ライフサイエンスコーパス: second

1 ilobases at a velocity of 60 base pairs per second.

2 ntal neurons over timescales on the order of seconds.

3 first phase (0-2 min) mediated by VAMP2 and second (2-10 min) and third phases (10-30 min) mediated

4 One-third provided a second 24-hour collection.

5 following incorporation of (-)3TC-MP, with a second (-)3TC-TP molecule bound to the active site in th

6 Second, 6 second-line new agents have been recently deve

7 The second, a 47-year-old, patient's metastatic tumor extrac

8 Second, a simple nonlinear zonal advection with no ad ho

9 Second, a site approximately 20 residues downstream of t

10 onsistently decreased the reliability of the second action potential in each burst of activity.

11 erol that contains 16:1 (Delta3trans) as its second acyl group.

12 Strikingly, Vpr also engages a second, adjacent region, which connects the HIRAN and AT

13 Our second advance: the development of a low cost, portable

14 the scattered flour for 60 seconds every 10 seconds after sieving through three types of flour sifte

15 ele in a functional configuration, while the second allele has recombined only the DJ sequences; the

16 city offsets of less than 600 kilometres per second and linear offsets of less than 100 kiloparsecs.

17 leuprolide alone, the placebo month, and the second and third months of estradiol/progesterone.

18 iotics were discontinued after 2 days in the second and third patients.

19 epcidin concentrations are suppressed in the second and third trimesters, thereby facilitating an inc

20 s at a range of time points spanning several seconds and subsequently sort a mixed-cell population of

21 nd (psi) is centered between 260-280 Hz; the second, and stronger, band is a broad peak in the 400-50

22 their membrane potential on the timescale of seconds, and little is known about the downstream effect

23 gher among first-degree relatives than among second- and third-degree relatives of OCD and TD/CTD pro

24 a cava (temporal resolution, five images per second; and spatial resolution, 150-mm field of view, an

25 In a second step, a second antibody to ERBB2 quantitatively detects the boun

26 The second application involves monitoring of foulant deposi

27 Here, we demonstrate that Ssp1 activates a second ARK, Ssp2/AMPKalpha, for cell proliferation in lo

28 44 (46%) patients developed a second asparaginase-associated pancreatitis, 22 (52%) of

29 ow-up we contacted participants to conduct a second assessment (n=158).

30 everal orders of magnitude, from less than a second at 12.5 K, 100 mW/cm(2) to (an estimated) severa

31 Second, attention manifests itself as a response-gain fu

32 stence of different shade tolerances and the second axis for coexistence among species with the same

33 Second, based on an exploratory factor analysis, a two-f

34 apidly decreased VPpp neuron activity within seconds, beginning prior to water ingestion, upon presen

35 ing data from both human fetal ear and mouse second branchial arch tissue confirmed that genes locate

36 ciations between medications of interest and second breast cancer events was observed when surveillan

37 leads to a non-negligible population of the second bright pipi* state, which affects the dynamics, a

38 to time-varying stimuli from milliseconds to seconds but also, reveals differential contributions of

39 zation could involve Ru-N covalent bond, the second C-H functionalization most likely involves Ru-O c

40 The risk of all second cancers was 1.3-fold higher for HL survivors with

41 In the second case, a multi-metallic structure was fabricated v

42 In the second case, the affinities of a broad-spectrum inhibito

43 Second, cells appear capable of leveraging these unique

44 The recent discovery of a second class of high-Tc materials, Fe-based superconduct

45 This is the second clinical report of bilateral anterior uveitis ass

46 Genes in the second cluster can be rapidly suppressed by IL-10 even a

47 When located at the first or second codon position, N1-methyladenosine (m1A) and m1G

48 Significant associations were verified in a second cohort (Berlin cohort, n = 66).

49 herent integration with a compatible, stable second component.

50 outpatient sites in seven countries and the second (COMPOSE-2) at 69 outpatient sites in six countri

51 nown, common Ub conformation and a distinct, second conformation wherein the last beta-strand is retr

52 Second, considering the potential of PI for hydrocarbons

53 n was highest in RHP asymmetric dyads of the second contest, irrespective of experience.

54 The second context is social relationships, which link attit

55 Second, CsgA fibres protect cells individually by coatin

56 follow-up time of 7.8+/-2.2 years after the second CT.

57 The second derived feature is the very short spinal cord, wh

58 d and assessed with FB PET/CT followed by 20-second DIBH PET/CT.

59 Second, differences are seen in the base stacking of pai

60 using ultrafast chiral chromatography in the second dimension are successfully applied to the separat

61 se of chiral stationary phases (CSPs) as the second dimension in 2D-LC, especially in the comprehensi

62 The second domain has a known SWIB/MDM2 fold, which was not

63 In the second domain type, STEM revealed disordered vacancies o

64 Major second dose delays were common, especially for patients

65 the first part of a two-part study with the second dose-expansion part ongoing and enrolling patient

66 Second, echocardiographic PH (based on variable definiti

67 the Movement Assessment Battery for Children-Second Edition), and behavior problems (defined as a Tot

68 This second effect is correlated with and probably results fr

69 We present an all-plasmonic 116-gigabits per second electro-optical modulator in which all the elemen

70 probe containing electrolyte solution and a second electrode placed in a bulk electrolyte bath, to p

71 Second, emerging data that naturally occurring polyphosp

72 A 15-second end-expiratory occlusion and end-inspiratory occl

73 haracterized C. neoformans GMP synthase, the second enzyme in the guanylate branch of de novo purine

74 fective in improving the visual outcome of a second event should it occur.

75 our, photographed the scattered flour for 60 seconds every 10 seconds after sieving through three typ

76 T) excitatory neurons immediately (in 2 to 3 seconds) evoked binge-like eating.

77 determine its resistance phenotype and in a second experiment, a subset was chosen to compare fitnes

78 The second extracellular loop domain (E2) is primarily respo

79 ve ophthalmic examinations for first eye and second eye cataract surgeries.

80 re to determine if patient age, and first or second eye surgery affect intra-operative pain control o

81 Compared with first eye surgery, second eye surgery resulted in higher postoperative NEI-

82 Compared with second eyes, first eyes had worse mean preoperative BCVA

83 lin E (IgE), forced expiratory volume in one-second (FEV1) and forced vital capacity (FVC).

84 regimen on the forced expiratory volume in 1 second (FEV1), as compared with placebo.

85 ding to locations across their marine range; second, for the fields that elicited significantly non-r

86 3 layer thickness, but the ratio between the second gap and the bulk state gap remained about the sam

87 The second gap value decreased with increasing Bi2Se3 layer

88 s disorder and further establish DZIP1L as a second gene involved in ARPKD pathogenesis.

89 and P removal coupled to N2O generation in a second generation CANDO process, CANDO+P.

90 d safety of idelalisib in combination with a second-generation anti-CD20 antibody, ofatumumab, in a s

91 ly significant difference in the efficacy of second-generation antidepressants (SGAs) versus most oth

92 n this study, we report the development of a second-generation BET protein degrader, BETd-246, which

93 ere is a paucity of contemporary data on the second-generation drug-eluting stent use within SVG, and

94 highly effective drugs, including first- and second-generation proteasome inhibitors, immunomodulator

95 measurements of prion seeding activity with second-generation real-time quaking-induced conversion (

96 Human PET imaging using the second-generation TSPO radiotracer [(11)C]DPA-713 reveal

97 To investigate second-hand stress, we first created a stimulus set of v

98 a large interfacial nonlinearity probed via second harmonic generation that is sufficient to achieve

99 We also combine second-harmonic generation spectroscopy with polarizatio

100 >/=10-12 hours; 586 481 nonfasting) from the second harvest of the Very Large Database of Lipids stud

101 pment, two progenitor populations, first and second heart fields (FHF, SHF), sequentially contribute

102 Second, hermaphrodites recognize pheromone as male if th

103 The proposed mutants were tested in a second high-throughput AFM SMFS experiment revealing tha

104 itching from the highest conducting state to second-highest conducting state and a conductance ratio

105 Second, histone nanodomain clusters decompact into monon

106 l NSCLP and altered DNA methylation may be a second hit contributing to penetrance.

107 Second, hyperbolic metamaterials consisting of ultrathin

108 unctionally interacts predominantly with the second Ig-like polycystic kidney disease (PKD) repeat do

109 This paper, the second in a Series of four papers, reviews available met

110 gether in a period of time on the order of a second in the solid-state at ambient temperatures, up to

111 r shape fluctuations at short time scales of seconds in human cells.

112 ely long autocorrelation times up to several seconds, in absence of microscopic displacement, (4) inc

113 These findings identify a second inducible barrier to CNS entry at the GL.

114 Second, infiltrating immune cell populations were decrea

115 m control to trastuzumab emtansine after the second interim overall survival analysis crossed the pre

116 degradation by H2O2 is well-established, the second intermediate, 1,4,5,8-naphthalenetetrone, is repo

117 rd rates predicted the classification of sub-second intervals (steeper dilation = "Longer" classifica

118 d54Se32(SePh)48(dmf)4](4-) nanoclusters; the second is a unique porous CdSe crystal.

119 Second, it incorporates the strand information in the al

120 irst is the formation of a new molecule, and second its crystallization.

121 Chrysopidae (green lacewings) is the second largest family in Neuroptera, and it includes med

122 Prostate cancer is the second leading cause of cancer deaths in US men.

123 BK virus (BKV)-associated nephropathy is the second leading cause of graft loss in kidney transplant

124 It is the second leading cause of maternal mortality worldwide and

125 elirium, psychiatric disease, dementia, or a second lesion is required.

126 Second, lesion network mapping was used to identify brai

127 The second-level approach ideally involves strategies to pre

128 Second-line antiretroviral therapy (ART) based on ritona

129 2.6, 95% CI 2.5-2.8; p<0.0001) and switch to second-line ART (HR 5.2, 4.4-6.1; p<0.0001]) compared wi

130 The incidence of VF on second-line ART was 12.9 per 100 person-years (n = 23),

131 -based regimens and reduced use of expensive second-line boosted protease inhibitor regimens, this po

132 on-recommended 5-drug regimen while awaiting second-line drug-susceptibility test (DST) results.

133 ority of phenotypic resistance to first- and second-line drugs in MDR and XDR-TB.

134 for first-line drugs and 32 days sooner for second-line drugs.

135 Results PEM every 3 weeks followed by second-line IPI was both more effective and less costly

136 Second, 6 second-line new agents have been recently developed and

137 s in patients with CRPC receiving first- and second-line NHT and, to the best of our knowledge, is th

138 tries and randomly assigned (1:1) to receive second-line oral buparlisib (100 mg once daily) or place

139 ncer, there is no established therapy in the second-line setting.

140 med RR-TB and those reported to have started second-line treatment.

141 perturbed by the excitonic state, and then a second linear-response TDDFT calculation is used to dete

142 Here we report a second lipid A modification mechanism that only function

143 A second lobe contains the ORC2/3 subunits.

144 rate transformation in the Yellow River, the second-longest river in China.

145 A second low-lying dark state, involving the nitrogen lone

146 The second major phase involves ecological shifts associated

147 t first measurement and 38.6+/-36.5 ng/mL at second measurement) than in controls (4.1+/-7.6 ng/mL, p

148 ose without at the first (median, 0 vs 9.5), second (median, 3.5 vs 9), and third (median, 0 vs 10.5)

149 which produces the cyclic dinucleotide (CDN) second messenger cGAMP to activate the signaling adaptor

150 RATIONALE: Although the second messenger cyclic AMP (cAMP) is physiologically be

151 w that Csm6 proteins are activated through a second messenger generated by the type III interference

152 Calcium (Ca(2+)) is an essential second messenger required for diverse signaling processe

153 ) focuses and insulates termination of local second messenger responses.

154 Phosphatidic acid (PA), a second messenger typically derived from the lipid-hydrol

155 by binding of a novel tetrameric form of the second messenger, 3-5 cyclic diguanylic acid (c-di-GMP)

156 mediator TGF-beta remained the same and the second messenger, Smad2/3, accumulated in the nucleus.

157 aryotic cells, including well-known roles as second messengers and cofactors that help regulate diver

158 PhyAmm) in complex with the known eukaryotic second messengers Ins(1,3,4,5)P4 and Ins(1,4,5)P3 Both e

159 hance signaling through canonical downstream second messengers, a phenomenon we term "GPCR priming."

160 duction required intracellular signaling via second messengers-cytosolic calcium, reactive oxygen spe

161 A second model simulated current and future ragweed pollen

162 Interaction with a second molecule of BF3 stabilizes the zwitterion and sup

163 aliper-like DNA-binding conformation and the second monomer exhibiting disrupted regulatory metal coo

164 nne chauffe, DBP and DEHP accumulated in the secondes more than in the brandy.

165 overuse provokes liver injury and it is the second most common cause of liver failure.

166 Tumors were the second most common lesion in both groups.

167 jects (53 carotids without IPH) to undergo a second MR examination (mean interval, 17 months +/- 4 [s

168 e in mean visual outcome of the first versus second NAION events (standardized mean differences of vi

169 A new design for second near-infrared window (NIR-II) molecular fluoropho

170 No differences in OS or second neoplasias were observed in in both trials.

171 Second neoplasms, spinal disorders, and pulmonary diseas

172 However, addition of the second nucleotide (kobs2) is 700-fold faster for tCfTP t

173 degrees C, cis-[Pd(IPr)2(eta(2)-O2)] adds a second O2 to form trans-[Pd(IPr)2(eta(1)-O2)2].

174 The second objective was to provide guidance regarding the o

175 The second observation is the discovery, in the inner layer

176 This is the second of the two White Papers from the fourth UC Davis

177 Here we report the rapid growth (seconds) of micrometre-sized, face-centred-cubic, three-

178 strong mass enhancement at the QCP, and the second one is insensitive to the QCP.

179 nonfunctional due to chronic rejection, the second one is viable yet considerably limited in complex

180 placebo for the first year, and Phl-SCIT the second one.

181 Factors associated with second opinion use were evaluated using logistic regress

182 certain results on genomic testing predicted second opinion use.

183 ely increase patient dissatisfaction, use of second opinions, or loss of the patient to a second surg

184 the DC surface potential is screened with a second optical pump pulse.

185 ecimens collected prior to initiation of the second or later lines of therapy.

186 , we analyze the precision of the first- and second-order analytical uncertainty approaches by compar

187 d by first-order cues (luminance) as well as second-order cues (contrast, texture).

188 e propose that momentum-space mapping of the second-order non-linear structure factor is the source o

189 Second, our evolutionary simulations demonstrated that a

190 ion, including exercise duration (535 vs 540 seconds; P = .62), estimated metabolic equivalent of tas

191 n, which binds to the IFN-beta promoter, and second, p38-mediated inactivation of the mRNA-destabiliz

192 f detection of this regime is defined with a second parameter (beta = 2) and is chosen in analogy to

193 The second part focuses on one of the most distinctive, but

194 In the second patient, we observed polyclonal seeding, in which

195 terminal modification may be combined with a second peripheral (4-chlorobiphenyl)methyl (CBP) additio

196 Strengthening by precipitation of second phase is the guiding principle for the developmen

197 The second phase of the biphasic force decay upon release of

198 soriented grains, and the suppression of big second phase particles in this 3.2 mum thick REBa2Cu3Ox

199 dock) newcomer SGs accounted for the reduced second-phase GSIS.

200 Second, plasmonic nanoparticles are explored as image co

201 which hydrolyze peptides with proline at the second position (P1').

202 prefers the basic amino acid arginine at the second position of the peptide, and hydrophobic and pola

203 The second prediction is that iron-related proteins are dram

204 ed as time from randomization to recurrence, second primary cancer, or death.

205 erarchical testing strategy was used for the second primary end point and the secondary end points in

206 ncrease in haematological adverse events and second primary malignancies, lenalidomide maintenance th

207 The second process depends on internal forward models that u

208 raction with Hac1, the master regulator of a second proteotoxic stress response, the unfolded protein

209 he extent that the carboxyl group acquires a second proton (1H(+)).

210 Interestingly, the addition of the second proton and nucleophile occurs in a 1,4-fashion, a

211 ring TB treatment [first quintile, referent; second quintile hazard ratio (HR)=1.03 [95% confidence i

212 ival (hazard ratios: first readmission 0.88, second readmission 0.90, third readmission 0.44; p > 0.0

213 otoactivatable chemistry toolbox here with a second reagent, sulfo-SBP (benzophenone).

214 ost probably by downregulating SDF-1 and the second receptor of the chemokine (CXCR4) expression.

215 ghted imaging), acquired within 8 minutes 45 seconds (referred to as biparametric MR imaging), and es

216 orter intervals of signaling quiescence, the second response is blunted relative to the first respons

217 r intervals of quiescence induce an enhanced second response.

218 ifferent levels of complexity, followed by a second resting-state scan.

219 butes to differentiation of gametes, and the second restricts the regulatory influence of new inserti

220 c leukaemia who were due to receive first or second salvage treatment were randomly assigned (1:1) vi

221 a contact lens-based approach in a single 2-second scan.

222 formation, we propose fitting both first and second scans simultaneously.

223 mm Hg or greater and less than 170 mm Hg at second screening underwent renal angiography and were ra

224 In contrast, a second segment, 15-25 WT, forms non-toxic labile beta-sh

225 offspring and exhibiting greater V k* in the second sex.

226 mutations in contact residues, or so-called "second shell" residues, that increase affinity are typic

227 Conditional analyses identified a second signal near CD163-APOBEC1.

228 We identified second-site mutations and growth conditions that suppres

229 hese interactions genetically and identified second-site suppressors of lethal mutations in SP.

230 in the rostral half of the claustrum, with a second, smaller patch of cells in the caudal, ventrolate

231 A second SPB-associated scaffold, Cut12, promotes SPB-asso

232 Treatment of the second-stage juveniles (J2) juveniles of PPN Meloidogyne

233 P)-dependent transaminase BioA catalyzes the second step in the biosynthesis of biotin in Mycobacteri

234 The second step involved anti-valgus osteotomy of the right

235 The second step uses the correlation between residuals of th

236 ptide with the more specific KalbTG and in a second step with the less specific MTG from Streptomyces

237 In a second step, a second antibody to ERBB2 quantitatively d

238 ach, which incorporates the alkanethiol in a second step, gives rise to a heterogeneous distribution

239 In a second step, gray scales, iodine deposition, and Hounsfi

240 In the second step, in the subset of participants with DLPFC DN

241 In the second step, the trisaccharide is specifically hydrolyze

242 In a second step, we selectively expanded this curated map wi

243 o determine the timing of acquisition of the second strain.

244 2 may be protective against infection with a second strain.

245 n of the beta-d-idopyranosides, so instead a second strategy was employed, which involved first carry

246 Characterization of a second strong allele confirms the function of PPR78 in n

247 second opinions, or loss of the patient to a second surgeon.

248 second surgical opinion, and surgery from a second surgeon.

249 Pathology reports of all patients having a second surgery and a 30% sample of those with 1 surgery

250 on with surgical decision making, receipt of second surgical opinion, and surgery from a second surge

251 A second team focused on replicating the key claim of an i

252 and design, as recently discussed during the second Telluride Science Research Center workshop organi

253 The RMS of a second test set composed of 913 examinations from the pu

254 ifferences between nonhuman species (G), the second that concerns observing individual differences wi

255 Second, the activity of neurons in OFC and MFC rapidly e

256 Second, the commercial software was used to assemble pai

257 Second, the DeOC containing saturates, aromatics, resins

258 without directing the lever arm forward; and second, the lever arm reaches the poststroke orientation

259 Second, the projection step comes first, implying all su

260 Second, the well-known synergism between metals and warm

261 The second theme described the need to 'fit in' with organis

262 Second, there may be high functional redundancy in the m

263 Moreover, greater improvement in second/third interdigit cortical separation distance fol

264 .8 mm translation per repetition time of 1.6 seconds throughout >10 minutes).

265 The second-tier tests include CT colonography every 5 years,

266 cate a human pathogen from the world for the second time ever.

267 hermally stable dimers dissociate on the sub-second timescale when subject to a stretching force of 1

268 highest of any cancer and the death rate was second to that of lung cancer.

269 pounds with Z isomer half-lives ranging from seconds to hours, to days and to years, and variable abs

270 to their light environment on a timescale of seconds to minutes.

271 A second tool enables authors to create interactive graphi

272 asmic domains via concerted movements of the second transmembrane segment and major coupling helix.

273 rofiles of progenitors between the first and second trimesters suggest that these cells had gestation

274 ch has shown that some species can perform a second type of startle called the S-start [5-7].

275 uman-like robots is, first, implausible and, second, undesirable.

276 early, with no increase in titer following a second vaccine dose.

277 the first validation cohort had 216, and the second validation cohort had 265 patients.

278 Our findings support the hypothesis that the second Vibrionaceae chromosome arose from an ancestral p

279 rtices that are stretched or compressed by a second vortex, we found conservation of total helicity.

280 rcinoscorpius-type claspers on the first and second walking legs in male individuals of Y. luopingens

281 r and matched previous related research; the second was added because it allowed the interpretation t

282 predominant presence of linalyl acetate; the second was characterized by chemotypes rich in cymyl-com

283 ck to consensus mutations" approach, and the second was computational design based on DeltaDeltaG cal

284 ndent, nonoverlapping replication cohorts: a second WB set (n = 448, acute) and two CD4 sets (n = 300

285 Second, we added gA-free DC22:1PC vesicles to both sides

286 Second, we demonstrate that reciprocal crosstalk does no

287 Second, we found conservation of tyrosine phosphorylatio

288 Second, we performed hierarchical clustering on the enti

289 Second, we physically adhered spheres to the surface of

290 Second, we quantified Snook distribution patterns when t

291 Second, we show that, whereas the thermopower is diffusi

292 Second, we used different K(+) concentrations to shift t

293 Second, we used two analyses to assess the spatial encod

294 Instead, a second Wg-responsive transcription factor, SoxNeuro (Sox

295 rance coverage and access to care during the second year of implementation, but it was also associate

296 The results suggest that by the second year of life, children make sophisticated and sub

297 UBJECTS AND Following ethics board approval, second year residents were randomized to a teaching inte

298 fe but emerge late in the first and into the second year.

299 " (37%) or "excellent" (44%), and most (55%) second-year fellows felt "fully prepared" for independen

300 e demonstrate how a missense mutation in the second zinc finger of Kruppel-like factor-1 (KLF1) leads