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1 tein lipase, secretory sphingomyelinase, and secretory phospholipase A2.
2 teins as well as HDL remodeling by group IIa secretory phospholipase A2.
3 mporally required for expression of type IIA secretory phospholipase A2.
4 underlie the pro-atherosclerotic effects of secretory phospholipase A2.
5 affolds as inhibitors of human nonpancreatic secretory phospholipase A2.
6 ipid migration into the active site of bound secretory phospholipase A2.
7 ncrease membrane order and susceptibility to secretory phospholipase A2.
8 cci proved to be a calcium-dependent enzyme, secretory phospholipase A2.
9 nfluencing the activity of the novel Group V secretory phospholipase A2.
10 es, P < .05) and modestly reduced release of secretory phospholipase A2.
12 animals with a PPARalpha activator increased secretory phospholipase A2 activity, which likely accoun
14 dy, we used this model to assess the role of secretory phospholipase A2 and cycloxygenase-2 in kerati
15 creased prostaglandin E2 production and both secretory phospholipase A2 and cycloxygenase-2 protein e
18 for proceeding with clinical outcome trials secretory phospholipase A2 and lipoprotein-associated ph
19 h roles in host defense, including lysozyme, secretory phospholipase A2, and alpha-defensins, termed
20 proteins and peptides, including statherin, secretory phospholipase A2, and defensins, were identifi
22 vascular cell adhesion molecule 1 (VCAM-1), secretory phospholipase A2, and malondialdehyde and hydr
23 of Paneth cell secretion: lysozyme; type II (secretory) phospholipase A2; and at least one intestinal
24 is, neutrophil degranulation, and release of secretory phospholipase A2 are predominantly mediated by
25 lipid deposition in mice, draw attention to secretory phospholipase A2 as an attractive target for t
26 ed that de novo synthesized groups IIA and X secretory phospholipase A2 can mediate arachidonic acid
30 ported that Pla2g5-null mice lacking group V secretory phospholipase A2 (gV-sPLA2) showed reduced eos
35 hment) technology, binds human nonpancreatic secretory phospholipase A2 (hnps-PLA2) with nanomolar af
36 ctivity as inhibitors of human nonpancreatic secretory phospholipase A2(hnps-PLA2) was developed.
37 s support the previously proposed model that secretory phospholipase A2 hydrolysis generates pro-athe
38 ave previously demonstrated up-regulation of secretory phospholipase A2 IIA (sPLA2 IIA) mRNA and prot
39 and antisense oligonucleotides (one against secretory phospholipase A2 IIa and the other against cyt
41 e presence of group IIA, group V and group X secretory phospholipase A2 in human or mouse atheroscler
44 reatment with 5 microm 12-epi-scalaradial, a secretory phospholipase A2 inhibitor, caused similar cha
45 considerable light on the mechanism by which secretory phospholipases A2 interact with substrate aggr
46 levels and response to barrier disruption of secretory phospholipase A2 isoforms, enzymes that mediat
47 its efficacy against gram-positive bacteria, secretory phospholipase A2 lacked bactericidal activity
48 hils, where its members include lactoferrin, secretory phospholipase A2, lysozyme, and the cathelicid
49 , particularly serum amyloid A and group IIa secretory phospholipase A2, may alter reverse cholestero
50 toferrin), but did not affect the release of secretory phospholipase A2 or lipopolysaccharide-binding
51 ion in antigen-challenged allergic subjects, secretory phospholipase A2 (PI.A2) and acetyl hydrolase
53 demonstrate that in activated mast cells (i) secretory phospholipase A2 (PLA2) mediates the release o
54 V phospholipase A2 is a recently discovered secretory phospholipase A2 (PLA2) that has been shown to
55 ns of two chemically unrelated inhibitors of secretory phospholipase A2 (PLA2), bromphenacyl bromide
58 , providing the first direct evidence that a secretory phospholipase A2 plays a role in stimulation-i
60 phage-specific expression of human group IIA secretory phospholipase A2 promotes atherosclerotic lipi
62 pe TNF tended to be a more potent inducer of secretory phospholipase A2 release than the p55 specific
65 fluid LTB4 , LTE4 , PGD2 , and PGE2 , plasma secretory phospholipase A2 (sPLA2 ), and 11beta prostagl
70 ls of the Paneth cell antimicrobial molecule secretory phospholipase A2 (sPLA2) and the goblet cell g
71 9 lymphoma cells to exogenous group IIA or V secretory phospholipase A2 (sPLA2) caused an initial rel
73 ing the contribution of low molecular weight secretory phospholipase A2 (sPLA2) enzymes in eicosanoid
74 Four related genes encode four different secretory phospholipase A2 (sPLA2) enzymes in mammals, n
81 hidonic acid (AA) induced by the addition of secretory phospholipase A2 (sPLA2) isotypes to bone marr
84 he acute phase of the inflammatory response, secretory phospholipase A2 (sPLA2) reaches its maximum l
85 KEGG pathways, we found expression levels of secretory phospholipase A2 (sPLA2), lysophospholipid acy
87 lipase expressed by keratinocytes is group X secretory phospholipase A2 (sPLA2), which liberates larg
88 This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular
92 se of cyclooxygenase 2, type I collagen, and secretory phospholipase A2 type IIA mRNA, but not those
94 , whereas adult mice expressed more group 10 secretory phospholipase A2, Wnt5a, and transglutaminase
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