ライフサイエンスコーパス: selective

1 PK1-vinculin interaction is conformationally selective.

2 ting the terminase complex could be safe and selective.

3 of mEC cells can be categorized as spatially selective.

4 We have developed selective 5-HT2C ligands and herein describe their precl

5 dentification of compound 25 as a potent and selective A2A adenosine receptor (A2AAdoR) antagonist wi

6 This study aimed to reveal the selective accumulation of rare variants in the coding an

7 Given its selective action on the omega1 subtype of the gamma-amin

8 three Cre-driver mouse lines, we found that selective activation of glutamatergic PPT neurons induce

9 native plant Amyris texana was found to have selective activity against MDA-MB-453 cells, a model of

10 tussis and B. bronchiseptica may result from selective adaptation of B. pertussis to the human host.

11 heavy hydrogen isotopes from hydrogen gas by selective adsorption at Cu(I) sites in a metal-organic f

12 alizing antibodies did not bind, conferred a selective advantage in the immune systems of infected ho

13 ssume that modern humans benefited from some selective advantage over Neanderthals, which led to the

14 ncoded by TP53) provides cancer cells with a selective advantage under conditions of hypoxia, but lit

15 Seladelpar is a potent, selective agonist for the peroxisome proliferator-activa

16 Using novel mGlu receptor subtype-selective allosteric modulators along with knockout mice

17 ngs have implications for the development of selective allosteric modulators.

18 have been subjected to these studies of site-selective alteration including polyketides, glycopeptide

19 processed cereal-based foods, sensitive and selective analysis for very low concentrations of these

20 (ii) Selective and cooperative binding of both an acetato lig

21 Swainson's Thrushes were only slightly selective and did not appear to forecast.

22 We demonstrate that the sensor is selective and is able to quantify diclofenac in tap wate

23 ional design approach we discovered a highly selective and potent BTK kinase inhibitor (CHMFL-BTK-11)

24 livery, opening several exciting avenues for selective and prolonged cardiac therapeutics.

25 data support the idea that GlcSph is a more selective and sensitive biomarker than GlcCer for neuron

26 roperties are very much demanded in terms of selective and sensitive chemosensors fabrication.

27 This probe combines highly selective and sensitive ex vivo detection of endogenous

28 nd immunotoxic nature of ochratoxin A (OTA), selective and sensitive monitoring of this molecule in f

29 However, developing active, selective and stable electrocatalysts is challenging and

30 hat these neuron types are not directionally selective and that selectivity arises in the T4 dendrite

31 Rapid, selective, and highly controllable iridium-catalyzed all

32 Herein, we describe a simple, selective, and mild procedure for the construction of (h

33 ing the continuing development of efficient, selective, and sustainable technologies for their prepar

34 s and frailty, we describe a novel series of selective androgen receptor modulators (SARMs).

35 The final diagnosis was established based on selective angiography, which was followed by transcathet

36 The resulting stable and potent FPR2-selective antagonists (i.e., RhB-(Lys-betaNphe)n-NH2; n

37 dehyde-3-phosphate dehydrogenase as the most selective antiparasitic targets.

38 ) in living cells with simple, sensitive and selective assays are significantly interesting.

39 dence from studies of different varieties of selective attention and examine how these varieties alte

40 ng alters the neural mechanisms that support selective attention.

41 Furthermore, the structure of the Na(+)-selective AtTPC1 mutant elucidates the structural basis

42 parietal junction contributes to controlling selective auditory attention in "cocktail party" situati

43 The endothelium serves as a size-selective barrier and tightly controls the fluid exchang

44 h previously reported teratogenic effects of selective BCR-ABL inhibitors in humans and developmental

45 hat of transition-metal-catalyzed chemistry (selective beta-hydrogen elimination step).

46 de polymorphism (SNP) detection using highly selective BiDz sensors targeting loci associated with sp

47 In particular, the selective binding of sulfate with artificial receptors i

48 Glycan array analysis confirmed selective binding of the CRD to glycans that contain Man

49 nition ligands that are capable of exquisite selective binding, and seamless integration at a level c

50 is of phospholipids using abiotic but highly selective bioconjugation reactions.

51 gel matrix have highlighted the specific and selective biosensor response towards the target protein.

52 Therefore, selective blockade of interleukin-23 via inhibition of p

53 of a combination of photocromic lens with a selective blue-violet light filter showed functional ben

54 Selective breakdown of brain networks during progression

55 substrate has been exploited to achieve meta-selective C-H activation by using a covalently attached,

56 h anti MC-LR antibody Fab' fragments for the selective capture of MC-LR from aqueous media and blood

57 In selective cases, however, limited field of view CBCT may

58 For vehicles with OEM DPFs and Selective Catalytic Reduction Systems, PNEFs under highw

59 We combine this selective cathode with a carbon-supported palladium (Pd/

60 Most viroporins are monovalent selective cation channels, with few showing the ability

61 rlie external task engagement, and highlight selective changes in brain connectivity supporting incre

62 radigm, we have identified JNJ0966, a highly selective compound that inhibited activation of MMP-9 zy

63 dents, indicating fundamental differences in selective connectivity that seem unexpected for closely

64 ecause protein-coding regions are under high selective constraints, these variants occur at low frequ

65 ht functional group control, that facilitate selective conversion of 1 and 2 to the rare 5/6/6/7/5- a

66 Therefore, the selective conversion of a single hydroxyl group in natur

67 Here, we describe site-selective, copper-promoted couplings of boronic acids wi

68 We also uncover selective correlations between changes in signal diversi

69 Across individuals, we observed selective correlations between the level of GABA and the

70 A mild, oxidant-free, and selective Cp*Co(III) -catalyzed amidation of thioamides

71 ute (NCI)-60 cell line screen and relatively selective cytotoxicity against melanoma cells.

72 s with better pharmacokinetics, functionally selective D1 ligands, and D1R positive allosteric modula

73 Igf1r-deficient mice exhibited no AHR, and a selective decrease in blood and BALF eosinophils, lung I

74 e-causing mutation in human STN1 engenders a selective defect in POLA2-binding and PP stimulation, in

75 binding protein BRF1, hence resulting in the selective degradation of mRNAs.

76 Correspondingly, beta-cell-selective deletion of StarD10 in mice led to impaired gl

77 me a novel anticancer strategy, leading to a selective depletion of cancer-relevant proteins after tu

78 plate was developed for highly sensitive and selective detection of hydrogen peroxide (H2O2).

79 Selective detection of norovirus was accomplished by fun

80 Selective detection of signal over noise is essential to

81 ve/confirmatory method was developed for the selective determination of marker residue 22,23-dihydroa

82 ly are pivotal regulators of several lineage-selective differentiation programs.

83 Selective disruption of Munc13 autoinhibition profoundly

84 e approach for simple, rapid, sensitive, and selective DNA detection.

85 s have demonstrated that Hop1 is a structure-selective DNA-binding protein exhibiting high affinity f

86 l drug development, in particular regionally selective dopaminergic modulation, and the potential of

87 tion, mTORC1 activity declined paralleling a selective down-regulation of SREBP target gene expressio

88 Recent evidence suggests value for both selective drain placement and early drain removal for PD

89 t responses will enable novel routes for PTP-selective drug design, important for managing diseases s

90 and Satb2 are expressed in ON-OFF direction-selective (DS) RGCs, complementing our previous work dem

91 ues of these mice was a manifestation of the selective effect of TRPC3 on apoptosis of M1 macrophages

92 In summary, GBAi is a selective, efficient, and convenient tool to dissect the

93 Interestingly, this selective electrical coupling relates to a coordinated i

94 ue strategy for designing more efficient and selective electrocatalysts for CO2RR to valuable chemica

95 free, inexpensive, excellent, sensitive and selective electrochemical aptasensor based on sandwich a

96 The PEDOT-C14-based solid contact (SC) ion-selective electrodes (ISEs) (H(+), K(+), and Na(+)) have

97 ing polymer-based solid contact (SC) for ion-selective electrodes (ISEs) that could become the ultima

98 ve optodes (ISOs), the optical analog of ion-selective electrodes, have played an increasingly import

99 nstatement was correlated with the extent of selective elimination of nNOS interneurons.

100 tiviral immunity in metazoans, including the selective elimination of viral components.

101 ally, extended TNF treatment resulted in the selective enrichment of clonal variants with high ST6Gal

102 We show that the selective Epac activator 8-(4-chloro-phenylthio)-2'-O-me

103 nating chemical terminations and thus enable selective epitaxy during the VAN growth.

104 ective with maturation; we hypothesized that selective exclusion of molecules needed for growth may c

105 DG) of the hippocampus, we hypothesized that selective expression of dominant-negative C-terminus-tru

106 Selective expression of the APOL1 G0 or G1 transgene in

107 atment with beta-N-acetylglucosaminidase and selective extension of the other arms.

108 the sensitive surface of a conventional ion-selective field effect transistor (ISFET) with the affor

109 her flagellar sterol enrichment results from selective flagellar partitioning of specific sterol spec

110 An alternative neuraminidase selective for 2-3 sialic acid linkages generated a KM va

111 of an anti-migraine drug that appears to be selective for Adelta-fibers (peripherally) and HT neuron

112 The NSP4 VPD was selective for cations over anions and channel activity w

113 Firing rates of some neurons were phasically selective for conditioned stimuli in a way that depended

114 at was in; nearly all neurons were tonically selective for environments in a way that depended on whi

115 These Nanobodies were most selective for EphA4, with residual binding to EphA7 only

116 ch has spurred the development of inhibitors selective for individual MMPs.

117 heterologous expression system, TbAAT10-1 is selective for ornithine, whereas TbAAT2-4 transports bot

118 neurons downstream of primary receptors are selective for specific stimulus features, and they deriv

119 and surface alloys, which we find to be more selective for the formation of multi-carbon products tha

120 gamma-MSH-NH2 (compound 5), which is 16-fold selective for the hMC1R (EC50 = 4.5 nM) versus other mel

121 ny of the neurons in early visual cortex are selective for the orientation of boundaries defined by f

122 surrounding geochemical regimes is a strong selective force shaping microbial communities throughout

123 Our findings provide insights into the selective forces and ecological factors that may have dr

124 ntrols, but the relative importance of these selective forces is unknown.

125 id ecological change, one of the most potent selective forces, sexual selection, remains curiously un

126 molecule functional mimetics of H2-RLX with selective, full agonist or positive allosteric modulator

127 The selective glial stimulation did not affect transmural io

128 T bromodomain inhibitor I-BET151 resulted in selective growth inhibition, whereas treatment of leukae

129 c driver (K-562 cell line) did not result in selective growth inhibition; this is similar to the find

130 ecules, the use of typical protocols for the selective halogenation of electron-deficient and straine

131 Using fMRI, we found the typical selective hand-tool overlap (HTO) not only in typically

132 limits) with high spatial resolution through selective helium ion irradiation with a well-controlled

133 protein targets (low in alpha) and is highly selective (high in beta) in forming the probe-protein ad

134 the discovery of noncovalent reversible and selective human factor D (FD) inhibitors with drug-like

135 GS-5745, a potent, highly selective humanized monoclonal antibody inhibitor of MMP

136 ions in antigenicity, apparently by inducing selective immunological amnesia.

137 s from multiple viewpoints, and has revealed selective impairments during scene discrimination follow

138 recently been described as highly beta-cell selective in the human pancreas and constitutes a tentat

139 ROCK-positive cell types, corroborating the selective in vivo effect on fibrosis.

140 cted interest as a photonic approach for the selective inactivation of virus contaminations in biolog

141 Given the importance of selective information processing in nearly all domains o

142 rs the early cortical responses that support selective information processing.

143 Selective inhibition of individual ligands revealed that

144 Selective inhibition of T-channels and global deletion o

145 Here, a Grp94-selective inhibitor facilitated mutant myocilin degradat

146 ine, suggesting that it may provide a highly selective inhibitor of MEK1/2 for use as a cancer therap

147 CFI-402257 is a novel, selective inhibitor of Mps-1 with antineoplastic activit

148 b, an orally bioavailable clinical stage CDK-selective inhibitor, potently blocks CDK9, the transcrip

149 the clinic to treat leukemia, but tight and selective inhibitors are not available for Bcl-2 paralog

150 hts the need for brain-penetrant IDH1 mutant-selective inhibitors as an alternative therapeutic optio

151 Selective inhibitors could help unveil the mechanisms by

152 is the absence of chemical tools designed as selective inhibitors for IKKalpha over IKKbeta.

153 he first time a series of novel, potent, and selective inhibitors of IKKalpha.

154 ffold would allow access to a series of PAD2-selective inhibitors with enhanced cellular efficacy.

155 be sufficient to explain Pre1a's potent and selective inhibitory effect on the fast inactivation pro

156 iNOS siRNA and 1400W, a selective iNOS inhibitor, abolished the ameliorative eff

157 Data suggest selective internal radiotherapy (SIRT) in third-line or

158 ural products into a ketone would enable the selective introduction of unnatural functionality.

159 hondrial calcium uniporter (MCU) is a highly selective ion channel that transports Ca(2+) into the mi

160 Furthermore, we developed a kinome selective irreversible inhibitor 45a with an IC50 value

161 exquisite spatial and temporal control, the selective isomerization of polarized alkenes underpins a

162 Facile, highly Z-selective isomerizations are observed for allyl ethers u

163 Finally, selective killing of Mtb-infected macrophages and subseq

164 Previously studied selective KOP-r antagonists have unusual pharmacodynamic

165 ctivated smart probes greatly facilitate the selective labeling of biomolecules in living system.

166 Selective labeling of blood monocyte subsets indicates t

167 raocular pressure (IOP)-lowering efficacy of selective laser trabeculoplasty (SLT) as sole therapy fo

168 An ER-beta-selective ligand increased markers of tricarboxylic acid

169 s) using concurrent EEG-fMRI and a sustained selective listening task, in which one out of two compet

170 This resulted in a selective loss of approximately 60% of layer VI A1-MGBv

171 ated a novel mutant mouse, dys-1A(-/-), with selective loss of dysbindin-1A and investigated schizoph

172 ses, thereby establishing MOB1 variants with selective loss-of-interaction.

173 are excited by visual motion in a direction-selective manner.

174 Activating triggers, selective markers, and the residual regenerative potenti

175 The design of selective matrix metalloproteinase (MMP) inhibitors that

176 Furthermore, a selective Mcl-1 inhibitor restores regorafenib sensitivi

177 ng C-DIM compounds may serve as a potent and selective means to enhance memory and synaptic plasticit

178 with and without an additional potassium ion-selective membrane (ISM) coating, following their first

179 , which in combination with all kinds of ion-selective membranes (ISMs) would match the performance c

180 formance, short-lifetimes, and expensive ion-selective membranes as well as high price, toxicity, and

181 A series of sodium selective membranes with magnetic nano-inclusions using

182 ovide an active, first generation MOF-based, selective methane oxidation catalyst.

183 thymus as a DC-poietic organ, which provides selective microenvironments permissive for DC developmen

184 Compound III, a selective MMP7 inhibitor, decreased development of invas

185 rapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways.

186 Our results show a selective modulation of preparatory motor activity follo

187 Several mimics exhibited selective modulatory effects on hUII- and URP-associated

188 hole-injection-assisted reactions happen at selective molecular sites controlled by the STM tip.

189 of a nucleophilic substitution reaction, the selective mono-alkylation of aliphatic amines by unactiv

190 ray response can be explained with the "site-selective" Mott scenario without real charge order on Ni

191 Use of the beta2-selective nAChR antagonist, dihydro-beta-erythroidine, s

192 We reason that the resulting tissue selective negative feedback regulation is essential to e

193 port the discovery of a transient, spatially selective neural signal in humans that encodes the relat

194 untington's disease (HD) is characterized by selective neurodegeneration that preferentially occurs i

195 e temporal tuning of the first directionally selective neuron in the ON motion pathway (T4) as well a

196 which injection of diphtheria toxin induces selective neutrophil ablation.

197 tor defects were worsened by mecamylamine, a selective nicotinic antagonist.

198 Moreover, selective NPY2 and NPY5 receptor antagonists restored va

199 minoxylation reaction, and Still-Gennari (Z)-selective olefination reactions.

200 metamaterial particles (THMMP) that display selective, omnidirectional, tunable, broadband absorptio

201 ree previously uncharacterized, nondirection-selective ON-OFF RGC types that represent a distinct set

202 , inhibition of CIN firing with the mu/delta selective opioid [Met(5)]enkephalin (1 mum) decreased sp

203 ssion of cancer and may provide specific and selective options for diagnosis as well as for therapeut

204 Ion-selective optodes (ISOs), the optical analog of ion-sele

205 analysis approach, our results indicate that selective optogenetic stimulation of TH(VTA) neurons enh

206 also toward resistant strains, and they were selective over other bacterial species and eukaryotic ce

207 e demonstrated in a metal-free heterogeneous selective oxidation of 5-hydroxymethyl-furfural (HMF) to

208 nium catalyst with a unique efficacy for the selective oxidation of a single hydroxyl group among man

209 A selective peptide inhibitor of AMPH-dependent traffickin

210 nd structural data, we were able to design a selective peptide inhibitor of APN that was an effective

211 Using selective peptide inhibitors of the CXCL1-CXCR2 signalin

212 Although selective pericyte loss in stable adult retinal vessels

213 Genetic ablation and selective pharmacologic inhibition of ASIC1a reduces neu

214 Pan-PI3K and p110alpha-selective pharmacological inhibition effectively blocks

215 mode is exploited by sterically bulky HDAC6-selective phenylhydroxamate inhibitors.

216 sed in view of their special role in special selective photocatalysis, namely epoxidation reactions,

217 CAAC)ArB:] borylene that can be liberated by selective photolytic CO extrusion and that, although hig

218 This work led to the discovery of a highly selective PI3Kbeta/delta inhibitor displaying excellent

219 illed Gram-negative bacteria by forming size-selective pores that permeabilized bacterial membranes.

220 and benzoquinazoline-12 (BQZ-12), two highly selective positive allosteric modulators (PAMs) of M1 mA

221 ed as solid phase extraction sorbent for the selective preconcentration and determination of AMP in c

222 Unusual selective/preferential transport of Li ions is demonstra

223 This reaction enables the selective preparation of ozonides without the use of ozo

224 bservations indicate that genes under weaker selective pressure accumulate more maladaptive substitut

225 Self-replication and evolution under selective pressure are inherent phenomena in life, and b

226 rum transmission was used to investigate the selective pressure exerted on parasite populations by us

227 pread of MDROs include oversight to decrease selective pressure for MDROs by promoting appropriate an

228 n of this strategy, it has been unclear what selective pressure maintains the fitness of this develop

229 f SPI-2 T3SS effectors in the context of the selective pressures encountered by S. enterica in vivo.

230 ing population use of 4C antibiotics reduced selective pressures favouring multidrug-resistant epidem

231 This novel tumour-selective pretargeting approach may be used to improve e

232 d xanthene (Xan), we show here that KIE is a selective probe that identifies the experimentally react

233 osine A2A receptor ligands with functionally selective properties between Gs and Golf signaling.

234 nsional infrared (2D IR) and IR polarization selective pump-probe (PSPP) spectroscopies were used to

235 With selective pumping of chlorophyll f at 740 nm, we observe

236 sitron emission tomography (PET) and the MOR-selective radioligand [(11)C]carfentanil.

237 5-Cyano compounds are especially potent and selective rat and human nNOS inhibitors.

238 Immunoblotting and selective reaction monitoring were used to quantify tyro

239 Selective readout of either synchronous or asynchronous

240 g of asymmetrical antigen is enabled through selective recruitment and structural plasticity within t

241 Furthermore, plasticity forms involve selective recruitment of previously active or silent syn

242 ted as an efficient and stable electrode for selective reduction of CO2 to ethanol.

243 sion accounted for reduced first-phase GSIS, selective reduction of exocytosis of short-dock (but not

244 maging studies have identified multiple face-selective regions in the brain, but the functional conne

245 In the face-selective regions only, responses were more similar to t

246 Development of face-selective regions, but not place-selective regions, is d

247 ent of face-selective regions, but not place-selective regions, is dominated by microstructural proli

248 (free and total recall of the Free and Cued Selective Reminding test, ten Mini-Mental State Examinat

249 en lights were extinguished, suggesting that selective removal of light during nights with substantia

250 rrhosis suggest the therapeutic potential of selective renal vasodilation using serelaxin as a new tr

251 inge flow injection analysis (MSFIA), with a selective resin ((weak base extraction chromatographic (

252 During this time selective responsiveness to monkey faces emerges.

253 oupled with fluorocarbon coating, to achieve selective segregation of ionic and/or hydrophilic analyt

254 been developed, and the corresponding sodium selective sensors were obtained for the first time.

255 nguage and music experience seem to induce a selective sensory gain along acoustic dimensions that ar

256 morphology, studied in vivo, play a role in selective sensory processing in the M-cell.

257 Only one case report suggested benefit from selective serotonin reuptake inhibitor/serotonin-norepin

258 ting, it was generally unclear if outpatient selective serotonin reuptake inhibitor/serotonin-norepin

259 during cognitive-behavioral therapy (CBT) or selective serotonin reuptake inhibitors (SSRIs).

260 Current treatments, such as selective serotonin reuptake inhibitors, are not ideal b

261 radiation dosimetry in humans for the highly selective sigma-1 receptor PET agent (18)F-6-(3-fluoropr

262 t the water interface and the differentially selective solvation, act to enhance the concentration of

263 We further showed that the cargo-selective sorting nexin Snx3 is required for Neo1 traffi

264 ology to enable quantitative measurement and selective sorting of single cells based on the uptake of

265 s from human subjects while they performed a selective spatial attention task over the course of 1 m

266 urfaces is the tailored rainbow trapping and selective spatial frequency separation of electromagneti

267 xploited to construct a highly sensitive and selective SPR chip for folate biomarker sensing in serum

268 participants of both sexes during a stimulus-selective stop-signal task and performed strategy-depend

269 ng pathway and underscores the need for more selective strategies to therapeutically target NF-kappaB

270 due to the generation of highly reactive and selective sulfate radical (SO4(*-)).

271 rrier extraction science and nanoscale regio-selective surface chemistry.

272 robial communities predominantly assemble by selective survival of taxa able to persist under extreme

273 rn Cambodia, signifying a hard transnational selective sweep.

274 ce varieties show remnants of the effects of selective sweeps in previously identified domestication

275 We have identified selective sweeps underlying quantitative trait loci/gene

276 ence of extinction, bottleneck events and/or selective sweeps within a spring and low migration betwe

277 Predictable site selective syn-dihydroxylation of diolefins is shown.

278 tions in flow cell design that make possible selective syntheses with high conversion of reactant to

279 ed whether this mechanism generalizes to OFF-selective T5 cells and to all four subtypes of both cell

280 s of the anti-EGFR GA201 mAb were tested for selective targeting and eradication of double-positive h

281 nections from early visual areas to the face-selective temporal area in individuals with early and pr

282 These findings reveal an important role for selective termination of lncRNA transcription in both eu

283 atalyzing the ORR, FeNx Cy moieties are more selective than Fe particles encapsulated in N-doped carb

284 ty (PIM-TMN-Trip) that is substantially more selective than PTMSP.

285 This work provides a method for testing selective theories of language change against a null mod

286 to understand resistance mechanisms to BCL-2-selective therapy and how to overcome resistance.

287 Here, we show that a highly selective TLR7 agonist, GS-9620, activated HIV from peri

288 Therefore, an immunoassay selective to TETS was developed.

289 r thrombin and is 4 orders of magnitude more selective towards thrombin than to the other serine prot

290 The association of CD16a-inducible NK cell-selective transcripts CD160 and XCL1 with biopsies with

291 or the more stable silanone 2b (R = t-Bu), a selective transformation to the first reported room temp

292 have general implications for the design of selective transformations involving deprotonation of hig

293 ns to implement complex routing networks and selective transport functionalities in chip-based device

294 regs but not on Teff cells, was required for selective Treg proliferation.

295 s application of an osmotic gradient and the selective TRPV4 agonist GSK1016790A, enhanced TRPV4 acti

296 modulation of the gain and tuning of feature-selective units in visual cortex.

297 Selective use of screening for CAC might be considered i

298 Valbenazine (NBI-98854) is a novel, highly selective vesicular monoamine transporter 2 inhibitor th

299 hemes, including the contributions of aging, selective vulnerability and non-cell-autonomous factors

300 Transportation into axons becomes selective with maturation; we hypothesized that selectiv