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1 4 receptors and Myo2 motors per transporting secretory vesicle.
2 JA signaling that promotes the formation of secretory vesicles.
3 Ypt32p-GTP to recruit Sec2p to Golgi-derived secretory vesicles.
4 ation that is required for the exocytosis of secretory vesicles.
5 tion for full and partial collapses of large secretory vesicles.
6 rostatic interactions and may associate with secretory vesicles.
7 disorganized trafficking and fusion between secretory vesicles.
8 tilisin-like serine protease SUB1 in exoneme secretory vesicles.
9 5-HT(1B)), was delivered to the dendrites in secretory vesicles.
10 nd is present in purified human neuropeptide secretory vesicles.
11 ess that drives the budding and transport of secretory vesicles.
12 n compromised growth and the accumulation of secretory vesicles.
13 c reticulum (ER) and formation of many large secretory vesicles.
14 (GEF) that activates the Rab GTPase Sec4p on secretory vesicles.
15 ease of small molecules that are packaged in secretory vesicles.
16 (CgB) represent the major proteins of these secretory vesicles.
17 olved proteins only from plasma membranes or secretory vesicles.
18 intermediate forms that are then packed into secretory vesicles.
19 oduction of POMC-derived peptide hormones in secretory vesicles.
20 nsistent with its extralysosomal function in secretory vesicles.
21 , indicating that they function as bona fide secretory vesicles.
22 oviding a mechanism for PTPMEG2 targeting to secretory vesicles.
23 microm) basal cytoplasmic process devoid of secretory vesicles.
24 mogranin A neuropeptides that are present in secretory vesicles.
25 nsporting monoamines from the cytoplasm into secretory vesicles.
26 participates in the docking of a variety of secretory vesicles.
27 e growth and the depolarized accumulation of secretory vesicles.
28 hain, bearing bound IL-4, was mobilized into secretory vesicles.
29 ysaccharide, is trafficked within post-Golgi secretory vesicles.
30 preformed IL-4 from eosinophil granules into secretory vesicles.
31 e to promote Rab1-dependent binding of early secretory vesicles.
32 s6p, which sort selected cargo proteins into secretory vesicles.
33 or CFTR revealed its presence exclusively in secretory vesicles.
34 y1 functions selectively in the transport of secretory vesicles.
35 ology and interconnections of TGN-associated secretory vesicles.
36 nt in the concentration of catecholamines in secretory vesicles.
37 of Myo2 with its receptor, the Rab Sec4, on secretory vesicles.
38 holipid is enriched on the cytosolic face of secretory vesicles.
39 ort proteins at the trans-Golgi network into secretory vesicles.
41 defects at a late stage of the pathway, with secretory vesicles accumulating near exocytic sites.
42 d functions to regulate trafficking of early secretory vesicles, activation of T cells, and expressio
44 hizosaccharomyces pombe, Myosin Vs transport secretory vesicles along actin cables, which are dynamic
45 cumulation of solutes inside chromaffin cell secretory vesicles, although this has yet to be demonstr
46 partners that facilitates maturation of the secretory vesicle and helps to promote the directionalit
50 show that myosin-V is activated by binding a secretory vesicle and that myosin-V mutations that compr
51 osine phosphate family located in dense core secretory vesicles and a major autoantigen in type 1 dia
52 run (KR) is an unconventional fusion between secretory vesicles and a target membrane that releases i
53 id formation during packing of peptides into secretory vesicles and amyloid dissociation upon release
55 -SAAS, which are stored in and released from secretory vesicles and are expressed widely in nervous,
58 rminal signal sequence allowing targeting to secretory vesicles and cytokine secretion, whereas usage
59 ClC-3 to polymorphonuclear leukocytes (PMN) secretory vesicles and demonstrated that it is required
60 shworks, and both caused homotypic fusion of secretory vesicles and formation of aqueous vacuoles in
61 his agent inhibited stimulated exocytosis of secretory vesicles and gelatinase and specific granules
62 ves a dual function, to both recruit Sro7 to secretory vesicles and inhibit its Rab-dependent tetheri
63 primary CPECs, including self-assembly into secretory vesicles and integration into endogenous choro
65 Ypt11, receptors for essential transport of secretory vesicles and mitochondria, respectively, bind
66 of IA-2 and IA-2beta, structural proteins of secretory vesicles and modulators of neuroendocrine secr
67 ons correspond to a paucity of foveolar cell secretory vesicles and notable loss of stomach but not i
68 cellular material into the bud: Myo2p moves secretory vesicles and organelles, whereas Myo4p transpo
70 e of phosphatidylserine in lipid bilayers of secretory vesicles and plasma membranes couples the doma
71 The zinc transporter ZnT2 imports zinc into secretory vesicles and regulates zinc export from the ma
72 ssibly modified in the acidic compartment of secretory vesicles and requiring a release mechanism tha
73 roups redundantly mobilize G2A latent within secretory vesicles and result in G2A receptor/Galphai/ph
76 proximately 3-fold increase in the number of secretory vesicles and the insulin content of cells.
77 hosphorylated after it has been recruited to secretory vesicles and the level of PI(4)P has been redu
79 transmitters bind to a charged matrix within secretory vesicles, and release requires entry of counte
80 d CSLF6 to the endoplasmic reticulum, Golgi, secretory vesicles, and the PM and CSLH1 to the same loc
82 embrane system and packaged in Golgi-derived secretory vesicles, Arabidopsis (Arabidopsis thaliana) s
83 dhesive ligands mobilized from intracellular secretory vesicles are capped to the posterior end of th
85 n proteins suggests that the hypothesis that secretory vesicles are formed from plasma membranes by e
89 ds perceive the haptoelectrical stimulation, secretory vesicles are tailored to be released in a sequ
93 to synaptic vesicles and to large dense-core secretory vesicles as reported previously, whereas synap
94 vesicles recruited during phagocytosis were secretory vesicles as their recruitment was sensitive to
95 ents are brought to these sites by riding on secretory vesicles as they are actively transported alon
98 exocytic machinery responsible for fusion of secretory vesicles at specific sites on the plasma membr
100 exocyst mediates the tethering of post-Golgi secretory vesicles at the plasma membrane for exocytosis
101 eric protein complex that tethers post-Golgi secretory vesicles at the plasma membrane for exocytosis
102 n complex implicated in tethering post-Golgi secretory vesicles at the plasma membrane in preparation
103 t, a conserved multiprotein complex, tethers secretory vesicles before fusion with the plasma membran
105 ynthase Mcs1 moves to the plasma membrane in secretory vesicles, being delivered by kinesin-1 and myo
106 secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine
108 asplakinolide rapidly disrupted transport of secretory vesicles, but each drug caused distinct respon
109 cal for the docking and fusion of post-Golgi secretory vesicles, but not for their transport to the P
110 d on the Golgi is normally incorporated into secretory vesicles, but the fate of that pool has been u
111 We propose that the exocyst is recruited to secretory vesicles by the combinatorial signals of Sec4-
114 at when Uso1 is inappropriately recruited to secretory vesicles by Ypt1-SW1(Sec4), the extended coile
115 its host cell requires protein release from secretory vesicles, called dense granules, to maintain t
117 In budding yeast, two classes of post-Golgi secretory vesicles carrying different sets of cargoes ty
119 ia a fusion pore that then dilates until the secretory vesicle collapses into the PM; or by "kiss-and
121 for the targeting of this phosphatase to the secretory vesicle compartment by association with other
122 ibuted throughout the cytoplasm and numerous secretory vesicles concentrated near the locular side.
124 ertebrate MICAL-1 regulates the targeting of secretory vesicles containing immunoglobulin superfamily
125 toward the cell membrane and filopodia, and secretory vesicles containing the HSP90alpha-AHA1-surviv
126 membrane, the endoplasmic reticulum and the secretory vesicles contribute to the milk fat globule me
127 otein architecture of the 'human' dense core secretory vesicles (DCSV) to understand mechanisms for s
129 ntly, cathespin L expression was directed to secretory vesicles, demonstrated by colocalization of ca
130 nt cell type is unique in containing a giant secretory vesicle derived from the Golgi apparatus.
131 cate that XGA is secreted by a novel type of secretory vesicles derived from trans-Golgi cisternae.
133 with redistribution of CypB(W128A)-GFP into secretory vesicles disconnected from the ER/Golgi networ
134 e cell plasma membrane, where membrane-bound secretory vesicles dock and fuse to release intravesicul
138 d mechanism for recruitment of Golgi-derived secretory vesicles during phagosome biogenesis, which wa
139 d that PI(4)P is required for late Golgi and secretory vesicle dynamics and targeting and, as a resul
142 mbrane-enriched fractions, 418 (37%) only in secretory vesicle-enriched membrane fractions, and 127 (
143 olved in the calcium-dependent regulation of secretory vesicle exocytosis in neurons and neuroendocri
144 Understanding the functional consequences of secretory vesicle exocytosis requires knowledge of their
145 phatase (V-ATPase) is directly implicated in secretory vesicle exocytosis through a role in membrane
146 sma membrane where it functions in regulated secretory vesicle exocytosis, but it is also found on in
148 ament (F-actin) coats around the exocytosing secretory vesicles followed by direct retrieval of some
149 g a positive-feedback loop that prepares the secretory vesicle for fusion with the plasma membrane.
152 nt, budding yeast grows rapidly transporting secretory vesicles for localized growth and actively seg
153 transporter 3 (VGLUT3) loads glutamate into secretory vesicles for neurotransmission and is expresse
154 to provide an essential role in delivery of secretory vesicles for polarized growth and in the trans
155 olytic fragments that function in chromaffin secretory vesicles for release of bioactive molecules fo
161 owed that G2A resides in the plasma membrane/secretory vesicle fraction and not in neutrophil primary
162 lysis, MRP-14 was present in plasma membrane/secretory vesicle fractions and gelatinase and specific
163 P bound Sec4p is required for the transit of secretory vesicles from the trans-Golgi to sites of pola
165 (syt), a transmembrane protein localized to secretory vesicles, functions as a Ca2+ sensor that faci
166 a ubiquitous process in eukaryotes, whereby secretory vesicles fuse with the plasma membrane and rel
167 to occur either by "full fusion," where the secretory vesicle fuses with the plasma membrane (PM) vi
168 ng the apical plasma membrane at the site of secretory vesicle fusion and re-assembled directionally
169 C2B domain of Synaptotagmin-1 participate in secretory vesicle fusion, and in more upstream steps, es
172 h HCN channels, which are located on or near secretory vesicles, have an important role in modulating
173 cellular structures that are consistent with secretory vesicles, however, in most cell types studied,
174 pool or by Ca(2+)-dependent exocytosis from secretory vesicles, i.e., by a mechanism similar to the
175 hat affect the recruitment of the exocyst to secretory vesicles identified genes encoding clathrin an
176 ules correlated with the positions of single secretory vesicles in a functionally rescued Munc18-1-nu
177 ere we show that vti1a is absent from mature secretory vesicles in adrenal chromaffin cells, but loca
178 CHGA) is coreleased with catecholamines from secretory vesicles in adrenal medulla and sympathetic ax
179 ired for the formation of large, specialized secretory vesicles in gastric zymogenic (chief) cells (Z
181 ored in, and secreted from, large dense-core secretory vesicles in nerve terminals in the median emin
183 Mini202, we measured the pH of catecholamine secretory vesicles in PC-12 cells (pH approximately 5.9)
184 eviously unprecedented role of Golgi-derived secretory vesicles in phagocytic uptake, the key innate
186 th the tether and the motor reside on moving secretory vesicles in yeast cells, a necessary feature f
187 that Rab26 selectively directs synaptic and secretory vesicles into preautophagosomal structures, su
188 te and instead rapidly reseals such that the secretory vesicle is retrieved almost fully intact.
189 ne (PS) in the mammalian plasma membrane and secretory vesicles is maintained, in part, by an ATP-dep
192 organized, analysis of directed transport of secretory vesicles is still biased toward the bud, refle
193 (ATPase II), originally isolated from bovine secretory vesicles, is a member of this subfamily based
195 nofluorescence was detected in lysosomes and secretory vesicle-like organelles in LG acinar cells and
196 ulation through a role in modulating insulin secretory vesicle localization and/or fusion via actin r
197 acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network.
198 he actin coats results from the union of the secretory vesicle membrane and PM and that this compartm
199 ged regions in SNARE proteins in synaptic or secretory vesicle membrane lipid bilayers with positivel
200 logies to develop a more complete catalog of secretory vesicle membrane proteins and to compare the p
203 a fusion pore opens between the plasma and a secretory vesicle membranes; typically, when the pore di
204 Previous in vitro studies have found that secretory vesicle motion at many sites of release is con
205 photobleaching analysis, we first show that secretory vesicles move toward and accumulate at the tip
206 erved surface residues that are required for secretory vesicle movement, but not vacuole movement.
208 on of cathepsin V with enkephalin and NPY in secretory vesicles of human neuroblastoma cells was illu
211 the cytoplasm, RIG-I and MDA-5 are stored in secretory vesicles of neutrophils and showed that RIG-I
212 TgCPC1 and TgCPC2 localize to constitutive secretory vesicles of tachyzoites, the dense granules.
214 e increased levels of (Met)enkephalin within secretory vesicles of the regulated secretory pathway.
216 complex and Rab11 GTPase Ypt3 help to tether secretory vesicles or tubulovesicular structures along t
217 nalysis of membrane-bound containers such as secretory vesicles, organelles, and exosomes can provide
218 at the > or =30-fold (H+) difference between secretory vesicles (pH < or = 5.7) and the cytoplasm (pH
219 lutamate)-SNARE essential for Ca2+-dependent secretory vesicle-plasma membrane fusion in neuroendocri
221 s up cytosolic monoamines into intracellular secretory vesicles, preventing their neurotoxicity in th
222 two-hybrid screening identified a number of secretory vesicle proteins that interacted directly with
223 ntigens in type 1 diabetes and transmembrane secretory vesicle proteins, results in impaired secretio
224 les released during the fusion of individual secretory vesicles provides information about molecular
225 r, the trans-Golgi network Rab Ypt31/32p and secretory vesicle Rab Sec4p each bind directly, but dist
226 n in the biogenesis or maintenance of mature secretory vesicles, raising the possibility of a complet
230 domains of positively charged amino acids of secretory vesicle SNARE proteins with similar domains of
231 of at least 24 carbon atoms are enriched in secretory vesicle subdomains of the TGN and are critical
232 his loop results in a modest accumulation of secretory vesicles, suggesting impaired exocyst function
234 intermolecular steps via which they prepare secretory vesicles (SVs) for fusion is key to understand
240 qt-SM is enriched in a subset of TGN-derived secretory vesicles that are also enriched in a glycophos
242 that control biogenesis and fusion of early secretory vesicles that exit the ER and host proteins th
244 tion of beta-secretase activity in regulated secretory vesicles that produce beta-amyloid (Abeta).
245 dentification of the major proteins in these secretory vesicles that provide dynamic storage and secr
246 nules of adrenal medulla represent regulated secretory vesicles that secrete neuropeptides and catech
248 Sec2p, is needed for polarized transport of secretory vesicles to exocytic sites and for exocytosis.
251 g by E-Syt1 (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation b
252 pathway, from the endoplasmic reticulum via secretory vesicles to release into the interstitial spac
253 complex required for targeting and fusion of secretory vesicles to sites of exocytosis at the plasma
254 exocyst subunits, which function in docking secretory vesicles to sites of polarized secretion, in t
255 multiprotein complex essential for tethering secretory vesicles to specific domains of the plasma mem
256 complex plays an essential role in tethering secretory vesicles to specific domains of the plasma mem
257 lex that has been implicated in tethering of secretory vesicles to specific regions on the plasma mem
260 he activity of molecular motors that deliver secretory vesicles to the growth region or which mediate
261 ex implicated in the tethering of post-Golgi secretory vesicles to the plasma membrane before fusion.
262 was believed to target and tether post-Golgi secretory vesicles to the plasma membrane during exocyto
263 hat align in a side-by-side manner to tether secretory vesicles to the plasma membrane in preparation
264 rmissive conditions, although trafficking of secretory vesicles to the plasma membrane is unimpaired,
265 complex mediates the tethering of post-Golgi secretory vesicles to the plasma membrane prior to fusio
268 is process involves the polarized traffic of secretory vesicles to the Spitzenkorper (SPK) and their
269 sicaceae dry stigma to deliver cargo-bearing secretory vesicles to the stigmatic papillar plasma memb
272 able actin cables, accompanied by defects in secretory vesicle traffic during polarized growth and se
276 ion inhibits a vesicle "priming" step, after secretory vesicle trafficking to "docking" sites but bef
277 cle of myosin-V in its essential function of secretory vesicle transport along actin cables in yeast.
278 Myo2-mediated transport processes, including secretory vesicle transport, mitochondrial inheritance,
280 that intracellular cytokine receptors within secretory vesicles transport their cognate cytokines req
284 (diameter approximately 200 nm), a model for secretory vesicles, were prepared by extrusion and loade
285 and Snc2p from the plasma membrane into new secretory vesicles where they act to recruit the exocyst
286 he trans-Golgi network and possibly immature secretory vesicles, where it may be involved in the form
287 ytoplasmic face of the enclosing membrane of secretory vesicles, where it regulates vesicle size by p
288 th is supported by tip-directed transport of secretory vesicles, which accumulate temporarily in a st
289 hese cells have an abundance of large apical secretory vesicles, which contain highly glycosylated ma
290 meric protein complex required for tethering secretory vesicles, which is a prerequisite for membrane
291 ve peptides are packaged in large dense-core secretory vesicles, which mediate regulated secretion by
292 e hypothesis is that diffusion can transport secretory vesicles, while actin plays a regulatory role
294 dundantly with Boi1 to promote the fusion of secretory vesicles with the plasma membrane at sites of
295 re required for a late step in the fusion of secretory vesicles with the plasma membrane of the growi
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