ライフサイエンスコーパス: sebocyte

1 d synthesis in primary and transformed human sebocytes.

2 ressed in freshly dispersed than in cultured sebocytes.

3 esteryl esters, and wax esters in OG-treated sebocytes.

4 y of antimicrobial peptide activity in human sebocytes.

5 AMP)-mediated innate immune defense of human sebocytes.

6 ic acid did not induce cytotoxicity to human sebocytes.

7 1, and stearoyl-CoA desaturase mRNAs in SZ95 sebocytes.

8 pression, in turn, stimulates lipogenesis in sebocytes.

9 and time-dependent decreases in viable SEB-1 sebocytes.

10 amma activation and COX-2 expression in SZ95 sebocytes.

11 ncreased PPARgamma reporter activity in SZ95 sebocytes.

12 entiation into interfollicular epidermis and sebocytes.

13 stimulates proliferation of undifferentiated sebocytes.

14 uman facial skin, human sebocytes, and SEB-1 sebocytes.

15 n the hair follicle infundibulum, and in the sebocytes.

16 follicles into interfollicular epidermis and sebocytes and causes loss of LRC primarily through proli

17 ure, plus the active migration of individual sebocytes and cohorts of sebocytes, were measured.

18 high extent before and after culture in both sebocytes and epidermal cells.

19 wed a subnormal level of FATP4 expression in sebocytes and exhibited abnormal development of both seb

20 y suppressing the NF-kappaB pathway in SEB-1 sebocytes and HaCaT keratinocytes.

21 Studies in sebocytes and human sebaceous glands indicate that agoni

22 Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lip

23 stem cell compartment and differentiate into sebocytes and interfollicular epidermis at the expense o

24 d cell cycle proteins were examined in SEB-1 sebocytes and keratinocytes.

25 P450c17, and steroidogenic factor 1 in SEB-1 sebocytes and sebaceous glands was compared to mRNA leve

26 olism and one gene, PLIN2, expressed only by sebocytes and subcutaneous fat cells.

27 us glands IHH is expressed in differentiated sebocytes and the transcription factor GLI1 is activated

28 nd activity of PPARs in human skin and SEB-1 sebocytes and to assess the effects of PPAR ligands on s

29 ivated receptor-gamma, which is expressed in sebocytes, and contribute to secretory differentiation i

30 rmis in human skin, rat skin, cultured human sebocytes, and rat preputial cells.

31 otein-1 (SREBP-1) signaling pathway in SEB-1 sebocytes, and reduced inflammation by suppressing the N

32 1 was documented in human facial skin, human sebocytes, and SEB-1 sebocytes.

33 uclei and resistin in the cytoplasm of basal sebocytes, and stearoyl CoA desaturase in the cytoplasm

34 rt that 13-cis RA induces apoptosis in SEB-1 sebocytes as shown by increased Annexin V-FITC staining,

35 fense by inducing the expression of hBD-2 in sebocytes as well.

36 ubset of differentiated keratinocytes called sebocytes, as demonstrated by Northern blot analysis, in

37 fibrate, induced lipid droplet formation in sebocytes but not epidermal cells.

38 ted receptor gammal mRNA was demonstrated in sebocytes, but not in epidermal cells; it was more stron

39 cycle arrest and induces apoptosis in SEB-1 sebocytes by a RAR-independent mechanism, which contribu

40 We hypothesized that sebocyte cell culture systems lack activators of the per

41 he Hedgehog pathway thus plays a key role in sebocyte cell fate decisions and is a potential target f

42 is and immunofluorescence of an immortalized sebocyte cell line (SZ95) revealed the presence of hista

43 gene is induced by TLR2 signaling in a human sebocyte cell line.

44 Cooling disrupted sebocyte cell membranes, alkaline phosphatase activity,

45 performance liquid chromatography, untreated sebocytes contained 6.27 (+/-0.73) nmol squalene per 10(

46 athways of differentiation in adipocytes and sebocytes could be similar and therefore further underst

47 le by western blotting in the supernatant of sebocyte culture incubated with each FFA, but not with a

48 The supernatant of FFA-incubated sebocyte culture showed antimicrobial activity against P

49 show the presence of histamine receptors on sebocytes, demonstrate how an antagonist to these recept

50 pidermis; however, the signals that regulate sebocyte development are poorly understood.

51 the Hedgehog pathway selectively suppressed sebocyte development, Hedgehog pathway activation led to

52 aceous glands expressed molecular markers of sebocyte differentiation and were functional, secreting

53 PTCH1 and IHH are up-regulated during human sebocyte differentiation in vitro and inhibition of hedg

54 Very little sebocyte differentiation occurs, however, in primary or

55 Ectopic sebocyte differentiation was another hallmark of the phe

56 initial wave of sebaceous gland duplication sebocyte differentiation was inhibited.

57 As lipogenesis is key to both adipocyte and sebocyte differentiation we hypothesize that sebocytes f

58 mis Blimp1 is important for keratinocyte and sebocyte differentiation, its role in dermal fibroblasts

59 ltiple aspects of skin physiology, including sebocyte differentiation, keratinocyte proliferation, ep

60 esses hair differentiation and gives rise to sebocyte differentiation.

61 a distinct role of long chain fatty acids in sebocyte differentiation.

62 The hallmark of sebaceous epithelial cell (sebocyte) differentiation is the accumulation of fused n

63 palmitic acid, or oleic acid (OA) with human sebocytes dramatically enhanced their expression of huma

64 sebocyte differentiation we hypothesize that sebocytes follow a similar program of differentiation to

65 y, antihistamines could potentially modulate sebocyte function directly.

66 ys are involved in the specific processes of sebocyte growth and development.

67 the roles of specific retinoid receptors in sebocyte growth and differentiation, by testing the effe

68 etinoid X receptors differ in their roles in sebocyte growth and differentiation: (i) retinoic acid r

69 ow that deletion of Acbp in mouse results in sebocyte hyperplasia and sparse, matted hair with a grea

70 ected MPZL3 protein in the keratinocytes and sebocytes in the skin.

71 sphatase activity, and significantly reduced sebocyte lipid content.

72 ose and lipid metabolism, thereby inhibiting sebocyte lipogenesis.

73 uced transcription of SREBP target genes and sebocyte lipogenesis.

74 expression is restricted to differentiating sebocytes located in the suprabasal layers of the sebace

75 rget genes but also stimulated expression of sebocyte markers, suggesting that it may determine the d

76 tivation and long chain fatty acids finalize sebocyte maturation and are capable of stimulating epide

77 .1 mM stimulated significantly more advanced sebocyte maturation than any other treatment, including

78 turase in the cytoplasm of basal and luminal sebocytes of human scalp skin.

79 sheath and hair shaft and in the most mature sebocytes of the sebaceous gland and preputial, meibomiu

80 ages whereas IHH stimulates proliferation of sebocyte precursors.

81 erentiation of the sebaceous gland, with the sebocytes producing little or no sebum and undergoing ab

82 d hyperplasia resulted from expansion of the sebocyte-producing zone in sebaceous glands, with partic

83 he transcription factor GLI1 is activated in sebocyte progenitors, suggesting a paracrine signaling m

84 noleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient r

85 (termed 4.1) possesses activity to suppress sebocyte-specific expression and induce expression in th

86 sebocytes, we established a mouse line with sebocyte-specific expression of Cre recombinase.

87 s failed to elicit a PGE(2) response in SZ95 sebocytes stably expressing a dominant-negative PPARgamm

88 Cooling produced characteristic changes in sebocyte structure and migration.

89 on and lipid metabolism, their expression in sebocytes suggests they may also play a similar role in

90 on of proinflammatory cytokine IL-8 in human sebocyte SZ95 cells.

91 , lipogenesis assays were performed in SEB-1 sebocytes that were treated with PPAR ligands and isotre

92 amines were investigated for their effect on sebocytes, the major cell of the sebaceous gland respons

93 that IGF-1 transmits its lipogenic signal in sebocytes through activation of Akt.

94 450scc and P450c17 was demonstrated in SEB-1 sebocytes using radioimmunoassay.

95 histone H4 in the antimicrobial activity of sebocytes was confirmed by a specific neutralizing antib

96 f galectin-12, resistin, and SREBP-1 in SZ95 sebocytes was confirmed by Western blot analysis.

97 The sebaceous phenotype of SEB-1 sebocytes was confirmed using immunohistochemistry, Oil

98 the enhanced antimicrobial activity of human sebocytes was neutralized by anti-hBD-2 IgG.

99 d3, which is expressed exclusively in mature sebocytes, we established a mouse line with sebocyte-spe

100 Although not previously demonstrated in sebocytes, we report that 13-cis RA induces apoptosis in

101 When sebocytes were incubated with an H-1 receptor antagonist

102 Acid-soluble protein extracts of SEB-1 sebocytes were separated by reverse-phase high-performan

103 Sebocytes were treated with IGF-1 and assayed for activa

104 ation of individual sebocytes and cohorts of sebocytes, were measured.

105 Sebocytes, which are characterized by lipid accumulation

106 upregulate the expression of hBD-2 in human sebocytes, which may enhance the disinfecting activity o

107 ecause genetic tools that allow targeting of sebocytes while maintaining intact epidermal lipids are

108 lays a unique role in the differentiation of sebocytes, while peroxisome proliferator-activated recep

109 )36 fatty acid translocase on the surface of sebocytes with anti-human CD36 IgG or blocking the NF-ka

110 depleting LRC and induces differentiation of sebocytes within the interfollicular epidermis.