ライフサイエンスコーパス: selective pressure

1 may not be well maintained in the absence of selective pressure.

2 while cattle were in the feedlot, indicating selective pressure.

3 eting efficiency and function in response to selective pressure.

4 enes and their maintenance in the absence of selective pressure.

5 in both populations, indicating nonspecific selective pressure.

6 asing copy number, may be sites of secondary selective pressure.

7 w them to adapt to humans through continuous selective pressure.

8 natural and engineered proteins evolve under selective pressure.

9 HSV-2 glycoproteins were evolving under less selective pressure.

10 nctional SNPs under the influence of dietary selective pressure.

11 gued that mirror neurons must be a result of selective pressure.

12 oding sequences implying a dual evolutionary selective pressure.

13 to select reassortant viruses under in vivo selective pressure.

14 inhibitor, viral subtype, and level of drug selective pressure.

15 lls, such as astrocytes, proposed as a major selective pressure.

16 rge in genetic sequences of HIV through drug-selective pressure.

17 nd whether vaccine introduction will lead to selective pressure.

18 viral proteins to mutate under drug-mediated selective pressure.

19 suggesting that this region is under strong selective pressure.

20 ight diploid yeast strains in the absence of selective pressure.

21 and to identify the corresponding phenotypic selective pressure.

22 r mutation rates as a response to changes in selective pressure.

23 vaccine candidates in the context of strong selective pressure.

24 ids, shaping MPER-specific paratopes through selective pressure.

25 th and in response to multiple, co-occurring selective pressures.

26 unctions, to generate variation and adapt to selective pressures.

27 l genome evolution is shaped by a variety of selective pressures.

28 expression, possibly reflecting sex-specific selective pressures.

29 drug concentration, and (d) the strength of selective pressures.

30 sting that they have been maintained through selective pressures.

31 ersity, recombination, allele frequency, and selective pressures.

32 qualitative insights about the corresponding selective pressures.

33 ed pathogen that has continued to respond to selective pressures.

34 advantageous genes and adapt in the face of selective pressures.

35 pread throughout the lung, suggesting global selective pressures.

36 fferent environments, which impose different selective pressures.

37 tion, rapid demographic changes, and ongoing selective pressures.

38 netic responses of the two species to recent selective pressures.

39 bservations indicate that genes under weaker selective pressure accumulate more maladaptive substitut

40 Mutational hotspots indicate selective pressure across a population of tumor samples,

41 Evolutionary analyses identified positive selective pressure across the mammalian phylogeny, and d

42 iched for transposable elements suggesting a selective pressure acting on lncRNAs length and composit

43 he stasis is likely to be due principally to selective pressure acting on pollen morphogenesis becaus

44 which raises the possibility of evolutionary selective pressure acting on the structure of the coding

45 sistency between lineages, indicating common selective pressures acting at certain loci, particularly

46 th specialized functions as a consequence of selective pressures acting on a near-infinite set of pos

47 neral and rapid approach for identifying the selective pressures acting on a pathogen in individual p

48 The genetic substrate and the selective pressures acting on brain size are poorly unde

49 ts and their relevance for understanding the selective pressures acting on parasite evolution.

50 However, sex-dependent selective pressures acting outside of female fecundity h

51 erent populations have experienced different selective pressures affecting genome integrity.

52 overall initial kill may exert differential selective pressures, affecting long-term therapeutic out

53 ence of detectable viremia as well as strong selective pressure against cell culture-adaptive mutatio

54 Selective pressure against immune escape by pathogens ca

55 iruses from breakthrough infections revealed selective pressure against neutralization-sensitive viru

56 crobial resistance by removing antimicrobial selective pressure alone rely upon resistance imparting

57 founding third variable, namely variation in selective pressure among hosts.

58 milar taxa suggested dispersal and/or common selective pressures among zones.

59 Under selective pressure, amplified oncogenes are overexpresse

60 lammatory response to infection, will reduce selective pressure and hence minimize resistance emergen

61 This has resulted in a selective pressure and opportunity to reduce the levels

62 rinsic tradeoff between drug-imposed overall selective pressure and rate of adaptation.

63 y regulatory regions contain mutations under selective pressure and suggest a greater role for regula

64 subtype-specific differences in host immune selective pressure and the ecology of transmission (in p

65 be used to implement biologically realistic selective pressures and allows exploration of the space

66 suggesting that instability patterns reflect selective pressures and can potentially identify novel c

67 torical function or if the intense divergent selective pressures and geographical barriers have creat

68 remain, the greatest being understanding the selective pressures and molecular mechanisms that underl

69 nition-which can address questions about the selective pressures and proximate mechanisms driving cog

70 luded that various barriers impose different selective pressures and that simply enriching for invasi

71 Selective pressures and various DNA transactions have be

72 ility that has not arisen under conventional selective pressure) and evolvability (the capacity to ge

73 loci were identified as being under positive selective pressure, and mutations at loci encoding polys

74 nd adaptive evolutionary response to a novel selective pressure, and that explicitly (quantitative) g

75 iric broad-spectrum beta-lactam use creating selective pressure, and the resultant emergence of stabl

76 dynamics in the context of treatment-induced selective pressures, and indicate that transformation an

77 Thus, selective pressure appears to conserve the distribution

78 Instead we hypothesized that the selective pressure applied during the establishment of [

79 Self-replication and evolution under selective pressure are inherent phenomena in life, and b

80 Gene diversity and selective pressure are intriguing topics in the field of

81 ntial for trap function, suggesting that key selective pressures are in action.

82 nt subpopulations adapt to location-specific selective pressures as they migrate and evolve across sp

83 timing of entry of virus into the brain and selective pressure associated with viral adaptation to t

84 evidence that the viruses are facing complex selective pressures associated with cross-species transm

85 tic domains arose in response to distinctive selective pressures associated with the greater complexi

86 tory, customizable antimicrobials that enact selective pressure at the DNA level to reduce the preval

87 Selective pressures at the DNA level shape genes into pr

88 described flavivirus evolution in vivo under selective pressure by a host-based antiviral drug.

89 uential progression of viral evolution under selective pressure by a host-targeted antiviral compound

90 investigate evolution of a flavivirus under selective pressure by a host-targeted antiviral in vivo.

91 Thus, selective pressure by ssNAbs to maintain the N332 glycan

92 The regulating motif is under limited selective pressure by the host immune response and may p

93 Many red cell polymorphisms are a result of selective pressure by the malarial parasite.

94 Here, we probe ancient selective pressures by computing %GC-corrected rates of

95 demographic features, spatial processes, and selective pressures can result in the accumulation and e

96 Novel selective pressures derived from human activities challe

97 was not recorded, suggesting vaccine-induced selective pressure did not occur.

98 stitutions (dS) to evaluate the variation in selective pressure (dN/dS ratio) over branches and over

99 ivity and fitness and may therefore act as a selective pressure driving evolution, but evidence to su

100 Yersinia pestis transmission exerts intense selective pressure driving the local persistence of dise

101 f resilience and how they are related to the selective pressures driving structure.

102 have contributed to our understanding of the selective pressures driving the evolution and biology of

103 n humans, and they likely experienced strong selective pressures due to their unique lifestyle in the

104 cell lineages have been subject to rigorous selective pressure during development.

105 l importance as they suggest that changes in selective pressures during fibril propagation in the hum

106 f SPI-2 T3SS effectors in the context of the selective pressures encountered by S. enterica in vivo.

107 ng to the specific niches they reside in and selective pressures encountered therein.

108 The selective pressure exerted by different oseltamivir ther

109 Selective pressure exerted by HIV-1 protease inhibitors,

110 ded evolution approach that does not require selective pressure exerted by NAbs.

111 uch as pH and metal cations can modulate the selective pressure exerted by tetracycline for developme

112 uses shape their genomes under the continual selective pressure exerted by the host immune system is

113 rum transmission was used to investigate the selective pressure exerted on parasite populations by us

114 ortance in a range of species as well as the selective pressures exerted on viruses to antagonize it.

115 Falk and colleagues hypothesized that selective pressures favored late persistence of a metopi

116 Selective pressure favoring the Cys529 codon may have co

117 ing population use of 4C antibiotics reduced selective pressures favouring multidrug-resistant epidem

118 ing population use of 4C antibiotics reduced selective pressures favouring multidrug-resistant epidem

119 Hence, when mimics and models share common selective pressures, flexible imitation of models might

120 ingle cell-derived clones maintained without selective pressure for >100 rounds of cell division show

121 How then is the selective pressure for a single miRNA/target interaction

122 This may provide a selective pressure for acquisition of mutations in the D

123 sduction of AE and AE9a resulted in a strong selective pressure for AE-expressing cells.

124 and that KIR encoded by the B genes provides selective pressure for altered p53 in BCC tumors.

125 tial risk of anti-VEGF treatments owing to a selective pressure for an adaptive resistance mechanism

126 ed camouflage pattern, suggesting a possible selective pressure for animals to orient themselves appr

127 ant rickettsial pathogen, and creates strong selective pressure for emergence of and superinfection w

128 ample exposure and application of purifying, selective pressure for enzyme products.

129 ssure toward reduced affinity conflicts with selective pressure for greater interaction, situations c

130 that in rhesus monkeys, there is independent selective pressure for loss of babA and for overexpressi

131 nosome mitochondria, which may have provided selective pressure for maintenance of mitochondrial wyos

132 pread of MDROs include oversight to decrease selective pressure for MDROs by promoting appropriate an

133 use of antibiotics with the aim to decrease selective pressure for multidrug-resistant organisms in

134 There appears to be selective pressure for mycoplasmas to retain the genes n

135 ominant importance in understanding both the selective pressure for Notch mutations in T-ALL and resp

136 trophic levels, and may also exert a strong selective pressure for particular co-evolved herbivore-p

137 These results indicate selective pressure for production of GA4 in the distinct

138 ad to decreased pesticide use and reduce the selective pressure for resistant pathogens.

139 e anti-oncogenic effects of CDK5 can provide selective pressure for the down-regulation of DLC1, whic

140 of optimal resource allocation, indicating a selective pressure for the efficient design of cellular

141 H chain V region (IGHV) genes as alternative selective pressures for B cells in pSS.

142 Thus, as CO2 levels continue to rise, selective pressures for high levels of CA may be limited

143 ing from a common progenitor under different selective pressures for millions of years, the two genes

144 across orthologs, highlighting evolutionary selective pressures for VWF.

145 Understanding how selective pressure from chemotherapy directs the evoluti

146 Viruses are under relentless selective pressure from host immune defenses.

147 ly conserved across species, suggesting that selective pressure from host-specific viruses has driven

148 ator-associated pneumonia in particular, the selective pressure from prior use of broad-spectrum anti

149 be antibiotic resistant, which could reflect selective pressures from antibiotic use in food-animal p

150 ical studies and modeling to investigate how selective pressures from fire and predispersal seed pred

151 arbon fixation, yet hypotheses regarding the selective pressures governing RuBisCO evolution have bee

152 To investigate how this selective pressure has affected the genetic regulation o

153 n vivo and in vitro, suffer from inadvertent selective pressures (i.e., altering organism fitness), r

154 We speculate that the selective pressure imposed by competition between bacter

155 provide a valuable tool for the study of the selective pressure imposed by microorganisms on host gen

156 The selective pressure imposed resulted in suppressor mutati

157 s were selected by this method, indicating a selective pressure in ferrets for the novel combination

158 ve knowledge of the molecular networks under selective pressure in oncogenesis.

159 psular pneumococcal genes under differential selective pressure in SCD, which correlated with aspects

160 utionary twist underscores the importance of selective pressure in virus-host relationships.

161 r, how these activities are maintained under selective pressure in vivo remains elusive.

162 via the transfer of mobile genetic elements, selective pressure in vivo resulting in gene mutations,

163 namics of environmental variation and on the selective pressures in each condition.

164 rentiate in response to similar Ag-dependent selective pressures in malaria-exposed children and that

165 the need to investigate interactions between selective pressures in other cases of puzzling adaptive

166 isolated from mopane trees, to determine how selective pressures in the environment coincidentally ad

167 ough investigation of the impacts of diverse selective pressures including genetic alterations, thera

168 polar to equatorial regions due to changing selective pressures including heat, humidity, predation

169 tantly evolving as tumor cells face changing selective pressures induced by the cells themselves, the

170 ny variables, potentially involving external selective pressures induced by therapies.

171 the occurrence of teaching behaviour and the selective pressures influencing its presence.

172 highly variable environments and introduced selective pressures influencing the diversification of e

173 rs, possibly resulting from lineage-specific selective pressures inherent to each taxon.

174 emonstrating rapid spread of resistance when selective pressure is high.

175 However, their genetic stability under selective pressure is largely unknown.

176 However, this selective pressure is later relaxed when secondary consu

177 t life stages, resulting in unusually strong selective pressure levied by their host ants.

178 n of this strategy, it has been unclear what selective pressure maintains the fitness of this develop

179 Different selective pressures may also promote different rates of

180 ing is limited in CF lungs and that regional selective pressures may markedly differ.

181 Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenv

182 occi conserve this enzyme despite the lethal selective pressure of antibiotics.

183 t in leaf venation may be explained from the selective pressure of aridity, under which traits associ

184 ctive HCV suppression, demonstrate the added selective pressure of combination therapy, and confirm a

185 ctive HCV suppression, demonstrate the added selective pressure of combination therapy, and confirm a

186 tDNA demonstrated tumour evolution under the selective pressure of NAC e.g. in one case, urine analys

187 o the new infection, but in the new host the selective pressure of the immune response yields the div

188 skin pigmentation evolved in response to the selective pressure of ultra-violet radiation (UVR).

189 h and survival strategies in response to the selective pressures of life in a biological community, [

190 ism whose adaptive value originates from the selective pressures of life in biological communities, t

191 The selective pressures of widespread macrolide use and PCV7

192 exposure to phage infection imposes a strong selective pressure on bacteria to develop viral resistan

193 t of LCN2, demonstrating that LCN2 imparts a selective pressure on bacterial growth in the bladder.

194 of the study was shown to exert considerable selective pressure on both the extent and nature of Pseu

195 xternal region remained stable, suggesting a selective pressure on gp120 preferentially.

196 do not fully understand the effects of drug selective pressure on long-term drug resistance potentia

197 m Bacillus thuringiensis (Bt) places intense selective pressure on pest populations to evolve resista

198 evolution is determined by a combination of selective pressure on protein function and biophysical c

199 h as nutrient availability has a significant selective pressure on the biodiversity of microorganisms

200 rces for the gut microbiota, imposing strong selective pressure on the complex microbial consortium o

201 with microbial pathogens, which exert strong selective pressure on the immune systems of their hosts.

202 eated reactivation events, suggesting strong selective pressure on the viral genome to maintain seque

203 harsh northern conditions may impose greater selective pressure on timing of growth cessation, and th

204 in natural populations might be an important selective pressure on traits of bacteria that facilitate

205 Precision medicines exert selective pressure on tumour cells that leads to the pre

206 To determine the effect of selective pressure on variant frequency, we investigated

207 ccine-induced immunity does not exert strong selective pressure on viruses replicating in individual

208 d distribution of food resources is a strong selective pressure on wild primates.

209 These responses exert strong selective pressures on different parts of HIV's genome,

210 ch is consistent with differential impact of selective pressures on different regions of the skull.

211 a phylogeny for six species, with different selective pressures on G+C content among lineages, and c

212 n understanding the effects of distinct drug selective pressures on short-term and long-term tumor re

213 s novel, quantitative support for a shift in selective pressures on socio-sexual display mechanisms i

214 e need to remain unseen generate contrasting selective pressures on the eyes of mesopelagic inhabitan

215 bacterial genomes provided evidence that the selective pressures on the HK-RR interface are different

216 t with this hypothesis but implies different selective pressures on the immune system due to contrast

217 plored the impact of demographic history and selective pressures on the P. vivax genome by sequencing

218 tumor-type specific, suggesting differential selective pressures on the two tumor cell types.

219 therapeutic strategies that combine opposing selective pressures on this parasite transporter as an a

220 Vaccination can place selective pressures on viral populations, leading to cha

221 immune modulation, through differing immune selective pressures, on viral evolutionary behavior in a

222 but whether it relies upon extrinsic immune-selective pressure or is inherently orchestrated by onco

223 the potential for influenza viruses to evade selective pressures or adapt to new host environments.

224 ed as complex mixtures, presumably shaped by selective pressure over evolutionary timescales, some of

225 This change might have worked as a selective pressure over the metabolic pathways involved

226 trait architectures may be due to different selective pressures over time.

227 ed in the Southern Ocean suggests that other selective pressures, particularly food availability and

228 kbone dynamics have been subject to moderate selective pressure, perhaps contributing to our observat

229 s, which do not reflect the complexities and selective pressures present in an infected organism.

230 substitution and be favoured in response to selective pressures presumably related to the presence o

231 n that tumour evolution may be influenced by selective pressure provided by therapy, in a similar fas

232 e influences evolutionary rates by modifying selective pressures rather than through its effect on en

233 indicating that carnivores are under strong selective pressure related to diet.

234 vent target elimination under miRNA-mediated selective pressure, restricting their use in vaccine dev

235 ential to provide valuable insights into the selective pressures shaping decision-making during evolu

236 e-ranging implications for understanding the selective pressures shaping host ecology and ecosystem s

237 In this study, we sought to understand the selective pressures shaping the Ig-producing cell repert

238 ulation appeared to diversify in response to selective pressures, showing a statistically significant

239 tionships of obligate mutualists may lead to selective pressures similar to those seen in parasites,

240 The innate immune system has evolved under selective pressure since the radiation of multicellular

241 iate assumption because spatial variation in selective pressures such as temperature can lead to loca

242 hin and between commensals in the absence of selective pressure, such as an antibiotic.

243 s for their ability to evolve in response to selective pressure, such as the presence of antiviral dr

244 of proteins to respond rapidly to divergent selective pressures, such as sexual conflict or reproduc

245 tic tumor- and tissue-specific variations in selective pressures suggest that cancer cells with advan

246 omain TLR genes underwent stronger purifying selective pressures than three-domain TLR genes in mamma

247 that TRmIND is under different evolutionary selective pressures than TRmD.

248 The selective pressure that drives antigenic changes in infl

249 fragmentation to produce a strong Darwinian selective pressure that drives forward the rapid emergen

250 enced in the environment can act as a strong selective pressure that drives the evolution of life his

251 Nutrient scarcity is a selective pressure that has shaped the evolution of most

252 neous delivery of dual Ags may alleviate the selective pressure that is thought to potentiate antigen

253 ase the use of antibiotics, thereby reducing selective pressure that leads to antibiotic resistance m

254 Antimicrobial drug use generates selective pressure that may lead to resistance against t

255 The disturbance imposed a strong selective pressure that persisted for up to 10 days, aft

256 ly that these lymphoma cells have adapted to selective pressure that promotes cell death by altering

257 ange their environment, thereby imposing new selective pressures that can modify their biological tra

258 ase environments and are subject to shifting selective pressures that can result in pathoadaptation o

259 to understand the nature and strength of the selective pressures that contributed to shape current pa

260 er the negative evolutionary change, nor the selective pressures that drive it, are apparent on the p

261 The selective pressures that drive strain divergence, which

262 ur understanding of local adaptation and the selective pressures that drive the extensive phenotypic

263 widespread use of antibiotics has generated selective pressures that have driven the emergence of re

264 ithin and among hosts and separates distinct selective pressures that impose differences in both the

265 Here we describe potential selective pressures that led to the fixation of laborato

266 nged, and suggest that climate is one of the selective pressures that led to their speciation.

267 ally and together, in order to elucidate the selective pressures that maintain multi-modal defence me

268 We review the putative selective pressures that may have led to the evolution o

269 t with bacteria, but they also highlight new selective pressures that may have promoted the evolution

270 s to identify biases in gene content and the selective pressures that preserved the surviving ancestr

271 ors, the recognition of the species-specific selective pressures that seasonal change presents for ea

272 target HCV nonstructural proteins, and with selective pressure, the virus may develop a resistant st

273 Early environmental conditions and the selective pressures they impose may help to explain vari

274 ast number of these ancient variants and the selective pressures they survived yield insights into ge

275 nd infectious diseases have imposed a strong selective pressure throughout human history.

276 sert stability suggested that RSV F is under selective pressure to be silenced during vector replicat

277 if cheaters are punished, there is a strong selective pressure to cooperate.

278 s substantial metabolic energy, resulting in selective pressure to decrease resource consumption by t

279 n have led to the idea that GAS may be under selective pressure to decrease secreted SpeB protease ac

280 result, the mosaics are not under long-term selective pressure to encode a functional protein; conse

281 n and therefore place microbes under extreme selective pressure to evolve resistance.

282 In particular, in SDS there is enormous selective pressure to expand TP53-mutated HSPCs, suggest

283 rest of the amino acid sequence despite the selective pressure to keep terminase gene products activ

284 evolved multiple times, suggesting a strong selective pressure to minimize predation risk.

285 Importantly, FL BCR is characterized by a selective pressure to retain surface immunoglobulin M (I

286 n a dynamic scoring function, which uses the selective pressure to score aligned residues.

287 ance may release former constraints on other selective pressures to breed early, such as seasonal dec

288 cence, which is under identical age-specific selective pressures to fertility.

289 s of social affiliation dynamics may provide selective pressures to limit the size of behaviorally-de

290 limited power for differentiating among the selective pressures to which closely linked selected sit

291 ate an early origin of rods, implying strong selective pressure toward dim-light vision in Cambrian e

292 ent than expected by chance, consistent with selective pressure tuning ASE at multiple regulatory ste

293 explain the uniqueness of our brain and the selective pressures under which it evolves.

294 often occurred in the distant past, and the selective pressures underlying these ancient events have

295 fer and more stable than strains obtained by selective pressure via mutagenic nucleotides or adaptati

296 domestication/evolution of crop plants, the selective pressure was human imposed and involved humans

297 To detect loci under selection and estimate selective pressure, we also developed a new method compa

298 th compact genomes and rapid evolution under selective pressure will be a rich source of examples of

299 , we show that the nonlinearity of change in selective pressure with phenotype matters more to popula

300 read, allopatric clades, it is unlikely that selective pressures would be so similar across such diff