ライフサイエンスコーパス: secretory pathway

1 ses [most likely serine proteases] along the secretory pathway).

2 ture VLDL particles occurs through the Golgi secretory pathway.

3 sential for the movement of IRAP through the secretory pathway.

4 proximal and distal points in the regulated secretory pathway.

5 of GluR trafficking at an early step in the secretory pathway.

6 s), the prominent component in the dendritic secretory pathway.

7 tional modification in proteins entering the secretory pathway.

8 ehaviors simultaneously as they traverse the secretory pathway.

9 n from the PLC and their transit through the secretory pathway.

10 nts and is dependent on the acidic pH in the secretory pathway.

11 eventually traffic out of the ER through the secretory pathway.

12 disulfide formation in proteins entering the secretory pathway.

13 ermines the fate of aberrant proteins in the secretory pathway.

14 d the other with a role in disruption of the secretory pathway.

15 neuropeptide hormones through the regulated secretory pathway.

16 acellular protein phosphorylation within the secretory pathway.

17 ains by sensing the organellar pH within the secretory pathway.

18 new insights into the use of red FPs in the secretory pathway.

19 ulation of their transport through the early secretory pathway.

20 organellar compartments as they transit the secretory pathway.

21 retained by cellular quality control in the secretory pathway.

22 ia a late endosomal/lysosomal unconventional secretory pathway.

23 have a partial secretion block later in the secretory pathway.

24 erologous secretory protein to the regulated secretory pathway.

25 c membrane proteins that are targeted to the secretory pathway.

26 reticulum-to-Golgi trafficking in the early secretory pathway.

27 rograde trafficking in the constitutive-like secretory pathway.

28 on of Rab1 affects Scabrous and Delta in the secretory pathway.

29 posure to the acidic environment of the late secretory pathway.

30 d phosphorylation as it traffics through the secretory pathway.

31 fic fluorescence sensors that traffic in the secretory pathway.

32 roles for protein quality control within the secretory pathway.

33 dial Golgi and traversing the unconventional secretory pathway.

34 hydrophobic signals for localization to the secretory pathway.

35 n of folding-defective proteins in the early secretory pathway.

36 ) for proper folding before release into the secretory pathway.

37 yosin motor activity and is dependent on the secretory pathway.

38 from other cargoes using the "constitutive" secretory pathway.

39 cytokines are not secreted via the classical secretory pathway.

40 ation of the Golgi apparatus that blocks the secretory pathway.

41 gnal peptide for release along the classical secretory pathway.

42 sing the pH gradient maintained within their secretory pathway.

43 otein for AP-3 in formation of the regulated secretory pathway.

44 mer dissociated during transport through the secretory pathway.

45 lly cytosolic proteins were recruited to the secretory pathway.

46 dominantly localized to the ER and the early secretory pathway.

47 saggregating drug these proteins transit the secretory pathway.

48 trafficking through the compartments of the secretory pathway.

49 esis efficiency of mutant channels along the secretory pathway.

50 cellular compartment follow the conventional secretory pathway.

51 exity of organelle movement within the plant secretory pathway.

52 by proprotein convertase(s) (PCs) along the secretory pathway.

53 egating FM domain that face the lumen of the secretory pathway.

54 icking of the many proteins that rely on the secretory pathway.

55 d protein cargo as it traverses the cellular secretory pathway.

56 utated enzyme and its processing through the secretory pathway.

57 se from the LMAN1.MCFD2 complex in the early secretory pathway.

58 egradation clears aberrant proteins from the secretory pathway.

59 ing protein and lipid flux through the early secretory pathway.

60 transmembrane proteins involved in the early secretory pathway.

61 ty, Golgi organization, and flux through the secretory pathway.

62 ematologic, result from defects in the early secretory pathway.

63 from the cell, nonbulky proteins reenter the secretory pathway.

64 d provide the entryway for proteins into the secretory pathway.

65 is secreted from cells by an unconventional secretory pathway.

66 ular specialization at an early stage of the secretory pathway.

67 the conventional endoplasmic reticulum-Golgi secretory pathway.

68 otein (APP) is trafficking through the early secretory pathway.

69 rane-bound compartment to another within the secretory pathway.

70 g and trafficking of proteins that enter the secretory pathway.

71 s, a membrane organelle in the center of the secretory pathway.

72 ant torsinA alters protein processing in the secretory pathway.

73 shown to increase immature APP in the early secretory pathway.

74 for copper increases, especially within the secretory pathway.

75 ng of channels to forward trafficking in the secretory pathway.

76 s copper transport from the cytosol into the secretory pathway.

77 panded repertoire of cargo that transits the secretory pathway.

78 of newly synthesized GluA3 receptors to the secretory pathway.

79 icles is crucial to homeostasis in the early secretory pathway.

80 tes Sec4p, the final Rab GTPase of the yeast secretory pathway.

81 abolic and electrical signals in the insulin secretory pathway.

82 e critical for the evolution of an efficient secretory pathway.

83 ion to the periplasmic space via the general secretory pathway.

84 and trafficking of proteins targeted to the secretory pathway.

85 lain many observed aspects of the eukaryotic secretory pathway.

86 the bloodstream independently of the B-cell secretory pathway.

87 P)-mediated trafficking in the endocytic and secretory pathways.

88 an important regulator in both endocytic and secretory pathways.

89 sors for Ca(2+) and PI(4,5)P2 in a myriad of secretory pathways.

90 ith decreased levels of proteins involved in secretory pathways.

91 b networks will be common to other regulated secretory pathways.

92 mbranes that traffic in the endocytic and/or secretory pathways.

93 port mechanism of T6 and other characterized secretory pathways.

94 al transduction pathways and inhibiting host secretory pathways.

95 for ERES components to rebuild a functional secretory pathway after re-addition of amino-acids actin

96 The secretory pathway along which newly synthesized secretor

97 protein glycosylation reactions in cellular secretory pathways, also act as important extracellular

98 ch is involved in membrane remodeling in the secretory pathway and a known target of sorafenib, was f

99 patially restricted entry into the dendritic secretory pathway and accumulate in recycling endosomes

100 hese sex-related gene sets were enriched for secretory pathway and alga-specific genes.

101 ns appear to be exported through the general secretory pathway and deliver a variety of tRNase toxins

102 Here, we demonstrate that UNC93B1 enters the secretory pathway and directly controls the packaging of

103 ects a vast array of proteins transiting the secretory pathway and diseases arise upon misregulation

104 on correlates with pronounced defects in the secretory pathway and greatly reduces the replication of

105 rd of all cellular proteins pass through the secretory pathway and hence undergo oxidative folding in

106 JAGN1 participates in the secretory pathway and is required for granulocyte colony

107 MORIN is independent of the COP-II-dependent secretory pathway and mediated by PI4P and sterol.

108 ird of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glyco

109 e rate of MHC class I maturation through the secretory pathway and prolongs the association of MHC cl

110 ce that pro-SdpC is secreted via the general secretory pathway and that signal peptide cleavage is a

111 IP13 transports excess zinc out of the early secretory pathway and that zinc overload in the endoplas

112 m is the port of entry for proteins into the secretory pathway and the site of synthesis for several

113 O-GlcNAc transferase, EOGT, functions in the secretory pathway and transfers O-GlcNAc to proteins wit

114 formed a comprehensive, unbiased analysis of secretory pathways and identified an unconventional lyso

115 ting, P/rds was prohibited from entering the secretory pathways and was retained in the Golgi apparat

116 ht to regulate protein trafficking along the secretory pathway, and demonstrate its importance for th

117 the beta-cell endoplasmic reticulum (ER) and secretory pathway, and ER stress is associated with beta

118 remains associated with TACE throughout the secretory pathway, and is stabilised at the cell surface

119 These genes all encode key regulators of the secretory pathway, and much of our knowledge of the secr

120 ic reticulum (ER), is trafficked through the secretory pathway, and released to generate extracellula

121 c pathway, the protein transport through the secretory pathway, and to the formation of a novel rever

122 Misfolded proteins of the secretory pathway are extracted from the endoplasmic ret

123 onomeric, suggesting that the effects on the secretory pathway are independent of E ion channel activ

124 copper transport from the cytoplasm into the secretory pathway, as well as copper export across the p

125 e identification of a novel regulator of the secretory pathway, bactericidal/permeability-increasing

126 a synthetic lethality network focused on the secretory pathway based exclusively on mutations.

127 Glycoproteins traversing the eukaryotic secretory pathway begin life in the endoplasmic reticulu

128 in differential membrane ordering along the secretory pathway but also specifically localize diverse

129 t) accumulates on the Golgi during the early secretory pathway, but not after endocytosis.

130 oxic protein aggregates that form within the secretory pathway, but not those that form in the cytoso

131 R appears to influence the efficiency of the secretory pathway by affecting ER-mediated quality contr

132 teases have evolved to exploit the pH of the secretory pathway by altering the spatial juxtaposition

133 This perturbation of the secretory pathway by Ctx was not only observed in Xenopu

134 Additionally, disruption of the secretory pathway by IBV E correlates with a form that i

135 We quantified their effects on the secretory pathway by measuring secretion of the reporter

136 The Golgi/secretory pathway Ca(2+)/Mn(2+)-transport ATPase (SPCA1a

137 L-1) is required for actin and P-type ATPase secretory pathway calcium ATPase (SPCA)-dependent sortin

138 us studies have shown that disruption of the secretory pathway can be replicated by expression of ind

139 Our data suggest that GPR31 acts as a secretory pathway chaperone for KRAS4B.

140 d collagen II synthesis with upregulation of secretory pathway coat protein complex II components.

141 ting receptors (VSRs) between early and late secretory pathway compartments is regulated by signals i

142 It controls the production both of secretory pathway components and cargoes, including apol

143 e Rab27a-dependent lysosomal trafficking and secretory pathways contributes to the correction of some

144 and the entry of the trans-Golgi network in secretory pathway could be signal dependent.

145 complex.trappc11mutants are characterized by secretory pathway defects, reflecting disruption of the

146 urons, we found that after synthesis via the secretory pathway, dendritic APP/BACE-1-containing vesic

147 traffic and organelle integrity in the plant secretory pathway depend on ARF-GTPases, which are activ

148 by regulating the abundance of PHT1s in the secretory pathway destined for plasma membranes, but als

149 begun to uncover how different parts of the secretory pathway directly and indirectly contribute to

150 on of STAT3 prevented the induction of these secretory pathways during pneumonia, with similar result

151 calized overexpression of Sly41 to the early secretory pathway elevates cytosolic calcium levels to s

152 inA contributes to protein processing in the secretory pathway, endocytosis, and the stability of syn

153 brane by establishing check points along the secretory pathway, especially during the export from the

154 The unconventional secretory pathway exports proteins that bypass the endop

155 product is channelled at the Golgi into the secretory pathway for deposition into the cell wall.

156 ecretion have been described that bypass the secretory pathway for the extracellular delivery of cyto

157 s secreted during adulthood by the canonical secretory pathway from female reproductive glands are ne

158 rience dramatic environmental changes in the secretory pathway, from the endoplasmic reticulum via se

159 entiation and a transcriptional regulator of secretory pathway genes in plants.

160 However, it is not known where in the secretory pathway GnT1IP-L inhibits MGAT1, nor whether G

161 gi compartments, but the role of COPI in the secretory pathway has been ambiguous.

162 ornaviruses to influence the function of the secretory pathway has important implications for host de

163 h results from protein misfolding within the secretory pathway, has a profound effect on cancer cell

164 n identified, the protein kinases within the secretory pathway have only recently been discovered, an

165 ease, multimerization, and polarity of the 3 secretory pathways have only been addressed separately,

166 tinguished by their differential reliance on secretory-pathway homeostasis.

167 in vesicle transport at several steps in the secretory pathway; however, its functional roles and eff

168 osylated channels appear to pass through the secretory pathway in a manner comparable with glycosylat

169 ome precursors; thus, PMEL must traverse the secretory pathway in a non-amyloid form.

170 VCs and surrounding tissues, and blocked the secretory pathway in a tissue-specific manner.

171 gh the highly insulin-responsive specialized secretory pathway in adipocytes.

172 into the secretory granules of the regulated secretory pathway in each cell type are required for nut

173 ransition in the lipid landscape divides the secretory pathway in early and late membrane territories

174 We assessed the role of the early secretory pathway in establishing PIN1 polarity in Arabi

175 cking of protein and lipid cargo through the secretory pathway in eukaryotic cells is mediated by mem

176 However, regulation of the secretory pathway in Leishmania is not well characterize

177 ptor trafficking follows an Rab1-independent secretory pathway in Leishmania.

178 Folding of proteins entering the secretory pathway in mammalian cells frequently requires

179 rganizes trafficking events within the early secretory pathway in response to GPCR signaling.

180 matrix (EEM) protein amelogenin disrupts the secretory pathway in the enamel-forming ameloblasts, res

181 ized and recycled through a highly regulated secretory pathway in these cells.

182 th Pc1(cFL) and Pc1(deN) traffic through the secretory pathway in vivo.

183 (ER) is the entry site of proteins into the secretory pathway in which protein folding occurs and te

184 ies EGF repeats in proteins that transit the secretory pathway, including Dumpy and Notch.

185 Other protein maturation processes in the secretory pathway, including ER-localized N-linked glyco

186 US5-2 target multiple components of the host secretory pathway, including VAMP3, RAB5C, RAB11A, SNAP2

187 destroyed Chlamydomonas Golgi, inhibited the secretory pathway, inhibited flagellar regeneration, and

188 NA interference-mediated inactivation of the secretory pathway inhibits bacteroid differentiation.

189 s in the endoplasmic reticulum and regulates secretory pathways, integrins, and Toll-like receptors,

190 om the endoplasmic reticulum/Golgi-dependent secretory pathway into the unconventional secretory path

191 The secretory pathway is a major determinant of cellular hom

192 he molecular decision to enter the regulated secretory pathway is a pre-Golgi event controlled by the

193 Copper delivery to the secretory pathway is an essential step in copper utiliza

194 ry pathway, and much of our knowledge of the secretory pathway is based on this initial discovery.

195 To determine whether the Rab1-dependent secretory pathway is conserved in parasites, we have ana

196 are elevated and protein transport along the secretory pathway is delayed.

197 Traffic of proteins within the secretory pathway is directed by cargo-bearing vesicles

198 hough most of the machinery acting along the secretory pathway is known and its function generally un

199 l-dependent sorting of proteins in the early secretory pathway is required for dynamic retention of e

200 ust trafficking within the constitutive-like secretory pathway is required for VAMP8- but not VAMP2-m

201 The secretory pathway is responsible for the synthesis, fold

202 r results have shown that the Rab1-regulated secretory pathway is well conserved, and hemoglobin rece

203 We conclude that FAM20A is likely a secretory pathway kinase and that loss-of-function mutat

204 We recently discovered a family of secretory pathway kinases that phosphorylate extracellul

205 oat protein H (CotH), and the Fam20C-related secretory pathway kinases.

206 te that the mutation inhibits the ameloblast secretory pathway leading to ER stress and an activated

207 ith machinery to tackle perturbations in the secretory pathway, like the unfolded protein response pa

208 e p62 is cleaved before exit from the acidic secretory pathway, low pH-dependent binding of E3 to the

209 re retained in the early compartments of the secretory pathway: mainly the endoplasmic reticulum, but

210 ation and O-glycosylation of proteins in the secretory pathway may be an important mechanism by which

211 ich occur frequently in the cytoplasm and in secretory pathways, may induce the formation of betaS fi

212 teins localized to the Golgi stack and early secretory pathway, mediate processes including Golgi sta

213 ontrast to endocytosis or recycling, how the secretory pathway mediates the localization of auxin car

214 The secretory pathway of eukaryotic cells packages cargo pro

215 he main catalysts for membrane fusion in the secretory pathway of eukaryotic cells.

216 nt secretory pathway into the unconventional secretory pathway of FGF2.

217 translocation as part of the unconventional secretory pathway of FGF2.

218 ng the molecular basis of the unconventional secretory pathway of FGF2.

219 reagents to identify N-glycans in the early secretory pathway of HeLa cells during subcellular fract

220 Within the secretory pathway of higher eukaryotes, the core of thes

221 To understand the role of LdRab1 in the secretory pathway of Leishmania, we have generated trans

222 ER-associated degradation clears the secretory pathway of misfolded proteins and mediates the

223 actin-mediated organelle movement within the secretory pathway of plant cells, and report on recent a

224 coprotein prM during virus maturation in the secretory pathway of the infected cell, explaining its c

225 ort the hypothesis that TG processing in the secretory pathway of TSHR-hyperstimulated thyrocytes alt

226 NHE8 regulates pH homeostasis in the protein secretory pathways of RPE.

227 little is known about the filamentous fungal secretory pathway or how it might be manipulated for imp

228 o regulate its anterograde routing along the secretory pathway, particularly its export from the ER.

229 recently characterized protein kinase in the secretory pathway, phosphorylates HRC on Ser96.

230 ide the first insight into the regulation of secretory pathway phosphorylation.

231 ifications during protein biosynthesis along secretory pathways play critical roles in determining th

232 pressing mutant SOD1 activate unconventional secretory pathways, possibly as a protective mechanism.

233 Our results establish Fam20C as the major secretory pathway protein kinase and serve as a foundati

234 In eukaryotic cells, secretory pathway proteins must pass stringent quality c

235 the Golgi casein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs.

236 e of the sharpest evolutionary signatures of secretory pathway proteins, and was therefore critical f

237 ion of proteins, most of which are not ER or secretory pathway proteins.

238 ation triggered a dual selection pressure on secretory pathway proteins: while sequons were positivel

239 etion efficacy, although passage through the secretory pathway reduces its cell-penetrating activity.

240 n impairs transporter maturation through the secretory pathway, reduces surface expression, and inhib

241 mmalian proteome that traverses the cellular secretory pathway, regulating glycoprotein folding and f

242 The secretory pathway remains a central paradigm of modern c

243 The exocyst is an essential component of the secretory pathway required for delivery of basolateral p

244 sn-linked oligosaccharides in the eukaryotic secretory pathway requires the trimming of nascent glyca

245 FSH released from the LH secretory pathway rescued ovarian defects in Fshb-null m

246 VPH1 and STV1, which target the vacuole and secretory pathway, respectively.

247 ntrol the early and late stages of the yeast secretory pathway, respectively.

248 FAM20C is a newly identified kinase on the secretory pathway responsible for the phosphorylation of

249 ion in viral egress by targeting VCP and the secretory pathway, resulting in a buildup of virions wit

250 2 within the ER (scFv4B12KDEL) and along the secretory pathway (scFv4B12) reduced the intracellular p

251 g and reveal that a GNL1/GNOM-mediated early secretory pathway selectively regulates PIN1 basal polar

252 liferation arrest associated with an altered secretory pathway (senescence-associated secretory pheno

253 Specifically, within the secretory pathway, significant populations of FPs misfol

254 Neutralization of the pH in the secretory pathway successfully rescued dimer association

255 However, only B5 traffics through the secretory pathway, suggesting that F13 uses another rout

256 ient to BFA than functioning of the cellular secretory pathway, suggesting that the role of GBF1 in t

257 V1.4, KV3.3, and KV3.4 channels early in the secretory pathway suggests a shared mechanism of channel

258 produce a higher flux of copper through the secretory pathway that balances copper in the cytosol an

259 sg101- and ISG15-dependent checkpoint in the secretory pathway that compromises influenza virus relea

260 A10 may form a complex with neurexins in the secretory pathway that facilitates surface transport of

261 LMAN1 is a cargo receptor in the early secretory pathway that is responsible for the efficient

262 nism of the folding state of proteins in the secretory pathway that targets unfolded/misfolded polype

263 me families for pathogenesis, illustrate the secretory pathway that transports CWDEs out of the funga

264 In the parasite secretory pathway, the HT motif is cleaved by the protea

265 and from constitutive, basal, and regulated secretory pathways, the latter two via Weibel-Palade bod

266 e focus on the first two compartments of the secretory pathway: the endoplasmic reticulum and Golgi.

267 regulates the dynamics of p115 in the early secretory pathway, thereby controlling trafficking from

268 it the tightly controlled pH gradient of the secretory pathway, thereby regulating activation within

269 As proteins enter the secretory pathway they are decorated by a 'glycan', whic

270 uring maturation of the proteins through the secretory pathway, they are modified by the addition of

271 m lumen regulates normal proteostasis of the secretory pathway; they also support therapies targeting

272 iferation arrest, associated with an altered secretory pathway, thought to promote tumor suppression

273 ssing can occur at neutral pH throughout the secretory pathway through the activity of furin-like pro

274 These studies reveal the importance of the secretory pathway to assemble and maintain full-length f

275 coordinately regulate reorganization of the secretory pathway to control cytokine secretion and faci

276 g cotranslational translocation early in the secretory pathway to downregulate receptor levels and in

277 s (PV) requires membranes of the host cell's secretory pathway to generate replication complexes (RCs

278 , p62, which is cleaved by furin in the late secretory pathway to produce mature E2 and a small perip

279 ertase furin requires the pH gradient of the secretory pathway to regulate its multistep, compartment

280 gered robust forward trafficking through the secretory pathway to the plasma membrane.

281 echanisms to adapt the functions of the late secretory pathway to the specific needs of the organism.

282 where Tomt and the Tmcs interact within the secretory pathway to traffic Tmc proteins to the hair bu

283 ther enterovirus, replication by controlling secretory pathway trafficking and Golgi complex morpholo

284 data implicate BPIFB6 as a key regulator of secretory pathway trafficking and viral replication and

285 sing to Abeta requires transport through the secretory pathway, trafficking of the substrate and acce

286 co-factors, because Psd1p re-directed to the secretory pathway undergoes autocatalysis normally and i

287 roteins in directing trafficking through the secretory pathway, we generated fluorescently tagged VSV

288 iroporin, causes disruption of the mammalian secretory pathway when exogenously expressed in cells.

289 e three P4Hs are shown to be targeted to the secretory pathway, where P4H5 forms dimers with P4H2 and

290 ry for the entrance of LH into the regulated secretory pathway, whereas FSHbeta does not traverse the

291 dulate and augment key aspects of the entire secretory pathway, whereas maladaptive UPR outputs trigg

292 s dispensable for COPI function in the early secretory pathway, whereas the N-terminal longin domain

293 olgi fragmentation and impose a block in the secretory pathway which reduces expression of major hist

294 enterovirus 71 (EV71), co-opt the host cell secretory pathway, which controls the transport of prote

295 a set of interconnected organelles form the secretory pathway, which encompasses the terrain that th

296 arge amounts of membrane protein through the secretory pathway, which makes these cells particularly

297 of the intrinsic factors that act along the secretory pathway, which may compromise product integrit

298 gates in Alzheimer's disease form within the secretory pathway while in Huntington's disease and amyo

299 f terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from

300 not depend on membrane traffic in the early secretory pathway, yet requires both Sec23 and Sec24AB.