ライフサイエンスコーパス: secosteroid

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1 a potent anti-proliferative/immunomodulatory secosteroid.

2 mediated the AP-1 activation induced by this secosteroid.

3 ds were also analyzed for these steroids and secosteroids.

4 n addition to its calciotropic function, the secosteroid 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))

5 cate that PLC-gamma is a direct substrate of secosteroid-activated c-Src in these cells.

6 The secosteroid alkylated three tryptic peptides: 251GQFYYIS

7 This secosteroid also induced a twofold increase in the activ

8 isomerase activity from inactivation by the secosteroid and did not slow the inactivation of 3beta-H

9 esis, the beta-ketoester 2 was carried on to secosteroid (-)-astrogorgiadiol (3), a naturally occurri

10 y bound steroid was separated from unreacted secosteroid by reversed phase HPLC.

11 mia) have created interest in examining this secosteroid clinically in kidney transplantation.

12 was incubated with the purified enzyme (30/1 secosteroid/enzyme molar ratio) to produce an 80% loss o

13 validate specificity, the affinity labeling secosteroid has identified peptides in the enzyme that a

14 horus, and pituitary hormones as well as the secosteroid hormone 1,25VD.

15 itamin D3, a major natural metabolite of the secosteroid hormone, 1alpha,25(OH)2D3, were chemically s

16 Thus, we have detected novel CYP11A1-derived secosteroids in the skin, serum and adrenal gland and ba

17 The secosteroid inactivated 3beta-HSD by only 20% during the

18 The mechanisms by which this secosteroid influences these important cellular processe

19 The actions of these secosteroids involve both rapid, nongenomic effects and

20 phy and radioimmunoassays indicated that the secosteroid product of CYP2R1 was 25-hydroxyvitamin D3.

21 hat clarifies the structural determinants of secosteroid recognition and validates the predictive pow

22 /MS analysis following derivatization with a secosteroid signal enhancing tag that imparted a permane

23 s the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists.

24 s identify 20(OH)D3 as a biologically active secosteroid that induces keratinocyte differentiation.

25 Vitamin D is a secosteroid that is metabolically activated and degraded

26 three peptides and shifted the alkylation by secosteroid to a single tryptic peptide (135EIIQNGHEEEPL

27 inase inhibitor, blocked the ability of this secosteroid to stimulate the translocation and tyrosine

28 articular emphasis on the potential of these secosteroids to prevent colon cancer.

29 a marker of CaCo-2 cell differentiation, in secosteroid-treated cells.

30 led to stimulate PI hydrolysis, but required secosteroid treatment of intact colonocytes, suggesting

31 the biologically active hormonal form of the secosteroid vitamin D-classically categorized as a regul

32 ylator, 5,10-secoestr-4-yne-3,10, 17-trione (secosteroid), was incubated with the purified enzyme (30

33 Ketones on the protein-bound secosteroid were radiolabeled by reduction with sodium b

34 Vitamin D is a secosteroid with known effects on calcium homeostasis th

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