ライフサイエンスコーパス: selection pressure

1 netic variation that has experienced reduced selection pressure.

2 , revealing that ASP does impose significant selection pressure.

3 ased substitution rates indicative of higher selection pressure.

4 nally important and thus subject to stronger selection pressure.

5 hat may have evolved in response to positive selection pressure.

6 at ac-Nglycs could be an alternative form of selection pressure.

7 henotype, due to phenotypic fluctuations and selection pressure.

8 s undergone a significant long-term shift in selection pressure.

9 miscuous activities presumed not to be under selection pressure.

10 autism genes would be under strong negative selection pressure.

11 paths to adaptation in response to the same selection pressure.

12 iral mutation/recombination and host-imposed selection pressure.

13 d to any asexual population under persistent selection pressure.

14 lly reversed with removal of the gemcitabine selection pressure.

15 s that are prone to antigenic drift and host selection pressure.

16 ences among subjects in T cell activation or selection pressure.

17 mulated later and more efficiently under low selection pressure.

18 in mutant BRCA1 protein under PARP inhibitor selection pressure.

19 evel, many of which resulted from changes in selection pressure.

20 iles of individual NP gene clones under drug selection pressure.

21 rget regions of the virus most vulnerable to selection pressure.

22 is not preserved, suggesting it may be under selection pressure.

23 tributed across the genome in the absence of selection pressure.

24 contaminated bedding and without antibiotic selection pressure.

25 olving trait when populations face a chronic selection pressure.

26 rated [PSI (+)] strains in absence of strong selection pressure.

27 ard, enabling adaptive responding under this selection pressure.

28 nctionality of defence traits, and herbivore selection pressure.

29 e seeking treatment resulted in the greatest selection pressure.

30 ckcrossing followed by stabilization through selection pressure.

31 nagement should account for this predictable selection pressure.

32 es it to proliferate under strong antibiotic selection pressure.

33 in microbial fuel cell (MFC) under specific selection pressure.

34 nfection-associated, short-term, within-host selection pressures.

35 l trait, a memory "bottleneck" cannot escape selection pressures.

36 y result from a coevolution under particular selection pressures.

37 ular the available mechanisms and the likely selection pressures.

38 ich these preferences change under different selection pressures.

39 e two clubs potentially evolved via distinct selection pressures.

40 ptation to the host environment and external selection pressures.

41 e biases that could be due to mutational and selection pressures.

42 ut conferring a fitness benefit under strong selection pressures.

43 eric free energy landscapes and evolutionary selection pressures.

44 vergently in unrelated taxa owing to similar selection pressures.

45 communities in nature, in the face of other selection pressures.

46 thine moths to respond to varying ecological selection pressures.

47 d are considered to result from sex-specific selection pressures.

48 geographically far apart, yet share similar selection pressures.

49 ntial for scent to be shaped by differential selection pressures.

50 maximize viral fitness under sequential drug selection pressures.

51 splay sites often balance sexual and natural selection pressures.

52 stance genes in the absence of antimicrobial selection pressures.

53 a likely reflection of different underlying selection pressures.

54 r between opposing male- and female-specific selection pressures.

55 ing the involvement of powerful evolutionary selection pressures [1].

56 ceptible, suggesting that factors other than selection pressure account for the clonal spread of drug

57 Selection pressure across entire CesA and Csl clades app

58 s to a mosaic of spatially divergent disease selection pressures across their naturally fragmented di

59 also make raptors especially vulnerable when selection pressures act against these axes.

60 eam components, and serve as a model for how selection pressures act differently on signaling vs. gen

61 We then looked for evidence of selection pressure acting on asp Using computer simulati

62 uences and investigated the various types of selection pressure acting on them.

63 fluctuations more important than the average selection pressures acting on each new mutation.

64 stem captured salient features of real-world selection pressures acting on NA.

65 The different selection pressures acting on the N- and C-terminal regi

66 ndent events, leading to a decoupling of the selection pressures acting on these phenotypes.

67 isolates, suggesting different evolutionary selection pressures acting on these two traits.

68 We also estimate the strength of the selection pressure against CNVs and correlate this again

69 , suggesting that Rps27l disruption impose a selection pressure against p53.

70 To determine why low selection pressure aided this evolution, all evolutionar

71 g an all-RNA substrate and imposing the same selection pressure, also leads to RNA hydrolysis.

72 bust to the presence of an additional strong selection pressure: an SBW25-specific virus.

73 In addition, selection pressure analyses showed that different select

74 c loci can be driven by host adaptive immune selection pressure and may reveal proteins important for

75 ages, as well as provide information such as selection pressure and mutation analysis.

76 is a combined effect of temporal changes in selection pressure and partial recognition loss.

77 erimentally how two evolutionary parameters, selection pressure and recombination, influenced the evo

78 ent strategies are urgently needed, avoiding selection pressure and thereby implying a reduced risk o

79 hese new factors, which introduce additional selection pressures and constraints, significantly influ

80 ow concentrations of insecticide, and allows selection pressures and dominance values to differ depen

81 tion rates, which permit rapid adaptation to selection pressures and have other important biological

82 which closely related species share similar selection pressures and limited dispersal from ancestral

83 of such different evolutionary histories for selection pressures and observed diversity in SIVsmm and

84 measuring repertoire diversity, quantifying selection pressure, and calculating sequence chemical pr

85 amples of adaptive introgression, grouped by selection pressure, and consider the level of supporting

86 ic RNA binding proteins (RBPs), evolutionary selection pressure, and coupling of AS with nonsense-med

87 ts that employed low or gradually increasing selection pressure, and recombination events either at t

88 d variants resulted from antiretroviral drug selection pressure, APOBEC-mediated editing, and natural

89 Future selection pressures are inherently unpredictable, so for

90 these findings to natural populations, where selection pressures are unknown.

91 HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors.

92 tidrug resistance might depend on antibiotic selection pressures arising from population use of speci

93 ty is probably accounted for by evolutionary selection pressure as a result of long-term host-pathoge

94 This can be attributed to strong selection pressure as populations moved to different par

95 sal and associated exchanges, with purifying selection pressure as the principal evolutionary force.

96 fitness constraints and identify non-obvious selection pressures as emergent features.

97 driven by the immune response, and purifying selection pressure asserted by deleterious mutations.

98 volution; they thus carry a signature of the selection pressures associated with choice behaviors.

99 mmals and is hypothesized to have arisen via selection pressures associated with environment, diet an

100 r predicted TF-related env mutations using a selection pressure-based approach, followed by an analys

101 e two fitness metrics and their estimates of selection pressures, before and during a demographic tra

102 Host defense may have been the original selection pressure behind the development of mechanisms

103 rough the population, thereby increasing the selection pressure between different habitats.

104 This indicates that different selection pressures between populations have resulted in

105 consistent with physical values, indicating selection pressures beyond the biophysical constraints i

106 in the nasopharynx (and thus less subject to selection pressure) but upregulated in the bloodstream (

107 These results show experimentally how low selection pressure can benefit the evolution of cooperat

108 We find that selection pressures can determine whether neofunctionali

109 The timing of selection pressure characterized individual epitope spec

110 Evolutionary rates and selection pressure coevolve with macrostructural and mic

111 The evident shift in selection pressures correlates to the regional European-

112 ion: they do not present us with group-level selection pressures counteracting individual-level ones,

113 The strong, opposing selection pressures, coupled with documented highly vari

114 es of the same TF would experience different selection pressures depending on their position in the g

115 s phylogenetic inference or methods to infer selection pressures; development of toy models and simul

116 s expressing HLA-B*57:01, we observed strong selection pressure driven by the HLA-B*57:03-KF11 respon

117 ion, latent reservoir dynamics, diversifying selection pressure driven by the immune response, and pu

118 Yet, selection pressures driving DENV microevolution within h

119 apical membrane Ag-1 vaccination alters the selection pressure during affinity maturation to favor c

120 ell sources, encompassing variable levels of selection pressure during reprogramming, influences the

121 control measures, removal of key antibiotic selection pressures during a national antibiotic steward

122 Our results support that different selection pressures (e.g. environmental constraints, hum

123 pacity of organisms to adapt to the multiple selection pressures encountered in natural environments.

124 omposite correlated random walks will, under selection pressures, evolve to resemble optimal Levy wal

125 Selection pressure exerted by the host insect as a resul

126 Competing selection pressures exerted at these different scales ca

127 We also found that the selection pressures exerted by different fitness landsca

128 in vascularized tissue, we investigated the selection pressures exerted by spatial and temporal vari

129 des of HSV-2 infection and imply that strong selection pressures exist to maintain the fidelity of th

130 uman strains since 1918, which suggests that selection pressure exists on this domain.

131 he recombination process has anticipated the selection pressures experienced during somatic evolution

132 Competition for substrates is a ubiquitous selection pressure faced by microbes, yet intracellular

133 This modular assembly implies a selection pressure favoring substrate channeling.

134 le-male competition constitutes an important selection pressure for broadcasting and attending to siz

135 These results indicate that selection pressure for enhanced viral fitness may drive

136 ing on exclusion or inclusion of a stringent selection pressure for hydrolysis.

137 ous substitution rates showed a more relaxed selection pressure for non-syntenic genes compared to sy

138 g-lasting alternative insecticides to reduce selection pressure for pyrethroid resistance and to prov

139 n a cost-effective manner while reducing the selection pressure for resistance to nonpyrethroid insec

140 tudies have identified herbivory as a likely selection pressure for the evolution of hyperaccumulatio

141 s over the last 10 Ma may have operated as a selection pressure for traits and behaviors in Homo such

142 They also indicate that selection pressures for animals to transmit important in

143 r these expanded areas arise through natural selection pressures for increased cognitive capacity or

144 minimization but instead reflect competitive selection pressures for integrated network topology as a

145 ugh these adaptations are assumed to reflect selection pressures for males to lower frequency compone

146 t species with low syntopy should have lower selection pressures for more constitutive (always presen

147 remained relatively stable despite prolonged selection pressure from antibiotics.

148 tical model of HIV evolution under dynamical selection pressure from multiple CTL clones to include p

149 Under selection pressure from pathogens, variable NK cell rece

150 ed, nocturnal insectivores, presumably under selection pressures from dinosaurs.

151 lect an evolutionary response to conflicting selection pressures from fire and seed predation.

152 This may result from the variety of selection pressures from herbivores, long distance gene

153 evolution by control agents, and contrasting selection pressures from other enemy species).

154 this population may be subject to divergent selection pressures from these two parasites, potentiall

155 Despite these selection pressures, genetic covariation of morphology,

156 al aspects of such a balance of mutation and selection pressure have been established by the quasispe

157 Thus, similar selection pressures have resulted in convergent evolutio

158 loop could arise in the field due to immune selection pressure; however, due to reduced HA stability

159 be viewed as a selection with two different selection pressures: (i) target-binding selection, and (

160 pecificities and by clear-cut differences in selection pressure imposed on the virus by those respons

161 ds were ineffective in disentangling the two selection pressures imposed by both the Env and ASP prot

162 ass I-restricted epitopes under reproducible selection pressure in HBV core; the possibility of viral

163 owed weaker clock-like behavior and stronger selection pressure in nef than in gp120, with the strong

164 inants were identified among mutations under selection pressure in non-candidate genes.

165 e on dietary choline would be under negative selection pressure in settings where choline intake is l

166 by life-long combinatorial antibiotic (ABX) selection pressure in the APPSWE/PS1DeltaE9 mouse model

167 ium induces survival pathways and provides a selection pressure in the continuum of ERG dependent neo

168 origin, Campylobacter is exposed to arsenic selection pressure in the food animal production environ

169 either emerges in response to an antifungal selection pressure in the individual patient or, more ra

170 less fit in mountain lions and under intense selection pressure in the novel host.

171 e identified nine residues in HBV core under selection pressure in the presence of 10 different HLA c

172 Residues under selection pressure in the presence of particular HLA cla

173 exhibited no evidence for positive Ag-driven selection pressure in their CDRs in contrast to non-pSS

174 al environmental change is expected to alter selection pressures in many biological systems, but the

175 regions using the selection rate and detect selection pressures in viral proteins and in the immune

176 tion event was followed by phases of various selection pressures, including purifying selection, rela

177 NA genome has evolved in response to complex selection pressures, including the need to maintain stru

178 nfections can provide insights into how host selection pressures-including immune responses and thera

179 composition of viral genomes is subjected to selection pressures independently of coding capacity and

180 tive selection, indicating that host-imposed selection pressure is an important force shaping PLV evo

181 their adaptation to environmental and human selection pressure is at the root of their remarkable di

182 developing mammary carcinomas, and that such selection pressure is higher in the presence of ErbB2 ac

183 Fittingly, the purifying selection pressure is markedly relaxed in these species

184 reaction is enzymatically driven, and that a selection pressure is operating to retain type II NAD(P)

185 that is subject to strong microenvironmental selection pressures later in tumor evolution.

186 r late mutations, which can explain why high selection pressure led to inefficient evolution.

187 Resulting selection pressures led to changes in diet and dietary a

188 result of niche construction, differences in selection pressures may be inherited across generations.

189 viding a transgenerational template on which selection pressures may operate ensuring optimal materna

190 In contrast, the selection pressures (measured as ratios of nonsynonymous

191 Our results illustrate that ecological selection pressures mold the structure of invertebrate b

192 interactions occurs through the interplay of selection pressures moving along multiple direct and ind

193 Our results show that GS applies selection pressure much more locally than BLUP, resultin

194 Our study demonstrates that the selection pressures of a 3(rd) generation cephalosporin

195 ilemma as one DNA sequence evolves under the selection pressures of multiple proteins.

196 opulations subjected to strong environmental selection pressures offer a window into the genetic unde

197 se of antimicrobials, potentially increasing selection pressure on bacteria to become resistant.

198 ese data indicate that infant CTLs can exert selection pressure on gag and nef epitopes in early infe

199 use novel environmental conditions alter the selection pressure on genes or entire subgenomes, adapti

200 ditionally, we provide evidence that relaxed selection pressure on glass sponge mtDNA - possibly a re

201 nodominance over Gag and strong Env-mediated selection pressure on HIV are observed only in subjects

202 thopoxviruses adapt to new environments, the selection pressure on individual genes may be altered, d

203 e consequences of serial passage with strong selection pressure on its fitness.

204 that the endosymbiont may not place negative selection pressure on its host herbivore in this system,

205 Furthermore, we identified an asymmetric selection pressure on Magnaporthe species.

206 al toxicants such as pesticides exert strong selection pressure on many species.

207 Extensive use of insecticides poses strong selection pressure on mosquito populations for resistanc

208 rol the disease have intensified, so has the selection pressure on mosquitoes to develop resistance t

209 In AM-host plants, the selection pressure on NSP1 is stronger than in non-AM ho

210 ia-aphid indirect effect could influence the selection pressure on plants, when considering species t

211 g evolution N-glycosylation triggered a dual selection pressure on secretory pathway proteins: while

212 Selection pressure on the coding gene regions follows th

213 cies, chemical mate guarding may also impose selection pressure on the long-range female sex pheromon

214 v Forrest, although required, does not exert selection pressure on the nematode to shift from HG type

215 revealed that mice continuously exerted CTL selection pressure on the persisting virus population.

216 f these two organisms is correlated with the selection pressure on the respective genes thereby direc

217 evidence consistent with arenavirus-mediated selection pressure on the TfR1 of the North American are

218 nal avidity (P < 0.0001) and drives stronger selection pressure on the virus than HLA-B*14-DA9.

219 ient glycan degrading systems exerts a major selection pressure on this microbial community.

220 ient glycan degrading systems exerts a major selection pressure on this microbial community.

221 ory of combat exerted powerful and sustained selection pressures on male groups, individual identific

222 Given the ubiquity of novel selection pressures on microbes, these results may help

223 c eukaryotic microbes may experience similar selection pressures on mutation rate as bacterial pathog

224 Invasive plants impose novel selection pressures on naive mutualistic interactions be

225 us in tropical forests, could strongly alter selection pressures on plants, resulting in widespread,

226 , group size and dispersal frequency, affect selection pressures on pro- and anti-social punishment.

227 ework for understanding the origin of global selection pressures on proteins.

228 Here, we investigate the selection pressures on sequence variants that predispose

229 Here, we investigate whether conflicting selection pressures on siderophore production by heavy m

230 investigated, the significance of non-social selection pressures on social behaviours has received li

231 Atlantic salmon (Salmo salar) parents alter selection pressures on their offspring with important co

232 The selection pressures operating on combinations of HLA all

233 ed with oncogene scores, suggesting opposing selection pressures operating on the two groups of cance

234 in local populations, suggesting either weak selection pressure or temporal variation in the targets

235 each site for each amino acid given a single selection pressure, or assess the extent to which these

236 ain how GCs maintain an adequate directional selection pressure over a large range of affinities thro

237 However, selection pressures over evolutionary time scales have l

238 hey adapted to divergent and then convergent selection pressures over hundreds of generations.

239 among the RNASE1 gene copies regarding their selection pressures, pI values and tissue expression pat

240 ycosylation processes are under high natural selection pressure, presumably because these can modulat

241 erved effects of parent-derived nutrients on selection pressures provide experimental evidence for ke

242 at regulates foraging activity, and that the selection pressure, related to climate, may grow stronge

243 lutionary implications of temporally varying selection pressures remain poorly understood.

244 terns in timing and persistence of antiviral selection pressure, remain, however, incompletely define

245 ectively, and show that serial passage under selection pressure remains an effective tool for studyin

246 l proteins, although the specific traits and selection pressures responsible for the maintenance of d

247 The low selection pressure resulted in higher efficiency of the

248 Our findings suggest selection pressures resulting from the different manure

249 ulting redundancy of RITS may have eased the selection pressure, resulting in progressive loss or tru

250 , consistent with the theory that antibiotic selection pressure results in clonal expansion of existi

251 opulation dynamics in response to increasing selection pressure revealed RNA inhibitors of RT that ar

252 We then used 26 accessions to estimate the selection pressures shaping evolution among the accessio

253 Selection pressures shaping the IgG and IgA repertoire w

254 nabling adaptive responding under this basic selection pressure.SIGNIFICANCE STATEMENT Among the most

255 y parallel phenotypes in response to similar selection pressures suggesting that there may be shared

256 BD+ (40%), 7 of whom (39%) relapsed Off-ATRA selection pressure, suggesting a possible active role of

257 wer children and are under stronger negative selection pressure than common sequence variants.

258 us of the protein has been subject to higher selection pressure than the C-terminal domain.

259 efined total use thresholds might remove the selection pressure that maintains antimicrobial resistan

260 A. coluzzii/A. gambiae hybrids, and provided selection pressure that swept the 2L divergence island t

261 ates adaptation in response to the immediate selection pressures that a virus experiences in its curr

262 e show that the same host-related ecological selection pressures that differentially adapt and reprod

263 actions is evidenced by the intense adaptive selection pressures that dominate the evolutionary histo

264 ity is virtually always retained, suggesting selection pressures that favor a short half-life of the

265 t mutant clones in a quiescent state, strong selection pressures that kill the wild type promote drug

266 e to diverse, ultimately ineffective, immune selection pressures that randomly change from host to ho

267 In seeking to understand the selection pressures that shaped the plant calcium-signal

268 Therefore, the selection pressure to amplify 5q in ccRCC is driven, at

269 hen performed, including in some cases a key selection pressure to cleave the substrate at a predeter

270 erse species, we demonstrate an evolutionary selection pressure to conserve residues crucial for allo

271 med that HPV-positive cancer cells are under selection pressure to continuously express the viral E6/

272 t strategies are likely to impose additional selection pressure to drive acquisition of mutations in

273 aptive immune system, may have evolved under selection pressure to encode a binding motif innately ca

274 their food source, there has presumably been selection pressure to evolve and maintain immune defense

275 P do not display this tendency, suggesting a selection pressure to fine tune allostery on changes to

276 oss only and therefore propose that there is selection pressure to preserve such genes as singletons.

277 These results imply that the selection pressure to reliably segregate DNA during cell

278 In general, we hypothesize an evolutionary selection pressure to retain slow relaxation dynamics-in

279 We sought mutations under similar selection pressure to those characterised as resistance

280 How selection pressures to escape immune recognition, mainta

281 ance of considering multiple and conflicting selection pressures to explain rewards.

282 e uncertainties pose a challenge when tuning selection pressures to isolate high-affinity ligands.

283 rnal niche for transgenerational co-adaptive selection pressures to operate.

284 ciation due to profound changes in molecular selection pressure, ultimately giving rise to an origina

285 ignatures of both purifying and diversifying selection pressures, unlike the seed DEFLs, which predom

286 including nucleotide substitution rates and selection pressures, using 14 IAV subtypes in 32 differe

287 term effects of a famine and the reversal of selection pressure via the survival component of annual

288 No evidence of HLA-B*57:01-KF11-associated selection pressure was identified in previous comprehens

289 g-distance migratory species in Europe, this selection pressure was not stronger in warmer springs, i

290 Evidence for selection pressure was recognized for several amino acid

291 Selection pressure was stronger in infants with non-seve

292 that this was indicative of postacquisition selection pressure, we also found that vaccine efficacy

293 ted, and their activities at three different selection pressures were determined.

294 le-specific behavioral traits and associated selection pressures, which are discussed in brief.

295 tated Ig sequences in vivo in the absence of selection pressures, which skew the observed mutation pa

296 onary) and strong positive (antigenic drift) selection pressures, which were coincident with advancin

297 curacy should be expected over error because selection pressures will have shaped social perception t

298 ss the mammalian phylogeny, and differential selection pressure within the artiodactyl and primate li

299 us an example of an acute infection in which selection pressures within infected individuals drive ra

300 In this study, we investigate host-specific selection pressures, within-host viral fitness, and inte