ライフサイエンスコーパス: secretin receptor

1 to complement this with other domains of the secretin receptor.

2 abeling a single protomer of the homodimeric secretin receptor.

3 calcitonin receptor with no activity at the secretin receptor.

4 the proposed third extracellular loop of the secretin receptor.

5 of four extracellular regions of the intact secretin receptor.

6 rther confirmed by mutagenesis of the intact secretin receptor.

7 ocumented, including the prototypic family B secretin receptor.

8 utive oligomers with themselves and with the secretin receptor.

9 a new molecular model of the ligand-occupied secretin receptor.

10 the glucagon-like peptide-1 receptor or the secretin receptor.

11 residues within secretin and the prototypic secretin receptor.

12 at the prototypic member of this family, the secretin receptor.

13 nd covalently labeled the Mr = 57,000-62,000 secretin receptor.

14 ligand and the amino-terminal domain of the secretin receptor.

15 expressing wild-type and chimeric calcitonin-secretin receptors.

16 d sequencing of labeled wild-type and mutant secretin receptors.

17 been described for both cholecystokinin and secretin receptors.

18 to suppress hormone action at the wild-type secretin receptor (1).

19 The secretin receptor, a class II GPCR, is a GRK substrate,

20 The endocytic pathway of the secretin receptor, a class II GPCR, is unknown.

21 Based primarily on studies with the secretin receptor, a prototype class B family member, th

22 The secretin receptor, a prototypic family B G protein-coupl

23 fuse pharmacophoric domain that binds to the secretin receptor, a prototypic member of the Class B fa

24 Since secretin receptors activate PKA, we tested the hypothesi

25 losest structurally related receptors to the secretin receptor also form constitutive oligomers with

26 ibrosis transmembrane conductance regulator, secretin receptor, and nuclear receptors.

27 t the carboxyl terminus of VPAC1, VPAC2, and secretin receptors, and performed BRET and morphologic f

28 Secretin receptors are also expressed both in PC dendrit

29 ence complementation to demonstrate that the secretin receptor associates specifically with RAMP3, bu

30 It covalently labeled the secretin receptor at a single site saturably and specifi

31 g a concentration-dependent cAMP response in secretin receptor-bearing cells.

32 s a potent stimulant of cAMP accumulation in secretin receptor-bearing Chinese hamster ovary-SecR cel

33 BRET studies showed that, like the secretin receptor, both VPAC receptors exhibited constit

34 de bonding pattern of the prototypic class B secretin receptor by applying the same paired cysteine m

35 ical sodium-dependent bile acid transporter, secretin receptor, cilia and cystic fibrosis transmembra

36 (CD44, CD24, EpCAM, aquaporin 5, claudin-4, secretin receptor, claudin-7, V-ros sarcoma virus oncoge

37 When these peptides probed 61 human secretin receptor cysteine-replacement mutants, a broad

38 on of PKCbetaII; and (iii) de novo expressed secretin receptor, cystic fibrosis transmembrane regulat

39 Secretin receptor-deficient mice are overtly normal and

40 Furthermore, secretin receptor-deficient mice show abnormal social an

41 We have generated secretin receptor-deficient mice to explore the relation

42 Although GRK activity appears important in secretin receptor desensitization in HEK 293 cells, prot

43 ing this epitope act as full agonists on the secretin receptor despite their lack of amino acid homol

44 on adrenomedullin activity, with increasing secretin receptor expression competing for RAMP3 associa

45 Similarly, secretin receptor expression had functional effects on a

46 Mth, like secretin receptor family members, has a large N-terminal

47 t mechanisms of desensitization exist in the secretin receptor family that should help protect recept

48 mologous to lectin, olfactomedin, mucin, the secretin receptor family, and a novel structural motif c

49 G-protein-coupled receptor, a member of the secretin receptor family.

50 elated to G protein-coupled receptors of the secretin receptor family.

51 As the secretin receptor forms constitutive homodimers, we expl

52 to demonstrate that the prototypic family B secretin receptor forms ligand-independent oligomeric co

53 chemical sequencing of photoaffinity-labeled secretin receptor fragments established that Val4 was th

54 The expression of secretin receptor gene and secretin-induced cAMP levels

55 al secretion was estimated by measurement of secretin receptor gene expression and adenosine 3',5'-cy

56 merization of the Class II G protein-coupled secretin receptor has been reported, but the molecular b

57 It covalently labeled the secretin receptor in a saturable and specific manner.

58 Overexpression of wild-type secretin receptor in Panc-1 cells driven by transfection

59 entified a novel abnormal spliceoform of the secretin receptor in pancreatic and bile duct cancers an

60 sence and function of molecular forms of the secretin receptor in pancreatic cancer cell lines and in

61 oratory suggest expression of a low affinity secretin receptor in seven cell lines derived from human

62 This represented a variant of the secretin receptor in which the third exon was spliced ou

63 receptors were observed for similarly tagged secretin receptors in which all or part of the amino-ter

64 Thus, like the AT(1A)R, secretin receptor internalization is not inhibited by re

65 cence imaging, and compare the properties of secretin receptor internalization to that of the beta(2)

66 lasma membrane localized receptors; however, secretin receptor internalization was not reduced by exp

67 The secretin receptor is a member of a structurally distinct

68 onstrate that the agonist occupied wild-type secretin receptor is predominantly in a guanine nucleoti

69 The secretin receptor is prototypic of a recently described

70 The secretin receptor is prototypic of a recently described

71 The secretin receptor is prototypic of the class II family o

72 on-PCR and sequencing demonstrated wild-type secretin receptor mRNA in each of four cell lines and th

73 ogical FRET was utilized to demonstrate that secretin receptor oligomerization occurred at the cell s

74 We conclude that secretin receptor oligomerization occurs through -GxxxG-

75 's membrane-spanning core is responsible for secretin receptor oligomerization.

76 Unlike secretin receptor oligomers that were unaffected by liga

77 We demonstrate agonist-dependent secretin receptor phosphorylation coincident with profou

78 with a model of secretin occupying a single secretin receptor protomer within the homodimeric recept

79 g cholecystokinin and acetylcholine, whereas secretin receptors regulate duct cells.

80 functionally important amino terminus of the secretin receptor represents a structurally independent,

81 hly aggressive malignancies that evolve from secretin receptor-rich ductular cells.

82 It covalently labeled the secretin receptor saturably in a single site.

83 The molecular mechanisms of secretin receptor signal termination are unknown.

84 phorylation appeared to be less important in secretin receptor signal termination.

85 cysteine residues within this region of the secretin receptor singly and in pairs resulted in loss o

86 nist (EC(50) = 72 +/- 6 pm) and bound to the secretin receptor specifically and with high affinity (K

87 in cancer, we evaluated whether an abnormal secretin receptor spliceoform were present, characterize

88 mulates ductal secretion by interacting with secretin receptor (SR) activating cyclic adenosine 3',5'

89 The secretin/secretin receptor (SR) axis is up-regulated by prolifera

90 way and is closely associated with increased secretin receptor (SR) expression.

91 tal secretion was assessed by measurement of secretin receptor (SR) gene expression and secretin-indu

92 al cholangiocytes, increasing DNA synthesis, secretin receptor (SR) gene expression, and adenosine 3'

93 measurement of secretin-induced choleresis, secretin receptor (SR) gene expression, and cyclic adeno

94 eptide hormone, secretin (SCT) that binds to secretin receptor (SR), is a key mediator in cholangiocy

95 (1) secrete bicarbonate by interaction with secretin receptors (SRs) through activation of cystic fi

96 These findings suggest that the secretin receptor system has an important role in the ce

97 a new radioiodinatable agonist ligand of the secretin receptor that incorporates a photolabile p-benz

98 Secretin receptors that are key for regulation of health

99 eloped a new probe for affinity labeling the secretin receptor through a photolabile benzoyl-phenylal

100 a single amino acid in the second TM of the secretin receptor to the corresponding residue in the PT

101 This study demonstrates that the ability of secretin receptor to undergo GRK phosphorylation and bet

102 of exogenous RAMP transfection, although the secretin receptor trafficks normally to the cell surface

103 This was attached to a homology model of the secretin receptor transmembrane bundle, with the two dom

104 carboxyl-terminal (COOH-terminal) truncated secretin receptor using flow cytometry and fluorescence

105 progressive cleavage of wild type and mutant secretin receptors (V13M and V16M) and sequence analysis

106 ssplicing is responsible for expression of a secretin receptor variant having the ability to suppress

107 r specimens and no normal tissue expressed a secretin receptor variant with exons 3 and 4 deleted.

108 gy model of the amino-terminal domain of the secretin receptor was developed using the NMR structure

109 tor-bearing Chinese hamster ovary cells, the secretin receptor was shown to have growth-inhibitory ef

110 n of a functional, N-terminal epitope-tagged secretin receptor was used to demonstrate agonist-depend

111 th the wild-type and COOH-terminal truncated secretin receptors was unaffected by GRK phosphorylation

112 tly transfected HEK 293 cells expressing the secretin receptor, we investigated its mechanisms of des

113 e first 10 residues of the N terminus of the secretin receptor were critical.

114 specific high-affinity dimeric state of the secretin receptor, which may be typical of family B G pr

115 ct cells expressing wild-type or C11A mutant secretin receptor with a cell-impermeant sulfhydryl-reac

116 This probe specifically bound to the secretin receptor with high affinity (IC50 = 13.2 +/- 2.

117 However, coexpression of secretin receptors with either type of VPAC receptor res

118 ide cleaved a series of wild type and mutant secretin receptors, yielding patterns that agreed with o