ライフサイエンスコーパス: selective advantage

1 CTL recognition, providing the virus with a selective advantage.

2 oss of chromosomes by cancer cells confers a selective advantage.

3 energy as fat between famines would be at a selective advantage.

4 y arise early during tumorigenesis or confer selective advantage.

5 ul conditions specific aneuploidies confer a selective advantage.

6 in the altered tumor environment, suggesting selective advantage.

7 reduction in bicarbonate demand may confer a selective advantage.

8 y some treatment while some subclones gained selective advantage.

9 ispensable residue that appears to confer no selective advantage.

10 aptation is due to new mutations of definite selective advantage.

11 y, a limited number of mutations that confer selective advantage.

12 ether it may result from or confer an innate selective advantage.

13 or other properties of this motif, provide a selective advantage.

14 ility, whereby the PNH clone does not have a selective advantage.

15 nments where biofilm formation may provide a selective advantage.

16 f the substrate that previously conferred no selective advantage.

17 ns of cells for which the plasmids provide a selective advantage.

18 g will increase when imprinting has a direct selective advantage.

19 ly, even in the apparent absence of a direct selective advantage.

20 gesting that this organization may provide a selective advantage.

21 through large populations typically confer a selective advantage.

22 mply that malignant stem cells have a modest selective advantage.

23 to avoid the stalk cell fate, it may have a selective advantage.

24 ations during clonal expansion that confer a selective advantage.

25 f-function or regulatory mutations may be of selective advantage.

26 ns, suggesting that the P53 mutations confer selective advantage.

27 ier hypotheses that such diversity confers a selective advantage.

28 ge is minimal, faster growing fibrils have a selective advantage.

29 in vivo, demonstrating tumor PD-L1 confers a selective advantage.

30 e to hypoxia, with these events conferring a selective advantage.

31 erved, suggesting that the process confers a selective advantage.

32 viruses that acquire these mutations have a selective advantage.

33 lls with more robust SMAD5 expression have a selective advantage.

34 s were most frequently mutated, suggesting a selective advantage.

35 when retaining memory of the past provides a selective advantage.

36 maintaining biological fitness and gaining a selective advantage?

37 of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators.

38 nd many American populations, would confer a selective advantage against vivax malaria.

39 tion and progression, cancer cells acquire a selective advantage, allowing them to outcompete their n

40 e persistent IL-15Ralpha expression are at a selective advantage and become founder cells, outgrow ot

41 The cells were isolated regardless of their selective advantage and differed only by the site of HPV

42 alled alginate provides P. aeruginosa with a selective advantage and facilitates survival in the CF l

43 s, individuals by healthy lobsters confers a selective advantage and highlights the importance of hos

44 We propose that this effect is linked to selective advantage and identify potential driver genes.

45 se "new" substitutions that enhance both the selective advantage and kinetic constants are positioned

46 The greatest selective advantage and OSBS activity are associated wit

47 We then discovered that the selective advantage and OSBS activity of the D297G mutan

48 We now report that both the selective advantage and OSBS activity of the D297G/I19F

49 tein, mediated by binding to GAGs, determine selective advantage and plaque size in BHK-21 cells, lev

50 The pattern of reduction depends on the selective advantage and recurrence rate of the sweeps.

51 ges of Gram-negative hosts suggests a strong selective advantage and that their role in the ecology o

52 nd self-renewal in healthy tissue, promoting selective advantage and tissue colonization.

53 in which transgenes are predicted to confer selective advantages and disadvantages to recipient host

54 ive to those that invoke external factors or selective advantage, and represents a null hypothesis fo

55 The selective advantages, and costs, of hornwort pyrenoids t

56 ate of the hypermutators was governed by the selective advantage arising from a reduced mutation rate

57 molecular mimicry (1) shows a key potential selective advantage arising from the partitioning of aaR

58 hat the new viral strains gained a potential selective advantage as a consequence of the acquired tra

59 rld to the New World and may have provided a selective advantage as begomoviruses adapted to a differ

60 Such chromosomal clustering may confer a selective advantage as it enables coordinated gene regul

61 We found that serotinous individuals have a selective advantage at high fire frequencies and low pre

62 paradoxical and yet key counterweight to the selective advantage attained by cells as they experiment

63 ted, plastic phenotype, which may serve as a selective advantage, because melanoma cells invade vario

64 (2) WASp(+) murine B cells exhibit a marked selective advantage beginning at the late transitional B

65 genetic and epigenetic changes that confer a selective advantage but also need strategies to avoid im

66 uency suggests that these mutations confer a selective advantage, but the biologic mechanism of this

67 ns that exist in larger numbers experience a selective advantage by being more stochastically robust

68 This mechanism may confer a selective advantage by increasing cell population homoge

69 that a "synthetic" genetic code can confer a selective advantage by increasing the number of function

70 tibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing speci

71 this interaction might explain the mutant's selective advantage by means of repression of stem cell

72 Genetic mutations that provide a selective advantage by promoting these characteristics h

73 lon carcinoma, may confer tumor cells with a selective advantage by providing a mechanism for blockad

74 codon reassignments would have a significant selective advantage compared to hosts utilizing the univ

75 gly, spirochetes containing lp28-3 were at a selective advantage compared to lp28-3-deficient spiroch

76 One possible selective advantage conferred by an encapsulated catalys

77 multiple spindles coupled with a subsequent selective advantage conferred by at least some aneuploid

78 enged with WT vs. H28-A2 escape mutants, the selective advantage conferred by glycan-mediated global

79 AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes i

80 ring great-ape evolution has been due to the selective advantage conferred by these genes and transcr

81 uestions remain regarding the mechanisms and selective advantages conferred by both of these symplast

82 fundamental trade-off between the short-term selective advantages (Cope's rule) and long-term selecti

83 We asked what selective advantage could have driven the transition fro

84 for compatible genotypes can evolve but its selective advantage diminishes quickly due to frequency-

85 key strategy in C. lusitaniae that confers a selective advantage during environmental challenges, inc

86 t whether T3SS-negative strains could have a selective advantage during in vivo infection.

87 suggests that some porin sequences confer a selective advantage during infection and/or transmission

88 , suggesting that the risk allele provides a selective advantage during tumor growth.

89 induced microtubule stabilization provides a selective advantage during tumor metastasis.

90 otoreceptors might have conferred particular selective advantages during evolution.

91 enhanced functional responses in vitro or to selective advantages during in vivo responses to cytomeg

92 When an introgressed archaic allele has a selective advantage, even rare interbreeding can lead to

93 ted hematologic defects that lack an in vivo selective advantage following gene correction may benefi

94 The strongest selective advantage for ADA-transduced cells occurred at

95 l dissociated from L11 at any time; thus the selective advantage for any further increase in stabilit

96 r events in different cells, contribute to a selective advantage for cancer cell proliferation.

97 flow cytometry-selected cells, demonstrating selective advantage for cells with multiple transposon i

98 penias that characterize AP syndrome and the selective advantage for clones that have lost the mutant

99 TrkC silencing by promoter methylation is a selective advantage for colorectal cell lines to limit t

100 e, we show that the Psb27 protein provides a selective advantage for cyanobacterial cells under condi

101 uch of the low-latitude oceans, generating a selective advantage for diazotrophic organisms capable o

102 In patients with mixed chimerism, selective advantage for donor-derived T cells and switch

103 at inhibit rumen protozoa may provide such a selective advantage for EcO157 to proliferate in lagoons

104 ocytes, we obtained suggestive evidence of a selective advantage for increased GNAQ(Q209L) expression

105 pression of XPC protein might also provide a selective advantage for initiation and progression of si

106 t during skin carcinogenesis that provides a selective advantage for initiation and progression of sq

107 ant-associated microbes, and thus provides a selective advantage for microbes such as P. syringae tha

108 model also successfully predicted a stronger selective advantage for more strongly activating gain-of

109 emostimuli called kairomones offers a strong selective advantage for potential prey animals.

110 potency and thus are not likely to provide a selective advantage for reprogramming.

111 accelerated evolution may be due to a larger selective advantage for resistance mutations in synergis

112 ation of a more robust biofilm may provide a selective advantage for strains that cause systemic dise

113 of HREs does not always provide an ultimate selective advantage for TEs, but may increase the probab

114 of a B cell for antigen is translated into a selective advantage for that B cell in immune responses

115 ed in the Wiskott-Aldrich syndrome, provides selective advantage for the development of naturally occ

116 ould be beneficial to therapy by providing a selective advantage for the expansion of stem cells.

117 end of the proto-spacer, suggesting a strong selective advantage for the phage that mutated in this r

118 imply defective phages and instead provide a selective advantage for the producing organisms.

119 Given a lack of selective advantage for this broadened signaling in the

120 he hypothesis that small body size confers a selective advantage for tropical rainforest hunter-gathe

121 2 promotes aerobic glycolysis and provides a selective advantage for tumor formation.

122 ed RNA editing in cancer cells may provide a selective advantage for tumor growth and resistance to a

123 e than homodimers, thereby providing further selective advantage for using heterodimers as morphogens

124 gous female WASp mice revealed a substantial selective advantage for WASp(+) vs WASp(-) iNKT cells.

125 munized individuals, identifying a potential selective advantage for wcjE inactivation and serotype 9

126 smids are extrachromosomal DNA that provides selective advantages for bacterial survival.

127 These experiments confirm that the selective advantages for viral yield and encapsidation s

128 nly accepted explanations for the individual selective advantages gained by shoaling.

129 at strategy A fixates in a B-population with selective advantage if the fitness of A is greater than

130 Although these adaptations may confer some selective advantage, if they are not appropriately regul

131 in vivo or ex vivo but confers a significant selective advantage in competitive mosquito infections i

132 n truncated LEC1 proteins may have been of a selective advantage in creating somatic propagules, beca

133 rain-specific genes may provide an isolate a selective advantage in environments and contribute to th

134 ose that directional rolling might provide a selective advantage in escape from parasitoid wasps that

135 persons expressing GM3/17 have potentially a selective advantage in HCMV defense.

136 Selective advantage in host tissues can also be gained b

137 izontally acquired by pathogens to provide a selective advantage in host tissues.

138 nfluencing birth weight may have conferred a selective advantage in human populations.

139 osis-like death in pneumococci and confers a selective advantage in nasopharyngeal cocolonization.

140 or viral replication but provide them with a selective advantage in nature.

141 clear whether cheating provides an important selective advantage in nature.

142 n these five tumor types and likely confer a selective advantage in oncogenesis.

143 or more gene clusters known to confer strong selective advantage in some environments.

144 panded "synthetic" genetic code can confer a selective advantage in the directed evolution of protein

145 no acid p-boronophenylalanine (BF) confers a selective advantage in the evolution of glycan-binding p

146 alizing antibodies did not bind, conferred a selective advantage in the immune systems of infected ho

147 TssM deubiquitinase may provide B. mallei a selective advantage in the intracellular environment dur

148 ll antigen receptor signaling and an in vivo selective advantage in the peripheral versus central B-c

149 table, amyloid-like aggregates that confer a selective advantage in the presence of specific antifung

150 hat grant spermatogonial stem cells (SSCs) a selective advantage in the testes of the father, but hav

151 Mutant FGFR3 may confer a selective advantage in the urothelium by overcoming norm

152 ical domain mutations in PIK3CA may confer a selective advantage in the urothelium in vivo by overcom

153 eling speculation that aneuploidy provides a selective advantage in these organs.

154 F10 carriage gives E. faecalis a significant selective advantage in this environment.

155 ation of the PTAP motif in p6(Gag) confers a selective advantage in viral replication by increasing G

156 Finally, WASp(+) Tregs exhibited a marked selective advantage in vivo in a WAS patient with a spon

157 se immunodeficiencies corrected cells have a selective advantage in vivo, and low numbers of gene-mod

158 19A) and CC695(19A) could reflect additional selective advantages in addition to resistance.

159 atures unique to each myosin type may confer selective advantages in cellular functions.

160 SAgs offer selective advantages in facilitating DFU infections and

161 mone receptors, suggesting that they provide selective advantages in natural environments.

162 dengue viruses, and the critical role of the selective advantages in the mosquito vector.

163 region by diverse pathogens suggests that a selective advantage is acquired.

164 onal B-cell stage; and (3) a similar in vivo selective advantage is manifest by mature WASp(+) human

165 This selective advantage is paired with a tradeoff in which m

166 Strength of selective advantage is presented for a range of disorder

167 This selective advantage is surprisingly small--0.004 +/- 0.0

168 of a lipid droplet, which despite the clear selective advantage it confers is also a harbinger of ce

169 us consequences, possibly as a result of the selective advantage it originally provided to either a h

170 ive evidence supports two hypotheses for the selective advantages leading to the origin of vocal lear

171 ond distinct cell population that may have a selective advantage, leading to variation of LOI in norm

172 This selective advantage occurs at the expense of resident in

173 ed with low Igmu-chain and can eliminate the selective advantage of "double-producers" that achieve h

174 We find no evidence for a selective advantage of a high polygenic risk of schizoph

175 We show that even a small selective advantage of a single cell within a large tumo

176 e disequilibrium generated by migration; the selective advantage of an inversion is dependent on the

177 By virtue of the acquired selective advantage of blocking virus-induced apoptosis,

178 other diseases, is confounded by the strong selective advantage of cells in which shRNA expression i

179 been the subject of much speculation, and a selective advantage of clusters of functionally related

180 For tumor growth, one selective advantage of concurrent mutation of RAS and PT

181 ropose that CsrD evolution was driven by the selective advantage of decoupling Csr sRNA decay from Cs

182 ignaling that could significantly reduce the selective advantage of deregulated activation of IGF1/IG

183 However, the selective advantage of female-biased sex ratios comes fr

184 To understand the selective advantage of genetically encoding more than 20

185 Two hypotheses have been proposed: A selective advantage of GPI(-) cells because of a second

186 Our results further reveal a potential selective advantage of Phe in certain situations, relati

187 ips among species in order to understand the selective advantage of producing milk with specific nutr

188 Furthermore, this finding suggests the selective advantage of specific combinations of genetic

189 and 6.0 (3-4 h) using a procedure that takes selective advantage of the large size of these cells.

190 n capability, leading to questions about the selective advantage of this activity.

191 ufficient for symbiosis, thus explaining the selective advantage of this allele at the mechanistic le

192 s in saturniid moths, further supporting the selective advantage of this anti-bat strategy.

193 However, the selective advantage of this enzyme is not known.

194 ation for both progressive emphysema and the selective advantage of this mutant allele.

195 The proposed selective advantage of this mutation for these primates

196 The selective advantage of this variation is not clear.

197 -dependent hematopoiesis consistent with the selective advantage of WASP-positive hematopoietic cells

198 nsion of a dominant homozygous subclone, the selective advantage of which is likely to reflect additi

199 One of the major selective advantages of GC-rich DNA is hypothesized to b

200 evolutionary selection, including potential selective advantages of mutation carriers in genes affec

201 lead to differing conclusions related to the selective advantages of sexual reproduction.

202 n be classified across species, and what the selective advantages of the capacity for mood are.

203 et, known as driver mutations, confer clonal selective advantage on cancer cells and are causally imp

204 elegans with metabolic plasticity and thus a selective advantage on different diets in the wild.

205 ogues of known accessory modules that confer selective advantage on host bacteria.

206 sults suggest that type IV pili may confer a selective advantage on K. kingae early in infection and

207 bility of most therapeutic genes to confer a selective advantage on the gene-corrected cells.

208 This reduction in viability may confer a selective advantage on undifferentiated lymphoid progeni

209 al breast epithelial cells, which provides a selective advantage once tumorigenesis has begun.

210 However, these mosaics have a selective advantage only in the presence of adaptive imm

211 d and heterogeneous conditions influence the selective advantage or disadvantage of antibiotic resist

212 The loss of competency may be due to a selective advantage or the irreversible transfer of loss

213 t-hedging, or adaptive tracking) has a clear selective advantage over all others.

214 duals that do not contribute socially have a selective advantage over altruists if both types receive

215 ssume that modern humans benefited from some selective advantage over Neanderthals, which led to the

216 ansgenic malaria-resistant mosquitoes have a selective advantage over nontransgenic mosquitoes.

217 ssary mutations the transformed cell gains a selective advantage over normal cells, and the mutation

218 e ribosome biogenesis and provide pre-LSCs a selective advantage over normal hematopoietic cells thro

219 ning elevated levels of plasticity acquire a selective advantage over other clonal populations within

220 he surfactant provides L. pneumophila with a selective advantage over other legionellae in the natura

221 talytic transformations would have enjoyed a selective advantage over other protocells in high Mg(2+)

222 bial pressure, 6 out of 11 mutants carried a selective advantage over the antimicrobial-sensitive par

223 lonization, the presence of spxB conferred a selective advantage over the DeltaspxB mutant, suggestin

224 eads to DSBs, and whether sleep provides any selective advantage over wake in their repair.

225 t that the HBeAg-negative variant may have a selective advantage over wild-type HBV within the livers

226 Our findings reveal a potential selective advantage possessed by multidrug-resistant-A.

227 Our results imply that the selective advantage produced by human chromosome 17p del

228 Paradoxically, there are limits to the selective advantage provided by increasing levels of ADE

229 he molecular (sequence) pathway by which the selective advantage provided by this protein can be impr

230 the model allows us to calculate the actual selective advantage provided by typical somatic mutation

231 In higher plants, they confer a selective advantage, providing information regarding not

232 s paper, we build on our recent work on the "selective advantage" relation among driver mutations in

233 ple cognitive abilities (each with their own selective advantage) requires no additional evolutionary

234 fraction exceeded 50%, suggesting additional selective advantage resulting from the loss of heterozyg

235 lthough the mechanisms of regulation and the selective advantage(s) of regulating cellular shape are

236 how that viruses with these mutations have a selective advantage since they are preferentially locate

237 expression of particular genes may provide a selective advantage such that it is conserved across spe

238 ge transaldolase may be a tradeoff for other selective advantages such as reduced gene size: we show

239 tion, we predict that revertant cells have a selective advantage that allows their clonal expansion a

240 e latter case, heterogeneity should confer a selective advantage that benefits the entire population.

241 kinase gene, which conferred an exceptional selective advantage that could be demonstrated through b

242 thelium plays a unique function, providing a selective advantage that gives rise to transgene-positiv

243 This separate large plasmid and the selective advantage that it confers in the antibiotic er

244 lleles at C157R, M378V and M681T conferred a selective advantage that varied spatially, and perhaps t

245 er or not this exclusion activity provides a selective advantage through maintenance of Stk activity

246 Therefore, this Vkappa gene may confer a selective advantage to anti-DNA Abs in diseased mice.

247 rum caspase inhibitor that likely provides a selective advantage to baculoviruses in different cellul

248 ations of estrogen and ER may provide a dual selective advantage to breast cancer cells by controllin

249 Therefore, Hsp72 provides a selective advantage to cancer cells by suppressing defau

250 investigate whether aneuploidy may confer a selective advantage to cancer cells, we employed a contr

251 pression of light-inducible genes provides a selective advantage to cavefish at the expense of a damp

252 character displacement may provide less of a selective advantage to cheating; second, cheats may trad

253 s do not have the necessary proliferative or selective advantage to evolve into a disease-relevant re

254 , suggesting that GTAC methylation confers a selective advantage to H. pylori.

255 rovides a path to tumor development, with no selective advantage to having both mutations.

256 of heterozygotes, may result in an apparent selective advantage to heterozygotes at the neutral locu

257 yI R-M cassette in Phi10394.4 could impart a selective advantage to host strain survival and may prov

258 common MHC alleles, which in turn provides a selective advantage to hosts carrying rare MHC alleles.

259 ll, our data show that aneuploidy can confer selective advantage to human cells cultured under non-st

260 ated nuclear antigen (LANA/orf73) provides a selective advantage to infected B cells by driving proli

261 sure to inflammatory cytokines can provide a selective advantage to infiltrating CD8(+) T cells by tr

262 n this model, each genetic polymer imparts a selective advantage to its protocell by, for example, co

263 ever, the PS was found to provide a distinct selective advantage to MHV.

264 age or death of their host offers no obvious selective advantage to microbial growth or survival.

265 ive virulence determinants may both confer a selective advantage to mucA mutant strains of P. aerugin

266 ic mutations in a single HSC that provides a selective advantage to mutant HSC over normal HSC and pr

267 owever, very high seed predation shifted the selective advantage to nonserotinous individuals even at

268 ations on space and/or growth factors gave a selective advantage to phenotypes derived from tumorigen

269 clock, acting with hormone signals, provides selective advantage to plants through anticipation of an

270 ibiotic production can actually decrease the selective advantage to producers.

271 sitive to COP1, implying that this confers a selective advantage to prostate epithelial cells.

272 lution, our findings suggest that there is a selective advantage to retaining polar, uncharged residu

273 d corresponding stress resistance provides a selective advantage to Runx1-deficient HSPCs, allowing t

274 Thus, Hsa confers a selective advantage to S. gordonii over S. sanguinis in

275 ly unrecognized role in providing a germline-selective advantage to spermatogonia for the recurrent m

276 trains and biofilm formation seems to give a selective advantage to the bacterium.

277 Thus, WASP expression conferred a selective advantage to the development of Kit-dependent

278 housekeeping genes suggests that they offer selective advantage to the genomes and ecosystems they i

279 t of large supergene complexes that confer a selective advantage to the individual.

280 lly, the resistance gene must confer a large selective advantage to the vector to surmount the effect

281 us-encoded miRNAs are likely to be of little selective advantage to the virus, and our approach provi

282 2013-16 epidemic, are suspected to confer a selective advantage to the virus.

283 ype p53 in glioblastoma cells could confer a selective advantage to these cells under the adverse con

284 ein was ablated because it provided a modest selective advantage to this clinical isolate in vitro.

285 rmidis, but also that this element confers a selective advantage to this ubiquitous commensal of the

286 These contexts gave a selective advantage to traits, such as dietary flexibili

287 inherent to viral populations may provide a selective advantage to viruses that can be fully exploit

288 ration of genome rearrangements that provide selective advantages to the invading microbe.

289 hway; yet their accumulation must have given selective advantages to the parasite.

290 a unique family of retroelements that confer selective advantages to their hosts by facilitating loca

291 ements have the potential to confer powerful selective advantages to their hosts, and their ability t

292 onse to specific challenges and can confer a selective advantage under certain environmental stresses

293 ncoded by TP53) provides cancer cells with a selective advantage under conditions of hypoxia, but lit

294 changes in amino acid function provided the selective advantage underlying the expansion of the gene

295 Defectors have a selective advantage unless a mechanism for evolution of

296 This trade-off may have provided a selective advantage when Homo transitioned to butchery u

297 t certain environment-altering traits have a selective advantage when those traits also contribute to

298 equence of behaviors that evolved to provide selective advantages when elicited by tall trees, but ar

299 ing development might offer dosage-dependent selective advantage, whereas rapid expression divergence

300 ) Initially, the two linked mutations have a selective advantage while rare and will increase in freq