ライフサイエンスコーパス: secretory protein

1 two lectins, a protease, and a cysteine-rich secretory protein).

2 fourth type-1 repeat is a fully independent secretory protein.

3 r mutant proteins and increased synthesis of secretory protein.

4 roduces a cellulose binding protein (Hg CBP) secretory protein.

5 tive Mycobacterium tuberculosis 30-kDa major secretory protein.

6 inases with proteolytic activity for parotid secretory protein.

7 a Calmodulin binding protein and a Cys-rich secretory protein.

8 glycoproteins, which include the bulk of the secretory proteins.

9 nal insertion, impeding the translocation of secretory proteins.

10 mbrane and promotes anterograde transport of secretory proteins.

11 ated degradation (ERAD) of multiple unfolded secretory proteins.

12 balance between demand for and synthesis of secretory proteins.

13 tively bound to the signal peptides of small secretory proteins.

14 nctions and facilitate the mass synthesis of secretory proteins.

15 ize native folding and impair trafficking of secretory proteins.

16 sential role in the production of lipids and secretory proteins.

17 manage biogenesis of specific transmembrane secretory proteins.

18 or, more importantly, to specific misfolded secretory proteins.

19 n and decreased expression of genes encoding secretory proteins.

20 of the correct pattern of disulfide bonds in secretory proteins.

21 pression of genes encoding prostate-specific secretory proteins.

22 functional groups and majority of them were secretory proteins.

23 tes, but also belonged to diverse classes of secretory proteins.

24 in the maturation and transport of unfolded secretory proteins.

25 (Pdi1p), which in turn can directly oxidize secretory proteins.

26 hway and thereby rescue the sorting of other secretory proteins.

27 lays a key role in catalyzing the folding of secretory proteins.

28 l surface, is utilized by trans-membrane and secretory proteins.

29 emands in the ER by degrading mRNAs encoding secretory proteins.

30 associations were established for 82 (9.0%) secretory proteins.

31 central role in the intracellular sorting of secretory proteins.

32 ificity of ARTC2.2 from membrane proteins to secretory proteins.

33 ite of synthesis and folding of membrane and secretory proteins.

34 ce for export that is not seen for classical secretory proteins.

35 chaperone, it does not interact with folded secretory proteins.

36 assembly and transportation of membrane and secretory proteins.

37 nt protein D, C-reactive protein, Clara cell secretory protein-16, IL-6 and -8, and tumor necrosis fa

38 A. ceylanicum excretory-secretory protein 2 (AceES-2), a highly immunoreactive m

39 an CAP superfamily member, the cysteine-rich secretory protein 2 (CRISP2), rescues the phenotype of y

40 s to a prostate autoantigen, seminal vesicle secretory protein 2 (SVS2), which we believe to be novel

41 Out of 908 secretory proteins, 581 (63.8%) have functions related t

42 cribe novel chaperone-like functions for the secretory protein 7B2, which is widely expressed in neur

43 Here, we show that Prostatic secretory protein 94 (PSP94) levels are reduced in ovari

44 h encodes beta-microseminoprotein (prostatic secretory protein 94).

45 In a random sampling of 130 genes encoding secretory proteins, about half were expressed above thre

46 Adiponectin is a secretory protein abundantly secreted from adipocytes.

47 r prevalent in tissues with high activity of secretory protein accumulation, including developing end

48 vides the driving force for the transport of secretory proteins across the cytoplasmic membrane of Es

49 The adipocyte-derived secretory protein adiponectin has been widely studied an

50 The adipocyte-specific secretory protein adiponectin is a particularly promisin

51 ases (PCs) furin, PC5, PACE4, and PC7 cleave secretory proteins after basic residues, including the H

52 Here, we compare the transport of soluble secretory proteins (albumin and alpha1-antitrypsin) with

53 Other major secretory proteins (amylase, proline-rich protein) are n

54 dentification and role of autotaxin (ATX), a secretory protein and a major source for extracellular l

55 Fetuin-A is a hepatic secretory protein and a novel risk factor for diabetes.

56 onchiolar epithelium co-expressed Clara cell secretory protein and alpha(7).

57 CRK1 abolished anterograde transport of the secretory protein and disrupted the localization of mult

58 cells were used to show that the CTRP5 is a secretory protein and that its secretion is impaired by

59 he translocation of a full-length microsomal secretory protein and was cleaved as part of the signal

60 On a large test set containing 98 secretory proteins and 6601 non-secretory proteins of hu

61 s, but a direct association between granular secretory proteins and actin-remodeling molecules has no

62 ermore, the expression of several epithelial secretory proteins and antimicrobial molecules was consi

63 t mechanism that applies to a major class of secretory proteins and indicate the co-existence of mult

64 ulum is the site of synthesis and folding of secretory proteins and is sensitive to changes in the in

65 ding trafficking and sorting of membrane and secretory proteins and posttranslational modification by

66 ted by decreased plasma levels of neutrophil secretory proteins and significantly decreased tissue in

67 anslationally recognizes signal sequences of secretory proteins and targets ribosome-nascent chain co

68 we investigated these two ER-retained mutant secretory proteins and the selectivity of their interact

69 roscopy revealed that Cab45 colocalizes with secretory proteins and the TGN Ca(2+) pump (SPCA1) in sp

70 l of extracellular proteolytic cleavage of a secretory protein, and reveals an important mechanism th

71 decreased levels of Clara cells, Clara cell secretory protein, and surfactant proteins B and C, with

72 The mechanisms by which secretory proteins, and granins in particular, are sorte

73 erexpresses the M. tuberculosis 30-kDa major secretory protein antigen 85B, which is 85% homologous w

74 embers of the CAP superfamily (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related

75 acterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP)

76 APS) domain, also known as the cysteine-rich secretory proteins/antigen 5/pathogenesis-related 1 prot

77 Secretory proteins are exported from the endoplasmic ret

78 Secretory proteins are exported from the endoplasmic ret

79 Secretory proteins are exported from the endoplasmic ret

80 In bacteria, secretory proteins are generally translocated after comp

81 Certain secretory proteins are known to be critical for maintain

82 Many plant pathogen secretory proteins are known to be elicitors or pathogen

83 When membrane proteins and secretory proteins are misfolded or incompletely folded,

84 Many secretory proteins are N-glycosylated, and despite some

85 Secretory proteins are only temporary cytoplasmic reside

86 Terminally misfolded or unassembled secretory proteins are retained in the endoplasmic retic

87 Parotid secretory proteins are stored in large dense-core secret

88 Many secretory proteins are targeted by signal sequences to a

89 In bacteria, most secretory proteins are translocated across the plasma me

90 The majority of secretory proteins are translocated into and across hydr

91 In bacteria most secretory proteins are transported across the plasma mem

92 Many bacterial proteins, including most secretory proteins, are translocated across the plasma m

93 AB27A pathway to regulate the trafficking of secretory proteins as exosomes.

94 the human proteome and identified over 1,050 secretory proteins as potential furin substrates.

95 lin and SPCA1/Pmr1 in sorting of the soluble secretory proteins at the TGN/late Golgi membranes in eu

96 y calcium ATPase (SPCA)-dependent sorting of secretory proteins at the trans-Golgi network (TGN).

97 +-ATPase, is one of the critical factors for secretory protein binding to the immobile phase and also

98 Here we discuss the key players that mediate secretory protein biogenesis and trafficking, highlighti

99 xport is selective for proinsulin over other secretory proteins, but the same effect is observed for

100 nslational targeting of nascent membrane and secretory proteins by the signal recognition particle (S

101 An unexpected connection between a secretory protein called PCSK9 and Sec24A, a well known

102 nt advances in our understanding of one such secretory protein called ROP16.

103 show that the expression of a heterodimeric secretory protein can be improved by harmonizing selecte

104 e show that both in vivo and in vitro, small secretory proteins can enter the ER posttranslationally

105 Accumulation of misfolded secretory proteins causes cellular stress and induces th

106 onditional mutant mouse with both Clara cell secretory protein (CC10)-Cre recombinase and the Lox-Sto

107 lf-organized into distinct Clara cell 10-kDa secretory protein (CC10+) airway-like and SPC+ saccular

108 performed for two pneumoproteins, Clara cell secretory protein (CC16) and surfactant protein D (SP-D)

109 Clara cell secretory protein (CC16) is associated with Th2 modulati

110 sed in lung epithelial cells [via Clara cell secretory protein (CCSP(cre))].

111 Clara cell secretory protein (CCSP) and interleukin 8 levels were a

112 oximal airways of the fetus; both Clara cell secretory protein (CCSP) and MUC5AC/5B mRNA and protein

113 orged and Clara cells accumulated Clara cell secretory protein (CCSP) in Munc13-2-deficient mice.

114 Clara cell secretory protein (CCSP) is specifically expressed in pu

115 lung fluid protein expression of Clara cell secretory protein (CCSP), a marker for Clara cells, in l

116 1), the alveolar stem cell marker Clara cell secretory protein (Ccsp), and the epithelial cell marker

117 ar microinjection, were bred with Clara cell secretory protein (CCSP)-rtTA activator mice.

118 These studies used bi-transgenic Clara cell secretory protein (CCSP)/IL-1beta mice that conditionall

119 In contrast, an integral membrane secretory protein (CD8alpha) is not enriched in these ca

120 Club cell secretory protein (Clara) (CC16) is produced mainly by b

121 total proteins) were identified as putative secretory proteins containing signal peptides.

122 n is a truncated member of the Cysteine-Rich Secretory Protein (CRISP) family, whose members include

123 CAP protein superfamily [i.e. cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis

124 To determine effects of conceptus secretory proteins (CSP) containing IFN-delta and IFN-ga

125 The secretory protein Dickkopf-1 (DKK-1) is a known Wnt anta

126 ion with two phases: a mobile phase in which secretory proteins diffuse as in the endoplasmic reticul

127 Secretory proteins drive these processes, so we screened

128 Selective overexpression of Human epididymal secretory protein E4 (HE4) points to a role in ovarian c

129 Eukaryotic secretory proteins exit the endoplasmic reticulum (ER) v

130 olutionarily conserved, approximately 34-kDa secretory protein expressed in the brain.

131 th inducible expression of p52 in Clara cell secretory protein-expressing airway epithelial cells.

132 To enhance secretory protein folding and promote adaptation to stre

133 synthetic inhibitors of essential processes (secretory protein folding or sterol biosynthesis) in the

134 Adiponectin is an adipocyte-specific secretory protein found in circulation in several differ

135 This report shows that secretory proteins from neuroendocrine cells will activa

136 erved mechanism to remove misfolded membrane/secretory proteins from the endoplasmic reticulum (ER).

137 required for the concentration and export of secretory proteins from the endoplasmic reticulum (ER).

138 The transport of secretory proteins from the endoplasmic reticulum to the

139 of the COPII-coated vesicles that transport secretory proteins from the endoplasmic reticulum to the

140 Transport of secretory proteins from the endoplasmic reticulum to the

141 complex II-coated vesicles, which transport secretory proteins from the endoplasmic reticulum to the

142 e the large scale prediction and analysis of secretory proteins from the Puccinia helianthi transcrip

143 of Eps15, significantly reduced the exit of secretory proteins from the TGN.

144 complex, the SecA ATPase, and a segment of a secretory protein fused into SecA.

145 Overexpression of the secretory protein glyceraldehyde-3-phosphate dehydrogena

146 a lysosomal enzyme recognition domain in the secretory protein glycopepsinogen by substituting in two

147 the intracellular bacteria and receives host secretory proteins important for bacterial development.

148 oimmunoprecipitated with a newly synthesized secretory protein in vitro and stimulated protein matura

149 le to mass production of functionally active secretory proteins in a silkworm-based expression platfo

150 ugh Fgfr2(cn) prostates continued to produce secretory proteins in an androgen-dependent manner, they

151 P mobility reports on the levels of unfolded secretory proteins in individual cells, independent of U

152 eoglycan, is crucial for storage of specific secretory proteins in mast cells, neutrophils, and cytot

153 Unlike regulated secretory proteins in other cell types, salivary protein

154 e emerged as important features of regulated secretory proteins in parasites of the phylum Apicomplex

155 Lipid transfer proteins (LTPs) are small secretory proteins in plants with defined lipid-binding

156 ry granules act as a distribution center for secretory proteins in salivary acinar cells.

157 Accumulation of misfolded secretory proteins in the endoplasmic reticulum (ER) act

158 After folding and assembly of nascent secretory proteins in the endoplasmic reticulum (ER), th

159 sport vesicles, function in trafficking some secretory proteins in yeast and higher eukaryotes.

160 Sec61 blockade affects a selective subset of secretory proteins including key signal-transmitting rec

161 Thus, increased plasma levels of neutrophil secretory proteins, including myeloperoxidase and elasta

162 es that were enriched in the epithelium were secretory proteins, including seminal vesicle protein se

163 The parotid gland contributes a variety of secretory proteins-including amylase, proline-rich prote

164 The majority of biosynthetic secretory proteins initiate their journey through the en

165 Ss occupied a more nonpolar environment than secretory proteins inside the aqueous ribosome tunnel, w

166 Incorporation of secretory proteins into ER-derived vesicles involves rec

167 import of small or intrinsically disordered secretory proteins into the ER based on their ability to

168 Translocation of secretory proteins into the lumen of the endoplasmic ret

169 or previously described and newly identified secretory proteins is confirmed in vivo and in vitro.

170 how plants exert quality control over their secretory proteins is less clear.

171 ctor for RRS and indicate that misfolding of secretory proteins is likely to significantly contribute

172 em, known for its role in quality control of secretory proteins, is unexpectedly responsible for the

173 ctoferrin (LF), and reduced expression of SV secretory protein IV (SVS IV).

174 sion of the major estrogen-inducible uterine secretory protein lactoferrin (LF), and reduced expressi

175 Because hLAL is a secretory protein, lal(-/-) phenotypes in other compartm

176 regulatory factor 8 (IRF8) and cysteine-rich secretory protein LCCL domain containing 2 (CRISPLD2).

177 here uncover a mechanism by which defects in secretory proteins lead to a dramatic reduction in their

178 potent GC, dexamethasone (Dex) increased the secretory protein load of ECM proteins in the ER of TM c

179 y of the endoplasmic reticulum (ER) with the secretory protein load of the cell.

180 When Clara cell secretory protein-membrane hen egg lysozyme/hemoglobin t

181 ERAD of a portion of secretory proteins might occur via signal-dependent regu

182 novel and powerful tool for reporting global secretory protein misfolding levels and investigating th

183 s, including a number of known components in secretory protein modification and sorting.

184 overlaid on navigation between non-reactive secretory protein molecular depots patterned at the plas

185 previously characterized two SNARE proteins, secretory protein (MoSec22) and vesicle-associated membr

186 r knockdown of SRP54 promoted degradation of secretory protein mRNA.

187 rmed that NS1 can promote the translation of secretory protein mRNAs based on the nucleotides within

188 A primary function of 5' regions in many secretory protein mRNAs is to encode an endoplasmic reti

189 een shown to secrete a protease termed major secretory protein (Msp).

190 Folding of transmembrane and secretory proteins occurs in the lumen of the endoplasmi

191 cytoplasmic protein, was found to be a major secretory protein of GAS and essential for bacterial sur

192 ontaining 98 secretory proteins and 6601 non-secretory proteins of human, our classifier achieved app

193 f ASP-like proteins, proteases, or excretory-secretory proteins of unknown function.

194 bility to limit deleterious effects of other secretory proteins on the ER.

195 ting our in silico prediction that out of 89 secretory proteins, only 14 are lipoproteins.

196 The secretory proteins participate in motility, invasion, an

197 We fused the soluble secretory protein peptidylglycine alpha-hydroxylating mo

198 trols, but increased apoptosis of Clara cell secretory protein-positive airway epithelial cells was o

199 (WNT) signaling pathway, is one endometrial secretory protein potentially involved in maternal-embry

200 wild-type or mutated signal sequences of the secretory protein preprolactin by in vitro translation o

201 In the current study, secretory proteins present in the cultured supernatants

202 Here we demonstrate that many secretory proteins produced by hematopoietic stem cells

203 s a ubiquitous organelle that plays roles in secretory protein production, folding, quality control,

204 in-producing pancreatic beta-cells with high secretory protein production.

205 impaired ligand binding also interfered with secretory protein production.

206 use neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cell

207 tope tag under the control of the Clara cell secretory protein promoter, which largely limited transg

208 Parotid secretory protein (PSP) and palate-lung-nasal epithelium

209 eport that the soluble cargo protein Parotid Secretory Protein (PSP) is bound to the membranes of sec

210 -carbonic anhydrase 6 (CA6) and anti-parotid secretory protein (PSP), which occur early in the course

211 amylase, proline-rich proteins, and parotid secretory protein (PSP)-to these functions.

212 anti-carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP).

213 the Mycobacterium tuberculosis 30-kDa major secretory protein (r30/antigen 85B [Ag85B]) (rLm30) as h

214 elle maturation as the redistribution of the secretory proteins Rab27a or Munc13-4 in response to LPS

215 )-associated degradation (ERAD) of misfolded secretory proteins, reflecting the fact that some level

216 Chromogranins are pro-hormone secretory proteins released from neuroendocrine cells, w

217 Most misfolded secretory proteins remain in the endoplasmic reticulum (

218 In eukaryotic cells, newly synthesized secretory proteins require COPII (coat protein complex I

219 isrupted endoplasmic reticulum export of the secretory proteins required for normal morphogenesis acc

220 Gene ontology analysis of the secretory proteins revealed an enrichment of hydrolase a

221 Administration of doxycycline to Clara cell secretory protein-reverse tetracycline-controlled transa

222 ence that DCG biogenesis is dependent on the secretory protein secretogranin (Sg) II, a member of the

223 ary to induce lactoferrin, an E(2)-regulated secretory protein selectively synthesized in the uterine

224 The secretory protein Slit2 and its receptors Robo1 and Robo

225 ecific for antibody secretion, because other secretory proteins such as IL-6 are released normally fr

226 (2+) These Cab45 oligomers specifically bind secretory proteins, such as COMP and LyzC, in a Ca(2+)-d

227 s and (ii) computational prediction of blood-secretory proteins supported by experimental validation.

228 of specialized cellular processes, including secretory protein synthesis and processing, exocytosis,

229 Restoration of normal rates of secretory protein synthesis and secretion may be a new t

230 Secretory protein synthesis begins in the endoplasmic re

231 hermore, the negative effect of BiP(T46G) on secretory protein synthesis was rescued by increased lev

232 drives acinar differentiation by maximizing secretory protein synthesis, stimulating mitochondrial m

233 te a maximum of membrane-bound polysomes for secretory protein synthesis.

234 of an isolated ATPase domain interfered with secretory protein synthesis.

235 slocation and folding machinery to influence secretory protein synthesis.

236 These results suggest new roles for secretory protein tertiary structure in hormone and tran

237 previous study showed that expression of the secretory protein TgMIC5 suppresses TgSUB1 activity, the

238 Dickkopf1 (DKK1) is a secretory protein that antagonizes oncogenic Wnt signali

239 Fetuin-A is a hepatic secretory protein that binds the insulin receptor and in

240 eptide attached to ChEL makes an independent secretory protein that binds to I-II-III, stabilizing it

241 Fetuin-A is a hepatic secretory protein that inhibits arterial calcium deposit

242 Fetuin-A is a multifunctional hepatic secretory protein that inhibits dystrophic vascular and

243 Fetuin-A is a multifunctional hepatic secretory protein that inhibits the action of insulin in

244 SPLUNC1 is a 25 kDa secretory protein that is expressed in nasal, oropharyng

245 The AGR2 gene encodes a secretory protein that is highly expressed in adenocarci

246 10A06 is a cyst nematode secretory protein that is most likely secreted as an eff

247 Ym1/Ym2 is a chitinase-like secretory protein that is transiently induced in alterna

248 o regions II-III also makes for an efficient secretory protein that neither demonstrably interacts no

249 is mediated under the positive regulation of secretory protein that possesses a cysteine and histidin

250 ung-nasal epithelium clone (PLUNC) are novel secretory proteins that are expressed in the oral cavity

251 associated proteins (PAP) are stress-induced secretory proteins that are implicated in immunoregulati

252 verexpression of Munc18b caused membrane and secretory proteins that are normally sent primarily to t

253 Secretory proteins that are not stored in large secretor

254 ty control protein ERp44 allows retrieval of secretory proteins that contain free thiols via a disulf

255 Membrane and secretory proteins that fail to pass quality control in

256 provided a uniquely broad view of Toxoplasma secretory proteins that participate in parasite survival

257 The TKDPs are secretory proteins that possess a carboxyl-terminal pept

258 ast growth factor 23 (FGF-23) and Klotho are secretory proteins that regulate mineral-ion metabolism.

259 nd DeltatatC strains identified 73 predicted secretory proteins that were present in reduced amounts

260 in the delivery of basolateral membrane and secretory proteins, the basolateral targeting of syntaxi

261 Like all other secretory proteins, the HIV-1 envelope glycoprotein gp16

262 spholipids for the subsequent trafficking of secretory proteins through the ER-Golgi network.

263 can be rationalized by lower trafficking of secretory proteins through their ERs.

264 to act as an escort factor by binding to the secretory protein thyroglobulin (Tg) in the ER, thereby

265 mutant proteins stimulated secretion of the secretory protein thyroglobulin with an efficiency simil

266 nals by efficiently directing a heterologous secretory protein to the regulated secretory pathway.

267 We observed the large majority of secretory proteins to be cotranslationally translocated,

268 isms are responsible for the distribution of secretory proteins to different secretory pathways from

269 -A) inserts or signal peptides from membrane/secretory proteins to explore the influence of nascent c

270 reciated heterogeneity in the recruitment of secretory proteins to the COPII vesicles that extends to

271 ee domains of life and delivers membrane and secretory proteins to the cytoplasmic membrane or endopl

272 nery responsible for delivering membrane and secretory proteins to the proper cellular destination.

273 Two distinct pathways deliver secretory proteins to the Sec61 protein translocase in t

274 ally delivers newly synthesized membrane and secretory proteins to the target cellular membrane.

275 GA expression, by siRNA, disrupted regulated secretory protein traffic by approximately 65%, while ta

276 Such ER stress and blockage of secretory protein traffic eventually resulted in Golgi c

277 Secretory proteins traffic from the ER to the Golgi via

278 oplasmic reticulum (ER) is rate-limiting for secretory protein trafficking because protein folding/as

279 lex II (COPII) mediates the initial steps of secretory protein trafficking by assembling onto subdoma

280 Secretory protein trafficking relies on the COPI coat, w

281 ate exocytosis, total protein synthesis, and secretory protein transport in response to a secretory s

282 cargo and coat subunits to promote efficient secretory protein transport.

283 After leaving the endoplasmic reticulum, secretory proteins traverse several membranous transport

284 logy employing disulfide bond formation of a secretory protein, trypsinogen (TG), that behaves in vit

285 Secretory proteins unable to assemble into their native

286 cell model and found that the key mast cell secretory protein VAMP8 becomes phosphorylated by PKC at

287 ression of some, but not all, genes encoding secretory proteins was inhibited by injection of xbp1 mo

288 ng associated with the discharge of parasite secretory proteins was not sufficient to induce this swi

289 ally expressed human growth hormone (hGH), a secretory protein, was packaged into DFV.

290 ht into ER homeostasis and the biogenesis of secretory proteins, we screened a genomewide collection

291 Additionally, 143 putative secretory proteins were categorized into 27 functional g

292 ro-ALP) accumulated in the ER, whereas other secretory proteins were transported at wild-type rates.

293 es and 33% were predicted to be nonclassical secretory proteins, whereas only 3% and 11%, respectivel

294 y A member 2 (BPIFA2), also known as parotid secretory protein, which we identified via a multiplex q

295 ite of synthesis and folding of membrane and secretory proteins, which, collectively, represent a lar

296 (ERAD), monitors the folding of membrane and secretory proteins whose biogenesis takes place in the e

297 NcCyP is a secretory protein with a predicted signal peptide of 17

298 toxin (EDN) is an eosinophil granule-derived secretory protein with ribonuclease and antiviral activi

299 It encodes ubiquitous, highly conserved, secretory protein with the poorly defined function.

300 which encodes ubiquitous, highly conserved, secretory protein with unknown function, leads to activa