ライフサイエンスコーパス: secretory

1 l tissue growth as well as reduced glandular secretory activity of the lesions.

2 activity were measured by Griess method and secretory alkaline phosphatase reporter activity assay,

3 eloblasts were capable of differentiating to secretory ameloblasts; this process, however, was appare

4 abolism, there is mounting evidence that the secretory and autophagy pathways are intimately linked a

5 The secretory and autophagy pathways can be thought of as th

6 specialized for different functions: basal, secretory and ciliated cells in the conducting airways a

7 ecent advances in understanding the roles of secretory and endocytic membrane trafficking pathways in

8 ally and evolutionarily, they unite not only secretory and endocytic organelles but also the flagellu

9 (and thus polarity) of Rab GTPases along the secretory and endocytic pathways are established by thei

10 retory pathway along which newly synthesized secretory and membrane proteins traffic through the cell

11 Basal, secretory and type II cells can be grown in three-dimens

12 Spikes reminiscent of exocytotic events in secretory animal cells progressively increased in freque

13 y, this Pet system was used to express early secretory antigen 6 (ESAT-6), an immunodominant and diag

14 sample was subjected to Toxocara excretory - secretory antigen ELISA (TES - ELISA).

15 amma production triggered by the 6-kDa early secretory antigen target (ESAT-6), taking into account t

16 M. tuberculosis 6-kDa early secretory antigenic target (ESAT-6) is a known potent vi

17 type VII secretion system ESX-1 [6-kDa early secretory antigenic target (ESAT-6) secretion system 1]

18 R) latency, but not classical immunodominant secretory antigens, to clearly differentiate LTBI from E

19 e cell surface of Bacteroidetes depends on a secretory apparatus known as type IX secretion system (T

20 translation initiation, the availability of secretory apparatuses, and the composition of the coding

21 lysosomal damage, the prototypical cytosolic secretory autophagy cargo IL-1beta is recognized by spec

22 cargo IL-1beta is recognized by specialized secretory autophagy cargo receptor TRIM16 and that this

23 How secretory autophagy diverges from degradative autophagy

24 results establish an oncogenic function for secretory autophagy in HNSCC stromal cells that promotes

25 Our findings identify a role for secretory autophagy in intestinal defense and suggest wh

26 Thus, secretory autophagy utilizes a specialized cytosolic car

27 Secretory autophagy was disrupted in Paneth cells of mic

28 Secretory autophagy was triggered in Paneth cells by bac

29 acterial infection, lysozyme is rerouted via secretory autophagy, an autophagy-based alternative secr

30 ing cytokine arrays, we identified potential secretory biomarkers of gemcitabine resistance (response

31 onserved mechanism that not only reduces the secretory burden on beta-cells but also avoids the poten

32 ntrol subjects, indicating reduced beta-cell secretory capacity and alpha-cell function.

33 disruption in ZnT2 function as a modifier of secretory capacity and lactation performance.

34 The secretory capacity of a cell is constantly challenged by

35 with pharmacological agents, which boost the secretory capacity of beta-cells, is linked to adverse s

36 ore, because of the remarkable signaling and secretory capacity of the GLP-1 system, we sought to dis

37 Thus, whether secretory cargo is locally trafficked in dendrites throu

38 ted cargo delivery, for both PM-destined and secretory cargo, providing the first evidence of selecti

39 sufficient by itself to induce and maintain secretory cell architecture.

40 of Apc and control intestinal stem cell and secretory cell homeostasis by downregulation of multiple

41 Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the so

42 ral hypersensitivity and impaired epithelial secretory cell lineages when they are adults.

43 (DBZ) to drive cellular differentiation into secretory cell lineages, we show that although goblet ce

44 its relationship with defects in epithelial secretory cell lineages.

45 oes the distinct cup-shaped morphology of SG secretory cells arise?

46 Professional secretory cells can produce large amounts of high-qualit

47 , despite known differences in the number of secretory cells in germ-free zebrafish and their convent

48 cies, photosynthesis also takes place in the secretory cells of glandular trichomes, which are epider

49 ave a particular Rubisco uniquely adapted to secretory cells where CO2 is released by the active spec

50 nitors forming a network of ducts and acini (secretory cells).

51 However, in secretory cells, Gbetagamma, SNAREs, and synaptotagmin i

52 These results suggest that in live secretory cells, membrane tension exerts inhibitory acti

53 (SGs) for Ca(2+)-evoked secretion in various secretory cells.

54 f chitin at the apical surface of individual secretory cells.

55 rarely studied for vesicular endocytosis in secretory cells.

56 ound exocytosis commonly observed in various secretory cells.

57 s of highly expressed genes defining certain secretory cellular lineages: albumin (ALB) in liver carc

58 thought to function as the Ca(2+) activated secretory chloride channel independent of CFTR.

59 membrane Conductance Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and in

60 transition from successful to failed insulin secretory compensation to obesity-related insulin resist

61 biological functions for trout pIgR or trout secretory component (tSC) remain unknown.

62 xin-1A (Syn-1A) levels contribute to insulin secretory deficiency.

63 Secretory diarrheas caused by bacterial enterotoxins, in

64 ntial utility of (R)-BPO-27 for treatment of secretory diarrheas caused by cholera and Escherichia co

65 y of (R)-BPO-27 for therapy of CFTR-mediated secretory diarrheas.

66 d the understanding of the physiological and secretory differences across recombinant protein product

67 The secretory duct begins as buds of chitin at the apical su

68 that thapsigargin is likely to be stored in secretory ducts in the roots.

69 nd only in the epithelial cells lining these secretory ducts.

70 ed to regulated exocytosis, leaving other MC secretory effector responses intact.

71 thway and the involvement of exosomes in mid-secretory endometrial functions.

72 croptotic cell death and a reduced number of secretory epithelial cells.

73 ER-exit and O-glycosylation influencing post-secretory fate.

74 ity establishment, alveolar development, and secretory function in the lactating mammary gland.

75 echanisms responsible for the development of secretory function in these cells are unclear.

76 Consistent with the role of Nnat in the secretory function of beta-cells, miR-708 overexpression

77 Acinar cells play an essential role in the secretory function of exocrine organs.

78 toimmune disease characterized by diminished secretory function of the exocrine glands.

79 um from female mice as follows: (a) improves secretory function, (b) reduces pro-inflammatory molecul

80 essed in the male pituitary being related to secretory function, and multiple genes more highly expre

81 racellular changes to establish and maintain secretory function.

82 imit salivary gland inflammation and improve secretory function.

83 (AT-RvD1) reduces inflammation and preserves secretory functioning in NOD/ShiLtJ SS-like mice.

84 e ducts, contribute substantially to biliary secretory functions and bile transport.

85 ar composition, architecture, and absorptive/secretory functions have been successfully developed, pr

86 cause rapid closure of the trap and activate secretory functions of glands, which cover its inner sur

87 ight into how bacterial exploitation of host secretory functions promotes pathogenesis.

88 We show that F-actin is also involved in secretory granule biogenesis and that myosin 1b cooperat

89 ecular events leading to hormone sorting and secretory granule formation at the level of the TGN are

90 ors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker fo

91 Our analysis identifies the pancreatic secretory granule membrane major glycoprotein 2 (GP2) as

92 ysis of purified whole secretory granules or secretory granule membranes uncovered their association

93 We conclude that Epac2A controls secretory granule release by binding to the exocytosis m

94 Knockdown of Kv2.1 expression reduces secretory granule targeting to the plasma membrane.

95 ells had a severe reduction in the number of secretory granules (SGs) docked onto the plasma membrane

96 binding protein that localizes to and primes secretory granules (SGs) for Ca(2+)-evoked secretion in

97 of exocytosis, during which the membranes of secretory granules (SGs) fuse with each other to form a

98 mbrane, where it accumulated specifically at secretory granules and rendered them more prone to under

99 und that myosin 1b controls the formation of secretory granules and the associated regulated secretio

100 actomyosin complex promote the biogenesis of secretory granules and thereby regulate hormone sorting

101 to recruit F-actin to the Golgi region where secretory granules bud.

102 essential for the recruitment of NMII to the secretory granules but plays a key role in the assembly

103 Willebrand factor, which is stored in unique secretory granules called Weibel-Palade bodies (WPBs).

104 transition, DeltaPsi and ROS increased, and secretory granules disappeared.

105 esent CMV antigen to TH1 cells, co-opting MC secretory granules for antigen processing and presentati

106 MCs co-opt their secretory granules for antigen processing and presentati

107 Zymogen secretory granules in pancreatic acinar cells express tw

108 ZnT8 mediates zinc enrichment in the insulin secretory granules of the pancreatic beta cell.

109 Our proteomic analysis of purified whole secretory granules or secretory granule membranes uncove

110 iability, reactive oxygen species (ROS), and secretory granules were assessed with parameter-indicati

111 Hormone secretion relies on secretory granules which store hormones in endocrine cel

112 les (GUVs) and smaller liposomes or purified secretory granules with high temporal and spatial resolu

113 of membrane-enclosed compartments, including secretory granules, endosomes, and lysosomes.

114 a plethora of bioactive compounds from their secretory granules, including mast cell-restricted prote

115 driving the remodeling of membranes of large secretory granules, which are integrated into the plasma

116 ase in the number of membrane-docked insulin secretory granules.

117 ial/lysosome trafficking, and generate large secretory granules.

118 upports the glucose-dependent recruitment of secretory granules.

119 lt, provoked by persistent expression of the secretory heavy chain of immunoglobulin M (micros), is w

120 Mucosal IgA or secretory IgA (SIgA) are structurally equipped to resist

121 We examined the relationship between secretory IgA (SIgA) on the mucosal surface of small air

122 st pathogens that complements the mucous and secretory IgA Ab-mediated system in the protection of in

123 t effects and sufficient to transfer delayed secretory IgA expression.

124 specific intestinal T-cell populations, and secretory IgA expression.

125 Uremia did not affect secretory IgA release into the ileum lumen or mucosal le

126 Secretory immunoglobulin A (SIgA) enhances host-microbio

127 VAMP8(-/-) acini are resistant to secretory inhibition by supramaximal CCK-8, and despite

128 Here, we show PGRN is a secretory lysosomal protein that regulates lysosomal fun

129 but involves enclosure within endosomes and secretory lysosomes.

130 integrated nanoscopy and spectroscopy of the secretory machinery with organelle tracking data in a ma

131 s of cellular morphology, surface phenotype, secretory mediators, and proliferative responses (referr

132 fide bonds, are a family of mucin-associated secretory molecules mediating many physiological roles t

133 scaling factor" that universally establishes secretory morphology in cells that perform regulated sec

134 This strongly suggests that secretory Munc18s in general control the accessibility o

135 f the endoplasmic reticulum (ER) to changing secretory needs, cells employ a dynamic intracellular si

136 functions, and its release is regulated from secretory neurons via the nutrient sensor AMPK.

137 epithelial renewal from Bmi1(+) cells, from secretory or absorptive progenitors, and from Paneth cel

138 for erythrocyte invasion, acting on rhoptry secretory organelle biogenesis.

139 Mammalian sperm feature a specialized secretory organelle on the anterior part of the sperm nu

140 fort has gone into analyzing the behavior of secretory organelles [9-13], and understanding the relat

141 Regulated exocytosis by secretory organelles is important for malaria parasite i

142 Weibel-Palade bodies (WPB) are secretory organelles of endothelial cells that undergo e

143 Micronemes and rhoptries are specialized secretory organelles that deploy their contents at the a

144 iated vesicles were of diverse endocytic and secretory origin.

145 s identify an exquisite mechanism of metered secretory output that precisely regulates release of the

146 The secretory pathway along which newly synthesized secretor

147 ch is involved in membrane remodeling in the secretory pathway and a known target of sorafenib, was f

148 patially restricted entry into the dendritic secretory pathway and accumulate in recycling endosomes

149 MORIN is independent of the COP-II-dependent secretory pathway and mediated by PI4P and sterol.

150 ird of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glyco

151 Glycoproteins traversing the eukaryotic secretory pathway begin life in the endoplasmic reticulu

152 The Golgi/secretory pathway Ca(2+)/Mn(2+)-transport ATPase (SPCA1a

153 Our data suggest that GPR31 acts as a secretory pathway chaperone for KRAS4B.

154 It controls the production both of secretory pathway components and cargoes, including apol

155 begun to uncover how different parts of the secretory pathway directly and indirectly contribute to

156 Folding of proteins entering the secretory pathway in mammalian cells frequently requires

157 The secretory pathway is a major determinant of cellular hom

158 te that the mutation inhibits the ameloblast secretory pathway leading to ER stress and an activated

159 ng the molecular basis of the unconventional secretory pathway of FGF2.

160 little is known about the filamentous fungal secretory pathway or how it might be manipulated for imp

161 e of the sharpest evolutionary signatures of secretory pathway proteins, and was therefore critical f

162 ion of proteins, most of which are not ER or secretory pathway proteins.

163 ation triggered a dual selection pressure on secretory pathway proteins: while sequons were positivel

164 The exocyst is an essential component of the secretory pathway required for delivery of basolateral p

165 where Tomt and the Tmcs interact within the secretory pathway to traffic Tmc proteins to the hair bu

166 remains associated with TACE throughout the secretory pathway, and is stabilised at the cell surface

167 ic reticulum (ER), is trafficked through the secretory pathway, and released to generate extracellula

168 copper transport from the cytoplasm into the secretory pathway, as well as copper export across the p

169 recently characterized protein kinase in the secretory pathway, phosphorylates HRC on Ser96.

170 ntrol the early and late stages of the yeast secretory pathway, respectively.

171 ion in viral egress by targeting VCP and the secretory pathway, resulting in a buildup of virions wit

172 dulate and augment key aspects of the entire secretory pathway, whereas maladaptive UPR outputs trigg

173 ia a late endosomal/lysosomal unconventional secretory pathway.

174 n of folding-defective proteins in the early secretory pathway.

175 lly cytosolic proteins were recruited to the secretory pathway.

176 from the cell, nonbulky proteins reenter the secretory pathway.

177 d provide the entryway for proteins into the secretory pathway.

178 is secreted from cells by an unconventional secretory pathway.

179 shown to increase immature APP in the early secretory pathway.

180 e critical for the evolution of an efficient secretory pathway.

181 ture VLDL particles occurs through the Golgi secretory pathway.

182 tional modification in proteins entering the secretory pathway.

183 disulfide formation in proteins entering the secretory pathway.

184 formed a comprehensive, unbiased analysis of secretory pathways and identified an unconventional lyso

185 ich occur frequently in the cytoplasm and in secretory pathways, may induce the formation of betaS fi

186 al transduction pathways and inhibiting host secretory pathways.

187 A genome-scale stoichiometric model of secretory phase metabolism in peppermint GTs was constru

188 Stat3 activation and a senescence-associated secretory phenotype (SASP) that coincided with the devel

189 that contribute to the senescent-associated secretory phenotype (SASP), and over expression of H2A.J

190 gh the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capa

191 lectively known as the senescence-associated secretory phenotype (SASP), which can reinforce the arre

192 rs contributing to the senescence-associated secretory phenotype (SASP).

193 anch that controls the senescence-associated secretory phenotype (SASP).

194 and acquisition of the senescence-associated secretory phenotype (SASP).

195 eration arrest and the senescence-associated secretory phenotype collaborate to enact tumor suppressi

196 G pathway promotes the senescence-associated secretory phenotype in primary human cells and in mice.

197 ent cell-cycle arrest and a pro-inflammatory secretory phenotype, and can be induced by a variety of

198 io-active factors (the senescence-associated secretory phenotype, or SASP), and reduced expression of

199 many-sided effects of senescence-associated secretory phenotype.

200 es and chemokines, the senescence-associated secretory phenotype.

201 ion, accumulation of organic acids, enhanced secretory phosphatase activity, and depletion of ATP in

202 KEGG pathways, we found expression levels of secretory phospholipase A2 (sPLA2), lysophospholipid acy

203 , whereas adult mice expressed more group 10 secretory phospholipase A2, Wnt5a, and transglutaminase

204 lle that matures a massive amount of nascent secretory polypeptides, is particularly sensitive to str

205 nd an upper reabsorptive duct leading to the secretory pore in the skin.

206 ubular structure of sweat glands has a lower secretory portion and an upper reabsorptive duct leading

207 pancreatic injury, and that blockade of this secretory process could increase autophagy induction.

208 be necessary, given their roles in different secretory processes in different tissues, the structural

209 reased M2 markers (CD206 and arginase-1) and secretory products (transforming growth factor beta and

210 (45-90 ng/mg protein) within their excretory/secretory products but few related lipid mediators as es

211 Their secretory products contain serine proteases that suppres

212 Here we show that secretory products from gastrointestinal microbiota deri

213 etected in whole worm extracts and excretory/secretory products of O. viverrini and reacted with sera

214 Comparing lymphocyte secretory profile from patients exhibiting high and low

215 Sex-dependent pituitary growth hormone (GH) secretory profiles-pulsatile in males and persistent in

216 r5 and Ascl2, reminiscent of label-retaining secretory progenitors.

217 the Mycobacterium tuberculosis 30-kDa major secretory protein (r30/antigen 85B [Ag85B]) (rLm30) as h

218 Fetuin-A is a hepatic secretory protein and a novel risk factor for diabetes.

219 show that the expression of a heterodimeric secretory protein can be improved by harmonizing selecte

220 potent GC, dexamethasone (Dex) increased the secretory protein load of ECM proteins in the ER of TM c

221 overlaid on navigation between non-reactive secretory protein molecular depots patterned at the plas

222 rmed that NS1 can promote the translation of secretory protein mRNAs based on the nucleotides within

223 A primary function of 5' regions in many secretory protein mRNAs is to encode an endoplasmic reti

224 lex II (COPII) mediates the initial steps of secretory protein trafficking by assembling onto subdoma

225 y A member 2 (BPIFA2), also known as parotid secretory protein, which we identified via a multiplex q

226 Many plant pathogen secretory proteins are known to be elicitors or pathogen

227 Secretory proteins are only temporary cytoplasmic reside

228 total proteins) were identified as putative secretory proteins containing signal peptides.

229 le to mass production of functionally active secretory proteins in a silkworm-based expression platfo

230 Translocation of secretory proteins into the lumen of the endoplasmic ret

231 f ASP-like proteins, proteases, or excretory-secretory proteins of unknown function.

232 The secretory proteins participate in motility, invasion, an

233 Chromogranins are pro-hormone secretory proteins released from neuroendocrine cells, w

234 Gene ontology analysis of the secretory proteins revealed an enrichment of hydrolase a

235 Additionally, 143 putative secretory proteins were categorized into 27 functional g

236 Out of 908 secretory proteins, 581 (63.8%) have functions related t

237 embers of the CAP superfamily (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related

238 Like all other secretory proteins, the HIV-1 envelope glycoprotein gp16

239 functional groups and majority of them were secretory proteins.

240 associations were established for 82 (9.0%) secretory proteins.

241 e folding, maturation, and deployment of the secretory proteome.

242 012), C-peptide (P = 0.004), and the insulin secretory rate (P = 0.020) compared with the control OGT

243 sting proinsulin-to-C-peptide and proinsulin secretory ratios during glucose potentiation were higher

244 les (76 from 'pre-receptive' and 88 from mid-secretory, 'receptive' phase endometria) using a robust

245 omics analysis of the RSV-induced epithelial secretory response in cells representative of the trache

246 reased CFTR activity may correspond to a pro-secretory response to H2S which may be endogenously prod

247 tial role for PKD1 in the beta-cell adaptive secretory response to high-fat feeding in mice.

248 basal and a Toll-like receptor-mediated ASL secretory response to the inhalation of cystic fibrosis

249 ITN application on conjunctival goblet cell secretory response.

250 provide evidence for its role in the insulin secretory response.

251 The secretory responses and exocytotic events evoked by CCK-

252 h and CCK-8 both dose-dependently stimulated secretory responses from human pancreas slices similar t

253 pecific IgE in serum and measurable basophil secretory responses to rPen a 1 (shrimp tropomyosin).

254 Acute islet cell secretory responses were determined under fasting, 230 m

255 gastric digestion, were required to diminish secretory responses.

256 hological changes, switching function from a secretory role to a cell primarily engaged in ionic tran

257 ptide cleavage site regardless of the native secretory route.

258 ent in COPII vesicles to embark on the Golgi secretory route.IMPORTANCE HCV assembly and release acco

259 ge sites were found in 463 of these putative secretory signal peptides.

260 ions, which also are similar to those of the secretory SNARE mutant, syp121 The syp121 and chc mutant

261 ism, linking the levels of substrates to the secretory status of ESX systems.

262 While research into secretory stress signaling has so far mostly focused on

263 that PT-triggered regulation of the synergid secretory system is important for synergid function duri

264 tein families putatively secreted by type II secretory system: PheA (CM-sec), LipA/LesA, VirK, and fo

265 ransport, which could modulate endocytic and secretory systems in intestinal cells.

266 anterior grooves and their coupling to venom secretory tissue provide Meiacanthus spp. with toxic ven

267 homeostasis in blood, lymphoid, mucosal and secretory tissues of 44 CMV seropositive and 28 seronega

268 protein recycling, REs also mediate forward secretory trafficking in neuronal dendrites and spines t

269 ontrols ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodes

270 Many intracellular pathogens exploit host secretory trafficking to support their intracellular cyc

271 host ER, a process that requires host early secretory trafficking.

272 GA), an essential organelle for conventional secretory trafficking.

273 genes, we observed robust regulation of the secretory trefoil factor family (TFF) members, including

274 We propose that secretory trichomes have a particular Rubisco uniquely a

275 secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine

276 olved in the calcium-dependent regulation of secretory vesicle exocytosis in neurons and neuroendocri

277 In its absence, secretory vesicle formation is impaired, leading to accu

278 acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network.

279 Post-Golgi secretory vesicles (SVs) containing the RAB11 orthologue

280 defects at a late stage of the pathway, with secretory vesicles accumulating near exocytic sites.

281 Cells lacking Boi1/2 accumulate secretory vesicles and are defective in bud growth.

282 ds perceive the haptoelectrical stimulation, secretory vesicles are tailored to be released in a sequ

283 vesicles recruited during phagocytosis were secretory vesicles as their recruitment was sensitive to

284 The tethering of the secretory vesicles before membrane fusion is mediated by

285 at when Uso1 is inappropriately recruited to secretory vesicles by Ypt1-SW1(Sec4), the extended coile

286 was mainly due to elevated concentration of secretory vesicles close to the cell membrane.

287 cate that XGA is secreted by a novel type of secretory vesicles derived from trans-Golgi cisternae.

288 d mechanism for recruitment of Golgi-derived secretory vesicles during phagosome biogenesis, which wa

289 eviously unprecedented role of Golgi-derived secretory vesicles in phagocytic uptake, the key innate

290 photobleaching analysis, we first show that secretory vesicles move toward and accumulate at the tip

291 dundantly with Boi1 to promote the fusion of secretory vesicles with the plasma membrane at sites of

292 re required for a late step in the fusion of secretory vesicles with the plasma membrane of the growi

293 vesicle trafficking and ultimately fusion of secretory vesicles with the plasma membrane.

294 Non-classical secretory vesicles, collectively referred to as extracel

295 e hypothesis is that diffusion can transport secretory vesicles, while actin plays a regulatory role

296 tilisin-like serine protease SUB1 in exoneme secretory vesicles.

297 ess that drives the budding and transport of secretory vesicles.

298 microm) basal cytoplasmic process devoid of secretory vesicles.

299 JA signaling that promotes the formation of secretory vesicles.

300 Protein C, a secretory vitamin K-dependent anticoagulant serine prote