follicles formed sebaceous glands and dermal papilla, normally establishe

60 ir loss, which were associated with atrophic sebaceous glands and fur lipid abnormalities.

61 mis is modestly hypoxic and portions of some sebaceous glands and hair follicles are moderately to se

62 oblasts, endothelial cells, and cells around sebaceous glands and hair follicles at day 2-4 postwound

63 mulates de novo hair follicle formation from sebaceous glands and interfollicular epidermis, while on

64 nfined to the hair follicle, but also lie in sebaceous glands and interfollicular epidermis.

65 of Setd8, leading to an irreversible loss of sebaceous glands and interfollicular epidermis.

66 s and exhibited abnormal development of both sebaceous glands and meibomian glands, specialized sebac

67 Lipid metabolism in sebaceous glands and preputial glands of rodents is regu

68 the melanocortin 5 receptor protein in human sebaceous glands and rat preputial glands was further ve

69 In human volunteers, cooling damaged sebaceous glands and reduced sebum output for 2 weeks, w

70 r both P450c17 and steroidogenic factor 1 in sebaceous glands and SEB-1 cells.

71 We determined the glycogen content of sebaceous glands and showed that during their incubation

72 as the major fatty acid desaturase in human sebaceous glands and suggests that the environment of th

73 ted the development of tumors of specialized sebaceous glands and suppressed tumors characteristic of

74 led to the morphogenesis and hyperplasia of sebaceous glands and sweat glands in mature mice, leadin

75 Messenger RNA was isolated from human sebaceous glands and the reverse transcriptase polymeras

76 s arose from the squamous epithelia and from sebaceous glands and were characterized histologically t

77 lpha was expressed in the outer root sheath, sebaceous gland, and dermal papilla, whereas CCAAT/enhan

78 ls, which reside in the adult hair follicle, sebaceous gland, and epidermis.

79 del for determining further functions of the sebaceous gland, and for understanding the regulation of

80 m cells in the bulge can generate epidermis, sebaceous gland, and hair bulb matrix cells.

81 generate the keratinocytes of the epidermis, sebaceous gland, and hair follicles.

82 -beta expression was confined to the matrix, sebaceous gland, and inner and outer root sheaths.

83 the majority of layers of the hair follicle, sebaceous gland, and interfollicular epidermis in a hair

84 comprising the hair follicle, an associated sebaceous gland, and overlying epidermis; however, the s

85 ate control of HS levels is required for HF, sebaceous gland, and sweat gland morphogenesis and HF cy

86 acanthosis and papillomatosis, hyperplastic sebaceous glands, and a cellular dermis.

87 mis and striking hyperkeratosis, hypoplastic sebaceous glands, and a fibrotic dermis.

88 fferentiated keratinocytes of the epidermis, sebaceous glands, and hair follicles.

89 of follicular orifices, striking absence of sebaceous glands, and hair shaft abnormalities in KP les

90 n substitutes formed pigmented hairs without sebaceous glands, and human-only skin substitutes formed

91 itted progenitors, formation of hypertrophic sebaceous glands, and increased epidermal differentiatio

92 pendages, such as hair, teeth, sweat glands, sebaceous glands, and mammary glands, requires the actio

93 In the eyelid, conjunctiva, sebaceous glands, and muscle and nerve tissues labeled m

94 nd hyperkeratosis, severe hyperplasia of the sebaceous glands, and structural alterations of hair fol

95 t; eosinophilic necrotic plugs formed within sebaceous glands, and the number of glands was significa

96 ncluding Harderian, preputial, lacrimal, and sebaceous glands, and was also shown to be required for

97 Our results suggest that the bulge and sebaceous gland are, respectively, non-permissive and pe

98 Importantly, the enlarged sebaceous glands are associated with an increased expres

99 eport that the interfollicular epidermis and sebaceous glands are hyperproliferative, coincident with

100 Current techniques for studying sebaceous glands are mostly static in nature, whereas th

101 ducts, and glands such as sweat, mucous and sebaceous glands, are initiated in development as placod

102 licle and a series of associated structures: sebaceous glands, arrector pili muscles, Merkel cells, a

103 aceous unit, containing the infundibulum and sebaceous gland as independent compartments, but contrib

104 basal layer, to hair follicles, eccrine and sebaceous glands as well as to endothelium of blood vess

105 s demonstrated further by (i) the absence of sebaceous-gland-associated lipase activity in asebia mic

106 d staining in a few cells at the duct of the sebaceous gland at the base of the hair follicles.

107 These results document sebaceous gland atrophy in nonscalp psoriasis, identify

108 The phenotypic effects of mEDA-A1 on sebaceous glands, but not on hair follicles, were revers

109 Although the human sebaceous gland can synthesize cholesterol from acetate

110 Sixteen cases of eyelid sebaceous gland carcinoma who received tumor excision at

111 In summary, sebaceous gland carcinomas, while characteristic of Muir

112 mma (PPARgamma) is thought to play a role in sebaceous gland cell function.

113 An SV40 immortalized human sebaceous gland cell line (SEB-1) was established in ord

114 stearoyl-CoA desaturase in the immortalized sebaceous gland cell line SZ95 and whole skin.

115 entiation of adipocytes and are expressed in sebaceous gland cells.

116 y skin substitutes formed external hairs and sebaceous glands, chimeric skin substitutes formed pigme

117 tures in the skin of a live mouse, including sebaceous glands, corneocytes, and adipocytes, with unpr

118 targeted interruption of this pathway in the sebaceous gland could be a desirable approach to reducin

119 ands, implying that selective destruction of sebaceous glands could be an effective treatment.

120 The formation of sebaceous gland-derived epithelial cysts does not fit th

121 tamin D receptor enhanced differentiation of sebaceous gland-derived hair follicles and stimulated ec

122 These results show that sebaceous-gland-derived glycerol is a major contributor

123 d153 were observed in the outer root sheath, sebaceous gland, dermal papilla, and connective tissue s

124 ted complete regeneration of hair follicles, sebaceous glands, dermis and cartilage.

125 ation (Plet1, Lrig1 Lef1, and beta-catenin), sebaceous gland development (adipophilin, Scd1, and oil

126 ntial involvement of the Hedgehog pathway in sebaceous gland development using transgenes designed to

127 t display striking abnormalities in hair and sebaceous gland development.

128 milar and therefore further understanding of sebaceous gland differentiation and lipogenesis and pote

129 postnatal skin, where all hair follicles and sebaceous gland differentiation are also repressed and o

130 ase-PCR (RT-PCR) and immunohistochemistry of sebaceous gland differentiation markers revealed reduced

131 hat involves an aberrant hair cycle, altered sebaceous gland differentiation with reduced sebum produ

132 a hair-loss phenotype that includes altered sebaceous gland differentiation, short hair shafts, aber

133 and lipogenesis and potential therapies for sebaceous gland disorders may be obtained from our knowl

134 gely unaffected but after an initial wave of sebaceous gland duplication sebocyte differentiation was

135 CARS microscopy revealed dynamic changes in sebaceous glands during the holocrine secretion process,

136 ausative role for melanocortin 5 receptor in sebaceous gland dysfunction, and in the absence of any a

137 the epithelium and appendages, including the sebaceous gland, eccrine glands, and apocrine glands, as

138 to the melanocortin 5 receptor localized to sebaceous glands, eccrine glands, hair follicles, and ep

139 rbing microparticles could be delivered into sebaceous glands, enabling local injury by optical pulse

140 expansion of the base of the hair follicle, sebaceous gland enlargement and abnormal clumping of the

141 led to alopecia, follicular hyperplasia and sebaceous gland enlargement as well as hyperplasia of th

142 These ectopic sebaceous glands expressed molecular markers of sebocyte

143 specific expression pattern within the human sebaceous gland for the two AWAT genes, consistent with

144 of glycerol generation from triglyceride in sebaceous glands for stratum corneum hydration was demon

145 ndages (hair follicles, apocrine glands, and sebaceous glands) for wound repair in model animals, the

146 omoter during the hair/vibrissa follicle and sebaceous gland formation.

147 og signaling also triggered the formation of sebaceous glands from footpad epidermis, in regions norm

148 abis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves

149 ebaceous follicles, prolonged suppression of sebaceous gland function, and apparent decrease in folli

150 eatment of skin disorders linked to abnormal sebaceous gland function, such as acne.

151 ble hair in PP skin may result from abnormal sebaceous gland function.

152 melanocortin 5 receptor is known to regulate sebaceous gland function.

153 Human apocrine and sebaceous glands function to secrete lipids, predominant

154 Follicles were complete with sebaceous glands, hair shafts and inner and outer root s

155 These results indicate that apocrine and sebaceous glands have the capacity to sequester dietary

156 ated with abnormal hair cycle, epidermal and sebaceous gland hyperplasia, hyperkeratosis, and increas

157 cluding cyclic and progressive hair loss and sebaceous gland hypertrophy.

158 and report here that SKO mice display marked sebaceous gland hypoplasia and depletion of sebaceous li

159 omozygous for either allele included extreme sebaceous gland hypoplasia, abnormally long anagen folli

160 ion in asebia J1 and 2 J mice, with profound sebaceous gland hypoplasia.

161 or phenotypes--irregularities of hair cycle, sebaceous glands hypoplasia, and a thinner epidermis--po

162 In normal sebaceous glands IHH is expressed in differentiated sebo

163 hysiology of acne vulgaris depends on active sebaceous glands, implying that selective destruction of

164 ic hypothesis based on the importance of the sebaceous gland in hair fiber sheath dissociation: in th

165 Sebaceous glands in all skin regions respond to treatmen

166 ifferentiated epidermis, hair follicles, and sebaceous glands in an in vivo environment.

167 Sebaceous glands in Fatp4 null skin grafted onto nude mi

168 dermis, hair follicles, sebaceous ducts, and sebaceous glands in sections of facial skin.

169 nt upper hair follicle immediately below the sebaceous glands in the follicle bulge.

170 incides with the morphological appearance of sebaceous glands in the neonatal rat.

171 irradiation to thermally disrupt overactive sebaceous glands in the skin which define the etiology o

172 delivered into human pre-auricular and swine sebaceous glands in vivo, using mechanical vibration.

173 l skin cooling causes preferential injury to sebaceous glands, in murine and swine models using a ran

174 Studies in sebocytes and human sebaceous glands indicate that agonists of peroxisome pr

175 re expressed in the differentiating cells of sebaceous gland, interfollicular epidermis and hair foll

176 ing in complete and reversible conversion of sebaceous glands into hair follicles.

177 The sebaceous gland is an integral part of the pilosebaceous

178 Selective cryolysis of sebaceous glands is achievable through brief, non-invasi

179 Our findings suggest that absence of sebaceous glands is an early step in KP pathogenesis, re

180 Inhibition of ACC activity in the sebaceous glands is designed to substantially affect seb

181 The only known function of human sebaceous glands is the provocation of acne.

182 the level of the sebaceous gland, or by the sebaceous gland itself, and that persistence of the foll

183 = 21), hidradenitis supprativa (n = 4), and sebaceous gland lesions comprising sebaceous nevi, adeno

184 nding of the molecular signaling involved in sebaceous gland lipid production is needed to develop th

185 energy homeostasis, feeding efficiency, and sebaceous gland lipid production, as well as immune and

186 um hydration, associated with a reduction in sebaceous gland lipids (wax diesters/monoesters, sterol

187 Insulin and IGF-1 stimulate sebaceous gland lipogenesis.

188 in the tail were disorganized and had excess sebaceous gland lobules.

189 reduced proliferation, and hair follicle and sebaceous gland loss in 30-d-old K5Cre beta1-null mice.

190 f histone H4 by holocrine secretion from the sebaceous gland may play an important role in innate imm

191 This study demonstrated that while sebaceous glands may be involved in hair eruption, they

192 genesis and differentiation, but accelerated sebaceous gland morphogenesis.

193 tative product of triglyceride hydrolysis in sebaceous glands, normalized stratum corneum hydration,

194 ve expression in an extrahepatic tissue, the sebaceous glands of cutaneous tissues.

195 BD-2, was also observed in the hair follicle sebaceous glands of mouse ear skin after an epicutaneous

196 esions are seen in the nail and nail bed and sebaceous glands of PC and SM patients, respectively.

197 ous glands and meibomian glands, specialized sebaceous glands of the eyelids.

198 e, including the ciliary body, the iris, the sebaceous glands of the tarsal plate, and the epithelium

199 s of endogenous Lef-1 expression seen in the sebaceous glands of vibrissa and hair follicles in trans

200 mediated by the follicle at the level of the sebaceous gland, or by the sebaceous gland itself, and t

201 etaining cells were found in the hair canal, sebaceous gland, or hair germ.

202 ice develop mild alopecia and hyperplasia of sebaceous glands, particularly around the eyes.

203 Sebaceous glands perform complex functions, and they are

204 nds and suggests that the environment of the sebaceous gland permits catalysis of the sebaceous-type

205 T1 plays an important role in normal fur and sebaceous gland physiology and provide evidence that lep

206 preputial system as an experimental model in sebaceous gland physiology.

207 bacterial colonization, or the deposition of sebaceous gland products.

208 oteins examined in vitro around comedones or sebaceous glands, providing solid evidence for suggested

209 a subpopulation of cells at the base of the sebaceous gland readily formed ectopic follicles, result

210 plied onto Yorkshire pig ears accumulated in sebaceous glands relative to the surrounding dermis.

211 r effect on sebocytes, the major cell of the sebaceous gland responsible for producing sebum.

212 conclude that interfollicular epidermis and sebaceous glands retain the ability to be reprogrammed i

213 llicles, interfollicular epidermis (IFE) and sebaceous glands, revealing a remarkable ability of the

214 Our results provide evidence that the sebaceous gland selectively utilizes fatty acids as 16:0

215 rough coat (rc) spontaneous mutation causes sebaceous gland (SG) hypertrophy, hair loss, and extracu

216 Its functions in the sebaceous gland (SG), however, remain poorly characteriz

217 s: the epidermis, the hair follicle, and the sebaceous gland (SG).

218 to potent androgens and estrogens within the sebaceous gland (SG).

219 3 channel and from triglyceride turnover in sebaceous glands (SG) are important determinants.

220 on, can be found in hair follicle-associated sebaceous glands (SGs) or in free SGs such as the Meibom

221 nocytes in the interfollicular epidermis and sebaceous glands (SGs) to differentiate along the hair f

222 K6a expression correlates with duct fate in sebaceous glands (SGs).

223 wth in vitro: follicles transected below the sebaceous gland show a type 1 growth pattern (the shaft

224 On histology, sebaceous glands showed acute damage and were smaller 20

225 riasis, identify a cytokine-regulated set of sebaceous gland signature genes, and suggest that loss o

226 h agonist anti-EDAR antibodies, we find that sebaceous gland size and function can be restored to wil

227 Sebaceous gland size and sebum production may serve as b

228 uroic acid significantly reduced hamster ear sebaceous gland size, indicating that this pro-drug appr

229 ids, cholesterol and its esters, and, in the sebaceous gland, squalene.

230 nd WNT10B, and downregulation of a marker of sebaceous glands, Steroyl-CoA desaturase.

231 ynthase mRNA was abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid

232 g identified copiously in hair follicles and sebaceous glands, suggesting a potential route of exit a

233 ing for DAX-1 was confined to the epidermis, sebaceous glands, sweat glands, and outer root sheath of

234 n affected tissues including hair follicles, sebaceous glands, taste buds, nails and sweat ducts.

235 uced by beta-catenin arise from areas of the sebaceous gland that have lost CRABP2 and FABP5; convers

236 dissociation: in the absence of a functional sebaceous gland the hair follicle is destroyed.

237 tant mouse underscores the importance of the sebaceous gland to follicular biology and presents an an

238 ternative-the in vivo, label-free imaging of sebaceous glands using Coherent Anti-Stokes Raman Scatte

239 teroidogenic factor 1 in SEB-1 sebocytes and sebaceous glands was compared to mRNA levels in ovarian

240 -CoA reductase activity in both apocrine and sebaceous glands was reduced following incubation with e

241 shly isolated and overnight maintained human sebaceous glands were determined using high performance

242 A1 transgenic mice was unaffected, but their sebaceous glands were hypertrophied and hyperplastic, co

243 Sebaceous glands were markedly atrophic in PP versus non

244 ining, and hair follicles, sweat glands, and sebaceous glands were moderately immunoreactive.

245 At 22 wk, new cartilage, hair follicles, and sebaceous glands were observed in the newly generated ti

246 Sebaceous glands were present but small compared with th

247 Klf5CN eyelid hair follicles and sebaceous glands were significantly enlarged, and the me

248 ial cells that encircled the root sheath and sebaceous glands were the source of the elastic fibers.

249 inability to reconstitute hair follicles and sebaceous glands when grafted onto mice, but epithelial

250 Conversely, incubation of whole sebaceous glands with compactin resulted in the stimulat

251 tology shows abnormal differentiation of the sebaceous gland, with the sebocytes producing little or

252 g (n = 16) were observed in benign cutaneous sebaceous glands, with expression in differentiated secr

253 expansion of the sebocyte-producing zone in sebaceous glands, with particularly high expression of t

254 hells in inducing photothermal disruption of sebaceous glands without damaging collateral skin.