ライフサイエンスコーパス: secretory IgA

1 ate host defense mechanisms and secretion of secretory IgA.

2 f immunization for preferential induction of secretory IgA.

3 nd male genital tracts contain more IgG than secretory IgA.

4 ed for lactadherin, butyrophilin, mucin, and secretory IgA.

5 elium and releases it into the cyst lumen as secretory IgA.

6 ous ligands C1q, mannose-binding lectin, and secretory IgA.

7 howed stronger bacterial neutralization than secretory IgA.

8 of the polymeric immunoglobulin receptor and secretory IgA.

9 ounts of gp41-specific IgG but low levels of secretory IgA.

10 serum immunoglobulin G (IgG) and intestinal secretory IgA.

11 and IgG antibodies, including subclasses and secretory IgA.

12 th substrate specificity for human serum and secretory IgAs.

13 Monomeric, dimeric, polymeric, and secretory IgA(2) derivatives of b12 reacted with gp120 a

14 in the respiratory tract, increased specific secretory IgA Ab in the vaginal and rectal tracts, and i

15 roduced higher titers of Ag-specific mucosal secretory IgA Ab levels when compared with MIP-1alpha.

16 st pathogens that complements the mucous and secretory IgA Ab-mediated system in the protection of in

17 DN elicited elevated levels of PspA-specific secretory-IgA Ab responses in external secretions and pl

18 protein A (PspA) would enhance PspA-specific secretory-IgA Ab responses, which could provide protecti

19 ectal mucosa that effectively stimulate both secretory IgA Abs and cytotoxic T lymphocytes in the gen

20 ls of BoNT-specific IgG Abs in plasma and of secretory IgA Abs in external secretions (nasal washes,

21 levels of OVA-specific IgG Abs in plasma and secretory IgA Abs in mucosal secretions (nasal washes, s

22 Both IgG and secretory IgA Abs in mucosal secretions have been implic

23 pecifically, SP contains naturally occurring secretory IgA Abs to environmental Ags of microbial orig

24 ated mice were found to contain neutralizing secretory IgA Abs.

25 Immune exclusion is performed mainly by secretory IgA, although there are back-up mechanisms in

26 ough induction of antimicrobial peptides and secretory IgA among others.

27 by gel filtration from whole saliva or mixed secretory IgA and alpha-amylase, the high molecular weig

28 GBOMP was an effective mucosal adjuvant for secretory IgA and IgG responses in the lungs of both mic

29 specific activity (percent inhibition/total secretory IgA and IgG) was strongly correlated with redu

30 D4+ T help, Th17, high avidity CD8+ CTL, and secretory IgA and IgG1 neutralizing Abs, at the site of

31 gens by promoting pIgR-mediated transport of secretory IgA and IgM into the airway.

32 was inhibited while degranulation induced by secretory IgA and PMA was not inhibited.

33 se formulations also evoked antigen-specific secretory IgA and provided protection against anthrax le

34 Here, we report that secretory IgA and secretory component preferentially act

35 contrast, neutrophils responded similarly to secretory IgA and serum IgA.

36 nt peanut allergen gene (pCMVArah2) produced secretory IgA and serum IgG2a.

37 ficantly higher interleukin (IL)-6/IL-1beta, secretory IgA, and lower lysozyme, and histatins 1 and 5

38 oth serum immunoglobulin G (IgG) and mucosal secretory IgA anti-CFA/I; 40% of the animals produced an

39 Both CT-A/LT-B and LT-A/CT-B promoted secretory IgA anti-OVA Ab, which established their reten

40 Plasma IgA Abs as well as secretory IgA anti-PA Abs in saliva, nasal washes, and f

41 of anti-P1 serum immunoglobulin G (IgG) and secretory IgA antibodies and the subclass distribution o

42 Moreover, secretory IgA antibodies from immunized mice were shown

43 , prevention of SIV infection in macaques by secretory IgA antibodies, up-regulation of CC chemokines

44 ly elevated, as were total, IgG1, IgG2a, and secretory IgA antibody levels in bronchoalveolar lavage

45 the booster immunization, at which time the secretory IgA antibody levels were significantly higher

46 ines were more effective in inducing a local secretory IgA antibody response than a salivary or serum

47 e lamina propria, which give rise to mucosal secretory IgA antibody responses.

48 serum immunoglobulin G (IgG) and/or mucosal secretory-IgA antibody titers than the aroA vaccine stra

49 -low mice degrade the secretory component of secretory IgA as well as IgA itself.

50 ely, IgG was detected in mucosal secretions; secretory IgA, as well as mucosal and systemic IgA Ab-se

51 barrier function was evaluated by measuring secretory IgA, bacterial adherence to the intestinal muc

52 nhibited by unlabeled secretory component or secretory IgA but not by serum IgA.

53 ates is monomeric; it cannot be converted to secretory IgA by T560 cells.

54 (pIgR)-binding site, which might explain why secretory IgA cannot initiate phagocytosis or bind to Fc

55 Secretory IgA (cervical IgA- and secretory piece-positiv

56 Consequently, secretory IgA competitively inhibited binding of vitrone

57 s, mucins, proline-rich proteins (PRPs), and secretory IgA complex.

58 n analysis adjusted for age at infection and secretory IgA concentration there was a significant diff

59 Secretory IgA contributes to humoral defense mechanisms

60 eosinophils were stimulated with immobilized secretory IgA, degranulation and superoxide production w

61 in vivo intracellular viral inactivation by secretory IgA during transcytosis is a mechanism of host

62 t effects and sufficient to transfer delayed secretory IgA expression.

63 specific intestinal T-cell populations, and secretory IgA expression.

64 Secretory IgA glycans bind gut bacteria, and an unusual

65 lymphoid tissue (GALT) in the production of secretory IgA has been well characterized.

66 confers increased stability on the resultant secretory IgA; however, the effect of secretory componen

67 ncentrations of intact Abs (human serum IgA, secretory IgA, IgG, or mouse anti-HA mAb), monocytes wer

68 Eosinophils stimulated by immobilized secretory IgA, immobilized IgA, immobilized IgG, or TNF-

69 Soluble secretory IgA immune complexes also induced degranulatio

70 s that polymeric Ig receptor (pIgR)-mediated secretory IgA immunity could be impaired in chronic uppe

71 ll subsets associated with the generation of secretory IgA immunity, the regulation of mucosal commen

72 The relative importance of secretory IgA in host defense was further shown by the f

73 The results demonstrate the critical role of secretory IgA in protection against pneumococcal nasal c

74 The roles of IgG and secretory IgA in the protection of the respiratory tract

75 approximately one-third that of immobilized secretory IgA in the same experiments.

76 ng-lasting HIV-specific serum antibodies and secretory IgA in the secretory nasal, vaginal, and intes

77 anscytosis of IgA and increases secretion of secretory IgA into saliva.

78 Secretory IgA is important in mucosal defense, but other

79 nisms in place to induce oral tolerance when secretory IgA is lacking.

80 r aim in this study was to determine whether secretory IgA is sufficient for protection of Peyer's pa

81 gen, how they favor isotype switching to the secretory IgA isotype, and how their GC responses may un

82 subclasses), IgA (including subclasses), or secretory IgA levels were seen, regardless of HIV status

83 and a subsequent increase in airway IgM and secretory IgA levels.

84 mesenteric lymph node/body weight ratio, and secretory IgA levels.

85 n devoid, assembled multivalent dimeric, and secretory IgA-like antibodies.

86 Thus, our data suggest that secretory IgA may play a key role in preventing streptoc

87 ith plasma IgG Ab serving as the back-up for secretory IgA-mediated protection in the nasal compartme

88 nophil superoxide production stimulated with secretory IgA or secretory component but not with serum

89 a2 integrins in eosinophil interactions with secretory IgA or secretory component.

90 In contrast to the pronounced dominance of secretory IgA over other immunoglobulin isotypes in huma

91 assayed for amylase, lactoferrin, lysozyme, secretory IgA, peroxidase, and total protein.

92 IgA is represented by secretory IgA, polymeric IgA, and monomeric IgA.

93 humoral effector, IgG2a, and to some extent secretory IgA produce protective immunity against chlamy

94 homeostasis through their well-known role in secretory IgA production and their emerging role in muco

95 methasone-treated rats significantly impairs secretory IgA, promotes bacterial adherence to the mucos

96 Uremia did not affect secretory IgA release into the ileum lumen or mucosal le

97 In some cases, both a serum IgG and secretory IgA response are induced to the recombinant pr

98 ects, in contrast, developed a serum IgG and secretory IgA response to a 22 kD protein, whereas 7 of

99 chi10057(pYA5199) resulted in a significant secretory IgA response to LcrV.

100 now show that the specificity of the mucosal secretory IgA response was also influenced by this MAb.

101 minant at all stages in the development of a secretory IgA response.

102 that the magnitudes of breast milk total and secretory IgA responses against a consensus HIV-1 envelo

103 t, the magnitudes of the breast milk IgA and secretory IgA responses against HIV-1 envelope proteins

104 The intestinal secretory IgA responses to FrgC were very similar in the

105 ization with LT via the skin induced mucosal secretory IgA responses to LT, protection could also be

106 Mucosal secretory IgA responses to oral or nasal vaccines were n

107 iter T1-SP10MN(A)-specific fecal and vaginal secretory IgA responses were observed, and the response

108 th TS plus CpG induce TS-specific T-cell and secretory IgA responses.

109 1 and type 2 biased vaccines induced similar secretory IgA responses.

110 n correlated with a reduction in CT-specific secretory-IgA responses in nasal passages and reproducti

111 immunoglobulin, breast milk (as a source of secretory IgA), ribavirin, and the anti-picornaviral age

112 high p.o. QS-21 doses triggered Ag-specific secretory IgA (S-IgA) Ab responses.

113 ol mice, but exhibited no IgE and negligible secretory IgA (S-IgA) Ab responses.

114 esponses with systemic IgG1, IgE and mucosal secretory IgA (S-IgA) antibodies (Abs).

115 affinity-purified immunoglobulin G (IgG) and secretory IgA (S-IgA) from immune secretions were adjust

116 Capsule-specific secretory IgA (s-IgA) in breast milk may enhance protect

117 Secretory IgA (S-IgA), a major humoral mediator of mucos

118 , including secreted immunoglobulins such as secretory IgA (S-IgA), which can bind and agglutinate ba

119 tors was identified to be the heavy chain of secretory IgA (S-IgA).

120 is study was designed to investigate whether secretory-IgA (S-IgA) Abs induced by a pneumococcal surf

121 with oral or nasal immunization enhanced the secretory IgA, serum IgG, and T cell responses.

122 IgG, but reduced IgA as well as low anti-OVA secretory IgA (SIgA )Ab responses in saliva and nasal wa

123 Secretory IgA (sIgA) Abs are polymeric Igs comprised of

124 atch M cells selectively bind and endocytose secretory IgA (SIgA) Abs.

125 mice immunized with Hcbetatre produced weak secretory IgA (sIgA) and plasma IgG Ab response.

126 Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of c

127 Mucosal IgA or secretory IgA (SIgA) are structurally equipped to resist

128 to IgA and secretory component revealed that secretory IgA (SIgA) dominated in all saliva samples.

129 ication or production of large quantities of secretory IgA (SIgA) for potential mucosal application h

130 tissue in rabbits, bind and retro-transport secretory IgA (sIgA) from the tear film.

131 d to as p24 in the text) HIV antigen through secretory IgA (SIgA) in nasal mucosae in mice.

132 From very early in life, secretory IgA (SIgA) is found in association with intest

133 Secretory IgA (SIgA) is the primary mucosal Ig and has b

134 molecular weight salivary antigen and (iii) secretory IgA (sIgA) light chain and alpha-amylase.

135 We examined the relationship between secretory IgA (SIgA) on the mucosal surface of small air

136 Secretory IgA (sIgA) plays a critical role in providing

137 In mucosal sites, secretory IgA (SIgA) protects the host through immune-ex

138 e no significant differences for tear IgA or secretory IgA (sIgA) reactivity to hsp60 or for tear sIg

139 n contrast, all immunization routes elicited secretory IgA (sIgA) responses at multiple mucosal sites

140 Stimulation of FlaA-specific intestinal secretory IgA (sIgA) responses required immunization wit

141 tracts contain the immunoglobulins (Ig)G and secretory IgA (sIgA) that function together in host defe

142 s host proteins, including factor H (FH) and secretory IgA (sIgA) via the secretory component.

143 hat the aggregation of E. coli K-12 by human secretory IgA (SIgA) was dependent on the presence of th

144 calcium, iron, and zinc bound to human milk secretory IgA (sIgA) was investigated.

145 ycoprotein B (gB) neutralize, levels of IgG, secretory IgA (sIgA), and mucosal IgA1 antibodies to HCM

146 mic changes in the levels of SFB coated with secretory IgA (sIgA), which resulted from the significan

147 al tract of suckling mammals, in the form of secretory IgA (SIgA).

148 omeric IgA [mIgA], polymeric IgA [pIgA], and secretory IgA [SIgA]) on OPC and susceptibility to cleav

149 he treated mice developed both serum IgG and secretory IgA specific for rNV.

150 th the functional importance of this natural secretory IgA, the mutant animals were more resistant to

151 IgA, were used to assess the contribution of secretory IgA vs total IgA in the induction of allergic

152 TS-specific secretory IgA was detectable in the tears of vaccinated

153 Although secretory IgA was found to be important for protection a

154 nd concentrations of butyrophilin, mucin, or secretory IgA was found.

155 Secretory IgA was less active than serum IgA1 and simila

156 HIV-specific secretory IgA was present in CVS of 10 (42%) of 24 women

157 knockout mice, which are devoid of serum and secretory IgA, were infected and then rechallenged with

158 cosal epithelium where it is cleaved to form secretory IgA, were used to assess the contribution of s

159 Secretory IgA, which targets enteric bacteria, regulates