ライフサイエンスコーパス: selective inhibition

1 possibility of monitoring its modulation and selective inhibition.

2 alytic domain held little promise to achieve selective inhibition.

3 dynamic signal profiles that are amenable to selective inhibition.

4 t the proteolytic sites directly but fail in selective inhibition.

5 re solved, showing the potential for species selective inhibition.

6 s shown to be expressed by NK cells, and its selective inhibition abrogated CD16 and CD62L shedding,

7 This chemotype exhibits highly selective inhibition against ALDH1A1 over ALDH3A1, ALDH1

8 benzyl)-ATP as a phosphate donor and for its selective inhibition by 1NA-PP1 and 2MB-PP1.

9 The selective inhibition by alkaloids from the class produce

10 Here we report beta5i-selective inhibition by asparagine-ethylenediamine (AsnE

11 SOAT1-selective inhibition by BeauIII was reproduced in intact

12 important mechanistic component of substrate-selective inhibition by flufenamic acid, mefenamic acid,

13 d the extent to which they could prepare for selective inhibition by providing or withholding informa

14 n AlkB, which reveal it as being amenable to selective inhibition by small molecules.

15 nance imaging data show that preparation for selective inhibition engages the inferior frontal gyrus,

16 e examine the behavioral and neural basis of selective inhibition focusing on the role of preparation

17 these inhibitors and the molecular basis of selective inhibition for PRMT1.

18 derlying mechanism responsible for substrate-selective inhibition has remained elusive.

19 or pan-group I, pan-group II, or PAK isoform selective inhibition has yet to be demonstrated.

20 onal ligand tethering (BOLT) and demonstrate selective inhibition (iBOLT) of protein function.

21 human homologs to suggest the possibility of selective inhibition if the MtTrxR-Trx interaction site

22 critical for resorptive function, and their selective inhibition in mature osteoclasts retards patho

23 ursued as attractive therapeutic targets for selective inhibition in patients with cancer.

24 As predicted, both lines demonstrated a selective inhibition in spontaneous release, suggesting

25 illustrated the therapeutic benefits of its selective inhibition in vivo.

26 iated platelet activation is attributed to a selective inhibition in VWF/GPIb-IX-induced phosphorylat

27 Our results suggest proactive selective inhibition is implemented within frontostriata

28 However, whether direction-selective inhibition is indispensable for direction sele

29 ctive drug targets to treat malaria as their selective inhibition leads to an arrest of the parasite'

30 dium, and raise the possibility that isoform-selective inhibition may allow inotropic responses witho

31 e potential in the treatment of RA, and HDAC-selective inhibition may improve the therapeutic margin

32 Allele-selective inhibition may involve cooperative binding of

33 gnificantly to DMD arrhythmogenesis and that selective inhibition may provide substantial benefit.

34 compounds were distinguished by a strong and selective inhibition of 7-dehydrocholesterol reductase (

35 Our study suggests that selective inhibition of a distinct Hsp90 family member h

36 Our results demonstrate the selective inhibition of a highly conserved metabolic enz

37 lass of compounds that protect cells through selective inhibition of a lipid kinase, PIP4Kgamma.

38 Selective inhibition of aberrant Cdk5 activity via genet

39 In myasthenic rats, selective inhibition of AChE is more effective in rescui

40 nt inhibition of NF-kappaBp65 activation and selective inhibition of activation of IFN regulatory fac

41 In summary, selective inhibition of activin A with a monoclonal anti

42 We aimed at determining whether selective inhibition of activin A would provide a regene

43 This event results in a selective inhibition of activity-dependent bulk endocyto

44 Selective inhibition of ADAM17 prevented the shedding of

45 nhances mammary tumor metastasis, results in selective inhibition of Akt3 expression and phosphorylat

46 Selective inhibition of ALDH-2 may have therapeutic pote

47 Consequently, selective inhibition of ALDH3A1 could increase chemosens

48 Selective inhibition of alpha-helix-mediated protein-pro

49 phagia exhibited by BDNF mutant mice because selective inhibition of alpha2delta-1 by gabapentin infu

50 following suprathreshold neuronal activity, selective inhibition of alpha3 almost completely abolish

51 Under basal conditions, selective inhibition of alpha3 using a low concentration

52 nomas in nude mice as a model, we found that selective inhibition of Ang2 by the peptide-Fc fusion pr

53 Selective inhibition of Ang2 throughout the infection by

54 , several therapeutic strategies rely on the selective inhibition of angiogenesis and the destruction

55 Selective inhibition of APC might therefore be effective

56 roved to be a very attractive target for the selective inhibition of archaea and actinobacteria.

57 We propose that selective inhibition of astrocytic GABA synthesis or rel

58 Our findings suggest selective inhibition of AT1 receptors within the nephron

59 Selective inhibition of ATR prevents Thr-1989 phosphoryl

60 Selective inhibition of BCAT1 activity results in decrea

61 Selective inhibition of beta-catenin/Tcf protein-protein

62 of the steviamine analogues showed good and selective inhibition of beta-mannosidase (Helix pomatia)

63 Importantly, selective inhibition of BIRC3 reversed therapeutic resis

64 , improves the clinical outcome, whereas non-selective inhibition of both forms of tumour necrosis fa

65 Selective inhibition of BRAF(V600E) by PLX4720 treatment

66 uced neurodegeneration and demonstrates that selective inhibition of c-Abl may be neuroprotective.

67 We demonstrate that selective inhibition of calpain 1 activation improves wo

68 Selective inhibition of cancer cells remains a challenge

69 The selective inhibition of cancer-associated human carbonic

70 tivation of caspase-3 and conversely whether selective inhibition of caspase-3 would abate calpain ac

71 Selective inhibition of CaV1.3 over other LTCC isoforms,

72 KACh either in Cav1.3(-/-) mice or following selective inhibition of Cav1.3-mediated L-type Ca(2+) (I

73 ent a molecular mechanism of nitrous oxide's selective inhibition of CaV3.2 low-voltage-activated (T-

74 CK increased cholesterol absorption, whereas selective inhibition of CCK1R and CCK2R with antagonists

75 ype and mutated p53, leading subsequently to selective inhibition of CDK2 and cyclin A expression and

76 By selective inhibition of CDK4/CDK6 with PD 0332991, which

77 Here we show selective inhibition of Cdk5/p25 -hyperactivation by TFP

78 To account for the selective inhibition of Cdk5/p25 activity, we propose th

79 Here we show that TFP5/TP5 selective inhibition of Cdk5/p25 hyperactivation in vivo

80 /cyclin T or CDK2/cyclin A, we conclude that selective inhibition of CDK9/cyclin T by members of the

81 Selective inhibition of cell adhesion, wound healing, an

82 THL treatment of M. tuberculosis resulted in selective inhibition of Chp2 over PapA3, confirming Chp2

83 uation of these inhibitors demonstrates that selective inhibition of CK1delta at sufficient central e

84 ytoplasm and the nucleus, and we showed that selective inhibition of class I Pak kinase activity in c

85 Selective inhibition of class IIa HDACs did not prevent

86 in coresident fibroblasts and was blocked by selective inhibition of CN or PKC alpha/epsilon or elimi

87 Furthermore, selective inhibition of corresponding circuit elements i

88 It is not known whether selective inhibition of COX-2 makes asthmatic responses

89 Behaviorally, substrate-selective inhibition of COX-2 reduced anxiety-like behav

90 pharmacological strategy involving substrate-selective inhibition of COX-2 to augment eCB signaling w

91 Selective inhibition of cytoplasmic Nsp1 or inactivation

92 Selective inhibition of D1-expressing prefrontal neurons

93 educed excessive alcohol consumption, as did selective inhibition of D1-MSNs or excitation of D2-MSNs

94 made to bring new chemical entities for the selective inhibition of DUBs based on these tools are al

95 et al. (2017) induce stem cell quiescence by selective inhibition of EGF/MAPK signaling and define cu

96 Additionally, we show that the selective inhibition of either the MAPK or AKT pathways

97 astasis by inhibiting tumor angiogenesis via selective inhibition of endothelial cell proliferation.

98 d astrocyte GDNF expression and suggest that selective inhibition of EP1 signaling might be a means t

99 knowledge for the first time, indicate that selective inhibition of EP2/EP4: (i) decreases growth an

100 Selective inhibition of EphB4 using a functional blockin

101 Whereas selective inhibition of ERK1/2 activation ameliorated ao

102 d kinase 1/2 (ERK1/2) in both cell lines and selective inhibition of ERK1/2 similarly decreases the b

103 Selective inhibition of exocytosis in SOD1G93A astrocyte

104 nyl fluoride analogs that exhibit potent and selective inhibition of FAAH.

105 Selective inhibition of FtsZ polymerization without impa

106 resulted in overactivation of LPA(1) through selective inhibition of G protein-coupled receptor kinas

107 with alterations in T-cell polarity and the selective inhibition of Gata3 and nuclear factor of acti

108 Selective inhibition of geranylgeranylated RhoA-associat

109 ed increase in [Ca](i) levels was reduced by selective inhibition of GluA2-lacking AMPARs.

110 Selective inhibition of GOT1 with (aminooxy)acetic acid

111 Selective inhibition of GSK3beta is sufficient to mainta

112 These results suggest that selective inhibition of HDAC3 could be useful in treatme

113 Indeed, selective inhibition of hepatic aPKC by adenoviral-media

114 ith fasting hyperglycemia, are reversible by selective inhibition of hepatic FoxO6 activity in diabet

115 old Kinase Suppressor of Ras 2 (KSR2) causes selective inhibition of hepatic GH signaling in neonatal

116 ffinity binding, the most effective, isoform-selective inhibition of HIF-2 in cells, and trigger the

117 ral input from the cranial dura, and found a selective inhibition of high-threshold but not wide-dyna

118 action may partly account for fremanezumab's selective inhibition of high-threshold, as a result of a

119 Selective inhibition of hLDH5 using small molecules hold

120 Both selective inhibition of Hsp90 and temperature stress inc

121 Previous studies reported potent and allele-selective inhibition of human huntingtin expression by s

122 Ideal pain mangement requires selective inhibition of hyperactive pain-sensing neurons

123 Selective inhibition of hypothalamic SIRT1 using a cell-

124 P34.5beta protein level is attributed to its selective inhibition of ICP34.5 splicing, which results

125 Collectively, the data suggest that selective inhibition of IDO1 may represent an attractive

126 h therapeutic potential for the targeted and selective inhibition of IgE-mediated allergic responses,

127 ed lumen patency via adaptive remodeling and selective inhibition of IH without affecting endothelium

128 oth compounds bind to GP130 and demonstrated selective inhibition of IL-6 induced STAT3 phosphorylati

129 Moreover, selective inhibition of inappropriately dispersed GAPDH

130 Furthermore, selective inhibition of individual GSK3 isozymes yields

131 Selective inhibition of individual ligands revealed that

132 cystine knot protein that shows exquisitely selective inhibition of insect V-ATPases.

133 To determine the effects of selective inhibition of intrarenal dopamine production,

134 be unique among IPKs, could be exploited for selective inhibition of IPK1 in future studies that inve

135 This study was undertaken to investigate how selective inhibition of JAK with tofacitinib (CP-690,550

136 Cell-based enzyme assays showed selective inhibition of JAK1/3-dependent pathways with 2

137 Selective inhibition of KDAC isoforms while maintaining

138 nases and provides an opportunity for highly selective inhibition of kinase activity through a non-AT

139 ubstrates more potently leading to substrate selective inhibition of kinase activity.

140 Selective inhibition of LC-NE neurons during stress prev

141 Here we explored the possibility of species-selective inhibition of lipoamide dehydrogenase (Lpd), a

142 ied two 2'-C-methyladenosine analogs showing selective inhibition of LRV1.

143 otentiates neutrophilic inflammation through selective inhibition of LTA4H aminopeptidase activity.

144 ncreased PGP, neutrophilic inflammation, and selective inhibition of LTA4H aminopeptidase, which ordi

145 strategy specifically modified host beds by selective inhibition of lymphangiogenesis but not hemang

146 Selective inhibition of lymphocyte activation through ab

147 understanding the biological implications of selective inhibition of mGlu2 in the CNS.

148 The powerful and selective inhibition of microbial (fungal and mycobacter

149 The selective inhibition of mitochondrial Ca(2+) uptake demo

150 etyl-p-benzoquinoneimine (NAPQI), caused the selective inhibition of mitochondrial complex II activit

151 These changes reflect selective inhibition of mitochondrial protein synthesis

152 Nonspecific inhibition of collagenases or selective inhibition of MMP-9 decreased pathological vas

153 n of a repressive form of Sp8 results in the selective inhibition of motor neuron generation and the

154 Later on, at 400 ms, a selective inhibition of motor resonance was found for ac

155 Selective inhibition of mPGES-1 might be a promising ste

156 Interestingly, selective inhibition of mPGES-1 was also associated with

157 Selective inhibition of mPGES-1 with either siRNA or iso

158 Selective inhibition of mTORC1 and mTORC2 through geneti

159 a therapeutic avenue to achieve complete and selective inhibition of mTORC1.

160 Notably, selective inhibition of mTORC2 triggered proteasome-medi

161 Based on these findings, we posit that the selective inhibition of MTP triglyceride transfer activi

162 Selective inhibition of mutant BRAF by using class I RAF

163 a divalent cation binding residue can enable selective inhibition of mutant IDH1 and suggest that dif

164 However, selective inhibition of mutant IDH1 enzyme function coul

165 The compounds exhibit potent and selective inhibition of Mycobacterium tuberculosis, the

166 tes both in vitro and in vivo, and show that selective inhibition of N-myristoylation leads to catast

167 Selective inhibition of neuronal nitric oxide synthase (

168 Pharmacological selective inhibition of neuronal NOS (nNOS) has the pote

169 These findings suggest that selective inhibition of NF-kappaB activation that result

170 main of p65 and provide a novel strategy for selective inhibition of NF-kappaB gene transcription.

171 In this study, we explored selective inhibition of NF-kappaB transcriptional activi

172 In addition, selective inhibition of nitric oxide synthase 1 restores

173 kbones, play critical roles in their subunit-selective inhibition of NMDAR ion channels, a finding th

174 involved in diverse physiological functions, selective inhibition of nNOS over other isoforms is esse

175 Therefore, developing small molecules for selective inhibition of nNOS over related isoforms (eNOS

176 Selective inhibition of NOD1 and NOD2 signaling could be

177 stimulation of insulin secretion through the selective inhibition of Nogo-A could be a novel therapeu

178 s mammalian counterpart may be exploited for selective inhibition of oncogenic growth driven by YAP h

179 Selective inhibition of oncogenic targets and associated

180 Conversely, selective inhibition of OSM by neutralizing antibody and

181 Such a rate regulation allows selective inhibition of osteosarcoma cells over hepatocy

182 se model in which p68 depletion results in a selective inhibition of p21 induction in several tissues

183 Here we show that the selective inhibition of p25/Cdk5 hyperactivation in vivo

184 Knockdown of pyrin and selective inhibition of p38 MAPK greatly attenuated casp

185 phthoflavone-like flavone derivatives showed selective inhibition of P450 1A1.

186 Selective inhibition of P450 enzymes is the key to block

187 Finally, we demonstrate selective inhibition of PABA biosynthesis in M. tubercul

188 Thus, TEM8 targeting may allow selective inhibition of pathological angiogenesis.

189 se phenotypes are similar to those caused by selective inhibition of Pbp2x by methicillin that preven

190 function of the PD-1/PD-L1 axis, and suggest selective inhibition of PD-L1 on donor T cells as a pote

191 This and selective inhibition of PDE5 protected the heart against

192 Antiplatelet therapy or selective inhibition of PDGFB might reduce biliary fibro

193 activated by designer drugs), we found that selective inhibition of Pdyn-expressing neurons in the r

194 he general mode of macrolide action involves selective inhibition of peptide bond formation between s

195 Importantly, selective inhibition of PFKFB3 expression and activity u

196 Selective inhibition of PGF2alphaEA versus prostaglandin

197 J-42041935 was used to compare the effect of selective inhibition of PHD to intermittent, high doses

198 ctivation in EBV+ B cell lymphomas, and that selective inhibition of PI3Kdelta by either siRNA, or a

199 Selective inhibition of PI3Kgamma and PI3Kdelta (using P

200 elta deficiency prolongs graft survival, but selective inhibition of PI3Kgamma or PI3Kdelta reveals a

201 Selective inhibition of PKA activity in AgRP neurons par

202 Thus, potent and selective inhibition of PKCtheta is expected to block au

203 ies of docked alkaloids correlate with their selective inhibition of PLA2 activity.

204 e mycoplasma from the tumor cell cultures or selective inhibition of PNPHyor by a PNP inhibitor resto

205 Selective inhibition of polarized endothelial cell migra

206 Selective inhibition of PRDX6 blocks Galphai depalmitoyl

207 3-d in a panel of cancer cell lines showed a selective inhibition of proliferation of a subset of AML

208 mpounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast ca

209 We previously demonstrated that selective inhibition of protein kinase Ctheta (PKCtheta)

210 We further show that selective inhibition of PRs in the brain by antisense ol

211 Also dissimilar to ToxB, selective inhibition of Rac does not inhibit MEK1/2/ERK1

212 In a manner similar to ToxB, selective inhibition of Rac induces CGN apoptosis associ

213 In contrast, selective inhibition of Rac induces CGN apoptosis by rep

214 to attenuate neuronal cell death induced by selective inhibition of Rac with NSC23766 but not apopto

215 Selective inhibition of Rac1 in just the proximal or dis

216 tion of estrogen receptor-alpha (ERalpha) or selective inhibition of RANKL in hematopoietic vs. mesen

217 Selective inhibition of Rho GTPases (particularly Rac1)

218 of IL-17 and IL-21 and support the idea that selective inhibition of ROCK2 could represent an importa

219 ase-binding loop alone is sufficient for the selective inhibition of serine proteases or whether othe

220 ell proliferation, nahuoic acid A (1) showed selective inhibition of SETD8 in U2OS osteosarcoma cells

221 Selective inhibition of SGLT2 over SGLT1 is critical for

222 imization in our continued effort to explore selective inhibition of SIRT2 as a potential therapy for

223 Furthermore, selective inhibition of SMAD3 or CCT6A efficiently suppr

224 their potential therapeutic application for selective inhibition of smooth muscle cell proliferation

225 Collectively, our data demonstrate that selective inhibition of soluble tumour necrosis factor i

226 Here we show that selective inhibition of soluble tumour necrosis factor i

227 Hence, the selective inhibition of specific integrins is of great m

228 Selective inhibition of spinal 5-hydroxytryptamine-2 rec

229 he immunodominance hierarchy in part through selective inhibition of subdominant CD8(+) T cell prolif

230 Selective inhibition of T-channels and global deletion o

231 However, selective inhibition of TBK1 precludes phosphorylation o

232 Altered membrane events induced selective inhibition of TCR-induced phosphorylation of r

233 Selective inhibition of tetraspanins may constitute an a

234 Selective inhibition of TGFbr2/ALK5 signaling in microgl

235 ed substructural features that influence the selective inhibition of the activation by p38alpha of th

236 ved aberrant Tau, but it remained unknown if selective inhibition of the activity of this Hsp70 isofo

237 Targeted and selective inhibition of the alternative complement pathw

238 chia coli by the T7 phage leads to rapid and selective inhibition of the bacterial RNA polymerase (RN

239 Selective inhibition of the bromo and extra C-terminal d

240 tension with reduced side effects due to its selective inhibition of the C-domain.

241 major therapeutic challenge is the need for selective inhibition of the canonical pathway without im

242 Selective inhibition of the chymotrypsin-like (CT-L) act

243 In DH but not EH rats, selective inhibition of the commissural nucleus tractus

244 Selective inhibition of the cytoplasmic class IIb HDAC6

245 More importantly, selective inhibition of the extracellular Hsp90alpha-Del

246 sed-loop optogenetic approach, we found that selective inhibition of the IL immediately after unreinf

247 rmal cells with suppressed tumorigenicity by selective inhibition of the MAPK/ERK/MYC signaling casca

248 rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cy

249 Selective inhibition of the mTORC1 cascade by rapamycin

250 ed transcriptional coactivator BRD4 leads to selective inhibition of the MYC oncogene in multiple mye

251 Selective inhibition of the neuronal isoform of nitric o

252 Selective inhibition of the NKA alpha2 isoform by low do

253 lycine gatekeeper residue in TgCDPK1 permits selective inhibition of the parasite enzyme over human k

254 These findings suggest that selective inhibition of the PI3K catalytic subunit p110d

255 Importantly, selective inhibition of the protein kinases Akt or mTOR

256 In addition, selective inhibition of the ROS generator NADPH oxidase

257 Selective inhibition of the slowly inactivating or late

258 All of the active compounds showed selective inhibition of the strand-transfer reaction ove

259 Here, we report that selective inhibition of the subset of VMN neurons that e

260 ayed as fragment-based leads, which procured selective inhibition of the target in the low micromolar

261 ntibody responses, and was associated with a selective inhibition of the TH-1 type factors T-bet, IL-

262 Selective inhibition of the transporter protein sodium-g

263 ng, we implemented a novel strategy aimed at selective inhibition of the TrkB-activated signaling pat

264 mice with a deletion of MuRF1 is due to the selective inhibition of the ubiquitin proteasome system.

265 be stimulative to cancer stem cells and that selective inhibition of these cells by treating with MIS

266 Selective inhibition of these MRP1 pumps inside live HeL

267 al connectivity between these two areas, and selective inhibition of these projections mimicked the b

268 Selective inhibition of these protein-protein interactio

269 Collectively, these results support selective inhibition of these specific caspases as an ef

270 l of megakaryopoiesis and reveal the lineage-selective inhibition of this axis as a likely mechanisti

271 ) influx is necessary for LTD induction, and selective inhibition of this distal dendritic Ca(2)(+) i

272 minant negative Hsc70 that resembles isoform selective inhibition of this important chaperone, we fou

273 tivation of focal adhesion kinase (FAK), and selective inhibition of this kinase is also sufficient t

274 atally and provide a proof of principle that selective inhibition of this pathway may be a viable opt

275 Selective inhibition of this Treg cell wave completely a

276 icidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS)

277 Selective inhibition of TNF receptor (TNFR) 1 signaling

278 We here show the therapeutic potential of selective inhibition of TNFR1 and activation of TNFR2 by

279 Selective inhibition of translation of mRNAs harboring l

280 interferon-gamma (IFNgamma), suggesting that selective inhibition of TYK2 kinase activity might be su

281 sm of E1s and suggest a general strategy for selective inhibition of UBL conjugation pathways.

282 These effects were not mimicked by selective inhibition of VEGFR2 despite equivalent vascul

283 Here, we report that the selective inhibition of VLA-4 expression on B cells impe

284 ssive symptoms in humans and, because of its selective inhibition of VMAT-2, it preferentially deplet

285 Our data establish the feasibility of selective inhibition of Wnt/beta-catenin transcriptional

286 cause no effective treatment for IPF exists, selective inhibition of Wnt/beta-catenin-dependent trans

287 ribe a novel role for IFN in the direct, and selective, inhibition of Cxcr2 chemokine ligands, which

288 that conducts nucleosome sliding, onto which selective 'inhibition-of-inhibition' modules are placed,

289 rtension or thrombosis than cyclooxygenase-2-selective inhibition or deletion in vivo.

290 ntrosomes, mitotic spindles and midbody, and selective inhibition or silencing of TBK1 triggers defec

291 These data suggest that allele-selective inhibition proceeds through an RNA interferenc

292 veral of these exhibited a highly potent and selective inhibition profile against CA IX.

293 s highly expressed in tumor tissues, and its selective inhibition provides a potential target for the

294 different abasic duplexes achieve potent and selective inhibition, providing a broad platform for sub

295 is critical for osteoclast function, and its selective inhibition retards physiological bone loss.

296 s narrowly tuned and receives prominent odor-selective inhibition through both direct and indirect pa

297 essing interneurons (FS-PARV), which provide selective inhibition to CCort pyramidal neurons.

298 ate that these interneurons convey direction-selective inhibition to wide-field neurons with opposite

299 Substrate-selective inhibition was attenuated by the addition of t

300 This allosteric site allows for selective inhibition with respect to the homologous huma