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1 psis, PS protein can be processed and SYS is secreted.
5 neal toxicity and that some species of coral secrete a substance known as palytoxin, a potent vasocon
8 We found that human iPSC-derived astrocytes secreted abundant apoE with apoE4 lipoprotein particles
9 y levels for years due to the immunoglobulin-secreting activity of long-lived plasma cells (LLPCs).
10 by OCN, thus suggesting that osteoblasts may secrete additional hormones that regulate different aspe
11 tion of the model by introduction of data of secreted adiponectin yielded a very close resemblance be
12 en intensively investigated, the function of secreted AGR2, especially its exact mechanism of action
13 of the pancreatic islet, including glucagon secreting alpha-cells, but particularly in insulin-secre
15 , triggered by pheromones that they produce, secrete and sense under conditions influenced by the env
16 zymatic activity of two key MMPs known to be secreted and activated in neuroinflammation, MMP2 and MM
19 eta-catenin signaling is in part achieved by secreted and membrane proteins that negatively control a
20 was ruled out using DHLMP2A mice, which lack secreted and membrane-bound Ab, yet harbor marginal zone
21 l library encoding approximately 100 million secreted and membrane-bound single-chain antibodies and
24 nce in TL1A-mediated expression between IFNG-secreting and non-secreting T cells (P < 1 x 10(-5)).
31 rated that DdPoxA is up-regulated and likely secreted at late multicellular development stages of D.
32 Microbe, Tegtmeyer et al. (2017) show that a secreted bacterial protease disrupts apical-junctional c
34 ing alpha-cells, but particularly in insulin-secreting beta-cells, where we provide evidence for its
36 rom ICOVIR-15K-cBiTE-infected cells, and the secreted BiTEs bound specifically to both CD3(+) and EGF
38 the type IV secretion system (VirB) and the secreted BPE005 protein, which were partially corroborat
39 naling.MANF is a neurotrophic factor that is secreted but also mediates the unfolded protein response
40 uals with the dG allele, where it was poorly secreted but highly functional, even at concentrations <
42 en together, our findings establish that EVs secreted by AFSC could target a specific signaling pathw
43 alloproteinase anthrax lethal factor (LF) is secreted by Bacillus anthracis to promote disease virule
44 ative signaling pathways mediated by factors secreted by BM stromal cells and involved a switch from
47 throferrone (ERFE) is a glycoprotein hormone secreted by erythroblasts in response to stimulation by
48 studies identified IL-6 and CXCL8 as factors secreted by EVTs that induce endothelial cell CCL14 and
49 Cerato-platanin proteins (CPs), which are secreted by filamentous fungi, are phytotoxic to host pl
50 ently been identified that protein effectors secreted by fungal pathogens can spread between host cel
51 4 (which we have renamed TseF) appears to be secreted by H3-T6SS and is incorporated into outer membr
52 el, our data indicate that HBD2 and HBD3 are secreted by hCVAM and directly contribute to its activit
54 ified as a cancer-promoting cytokine that is secreted by infiltrating immune cells in several cancer
55 pport a model wherein a pre-TfH wave of IL-4 secreted by interfollicular NKT cells triggers the seedi
56 of immunoglobulin A (IgA) are constitutively secreted by intestinal plasma cells to coat and contain
59 activation to better understand the factors secreted by mast cells that are relevant to the contribu
60 ayashi et al. (2017) show that exosomal miRs secreted by mesenchymal cells can regulate epithelial KI
61 Regulation of glucagon secretion by factors secreted by neighbouring beta- and delta-cells (paracrin
68 Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyog
69 ecretion enzyme is a potent phospholipase A2 secreted by the Gram-negative opportunistic pathogen, Ps
71 btilisin (50 nm to 2 mum), a serine protease secreted by the non-pathogenic bacterium Bacillus subtil
74 athogen-enriched protein families putatively secreted by type II secretory system: PheA (CM-sec), Lip
75 g tissue eosinophils and inflammation, mucus-secreting cell (MSC) numbers, type 2-associated cytokine
76 stellate cells (HSCs), the primary collagen-secreting cell in liver, and queried against a transcrip
79 w endogenous Spl expression level in insulin-secreting cells contributes to their extraordinary vulne
80 ted with low frequencies of ZIKV-specific Ab-secreting cells in lymph nodes and bone marrow, correlat
82 n and maintenance of these critical antibody-secreting cells may serve as potential therapeutic targe
84 ody production and the frequency of antibody-secreting cells were significantly elevated in NP, and t
85 ovide help to B cells for developing into Ab-secreting cells, were similar between responders and non
91 set of gp120-specific interleukin-21 (IL-21)-secreting CXCR5(+) CD4(+) T cells were significantly ass
95 Autocrine motility factor (AMF) is a tumor-secreted cytokine that stimulates tumor cell motility in
97 tional assessment of iMGLs reveals that they secrete cytokines in response to inflammatory stimuli, m
98 e damage occurs, immune cells infiltrate and secrete cytokines, including IL-6, to repair skeletal mu
99 , is located in pollinated flower styles and secreting downy hairs, transporting a derivative of camp
100 e is known about how and where effectors are secreted during infection, yet such knowledge is essenti
102 actin filament dynamics.Microbial pathogens secrete effector proteins into host cells to affect cell
103 strains contain genomic expansions of Type V secreted effectors (autotransporters) that are critical
104 at the study of inflammatory cells and their secreted effectors has provided important insights into
105 acteriaceae expressing the Yersinia HPI also secrete escherichelin, a second metallophore whose chemi
108 nduced in the resistant cancer cells and the secreted exosomes are intricately associated with the re
109 in APP C-terminal fragment (CTF) content in secreted exosomes, but had minimal effects on APP lysoso
110 quiescent HSCs to HSC myofibroblasts, which secrete extracellular matrix proteins responsible for th
115 t S. aureus protease SspA/V8 is the dominant secreted factor (in laboratory and AD clinical strains o
118 verall, our work demonstrates that astrocyte-secreted factors alter migration and morphology of metas
120 eige fats engage other metabolic tissues via secreted factors to influence systemic energy metabolism
123 e significance of the cytoplasmic versus the secreted form of mutant SOD1 in the pathology of ALS.
124 nd immunohistochemistry were used to analyze secreted frizzled-related protein 2 expression and prote
129 nd Streptococcus, are small, linear peptides secreted from cells and subsequently detected by sensory
130 alarmins." Alarmins are endogenous molecules secreted from cells undergoing nonprogrammed cell death
132 Further investigation suggested that CCL5, secreted from HCV-exposed macrophages, activates inflamm
134 T3 that can be formed upon iodination of TG secreted from PCCL3 (rat thyrocyte) cells was augmented
138 and beta cells and intestinal L and K cells, secreting glucagon, insulin, and the incretins glucagon-
141 oblasts from obese OA patients were found to secrete greater amounts of the pro-inflammatory cytokine
143 es through angiocrine factors, which include secreted growth factors (angiokines), extracellular matr
145 A) is a stable, monomeric, glycosylated, and secreted heme peroxidase with homology to mammalian pero
148 node cultures from VDR KO and B-VDR KO mice secreted higher IgE ex vivo than wild-type (WT) cultures
150 nts and oxygen required for fetal growth and secretes hormones that facilitate maternal allocation of
151 target Hsp90 in cancer, that is, the tumour-secreted Hsp90alpha, instead of the intracellular Hsp90a
154 n, T-bet, and Blimp-1, and that more of them secrete IFN-gamma and readily degranulate than non-ThCTL
155 d naive T cells from healthy volunteers also secreted IFN-gamma, IL-13, IL-22, and cytolytic molecule
157 tients, but not controls, were stimulated to secrete IgG and increase CD27 expression when cultured w
159 of CD4(+) effector memory T (TEM) cells that secrete IL-17A, but not IFN-gamma, was responsible for e
162 after autophagy blockade revealed levels of secreted IL6, IL8, and other cytokines were modulated by
163 nd activation markers, and proliferation and secreted immunoglobulin levels were analyzed by using fl
165 how a peculiar role for the chemokine CXCL12 secreted in early PDAC and for its receptors CXCR4/CXCR7
166 icroscopy analyses indicated that Cavin-2 is secreted in endothelial microparticles (EMPs) and is req
167 is responsible for the majority of proteins secreted in the blood (whether based on mass or range of
171 s are then expressed from mammalian vectors, secreted into culture media, purified by affinity chroma
172 bits both lipase and protease activities, is secreted into macrophages, and catalyzes host lipid hydr
174 zed extracellular vesicles, called exosomes, secreted into ML after trauma/hemorrhagic shock (T/HS) h
177 RFP) fusion protein with a signal peptide to secrete it from plant cells, did not passively re-enter
178 ural habitat and low-pH environment of toxin-secreting killer yeasts, K28 is structurally stable and
180 llular levels of NF-kappaB and calpain-2 and secreted levels of the proangiogenic proteins intercellu
181 ells incubated with ERBB inhibitors began to secrete ligands for the TGFbeta receptor and underwent E
183 e of VDAC channels in the transport of known secreted M. avium proteins, we demonstrated that the por
186 cells lie on the surface of the root cap and secrete massive amounts of mucilage that contains polysa
188 over, we show that starved human fibroblasts secrete matrix proteins that maintain the growth of star
193 hese data indicate that recombinant incretin-secreting microbes may offer a novel and safe means of m
194 We found that these cardiac myofibroblasts secrete milk fat globule-epidermal growth factor 8 (MFG-
195 that Gnb5 knockout in mice or in the insulin-secreting MIN6 cell line almost completely eliminates in
197 infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2
199 ate the expression of diverse genes encoding secreted molecules and extracellular matrix components t
200 e bone morphogenetic protein (Bmp) family of secreted molecules has been extensively studied in the c
201 embrane component of gram-negative bacteria, secrete more EVs than cholangiocytes incubated with vehi
206 on cells (RGCs) in the eye to characterize a secreted neuroprotective signal present in retinal astro
208 rage compartment and insulation barrier, and secretes numerous endocrine mediators such as adipokines
212 domonas quinolone signal (PQS) compound is a secreted P. aeruginosa virulence factor that contributes
213 ns, that HD5 is also expressed as an active, secreted peptide by epithelial ovarian and lung cancer c
214 (SIP)] during high cell density and uses the secreted peptide for cell-to-cell signaling to induce po
217 sing three determinants of pathogenesis: two secreted phospholipases C (PLCs; PlcA and PlcB) and a su
221 ly prominent pathogen Streptococcus pyogenes secretes potent immunomodulatory proteins known as super
225 MerTK and, when exposed to apoptotic cells, secreted proreparative cytokines, including transforming
228 utant EGFR, EGFRvIII, and abrogated gains in secreted proteases, MMP-2 and MMP-9, following radiation
229 rt-lived plasma cells (PCs) that can rapidly secrete protective antibodies within days of vaccination
231 ng the TGF-beta superfamily signaling with a secreted protein can alter the physiology and thermogeni
232 w that Sonic hedgehog (Shh), which encodes a secreted protein signal, is expressed in these sensory n
234 d it encodes a small ( approximately 27-kDa) secreted protein unrelated to other cytokine families, s
237 roteinase with thrombospondin motifs-4) is a secreted proteinase involved in inflammation and matrix
238 s one means by which Gram-negative pathogens secrete proteins into the extracellular milieu and/or ho
239 eria use type 2 secretion systems (T2SSs) to secrete proteins involved in virulence and adaptation.
242 e' screen of all Drosophila cell-surface and secreted proteins containing immunoglobulin superfamily
243 ly, we defined the repertoire of pollen tube-secreted proteins controlled by a group of MYB transcrip
251 enzymes that attach 16-carbon fatty acids to secreted proteins, revealed that neither enzyme will acc
256 The kielin/chordin-like protein (KCP) is a secreted regulator of the TGF-beta superfamily pathways
259 epidermal patterning factor (EPF) family of secreted signaling peptides regulate the frequency of st
261 ction of secreted proteases is stimulated by secreted signals that convey information about the utili
262 ng (QS) is a mechanism wherein P. aeruginosa secretes small diffusible molecules, specifically acyl h
263 hermore, we find that a combination of tumor secreted soluble factors and receptor-ligand interaction
264 neurosecretory neurons, including those that secrete some of the Drosophila insulin-like peptides.
265 on, and also demonstrates a novel role for a secreted staphylococcal protease as a requirement for th
269 g and skin-resident, antigen-specific, IL-22-secreting T cells are detectable in patients with beta-l
270 We demonstrated that in addition to being secreted, TFPI-2 was also distributed throughout the cyt
272 CX-9 functions in hypodermal seam cells that secrete the axon guidance cue UNC-129/BMP, and our data
274 ls (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-t
275 d proliferative potential yet preferentially secrete the Th1 and Th17 cytokines interferon-gamma and
276 hemokine-mediated recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBC
277 ed primarily and abundantly in the liver and secreted through the kidneys, exhibit male-biased expres
279 nate esters stimulated gammadelta T cells to secrete TNF-alpha in response to a variety of tumor cell
281 nse, it augmented the frequency of IFN-gamma secreting total T cells, T-helper and CTLs against both
283 sensing controlled virulence factors include secreted toxins responsible for extensive damage to host
287 on, CD19(pos), CD19(low), and CD19(neg) ASCs secrete vaccine-specific Abs and show linked IGHV repert
288 replicative niches, intracellular pathogens secrete various virulence proteins, called effectors, to
289 gineer the rhizosphere to their advantage by secreting various nutrients and secondary metabolites.
290 te cells, we show that a significant part of secreted vaspin is bound in the extracellular matrix on
291 culosis (Mtb) infection, in particular early secreted versus dormancy related latency antigens expres
294 so observed increased accumulation of IL-17A-secreting Vgamma4 gammadelta T cells and heightened leve
297 These data show that ammonia is not only a secreted waste product but also a fundamental nitrogen s
299 rotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory v
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